Therese Standal

Professor

Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences

therese.standal@ntnu.no +47 73598394 +47 72825351

Gastrosenteret, 433.03.012, Øya, Prinsesse Kristinas gate 1

Research activity

Multiple myeloma is a cancer caused by accumulation of malignant plasma cells within the bone marrow. Almost all myeloma patients suffer from an osteolytic bone disease, caused by increased numbers of cells degrading bone (osteoclasts) and reduced numbers of cells producing bone (osteoblasts). Bone destruction is also common in inflammtory diseases such as rheumatoid arthritis.

My research focus is on how myeloma cells, myeloma derived factors and inflammation affects the activity and differentiation of osteoblast and osteoclasts. .

Courses

Scientific, academic and artistic work

A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

Journal publications

Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese. (2021) Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience.
Moen, Ingrid Nyhus; Westhrin, Marita; Håland, Erling; Haug, Markus; Nonstad, Unni; Klaharn, Merisa; Standal, Therese; Starheim, Kristian K.. (2021) Smac-mimetics reduce numbers and viability of human osteoclasts. Cell death discovery. vol. 7:36.
Sponaas, Anne-Marit; Waage, Anders; Vandsemb, Esten; Misund, Kristine; Børset, Magne; Sundan, Anders; Slørdahl, Tobias Schmidt; Standal, Therese. (2021) Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?. Frontiers in Immunology. vol. 12:636375.
Ødegaard, Kristin Sirnes; Ouyang, Lingzi; Ma, Qianli; Buene, Glenn; Wan, Di; Elverum, Christer Westum; Torgersen, Jan; Standal, Therese; Westhrin, Marita. (2021) Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells. Journal of materials science. Materials in medicine. vol. 32 (97).
Aass, Kristin Roseth; Kastnes, Martin; Standal, Therese. (2020) Molecular interactions and functions of IL-32. Journal of Leukocyte Biology.
Westhrin, Marita; Holien, Toril; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sponaas, Anne-Marit; Sundan, Anders; Standal, Therese. (2020) Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone. JBMR Plus. vol. 4 (1).
Westhrin, Marita; Kovcic, Vlado; Zejian, Zhang; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Bondt, Albert; Holst, Stephanie; Misund, Kristine; Buene, Glenn; Sundan, Anders; Waage, Anders; Slørdahl, Tobias Schmidt; Wuhrer, Manfred; Standal, Therese. (2020) Monoclonal immunoglobulins promote bone loss in multiple myeloma. Blood.
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit. (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. Journal for ImmunoTherapy of Cancer (JITC).
Børset, Magne; Sundan, Anders; Waage, Anders; Standal, Therese. (2019) Why do myeloma patients have bone disease? A historical perspective. Blood reviews. vol. 00:100646.
Westhrin, Marita; Standal, Therese. (2019) N-glykosylering av serumproteiner endres ved myelomatose. Bestpractice Onkologi/Hematologi.
Zhang, Zejian; Westhrin, Marita; Bondt, Albert; Wuhrer, Manfred; Standal, Therese; Holst, Stephanie. (2019) Serum protein N-glycosylation changes in multiple myeloma. Biochimica et Biophysica Acta - General Subjects. vol. 1863 (5).
Holien, Toril; Westhrin, Marita; Moen, Siv Helen; Zahoor, Muhammad; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sundan, Anders; Standal, Therese. (2018) BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone. Blood. vol. 132.
Sponaas, Anne-Marit; Yang, Rui; Rustad, Even Holth; Standal, Therese; Thoresen, Aud; Vo, Camilla Dao; Waage, Anders; Slørdahl, Tobias Schmidt; Børset, Magne; Sundan, Anders. (2018) PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients. OncoTarget. vol. 9 (62).
Standal, Therese. (2018) Myelomatose - bein i ubalanse. Bestpractice Onkologi/Hematologi.
Westhrin, Marita; Moen, Siv Helen; Kristensen, Ida Bruun; Buene, Glenn; Mylin, Anne Kærsgaard; Turesson, Ingemar; Abildgaard, Niels; Waage, Anders; Standal, Therese. (2018) Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes. Biomarker Research. vol. 6 (21).
Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders. (2017) Monitoring multiple myeloma by quantification of recurrent mutations in serum. Haematologica. vol. 102 (7).
Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria; Giliberto, Mariaserena; Buene, Glenn; Sundan, Anders; Waage, Anders; Sponaas, Anne-Marit; Standal, Therese. (2017) Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss. Blood Advances. vol. 27 (1).
Moen, Siv Helen; Westhrin, Marita; Zahoor, Muhammad; Nørgaard, Nikolai Nordberg; Hella, Hanne; Størdal, Berit Fladvad; Sundan, Anders; Nilsen, Nadra J.; Sponaas, Anne-Marit; Standal, Therese. (2016) Caspase-8 regulates the expression of pro- and anti-inflammatory cytokines in human bone marrow-derived mesenchymal stromal cells. Immunity,Inflammation and Disease. vol. 4 (3).
Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders. (2015) The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma. Immunity,Inflammation and Disease. vol. 3 (2).
Sponaas, Anne-Marit; Nejati Moharrami, Neda; Feyzi, Emadoldin; Standal, Therese; Rustad, Even Holth; Waage, Anders; Sundan, Anders. (2015) PDL1 expression on plasma and dendritic cells in myeloma bone marrow suggests benefit of targeted anti PD1-PDL1 therapy. PLOS ONE. vol. 10:e0139867 (10).

Språkvelger

Therese Standal

Background and activities

Courses

Scientific, academic and artistic work

Journal publications

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