Sjoerd Hak
About
Nanomedicines are extensively studied for in vivo therapeutic and diagnostic applications. Although several nanodrugs have been clinically approved and many are in clinical trials, the medical potential of these agents remains to be fully exploited. There are multiple reasons for this unsatisfactory utilization, but an important underlying issue is incomplete understanding of nanoparticle in vivo applications.
In my group, we attempt to define the gaps in the knowledge about nanoparticle ‘in vivo behavior’, and develop and use a range of methods to address these issues. At the heart of our effort lie various in vivo imaging modalities, like whole animal optical imaging, magnetic resonance imaging, and intravital microscopy. Especially intravital microscopy has proven extremely powerful for studying nanoparticle drug release and tumor targeting kinetics, as well as nanoparticle interactions with various cells in real-time. For ex vivo analysis, we have implemented state-of-the-art flow cytometry approaches allowing us to map interactions of administered nanoparticles with numerous cell types. Using this combination of in vivo and ex vivo methods, we are now discovering pivotal roles for various cells of the immune system in nanoparticle in vivo applications.
Using the new and exciting insights we gained over recent years, we are aiming to develop novel nanotherapeutic approaches with a focus on cancer. At the same time, we continue to increase our understanding of nanoparticles’ complex ‘in vivo behavior’.
Publications
2022
-
Momoh, Jeffrey;
Kapsokalyvas, Dimitrios;
Vogt, Michael;
Hak, Sjoerd;
Kiessling, Fabian;
van Zandvoort, Marc.
(2022)
Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes.
Advanced Drug Delivery Reviews
Academic literature review
2021
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Sofias, Alexandros Marios;
Bjørkøy, Geir;
Ochando, Jordi;
Sønstevold, Linda;
Hegvik, Maria;
Davies, Catharina de Lange.
(2021)
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes.
Advanced Science
Academic article
2020
-
Priem, Bram;
van Leent, Mandy M. T.;
Teunissen, Abraham J. P.;
Sofias, Alexandros Marios;
Mourits, Vera P.;
Willemsen, Lisa.
(2020)
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell
Academic article
-
Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Senders, Max L.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Sanchez-Gaytan, Brenda L.;
van de Voort, Jan C.;
Toner, Yohana C..
(2020)
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.
Nature Nanotechnology
Academic article
-
Sofias, Alexandros Marios;
Toner, Yohana C.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Soultanidis, Georgios;
Elschot, Mattijs.
(2020)
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking.
ACS Nano
Academic article
2019
-
Sofias, Alexandros Marios;
Åslund, Andreas;
Hagen, Nils;
Grendstad, Kristin;
Hak, Sjoerd.
(2019)
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice.
Molecular Imaging and Biology
Academic article
-
Combes, Francis;
Sofias, Alexandros Marios;
Mc Cafferty, Séan;
Huysmans, Hanne;
De Temmerman, Joyca;
Hak, Sjoerd.
(2019)
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes .
Cancers
Academic article
2018
-
Sofias, Alexandros Marios;
Andreassen, Trygve;
Hak, Sjoerd.
(2018)
Nanoparticle Ligand-Decoration Procedures Affect in Vivo Interactions with Immune Cells.
Molecular Pharmaceutics
Academic article
-
Witzigmann, Dominik;
Hak, Sjoerd;
van der Meel, Roy.
(2018)
Translating nanomedicines: Thinking beyond materials? A young investigator's reply to `The Novelty Bubble’.
Journal of Controlled Release
Academic article
2017
-
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Hak, Sjoerd;
Peddis, Davide;
Bandyopadhyay, Sulalit;
Sandvig, Ioanna.
(2017)
Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.
Journal of materials chemistry. B
Academic article
-
Sanchez-Gaytan, Brenda L;
Fay, Francois;
Hak, Sjoerd;
Alaarg, Amr;
Fayad, Zahi A;
Perez-Medina, Carlos.
(2017)
Real-Time Monitoring of Nanoparticle Formation by FRET Imaging.
