Linn Sofie Snipstad
Background and activities
Ultrasound-enhanced delivery of drugs and nanomedicines for improved treatment of cancer and brain disease
Cancer treatment with chemotherapy is limited by inadequate delivery to the tumor and severe side-effects due to accumulation in healthy tissues. Encapsulation of drugs in nanoparticles can enable a more targeted delivery, improved efficacy and reduced toxicity. However, delivery of nanoparticles is often insufficient due to various biological barriers in the tumor. Ultrasound in combination with microbubbles has emerged as a promising method to enhance delivery of nanomedicines by sonopermeation. The biomechanical effects from the oscillating microbubbles enhance permeability of the vascular wall, and improve extravasation and distribution of the nanoparticles in the tumor, resulting in enhanced therapeutic efficacy. The same technique can also be used to open the blood-brain barrier in a non-invasive, localized and reversible manner to deliver various drugs to the brain. To be able to take sonopermeation into clinical practice, it is crucial to understand the underlying mechanisms. The overall aim of the project I am currently working on is to apply innovative tools to obtain novel insights in the mechanisms of ultrasound-mediated drug delivery, which will enable us to further optimize the technology for improved cancer therapy.
https://www.youtube.com/watch?v=sUXOnXy8fRs&t=107s
https://blog.medisin.ntnu.no/boblende-nanomedisin-mot-kreft-sofie-snipstad/#more-15100
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
Journal publications
- (2019) Forsker Grand Prix vil forandre forskningen din. Forskerforum.no.
- (2019) Mer medisin til kreftsvulsten ved hjelp av ultralyd og mikrobobler. Best Practice Gastroenterology.
- (2019) Therapeutic effect of cabazitaxel and blood-brain barrier opening in a patient-derived glioblastoma model. Nanotheranostics. vol. 3 (1).
- (2019) Effect of Ultrasound on the Vasculature and Extravasation of Nanoscale Particles Imaged in Real Time. Ultrasound in Medicine and Biology. vol. 45 (11).
- (2018) Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models. Journal of Controlled Release. vol. 279.
- (2018) Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLOS ONE. vol. 13 (1).
- (2018) Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft. Journal of Controlled Release. vol. 293.
- (2018) Nullfunn gir gullfunn. Forskerforum.no.
- (2018) Nullfunn gir gullfunn. Aftenposten (morgenutg. : trykt utg.).
- (2018) Ultralyd-mediert levering av nanomedisin - for bedre behandling av kreft og sykdommer i hjernen. Best Practice Onkologi/Hematologi. vol. 35.
- (2018) Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation. Expert Opinion on Drug Delivery. vol. 15 (12).
- (2018) The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy. Proceedings - IEEE Ultrasonics Symposium. vol. 2018 (October).
- (2017) Omtale av doktorgradsavhandling: Ultrasound-mediated delivery of nanomedicine across biological barriers - for improved treatment of cancer and diseases in the brain. Fra Fysikkens Verden.
- (2017) Styrer medisinen rett til svulsten. Dagens næringsliv.
- (2017) Ultralyd-mediert levering av nanomedisin - med bedre behandling av kreft og sykdommer i hjernen som mål. Onkonytt. vol. 2.
- (2017) Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts. Ultrasound in Medicine and Biology. vol. 43 (11).
- (2017) Quantification and qualitative effects of different PEGylations on poly(butyl cyanoacrylate) nanoparticles. Molecular Pharmaceutics. vol. 14 (8).
- (2017) Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT). Theranostics. vol. 7 (1).
- (2016) Labeling nanoparticles: Dye leakage and altered cellular uptake. Cytometry Part A. vol. 91 (8).
- (2015) Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery. Contrast Media & Molecular Imaging. vol. 10 (5).
- (2014) Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles. Cancer Nanotechnology. vol. 5 (1).
Report/dissertation
- (2017) Ultrasound-mediated delivery of nanomedicine across biological barriers - for improved treatment of cancer and diseases in the brain. 2017. ISBN 978-82-326-2452-2. Doktoravhandlinger ved NTNU (190).
Others
- (2020) High-speed optical characterization of the acoustic response of protein-and-nanoparticle-stabilized microbubbles. The 25th European symposium on Ultrasound Contrast Imaging ; Rotterdam. 2020-01-15 - 2020-01-17.
