Therese Stork Høiem
About
Hi! I am a PhD student in Medical Technology connected to May-Britt Tessems ERC Project ProstOmics at MR Cancer Centre, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology.
My PhD focuses on prostate cancer research, where the goal is to find biomarkers for aggressive types of prostate cancer. Today, indolent cases are treated the same way as life-threatening cancer which is a burden for the patient and the society. The way we are looking for severe cancer is by applying -omics investigation on donated cancer tissue. Using MR imaging (metabolomics), RNA sequencing (transcriptomics), gene expression (genomics) and MALDI MS imaging (proteomics) we can come closer by finding the spatial distribution of potential markers of aggressive disease.
Before starting my PhD, I worked one year as a staff engineer researching the effect of omega-3 fatty acids on colorectal cancer cell in the research group of Svanhild Schønberg/Caroline Pettersen at IKOM, NTNU. From my master degree in Molecular Medicine, I have previous experience in animal experiments and proteomics on pancreatic cancer from the research group of Experimental Surgery, IKOM, NTNU, led by MD PhD Duan Chen.
Publications
2023
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Andersen, Maria Karoline;
Giampà , Marco;
Midtbust, Elise;
Høiem, Therese Stork;
Krossa, Sebastian;
Tessem, May-Britt.
(2023)
Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging.
Methods in molecular biology
Academic article
2022
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Hansen, Ailin Falkmo;
Høiem, Therese Stork;
Selnæs, Kirsten Margrete;
Bofin, Anna M.;
Størkersen, Øystein;
Bertilsson, Helena.
(2022)
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.
NMR in Biomedicine
Academic article
-
Høiem, Therese Stork;
Andersen, Maria Karoline;
Martin-Lorenzo, Marta;
Longuespée, Rémi;
Claes, Britt S.R.;
Nordborg, Anna.
(2022)
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue.
Proteomics
Academic article
2021
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Samdal, Helle;
Olsen, Lene Christin;
Grøn, Knut Sverre;
Røyset, Elin Synnøve;
Høiem, Therese Stork;
Nervik, Ingunn.
(2021)
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids.
Biomedicines
Academic article
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Andersen, Maria Karoline;
Høiem, Therese Stork;
Claes, Britt S.R.;
Balluff, Benjamin;
Marta, Martin-Lorenzo;
Richardsen, Elin.
(2021)
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI.
Cancer & Metabolism
Academic article
2020
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Andersen, Maria Karoline;
Krossa, Sebastian;
Høiem, Therese Stork;
Buchholz, Rebecca;
Claes, Britt S.R.;
Balluff, Benjamin.
(2020)
Simultaneous detection of zinc and its pathway metabolites using MALDI MS imaging of prostate tissue.
Analytical Chemistry
Academic article
2019
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Høiem, Therese Stork;
Buchholz, Rebecca;
Claes, Britt S.R.;
Balluff, Benjamin.
(2019)
Simultaneous detection of the cancer biomarkers zinc and citrate in prostate cancer tissue using mass spectrometry imaging.
European Urology. Supplement
Abstract
2018
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Samdal, Helle;
Sandmoe, Malin Alise;
Olsen, Lene Christin;
Jarallah, Elaf Ali Hadi;
Høiem, Therese Stork;
Schønberg, Svanhild Margrethe Arentz.
(2018)
Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells.
The FEBS Journal
Academic article
Journal publications
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Andersen, Maria Karoline;
Giampà , Marco;
Midtbust, Elise;
Høiem, Therese Stork;
Krossa, Sebastian;
Tessem, May-Britt.
(2023)
Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging.
Methods in molecular biology
Academic article
-
Hansen, Ailin Falkmo;
Høiem, Therese Stork;
Selnæs, Kirsten Margrete;
Bofin, Anna M.;
Størkersen, Øystein;
Bertilsson, Helena.
(2022)
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.
NMR in Biomedicine
Academic article
-
Høiem, Therese Stork;
Andersen, Maria Karoline;
Martin-Lorenzo, Marta;
Longuespée, Rémi;
Claes, Britt S.R.;
Nordborg, Anna.
(2022)
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue.
Proteomics
Academic article
-
Samdal, Helle;
Olsen, Lene Christin;
Grøn, Knut Sverre;
Røyset, Elin Synnøve;
Høiem, Therese Stork;
Nervik, Ingunn.
(2021)
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids.
