Shreya Gopalakrishnan
About
I am currently a Senior Researcher in the CAG-IBD research group at the Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU, Norway. I obtained my Master’s degree in Infection and Immunity (2013) from University College London (UCL), UK, and completed my PhD in Mucosal Immunology at Kiel University, Germany, with a thesis focused on the role of X-linked inhibitor of apoptosis protein (XIAP) in intestinal homeostasis and inflammatory bowel disease (IBD). Following my PhD, I moved to Norway to join the CAG-IBD group at NTNU as a postdoctoral researcher, where I contributed to the establishment and development of patient-derived intestinal organoid platforms for studying epithelial biology and treatment responses in IBD.
In addition to my academic research experience, I worked at Johnson & Johnson Innovative Medicine in Belgium as a Postdoctoral Scientist in pre-clinical toxicology, where I developed high-throughput drug testing workflows using intestinal organoids, high-content imaging, and transcriptomic profiling. My research trajectory spans immunology, mucosal biology, organoid technology development, and translational toxicology, shaped by experience across academic and industrial environments including NTNU, Yale School of Medicine, and Johnson & Johnson.
My current work focuses on advancing human intestinal epithelial models and high-throughput quantitative pipelines to address clinically relevant questions in inflammatory bowel disease.
Research
https://www.ntnu.edu/cag-ibd/
Publications
2025
-
Sridhar, Arun;
Bakke, Ingunn;
Gopalakrishnan, Shreya;
Osoble, Nimo Mukhtar Mohamud;
Hammarqvist, Emilie Prytz;
Pettersen, Henrik Sahlin.
(2025)
Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids.
Scientific Reports
Academic article
2023
-
Walaas, Gunnar Andreas;
Gopalakrishnan, Shreya;
Bakke, Ingunn;
Skovdahl, Helene Kolstad;
Flatberg, Arnar;
Østvik, Ann Elisabeth.
(2023)
Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.
Frontiers in Immunology
Academic article
-
Gopalakrishnan, Shreya;
Bakke, Ingunn;
Hansen, Marianne Dore;
Skovdahl, Helene Kolstad;
Granlund, Atle van Beelen;
Sandvik, Arne Kristian.
(2023)
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids.
Frontiers in Immunology
Academic article
2022
-
Gopalakrishnan, Shreya;
Hansen, Marianne Dore;
Skovdahl, Helene Kolstad;
Roseth, Ingrid Aass;
Granlund, Atle van Beelen;
Østvik, Ann Elisabet.
(2022)
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in Immunology
Academic article
2021
-
Strigli, Anne;
Gopalakrishnan, Shreya;
Zeissig, Yvonne;
Basic, Marijana;
Wang, Jun;
Schwerd, Tobias.
(2021)
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
Science immunology
Academic article
-
Skovdahl, Helene Kolstad;
Gopalakrishnan, Shreya;
Svendsen, Tarjei Dahl;
Granlund, Atle van Beelen;
Bakke, Ingunn;
Ginbot, Zekarias.
(2021)
Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration.
Frontiers in Pharmacology
Academic article
2020
-
Bakke, Ingunn;
Bruland, Torunn;
Eriksen, Kaja Sørgård;
Skovdahl, Helene Kolstad;
Gopalakrishnan, Shreya;
Thorsvik, Silje.
(2020)
Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease.
Journal of Crohn`s and Colitis
Abstract
2016
-
Rausch, Philipp;
Basic, Marijana;
Batra, Arvind;
Bischoff, Stephan C.;
Michael, Blaut;
Thomas, Clavel.
(2016)
Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities.
International Journal of Medical Microbiology
Academic article
Journal publications
-
Sridhar, Arun;
Bakke, Ingunn;
Gopalakrishnan, Shreya;
Osoble, Nimo Mukhtar Mohamud;
Hammarqvist, Emilie Prytz;
Pettersen, Henrik Sahlin.
(2025)
Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids.
Scientific Reports
Academic article
-
Walaas, Gunnar Andreas;
Gopalakrishnan, Shreya;
Bakke, Ingunn;
Skovdahl, Helene Kolstad;
Flatberg, Arnar;
Østvik, Ann Elisabeth.
(2023)
Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.
Frontiers in Immunology
Academic article
-
Gopalakrishnan, Shreya;
Bakke, Ingunn;
Hansen, Marianne Dore;
Skovdahl, Helene Kolstad;
Granlund, Atle van Beelen;
Sandvik, Arne Kristian.
(2023)
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids.
Frontiers in Immunology
Academic article
-
Gopalakrishnan, Shreya;
Hansen, Marianne Dore;
Skovdahl, Helene Kolstad;
Roseth, Ingrid Aass;
Granlund, Atle van Beelen;
Østvik, Ann Elisabet.
(2022)
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in Immunology
Academic article
-
Strigli, Anne;
Gopalakrishnan, Shreya;
Zeissig, Yvonne;
Basic, Marijana;
Wang, Jun;
Schwerd, Tobias.
(2021)
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
Science immunology
Academic article
-
Skovdahl, Helene Kolstad;
Gopalakrishnan, Shreya;
Svendsen, Tarjei Dahl;
Granlund, Atle van Beelen;
Bakke, Ingunn;
Ginbot, Zekarias.
(2021)
Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration.
Frontiers in Pharmacology
Academic article
-
Bakke, Ingunn;
Bruland, Torunn;
Eriksen, Kaja Sørgård;
Skovdahl, Helene Kolstad;
Gopalakrishnan, Shreya;
Thorsvik, Silje.
(2020)
Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease.
Journal of Crohn`s and Colitis
Abstract
-
Rausch, Philipp;
Basic, Marijana;
Batra, Arvind;
Bischoff, Stephan C.;
Michael, Blaut;
Thomas, Clavel.
(2016)
Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities.
International Journal of Medical Microbiology
Academic article
Outreach
2023
-
Academic lectureWalaas, Gunnar Andreas; Gopalakrishnan, Shreya; Bakke, Ingunn; Skovdahl, Helene Kolstad; Flatberg, Arnar; Østvik, Ann Elisabeth. (2023) Fysiologisk hypoksi forbedrer vekst og funksjonell differensiering av humane tarmepitelorganoider. Norsk Gastroenterologisk Forening , Lillehammer 09.02.2023 - 11.02.2023