Therese Stork Høiem

About

Hi! I am a PhD student in Medical Technology connected to May-Britt Tessems ERC Project ProstOmics at MR Cancer Centre, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology.

My PhD focuses on prostate cancer research, where the goal is to find biomarkers for aggressive types of prostate cancer. Today, indolent cases are treated the same way as life-threatening cancer which is a burden for the patient and the society. The way we are looking for severe cancer is by applying -omics investigation on donated cancer tissue. Using MR imaging (metabolomics), RNA sequencing (transcriptomics), gene expression (genomics) and MALDI MS imaging (proteomics) we can come closer by finding the spatial distribution of potential markers of aggressive disease.

Before starting my PhD, I worked one year as a staff engineer researching the effect of omega-3 fatty acids on colorectal cancer cell in the research group of Svanhild Schønberg/Caroline Pettersen at IKOM, NTNU. From my master degree in Molecular Medicine, I have previous experience in animal experiments and proteomics on pancreatic cancer from the research group of Experimental Surgery, IKOM, NTNU, led by MD PhD Duan Chen.

Publications

2024

Andersen, Maria K.; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximilian; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein; Nervik, Ingunn; Sandsmark, Elise. (2024) Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer. Communications Biology
Academic article

2023

Andersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximilian; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein; Nervik, Ingunn; Sandsmark, Elise. (2023) Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer. Research Square
Academic article
Andersen, Maria Karoline; Giampà , Marco; Midtbust, Elise; Høiem, Therese Stork; Krossa, Sebastian; Tessem, May-Britt. (2023) Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging. Methods in molecular biology
Academic article

2022

Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck. (2022) Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy. NMR in Biomedicine
Academic article
Høiem, Therese Stork; Andersen, Maria Karoline; Martin-Lorenzo, Marta; Longuespée, Rémi; Claes, Britt S.R.; Nordborg, Anna; Dewez, Frédéric; Balluff, Benjamin; Giampà , Marco; Sharma, Animesh. (2022) An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue. Proteomics
Academic article

2021

Samdal, Helle; Olsen, Lene Christin; Grøn, Knut Sverre; Røyset, Elin Synnøve; Høiem, Therese Stork; Nervik, Ingunn; Sætrom, Pål; Wibe, Arne; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild. (2021) Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids. Biomedicines
Academic article
Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck. (2021) Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI. Cancer & Metabolism
Academic article

2020

Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane R.; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.. (2020) Simultaneous detection of zinc and its pathway metabolites using MALDI MS imaging of prostate tissue. Analytical Chemistry
Academic article

2019

Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Bathen, Tone Frost. (2019) Simultaneous detection of the cancer biomarkers zinc and citrate in prostate cancer tissue using mass spectrometry imaging. European Urology. Supplement
Conference abstract

2018

Samdal, Helle; Sandmoe, Malin Alise; Olsen, Lene Christin; Jarallah, Elaf Ali Hadi; Høiem, Therese Stork; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild. (2018) Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells. The FEBS Journal
Academic article

Journal publications

Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Bathen, Tone Frost. (2019) Simultaneous detection of the cancer biomarkers zinc and citrate in prostate cancer tissue using mass spectrometry imaging. European Urology. Supplement
Conference abstract
Andersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximilian; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein; Nervik, Ingunn; Sandsmark, Elise. (2023) Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer. Research Square
Academic article
Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck. (2022) Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy. NMR in Biomedicine
Academic article
Samdal, Helle; Olsen, Lene Christin; Grøn, Knut Sverre; Røyset, Elin Synnøve; Høiem, Therese Stork; Nervik, Ingunn; Sætrom, Pål; Wibe, Arne; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild. (2021) Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids. Biomedicines
Academic article
Samdal, Helle; Sandmoe, Malin Alise; Olsen, Lene Christin; Jarallah, Elaf Ali Hadi; Høiem, Therese Stork; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild. (2018) Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells. The FEBS Journal
Academic article
Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck. (2021) Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI. Cancer & Metabolism
Academic article
Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane R.; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.. (2020) Simultaneous detection of zinc and its pathway metabolites using MALDI MS imaging of prostate tissue. Analytical Chemistry
Academic article
Andersen, Maria Karoline; Giampà , Marco; Midtbust, Elise; Høiem, Therese Stork; Krossa, Sebastian; Tessem, May-Britt. (2023) Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging. Methods in molecular biology
Academic article
Høiem, Therese Stork; Andersen, Maria Karoline; Martin-Lorenzo, Marta; Longuespée, Rémi; Claes, Britt S.R.; Nordborg, Anna; Dewez, Frédéric; Balluff, Benjamin; Giampà , Marco; Sharma, Animesh. (2022) An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue. Proteomics
Academic article
Andersen, Maria K.; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximilian; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein; Nervik, Ingunn; Sandsmark, Elise. (2024) Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer. Communications Biology
Academic article

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