Biomedicines
Academic article
-
Andersen, Maria Karoline;
Høiem, Therese Stork;
Claes, Britt S.R.;
Balluff, Benjamin;
Marta, Martin-Lorenzo;
Richardsen, Elin.
(2021)
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI.
Cancer & Metabolism
Academic article
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Høiem, Therese Stork;
Buchholz, Rebecca;
Claes, Britt S.R.;
Balluff, Benjamin.
(2020)
Simultaneous detection of zinc and its pathway metabolites using MALDI MS imaging of prostate tissue.
Analytical Chemistry
Academic article
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Høiem, Therese Stork;
Buchholz, Rebecca;
Claes, Britt S.R.;
Balluff, Benjamin.
(2019)
Simultaneous detection of the cancer biomarkers zinc and citrate in prostate cancer tissue using mass spectrometry imaging.
European Urology. Supplement
Abstract
-
Samdal, Helle;
Sandmoe, Malin Alise;
Olsen, Lene Christin;
Jarallah, Elaf Ali Hadi;
Høiem, Therese Stork;
Schønberg, Svanhild Margrethe Arentz.
(2018)
Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells.
The FEBS Journal
Academic article
Knowledge Transfer
2023
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Academic lectureAndersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Viset, Trond; Størkersen, Øystein; Vandenbosch, Michiel. (2023) Spatial multiomics show lipid metabolism alterations in prostate cancer. Regional Mass Spectrometry Imaging Spring Workshop , Uppsala 2023-04-27 - 2023-04-29
2022
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein. (2022) Multiomics spatial analysis shows lipid metabolism alterations in prostate cancer. CA19105 EpiLipidNET Cost Action 3rd EpiLipidNET Action Meeting , Aveiro 2022-09-21 - 2022-09-23
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein. (2022) Multiomics spatial analysis shows lipid metabolism alterations in prostate cancer. Digitalt Life Digital Life Conference 2022 , Trondheim 2022-10-20 - 2022-10-21
2021
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Academic lectureAndersen, Maria Karoline; Midtbust, Elise; Claes, Britt S.R.; Giampà, Marco; Balluff, Benjamin; Heeren, Ron M.A.. (2021) Vacuum storage at -80°C offers optimal metabolite detection with MALDI-MSI. OurCon2021 , Digitalt 2021-10-12 - 2021-10-13
2020
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Academic lectureAndersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin. (2020) Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue. University of Gothenburg Swedish Symposium on Prostate Cancer Research , Gotherburg 2020-02-03 - 2020-02-04
2019
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Bucholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin. (2019) Simultaneous spatial detection of the cancer biomarkers zinc, citrate and aspartate in prostate tissue using MS imaging. Mass Spectrometry Imaging Society OurConVII , Saint-Malo 2019-10-28 - 2019-10-31
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Bucholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin. (2019) Simultaneous spatial detection of the cancer biomarkers zinc, citrate and aspartate in prostate tissue using MS imaging. European Association of Urology ESUR19 , Porto 2019-10-10 - 2019-10-12
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PosterAndersen, Maria Karoline; Høiem, Therese Stork; Balluff, Benjamin; Claes, Britt S.R.; Martin-Lorenzo, Marta; Richardsen, Elin. (2019) Altered metabolism in prostate cancer and stroma detected through MALDI-TOF MSI. Metabolomics Society Metabolomics 2019 , The Hague 2019-06-23 - 2019-06-27
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PosterHøiem, Therese Stork; Andersen, Maria Karoline; Martin-Lorenzo, Marta; Nordborg, Anna; Dewez, Frédéric; Balluff, Benjamin. (2019) Protocol optimization of MALDI MSI for spatial detection of peptides in fresh frozen prostate tissue. Mass Spectrometry Imaging Society OurCon VII , Saint-Malo 2019-10-28 - 2019-10-31
2018
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Academic lectureHøiem, Therese Stork. (2018) A Multi-omics Approach for Improved Prostate Cancer Diagnosis. Digital Life Norway Digital Life Norway Research School , Stiklestad 2018-05-30 - 2018-06-01
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PosterAndersen, Maria Karoline; Høiem, Therese Stork; Balluff, Benjamin; Martin-Lorenzo, Marta; Richardsen, Elin; Bertilsson, Helena. (2018) Altered metabolism in prostate cancer and stroma detected through MALDI-TOF MSI. IMSS IMSS II & OurCon VI Joint Meeting , Charleston 2018-11-11 - 2018-11-14