- (2020) Mechanisms and effects of nanoparticle-stabilized microbubbles designed for enhanced drug delivery. The 25th European symposium on Ultrasound Contrast Imaging ; Rotterdam. 2020-01-15 - 2020-01-17.
- (2019) MR-guided ultrasound for directed treatment: results from cabazitaxel in a prostate cancer model. The Future of Molecular Imaging Conference ; St Johns, Newfoundland. 2019-07-15 - 2019-07-17.
- (2019) THERAPEUTIC RESPONSE TO FREE CABAZITAXEL AND CABAZITAXEL LOADED NANOPARTICLES COMBINED WITH ULTRASOUND AND MICROBUBBLES IN A TRANSGENIC MOUSE PROSTATE CANCER MODEL. 19th Symposium for Therapeutic Ultrasound ; 2019-06-13 - 2019-06-15.
- (2019) Acoustic cluster therapy (ACT) ® - A novel dual frequency transducer mediates enhanced uptake of macromolecules in pancreatic ductal adenocarcinoma (PDAC). CIUS conference ; 2019-05-02 - 2019-05-03.
- (2019) From Drug Discovery to Preclinical Studies: SINTEFs Nanoparticle-Based Technologies for Cancer Treatment. 1st CA17140 Nano2Clinic COST Action Conference . COST; Riga. 2019-10-15 - 2019-10-17.
- (2019) Intratumoral microdistribution and therapeutic response of enzyme sensitive liposomes in human prostate cancer xenografts after ultrasound mediated delivery. The 19th International Symposium for Therapeutic Ultrasound ; 2019-06-13 - 2019-06-15.
- (2019) Nanomedicine and sonopermeation for treatment of cancer and brain disease. Norwegian NanoSymposium 2019 . NTNU NanoLab; Trondheim. 2019-10-16 - 2019-10-17.
- (2019) Nanomedisin og sonopermeering for målrettet behandling av kreft og hjernesykdommer. Norsk overlegeforenings Vårkurs . Norsk overlegeforening; Trondheim. 2019-04-24 - 2019-04-26.
- (2019) Nanomedisin og sonopermeering for målrettet behandling av kreft og hjernesykdommer. Faglig motivasjonsforedrag for Naturviterne . Natuviterne; Trondheim. 2019-09-18.
- (2019) Visual storytelling: dos, don’ts and possibilities. Motivasjonsforedrag for deltagere i Forsker Grand Prix 2019 . NTNU; Trondheim. 2019-05-08.
- (2019) Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time. OxCD3 Oncological Drug Delivery Conference ; Oxford. 2019-09-23 - 2019-09-24.
- (2019) Blood brain barrier opening and Therapeutic Effect of Free and Nanoencapsulated Cabazitaxel in an Invasive Patient-Derived Glioblastoma Model. NanoMed Europe . Nanomedicine European Technology Platform (ETPN); Braga. 2019-06-17 - 2019-06-19.
- (2018) Challenge cancer. Facebook [Internett]. 2018-10-23.
- (2018) Effect of focused ultrasound on biodistribution, tumour uptake and intratumoral microdistribution of enzyme sensitive liposomes in human prostate cancer xenografts. The 18th International Symposium for Therapeutic Ultrasound . International Society for Therapeutic Ultrasound (ISTU); Nashville, TN. 2018-05-14 - 2018-05-17.
- (2018) Ultrasound mediated delivery of enzyme sensitive nanoparticles in human prostate cancer xenografts. The 2nd Annual Conference for Digital Life Norway Research School ; 2018-05-30 - 2018-06-01.
- (2018) Fighting cancer with bubbly nanomedicine. TEDxTrondheim ConnecTED . TEDx; Trondheim. 2018-10-21.
- (2018) Nanomedicine and ultrasound for treatment of cancer and brain disease. FARM3003 - Famasøytisk innovasjon . NTNU; Trondheim. 2018-10-18.
- (2018) Nanomedicine and ultrasound for treatment of cancer and brain disease. International nanoscience student conference, INASCON ; Trondheim. 2018-08-07 - 2018-08-10.
- (2018) Nanomedicine for treatment of cancer and brain disease. Tekna Realistkveld/Hva skjer i fremtiden? . Tekna; Trondheim. 2018-03-08.