Angewandte Chemie International Edition
Academic article
-
Perez-Medina, Carlos;
Hak, Sjoerd;
Reiner, Thomas;
Fayad, Zahi A;
Nahrendorf, Matthias;
Mulder, Willem J. M..
(2017)
Integrating nanomedicine and imaging.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Academic literature review
2016
-
McDonagh, Birgitte Hjelmeland;
Singh, Gurvinder;
Hak, Sjoerd;
Bandyopadhyay, Sulalit;
Augestad, Ingrid Lovise;
Peddis, Davide.
(2016)
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.
Small
Academic article
-
Zhao, Yiming;
Fay, Francois;
Hak, Sjoerd;
Manuel Perez-Aguilar, Jose;
Sanchez-Gaytan, Brenda L;
Goode, Brandon.
(2016)
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.
Nature Communications
Academic article
-
Snipstad, Sofie;
Hak, Sjoerd;
Baghirov, Habib;
Sulheim, Einar;
Mørch, Ýrr Asbjørg;
Lelu, Sylvie.
(2016)
Labeling nanoparticles: Dye leakage and altered cellular uptake.
Cytometry Part A
Academic article
2015
-
Hak, Sjoerd;
Garaiova, Zuzana;
Olsen, Linda Therese;
Nilsen, Asbjørn Magne;
Davies, Catharina De Lange.
(2015)
The effects of oil-in-water nanoemulsion polyethylene glycol surface density on intracellular stability, pharmacokinetics, and biodistribution in tumor bearing mice.
Pharmaceutical Research
Academic article
-
Hak, Sjoerd;
Goa, Pål Erik;
Stenmark, Sebastian Tegnér;
Bjerkholt, Frøydis F;
Haraldseth, Olav.
(2015)
Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.
Magnetic Resonance in Medicine
Academic article
-
Mørch, Ýrr Asbjørg;
Hansen, Rune;
Berg, Sigrid;
Åslund, Andreas;
Glomm, Wilhelm;
Eggen, Siv.
(2015)
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery.
Contrast Media & Molecular Imaging
Academic article
-
Åslund, Andreas;
Berg, Sigrid;
Hak, Sjoerd;
Mørch, Ýrr Asbjørg;
Torp, Sverre Helge;
Sandvig, Axel.
(2015)
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles.
Journal of Controlled Release
Academic article
2014
-
Hak, Sjoerd;
Cebulla, Jana;
Huuse, Else Marie;
Davies, Catharina de Lange;
Mulder, Willem J. M.;
Larsson, Henrik.
(2014)
Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy.
Angiogenesis
Academic article
2013
-
Zhao, Yiming;
van Rooy, Inge;
Hak, Sjoerd;
Fay, Francois;
Tang, Jun;
Davies, Catharina De Lange.
(2013)
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.
ACS Nano
Academic article
-
Hak, Sjoerd.
(2013)
Improving nanoparticles for battling cancer.
Website (informational material)
-
Garaiova, Zuzana;
Hak, Sjoerd;
Davies, Catharina De Lange;
Hianik, Tibor.
(2013)
Interaction of nanoparticles with biomembranes and lipid vesicles modified by artificial receptors.
European Biophysics Journal
Abstract
2012
-
Hak, Sjoerd;
Helgesen, Emily;
Hektoen, Helga;
Huuse, Else Marie;
Jarzyna, Peter A.;
Mulder, Willem J.M..
(2012)
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging.
ACS Nano
Academic article
2010
-
Hak, Sjoerd;
Reitan, Nina Kristine;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2010)
Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles.
Angiogenesis
Academic literature review
2009
-
Kok, Maarten B.;
Hak, Sjoerd;
Mulder, Willem J.M.;
van der Schaft, Daisy W.;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Magnetic Resonance in Medicine
Academic article
-
Strijkers, Gustav J.;
Hak, Sjoerd;
Kok, Maarten B.;
Springer, Charles;
Nicolay, Klaas.
(2009)
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.
Magnetic Resonance in Medicine
Academic article
-
Hak, Sjoerd;
Sanders, Erik H.M.;
Agrawal, Prashant;
Langereis, Sander;
Grull, Holger;
Keizer, Henk M..
