Therese Standal
About
Research activity
Multiple myeloma is a cancer caused by the accumulation of malignant plasma cells in the bone marrow. These cancer cells depend on the bone marrow microenvironment for survival, and my research focuses on how the tumor microenvironment contributes to disease development.
I currently have three main projects:
1) Obesity and multiple myeloma
Obesity is associated with an increased risk of multiple myeloma. I study how adipocytes, immune cells, and cancer cells influence one another, and how these interactions contribute to disease development.
2) Spatial analyses of bone marrow biopsies
I use imaging mass cytometry and transcriptomic analysis of bone marrow tissue to identify tissue features associated with disease development.
3) The role of IL-32 in multiple myeloma
IL-32 is highly expressed in the cancer cells of a subgroup of patients with particularly poor survival. By knocking out IL-32 in cancer cells and immune cells, we investigate the importance of this pro-inflammatory cytokine in disease development.
ALUMNI
Former postdoctoral researchers
Kristin Roseth Aass 2025
Qianli Ma 2022
Siv Helen Moen 2021
Mohammad Zahoor 2019
Marita Westhrin 2019
Former PhD candidates as main supervisor
Ingrid Aass Roseth 2025
Synne Stokke Tryggestad 2024
Tonje Vikene Nedal 2024
Vlado Kovcic 2020
Kristin Ass Roseth 2020
Marita Westhrin 2015
Siv Helen Moen 2014
Berit Helen Grandaunet 2014
Former PhD candidates as co- supervisor
Mira Tilseth
Ingvild Bergdal Mestvedt
Md Abu Hanif Edan
Kristin Ødegaard 2022
Sofia Jönsson (Sahlgrenska Universitetssjukhuset, Sverige) 2011
Former MSc students (last five years)
Dina Manseth Felle 2026
Shaghayegh Moalemi 2026
Maren Frydenberg Sveen 2025
Eline Bjørnstad 2025
Charlotte Tvedt 2024
Ingeborg Austlid Grov 2024
MARTA DE LEÓN EGOZCUE 2024
Caroline Oksnes 2023
Nadia Ørning 2023
Competencies
Publications
2025
-
Roseth, Ingrid Aass;
Hatscher, Lukas;
Schiller, Chiara;
Johnstuen, Håkon Skjalg Selland;
Slørdahl, Tobias Schmidt;
Hov, Håkon;
Schapiro, Denis;
Standal, Therese.
(2025)
Multiplexed Imaging Reveals Immune-Metabolic Niches in Multiple Myeloma Linked to Progression and Bone Disease.
Blood Cancer Discovery
Academic article
-
Emma, Busarello,;
Giulia, Biancon,;
Ilaria, Cimignolo,;
Vittorio, Bontempi,;
Giorgia, Bucciarelli,;
Marianna, Ciuffreda,;
Zuhairia, Ibnat,;
Fabio, Lauria,;
Paolo, Macchi,;
Maria, Marino, Stefano.
(2025)
Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease | Nature Communications.
Nature Communications
Academic article
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel;
Hella, Hanne;
Ryan, Liv;
Standal, Therese;
Espevik, Terje.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
2024
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo;
Hella, Hanne;
Sponaas, Anne Marit;
Standal, Therese.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Academic article
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne;
Standal, Therese.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Academic article
2023
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya;
Standal, Therese.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Academic article
-
Ma, Qianli;
Rubenis, Kristaps;
Sigurjonsson, Olafur E.;
Hildebrand, Torben;
Standal, Therese;
Zemjane, Signe;
Locs, Janis;
Loca, Dagnija;
Haugen, Håvard Jostein.
(2023)
Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model.
Smart Materials in Medicine
Academic article
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine;
Standal, Therese.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Academic article
-
Ødegaard, Kristin Sirnes;
Westhrin, Marita;
Bin Afif, Abdulla Shaikh Abdul Qader;
Ma, Qianli;
Mela, Petra;
Standal, Therese;
Elverum, Christer Westum;
Torgersen, Jan.