- (2018) Nanomedisin and ultralyd for målrettet behandling av kreft og hjernesykdommer. TFOR0104 - Teknologi og samfunn . NTNU; Trondheim. 2018-12-05.
- (2018) Nanomedisin and ultralyd for målrettet behandling av kreft og hjernesykdommer. TFY4350 - Nanoteknologi, introduksjon . NTNU; Trondheim. 2018-11-20.
- (2018) Nanomedisin for behandling av kreft og hjernesykdommer. Inspirasjonsforedrag for linjeforeningen Delta i anledning kvinnedagen 2018 . Linjeforeningen Delta; Trondheim. 2018-03-09.
- (2018) Ultrasound for delivery of nanomedicine across biological barriers - for improved treatment of cancer and brain disease. MOL3015 - Nanomedisin II - terapi . NTNU; Trondheim. 2018-04-03.
- (2018) Visual scientific communication. The 2nd annual conference of Digital Life Norway Research School ; Stiklestad. 2018-05-30 - 2018-06-01.
- (2018) Sonoporation enhances delivery of nanomedicine for improved cancer treatment. 11th European and Global Summit for Clinical Nanomedicine, Targeted Delivery and Precision Medicine (CLINAM) ; Basel. 2018-09-02 - 2018-09-05.
- (2018) Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models. Controlled release society meeting . Controlled release society; New York. 2018-07-22 - 2018-07-24.
- (2018) Acoustic Cluster Therapy: Microdroplets boost microbubbles enhanced drug delivery. 23rd European Symposium on Ultrasound Contrast Imaging ; 2018-01-18 - 2018-01-19.
- (2018) Extravasation and distribution of nanoparticles and 2MDa dextran in tumor imaged by multiphoton microscopy during ultrasound sonication. CIUS spring conference 2018 ; Trondheim. 2018-04-25 - 2018-04-26.
- (2017) Bedre kreftbehandling med ultralyd, mikrobobler og nanopartikler. Ultralydsymposium 2017 . Norsk forening for ultralyddiagnostikk; Tønsberg. 2017-05-03 - 2017-05-05.
- (2017) Bedre kreftbehandling med ultralyd, mikrobobler og nanopartikler. Regional forskningskonferanse 2017 . St. Olavs hospital og NTNU; Trondheim. 2017-06-06 - 2017-06-07.
- (2017) Nanoparticle-stabilized microbubbles and ultrasound for enhanced drug delivery. Acoustic bubbles in therapy: recent advances with medical microbubbles, clouds and harmonic antibubbles . LE STUDIUM Loire Valley Institute for Advanced Studies; Tours. 2017-10-23 - 2017-10-24.
- (2017) Lokalisert cellegift som "magic bullet". Under dusken [Avis]. 2017-10-10.
- (2017) Intervju i P1 Ettermiddag om nanomedisin, NRK Hedmark og Oppland. NRK Radio [Radio]. 2017-01-13.
- (2017) Bringer medisin rett til kreftcellene og sparer friske celler. abcnyheter.no [Internett]. 2017-08-26.
- (2017) Bringer medisin rett til kreftcellene og sparer friske celler. Gemini.no [Fagblad]. 2017-08-25.
- (2017) Delivers medicine to cancer cells while protecting healthy cells. AlphaGalileo [Internett]. 2017-08-25.
- (2017) Delivers medicine to cancer cells while protecting healthy cells. eurekalert.org [Internett]. 2017-08-25.
- (2017) Delivers medicine to cancer cells while protecting healthy cells. geminiresearchnews.com [Internett]. 2017-08-25.
- (2017) Ny metode frakter medisin rett til kreftcellene og sparer de friske cellene. Forskning.no [Internett]. 2017-08-27.
- (2017) Acoustic Cluster Therapy (ACT) for improved treatment of cancer and brain diseases. The Nano@NTNU Symposium 2017 Highlighting nanoscience, nanotechnology and functional materials . Nano@NTNU; Trondheim. 2017-12-06 - 2017-12-07.
- (2017) Intervju om etikkregelverk for forsøksdyr. Her og Nå, NRK P1 [Radio]. 2017-10-18.
- (2017) Ultrasound-enhanced drug delivery using nanoparticle-stabilized microbubbles. EuroNanoForum 2017 ; Valletta, Malta. 2017-06-21 - 2017-06-23.