(2009)
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.
European journal of pharmaceutics and biopharmaceutics
Academic article
2008
-
Mulder, Willem J.M.;
Cormode, David P.;
Hak, Sjoerd;
Lobatto, Mark E.;
Silvera, Stefano;
Fayad, Zahi A.
(2008)
Multimodality nanotracers for cardiovascular applications.
Nature Clinical Practice Cardiovascular Medicine
Academic literature review
Journal publications
-
Momoh, Jeffrey;
Kapsokalyvas, Dimitrios;
Vogt, Michael;
Hak, Sjoerd;
Kiessling, Fabian;
van Zandvoort, Marc.
(2022)
Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes.
Advanced Drug Delivery Reviews
Academic literature review
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Sofias, Alexandros Marios;
Bjørkøy, Geir;
Ochando, Jordi;
Sønstevold, Linda;
Hegvik, Maria;
Davies, Catharina de Lange.
(2021)
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes.
Advanced Science
Academic article
-
Priem, Bram;
van Leent, Mandy M. T.;
Teunissen, Abraham J. P.;
Sofias, Alexandros Marios;
Mourits, Vera P.;
Willemsen, Lisa.
(2020)
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell
Academic article
-
Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Senders, Max L.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Sanchez-Gaytan, Brenda L.;
van de Voort, Jan C.;
Toner, Yohana C..
(2020)
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.
Nature Nanotechnology
Academic article
-
Sofias, Alexandros Marios;
Toner, Yohana C.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Soultanidis, Georgios;
Elschot, Mattijs.
(2020)
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking.
ACS Nano
Academic article
-
Sofias, Alexandros Marios;
Åslund, Andreas;
Hagen, Nils;
Grendstad, Kristin;
Hak, Sjoerd.
(2019)
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice.
Molecular Imaging and Biology
Academic article
-
Combes, Francis;
Sofias, Alexandros Marios;
Mc Cafferty, Séan;
Huysmans, Hanne;
De Temmerman, Joyca;
Hak, Sjoerd.
(2019)
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes .
Cancers
Academic article
-
Sofias, Alexandros Marios;
Andreassen, Trygve;
Hak, Sjoerd.
(2018)
Nanoparticle Ligand-Decoration Procedures Affect in Vivo Interactions with Immune Cells.
Molecular Pharmaceutics
Academic article
-
Witzigmann, Dominik;
Hak, Sjoerd;
van der Meel, Roy.
(2018)
Translating nanomedicines: Thinking beyond materials? A young investigator's reply to `The Novelty Bubble’.
Journal of Controlled Release
Academic article
-
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Hak, Sjoerd;
Peddis, Davide;
Bandyopadhyay, Sulalit;
Sandvig, Ioanna.
(2017)
Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.
Journal of materials chemistry. B
Academic article
-
Sanchez-Gaytan, Brenda L;
Fay, Francois;
Hak, Sjoerd;
Alaarg, Amr;
Fayad, Zahi A;
Perez-Medina, Carlos.
(2017)
Real-Time Monitoring of Nanoparticle Formation by FRET Imaging.
Angewandte Chemie International Edition
Academic article
-
Perez-Medina, Carlos;
Hak, Sjoerd;
Reiner, Thomas;
Fayad, Zahi A;
Nahrendorf, Matthias;
Mulder, Willem J. M..
(2017)
Integrating nanomedicine and imaging.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Academic literature review
-
McDonagh, Birgitte Hjelmeland;
Singh, Gurvinder;
Hak, Sjoerd;
Bandyopadhyay, Sulalit;
Augestad, Ingrid Lovise;
Peddis, Davide.
(2016)
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.
Small
Academic article
-
Zhao, Yiming;
Fay, Francois;
Hak, Sjoerd;
Manuel Perez-Aguilar, Jose;
Sanchez-Gaytan, Brenda L;
Goode, Brandon.
(2016)
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.
Nature Communications
Academic article
-
Snipstad, Sofie;
Hak, Sjoerd;
Baghirov, Habib;
Sulheim, Einar;
Mørch, Ýrr Asbjørg;
Lelu, Sylvie.
(2016)
Labeling nanoparticles: Dye leakage and altered cellular uptake.
Cytometry Part A
Academic article
-
Hak, Sjoerd;
Garaiova, Zuzana;
Olsen, Linda Therese;
Nilsen, Asbjørn Magne;
Davies, Catharina De Lange.
(2015)
The effects of oil-in-water nanoemulsion polyethylene glycol surface density on intracellular stability, pharmacokinetics, and biodistribution in tumor bearing mice.
Pharmaceutical Research
Academic article
-
Hak, Sjoerd;
Goa, Pål Erik;
Stenmark, Sebastian Tegnér;
Bjerkholt, Frøydis F;
Haraldseth, Olav.
(2015)
Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.
Magnetic Resonance in Medicine
Academic article
-
Mørch, Ýrr Asbjørg;
Hansen, Rune;
Berg, Sigrid;
Åslund, Andreas;
Glomm, Wilhelm;
Eggen, Siv.
(2015)
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery.
Contrast Media & Molecular Imaging
Academic article
-
Åslund, Andreas;
Berg, Sigrid;
Hak, Sjoerd;
Mørch, Ýrr Asbjørg;
Torp, Sverre Helge;
Sandvig, Axel.
(2015)
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles.
Journal of Controlled Release
Academic article
-
Hak, Sjoerd;
Cebulla, Jana;
Huuse, Else Marie;
Davies, Catharina de Lange;
Mulder, Willem J. M.;
Larsson, Henrik.
(2014)
Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy.
Angiogenesis
Academic article
-
Zhao, Yiming;
van Rooy, Inge;
Hak, Sjoerd;
Fay, Francois;
Tang, Jun;
Davies, Catharina De Lange.
(2013)
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.
ACS Nano
Academic article
-
Garaiova, Zuzana;
Hak, Sjoerd;
Davies, Catharina De Lange;
Hianik, Tibor.
(2013)
Interaction of nanoparticles with biomembranes and lipid vesicles modified by artificial receptors.
European Biophysics Journal
Abstract
-
Hak, Sjoerd;
Helgesen, Emily;
Hektoen, Helga;
Huuse, Else Marie;
Jarzyna, Peter A.;
Mulder, Willem J.M..
(2012)
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging.
ACS Nano
Academic article
-
Hak, Sjoerd;
Reitan, Nina Kristine;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2010)
Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles.
Angiogenesis
Academic literature review
-
Kok, Maarten B.;
Hak, Sjoerd;
Mulder, Willem J.M.;
van der Schaft, Daisy W.;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Magnetic Resonance in Medicine
Academic article
-
Strijkers, Gustav J.;
Hak, Sjoerd;
Kok, Maarten B.;
Springer, Charles;
Nicolay, Klaas.
(2009)
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.
Magnetic Resonance in Medicine
Academic article
-
Hak, Sjoerd;
Sanders, Erik H.M.;
Agrawal, Prashant;
Langereis, Sander;
Grull, Holger;
Keizer, Henk M..
(2009)
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Mulder, Willem J.M.;
Cormode, David P.;
Hak, Sjoerd;
Lobatto, Mark E.;
Silvera, Stefano;
Fayad, Zahi A.
(2008)
Multimodality nanotracers for cardiovascular applications.
Nature Clinical Practice Cardiovascular Medicine
Academic literature review
INFORMASJONSMATR
-
Hak, Sjoerd.
(2013)
Improving nanoparticles for battling cancer.