- (2017) Boblende nanomedisin mot kreft. Gjesteforelesning, Lillehammer Pensjonistuniversitet . Lillehammer Pensjonistuniversitet; Lillehammer. 2017-11-21.
- (2017) Boblende nanomedisin mot kreft. Researchers Night 2017 . NTNU; Trondheim. 2017-09-29.
- (2017) Boblende nanomedisin mot kreft. Fagmøte på Statoil Rotvoll . Statoil; Statoils forskningssenter på Rotvoll, Trondheim. 2017-04-19.
- (2017) Boblende nanomedisin mot kreft. Fagsnakk, Bibliotek for medisin og helse . Bibliotek for medisin og helse, NTNU/St. Olavs hospital; Trondheim. 2017-04-25.
- (2017) Boblende nanomedisin mot kreft. Nettverkssamling for realfagslærere i Sør-Trøndelag . Byåsen videregående skole; Trondheim. 2017-03-15.
- (2017) Boblende nanomedisin mot kreft. Jentedagen 2017 . NTNU; Trondheim. 2017-02-02.
- (2017) Ultralyd-mediert levering av nanomedisin – for bedre behandling av kreft og sykdommer i hjernen. Gjesteforelesning, Avdeling for komparativ medisin . Avdeling for komparativ medisin, NTNU; 2017-10-19.
- (2017) Nanoparticle-stabilized microbubbles for ultrasound-mediated drug delivery and treatment of human breast adenocarcinoma in mice. The Nano@NTNU Symposium 2017, Highlighting nanoscience, nanotechnology and functional materials . NTNU NanoLab; Trondheim. 2017-12-06 - 2017-12-07.
- (2017) Nanoparticle-stabilized microbubbles for ultrasound-mediated drug delivery and treatment of human breast adenocarcinoma in mice. The 22nd European Symposium on Ultrasound Contrast Imaging . Erasmus MC Rotterdam; Rotterdam. 2017-01-19 - 2017-01-20.
- (2017) Nanoparticle-stabilized microbubbles for ultrasound-mediated drug delivery to tumors and the brain. CIUS Spring conference . CIUS - Centre for Innovative Ultrasound Solutions; Trondheim. 2017-04-25 - 2017-04-26.
- (2017) Blir mer treffsikre i kreftbehandlingen. Aftenposten vitenskap [Avis]. 2017-07-01.
- (2017) Acoustic cluster therapy boosts delivery of drugs in brains and tumors. Acoustic bubbles in therapy recent advances with medical microbubbles, clouds and harmonic antibubbles . LE STUDIUM; Tours. 2017-10-23 - 2017-10-24.
- (2017) Safe and temporal opening of the blood brain barrier using Acoustic Cluster Therapy. The 22 European Symposium on Ultrasound Contrast Imaging . Erasmus MC Rotterdam; Rotterdam. 2017-01-19 - 2017-01-20.
- (2017) Intervju om nanomedisin og cellegift, God Ettermiddag Trøndelag. NRK Radio [Radio]. 2017-09-04.
- (2016) What's your story and how do you visualize it?. DION's 20th anniversary celebration . DION; Trondheim. 2016-12-07.
- (2016) Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. 10th Annual MedViz Conference . MedViz; Bergen. 2016-09-07 - 2016-09-09.
- (2016) Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma and melanoma metastases. 8th National Conference in Medical Imaging . MedIm and Centre for Innovative Ultrasound Solutions; Trondheim. 2016-11-21 - 2016-12-21.
- (2016) Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. 67th conference of SCANDEM . Nordic Microscopy Society; Trondheim. 2016-06-07 - 2016-06-10.
- (2016) Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. American Association of Cancer Research Annual Meeting 2016 . American Association of Cancer Research; New Orleans. 2016-04-16 - 2016-04-20.
- (2016) Forsker Grand Prix 2016, nasjonal finale i Bergen. null [TV]. 2016-10-01.
- (2016) Intervju, God morgen Trøndelag. NRK Trøndelag [Radio]. 2016-09-29.
- (2016) Forsker Grand Prix 2016, regionfinale i Trondheim. NRK [TV]. 2016-09-29.
- (2016) Hvordan drepe kreftceller ved hjelp av gassbobler?. Teknologirevolusjon innen kreftterapi . Tekna; Oslo Cancer Cluster. 2016-10-26.