Website (informational material)
Media
2022
-
PosterBokil, Ansooya Avinash; Børkja , Mathieu Le Boulvais ; Wolowczyk, Camilla; Bofin, Anna Mary; Hak, Sjoerd; Giambelluca, Miriam Soledad. (2022) DISCOVERING MARKERS THAT IDENTIFY PRO-METASTATIC IMMUNE CELL SUBSETS. European Society for Medical Oncology European Society for Medical Oncology Immuno-Oncology Congress , Geneva 2022-12-07 - 2022-12-09
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PosterWolowczyk, Camilla; Bokil, Ansooya Avinash; Hak, Sjoerd; Bjørkøy, Geir; Giambelluca, Miriam Soledad. (2022) A new role for CXCL3 in shaping the metastatic tumor microenvironment . ESMO IMMUNO-ONCOLOGY CONGRESS 2022 2022-12-07 - 2022-12-09
2021
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InterviewBorgos, Sven Even F.; Benjaminsen, Christina; Hak, Sjoerd. (2021) Hvor sikre er koronavaksinene?. Gemini.no Gemini.no [Internet] 2021-01-14
2019
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LectureSofias, Alexandros Marios; Pérez-Medina, Carlos; Mulder, Willem J.M.; Hak, Sjoerd. (2019) Unraveling the intricate in vivo fate of active-targeting nanomedicines. NanoSymposium 2019 2019-10-16 - 2019-10-17
2018
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PosterHak, Sjoerd; Hagen, Nils; Sofias, Alexandros Marios; Åslund, Andreas; Davies, Catharina de Lange. (2018) Simple and robust intravital microscopy procedures in TIE2GFP mice. ESCDD 2018 2018-04-11 - 2018-04-13
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LectureSofias, Alexandros Marios; Ochando, Jordi; Flobak, Åsmund; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Tumor targeting by cRGD-modified nanoparticles is dominated by immune cell hitchhiking. WMIC 2018 2018-09-12 - 2018-09-15
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LectureSofias, Alexandros Marios; Ochando, Jordi; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Hitchhiking with immune cells: Dominant tumor targeting mechanism for cRGD-modified nanoparticles. TMII 2018 2018-04-26 -
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PosterSofias, Alexandros Marios; Ochando, Jordi; Grendstad, Kristin; Flobak, Åsmund; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Tumor angiogenesis targeting by cRGD-modified nanoparticles is dominated by neutrophil hitchhiking. ESCDD 2018 2018-04-11 - 2018-04-13
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PosterSofias, Alexandros Marios; Ochando, Jordi; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Circulating phagocytes contribute to angiogenesis targeting by cRGD-conjugated nanoparticles. NanoDDS 2018 2018-09-21 - 2018-09-23
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PosterSofias, Alexandros Marios; Hak, Sjoerd. (2018) Embracing the Stealth Mode: Composing cRGD-modified lipid based nanoparticles able to escape extensive phagocytosis. CRS 2018 2018-07-22 - 2018-07-24
2017
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LectureMolska, Alicja; Sofias, Alexandros Marios; Nyman, Axel Karl Gottfrid; Hak, Sjoerd; Widerøe, Marius. (2017) Melatonin treatment for hypoxic-ischemic brain injury. Lipid-based nanoparticles as a platform for drug delivery. NRSN The 5th National PhD Conference in Neuroscience , Sommarøy 2017-09-20 - 2017-09-22
2016
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PosterMolska, Alicja; Hak, Sjoerd; Widerøe, Marius. (2016) Lipid-based nanoparticles as a platform for drug delivery - melatonin treatment of hypoxic-ischemic brain injury. Medlm and CIUS The 8th National PhD Conference in Medical Imaging , Trondheim 2016-11-21 - 2016-11-22
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PosterSofias, Alexandros Marios; Widerøe, Marius; Davies, Catharina De Lange; Haraldseth, Olav; Hak, Sjoerd. (2016) Elucidating targeting kinetics towards integrins: A quantitative study. Norwegian Research School in Medical Imaging The 8th National PhD Conference in Medical Imaging - MedIm 2016 , Trondheim 2016-11-21 - 2016-11-22
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PosterHak, Sjoerd; Zhao, Yiming; Mulder, Willem J.M.; de Lange Davies, Catharina; Haraldseth, Olav. (2016) A fluorescence Resonance energy transfer method to study payload release kinetics from lipid-based nanoparticles. European Symposium on Controlled Drug Delivery 2016-04-13 - 2016-04-15