- (2016) Boblende nanomedisin mot kreft. Guest lecture at "Forkurs for ingeniørutdanning" in the course "Technology and Society" . HiST/NTNU; Trondheim. 2016-12-01.
- (2016) Boblende nanomedisin mot kreft. Guest lecture at Kristen Videregående skole Trøndelag (KVT), "Frisk forskning" . Kristen Videregående skole Trøndelag (KVT); Trondheim. 2016-11-30.
- (2016) Boblende nanomedisin mot kreft. Hospitering for elever fra forskerlinjen ved Byåsen videregående skole . NTNU og Byåsen videregående skole; 2016-11-07.
- (2016) Boblende nanomedisin mot kreft. Prestasjonskonferansen Vest . Olympiatoppen; Bergen. 2016-11-09.
- (2016) Boblende nanomedisin mot kreft. Guest lecture at the Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital ; Trondheim. 2016-10-21.
- (2016) Nanoparticle-stabilized microbubbles for ultrasound-mediated drug delivery to tumors. The 14th edition of the European Symposium on Controlled Drug Delivery ; Egmond aan Zee. 2016-04-13 - 2016-04-15.
- (2016) Boblende nanomedisin mot kreft, Blogpost at NTNU Tech Zone.
- (2016) Nanopartikler som budbringer. Under Dusken, NR. 14 - 102. ÅRGANG 25.10.16 - 08.11.16 [Avis]. 2016-10-25.
- (2016) Boblende nanomedisin mot kreft, Blogpost at #NTNUMedicine (The Medical Faculty, NTNU).
- (2016) Physical characterisation of vasculature and nanoparticle accumulation in five tumor xenografts. MEDIM conference . MEDIM; Trondheim. 2016-11-21 - 2016-11-22.
- (2016) PEGylation of PBCA nanoparticles - A quantitative and qualitative study. Nano@NTNU Symposium ; Trondheim. 2016-11-17 - 2016-11-18.
- (2015) Nanomedisin i kreftbehandling. Hospitering for elever fra forskerlinjen ved Byåsen videregående skole . NTNU og Byåsen videregående skole; Trondheim. 2015-11-03 - 2015-11-03.
- (2015) Nanomedisin i kreftbehandling. Bestill en Kreftforsker 2015 . Kreftforeningen; Trondheim Katedralskole. 2015-10-13 - 2015-10-13.
- (2015) Ultrasound-mediated drug delivery of multifunctional nanoparticles to tumors. The 7th National PhD Conference in Medical Imaging . Norwegian Research School in Medical Imaging; Oslo. 2015-11-16 - 2015-11-17.
- (2015) Nanoparticle accumulation and vascular characteristics studied in five different human tumor xenografts. MEDIM phd conference . MEDIM; Oslo/Fornebu. 2015-11-16 - 2015-11-17.
- (2014) Intracellular delivery of hydrophobic drugs from nanoparticles and intracellular degradation of the nanoparticles measured by FLIM and spectral analysis. .14th International European Light microscopy initiative (ELMI) meeting ; Oslo. 2014-05-20 - 2014-05-23.
- (2014) Ultrasound-mediated delivery of nanoparticles to tumour tissue. Virtual Physiological Human Conference ; Trondheim. 2014-09-09 - 2014-09-12.
- (2014) Optimization and Characterization of PACA Nanoparticles for Drug Delivery and Imaging. 41st Annual Meeting of the Controlled Release Society . Controlled Release Society; Chicago. 2014-07-12 - 2014-07-16.
- (2014) Multifunctional RGD targeted nanoparticles for drug delivery and diagnostic purposes. The 2014 Joint National PhD Conference in Medical Imaging and MedViz Conference . Norwegian Research School in Medical Imaging; Bergen. 2014-06-17 - 2014-06-18.
- (2013) Characterization of nanoparticles and microbubbles. Nanobiotechnology International Workshop, EC Joint Research Centre . European Commission; Ispra. 2013-12-03 - 2013-12-05.
- (2013) Mechanisms for delivery of hydrophobic drugs from polymeric nanoparticles to cancer cells. Konferanse . MedIm - Nasjonal forskerskole i medisinsk avbildning; Tromsø. 2013-10-02 - 2013-10-03.