2015
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PosterMcDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Sandvig, Ioanna. (2015) L-DOPA-coated manganese oxide nanoparticles as dual MRI contrast agents and potential drug delivery vehicles . Scandinavian Physiological Society Nordic Neuroscience 2015 , Trondheim 2015-06-10 - 2015-06-12
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PosterHak, Sjoerd; Åslund, Andreas K. O.; Zhao, Yiming; Mulder, Willem J.M.; Haraldseth, Olav; Davies, Catharina De Lange. (2015) A fluorescence resonance energy transfer labeling method to study dissociation kinetics of lipid-based nanoparticles. World Molecular Imaging Conference 2015-09-02 - 2015-09-05
2014
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LectureÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Widerøe, Marius. (2014) Nanoparticle-microbubbles and focused ultrasound to penetrate the blood-brain barrier. COST action TD1004 COST TD1004 Action: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery , Kaya Ramada Hotel, Istanbul 2014-10-03 - 2014-10-04
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PosterÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Sandvig, Axel; Torp, Sverre Helge. (2014) Delivery of multifunctional nanoparticles across the blood-brain barrier. Medim/medviz The 2014 Joint National PhD Conference in Medical Imaging and MedViz Conference , Grand Terminus Hotel, Bergen, Norway 2014-06-17 - 2014-06-18
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LectureÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel. (2014) Multifunctional nanoparticles for drug delivery across the blood-brain barrier. Biofysikkmøtet 2014 , Soria Moria, Holmenkollen 2014-03-06 - 2014-03-07
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Academic lectureHak, Sjoerd; Zuzana, Garaiova; Olsen, Linda Therese; Nilsen, Asbjørn Magne; Davies, Catharina De Lange. (2014) The Effects of Oil-in-water Nanoemulsion Polyethylene Glycol Surface Density on Intracellular Stability, Pharmacokinetics, and Biodistribution in Tumor Bearing Mice. WMIS World Molecular Imaging Conference , Seoul 2014-09-17 - 2014-09-20
2013
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Academic lectureHak, Sjoerd. (2013) Targeted particles and polymers. WMIS World Molecular Imaging Conference , Savannah 2013-09-18 - 2013-09-21
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Academic lectureHak, Sjoerd; Cebulla, Jana; Huuse, Else Marie; Davies, Catharina De Lange; Mulder, Willem J.M.; Larsson, Henrik BW. (2013) Tumor Targeting Kinetics of Ligand-Functionalized Nanoparticles Studied with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Intravital Microscopy. WMIS World Molecular Imaging Conference , Savannah 2013-09-18 - 2013-09-21
2011
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PosterHak, Sjoerd; Emily, Helgesen; Hektoen, Helga H; Sæterbø, Kristin Grenstad; Marte, Thuen; Mulder, Willem J. M.. (2011) Combined in vivo confocal laser scanning microscopy and magnetic resonance imaging to study an avb3-integrin targeted nanoemulsion. World Molecular Imaging Conference 2011-09-10 -
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PosterHak, Sjoerd; Thuen, Marte; Jarzyna, Peter A.; Mulder, Willem J.M.; Syversen, Tore; Haraldseth, Olav. (2011) Combined in vivo confocal laser scanning microscopy and magnetic resonance imaging to study an αvβ3-integrin targeted nanoemulsion. International Society for Magnetic Resonance in Medicine 2011-05-07 -
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PosterHak, Sjoerd; Helgesen, Emily; Hektoen, Helga H; Sæterbø, Kristin Grendstad; Thuen, Marte; Mulder, Willem J. M.. (2011) The effect of polyethylene glycol surface density on the targeting efficiency of αvβ3-integrin specific nanoparticles. PhD conference Norwegian Research School in Medical Imaging 2011-11-20 -
2010
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PosterHak, Sjoerd; Jarzyna, Peter A.; Mulder, Willem J.M.; Thuen, Marte; Reitan, Nina Kristine; Haraldseth, Olav. (2010) Combined in vivo MRI and in vivo CLSM to study the behavior of multifunctional nanoemulsions. Society for Molecular Imaging World Molecular Imaging Conference , Kyoto 2010-09-07 - 2010-09-10