(2023)
The effects of surface treatments on electron beam melted Ti-6Al-4V disks on osteogenesis of human mesenchymal stromal cells.
Biomaterials Advances
Academic article
2022
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma.
Scientific Reports
Academic article
-
Kohtala, Sampsa;
Nedal, Tonje Marie Vikene;
Kriesi, Carlo Rene;
Moen, Siv Helen;
Ma, Qianli;
Ødegaard, Kristin Sirnes;
Standal, Therese;
Steinert, Martin.
(2022)
Automated Quantification of Human Osteoclasts Using Object Detection.
Frontiers in Cell and Developmental Biology
Academic article
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Bouma, Siri Anshushaug;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival.
British Journal of Cancer
Academic article
2021
-
Sponaas, Anne-Marit;
Waage, Anders;
Vandsemb, Esten;
Misund, Kristine;
Børset, Magne;
Sundan, Anders;
Slørdahl, Tobias Schmidt;
Standal, Therese.
(2021)
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?.
Frontiers in Immunology
Academic literature review
-
Moen, Ingrid Nyhus;
Westhrin, Marita;
Håland, Erling;
Haug, Markus;
Nonstad, Unni;
Klaharn, Merisa;
Standal, Therese;
Starheim, Kristian K..
(2021)
Smac-mimetics reduce numbers and viability of human osteoclasts.
Cell death discovery
Academic article
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
van den Brink, Luca Mare;
Roseth, Ingrid Aass;
Westhrin, Marita;
Zahoor, Muhammad;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Academic article
-
Ødegaard, Kristin Sirnes;
Ouyang, Lingzi;
Ma, Qianli;
Buene, Glenn;
Wan, Di;
Elverum, Christer Westum;
Torgersen, Jan;
Standal, Therese;
Westhrin, Marita.
(2021)
Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells.
Journal of Materials Science: Materials in Medicine
Academic article
2020
-
Westhrin, Marita;
Holien, Toril;
Zahoor, Muhammad;
Moen, Siv Helen;
Buene, Glenn;
Størdal, Berit Fladvad;
Hella, Hanne;
Yuan, Huipin;
Bruijn, Joost D de;
Martens, Anton.
(2020)
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone.
JBMR Plus
Academic article
-
Aass, Kristin Roseth;
Kastnes, Martin;
Standal, Therese.
(2020)
Molecular interactions and functions of IL-32.
Journal of Leukocyte Biology
Academic article
-
Yang, Rui;
Elsaadi, Samah;
Misund, Kristine;
Abdollahi, Pegah;
Vandsemb, Esten;
Moen, Siv Helen;
Kusnierczyk, Anna;
Slupphaug, Geir;
Standal, Therese;
Waage, Anders.
(2020)
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade.
Journal for ImmunoTherapy of Cancer (JITC)
Academic article
-
Westhrin, Marita;
Kovcic, Vlado;
Zejian, Zhang;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene;
Bondt, Albert;
Holst, Stephanie;
Misund, Kristine;
Buene, Glenn;
Sundan, Anders.
(2020)
Monoclonal immunoglobulins promote bone loss in multiple myeloma.
Blood
Academic article
-
Standal, Therese;
Aass, Kristin Roseth.
(2020)
The role IL-32 in multiple myeloma.
NTNU Open
Doctoral thesis
-
Standal, Therese;
Kovcic, Vlado.
(2020)
New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma.
Norges teknisk-naturvitenskapelige universitet
Doctoral thesis
2019
-
Zhang, Zejian;
Westhrin, Marita;
Bondt, Albert;
Wuhrer, Manfred;
Standal, Therese;
Holst, Stephanie.
(2019)
Serum protein N-glycosylation changes in multiple myeloma.
Biochimica et Biophysica Acta - General Subjects
Academic article
-
Holien, Toril;
Westhrin, Marita;
Standal, Therese.
(2019)
BMP4-genterapi hemmer vekst av myelomceller, men har også hemmende effekt på trabekulært ben i mus.
Bestpractice Onkologi/Hematologi
Professional article
-
Westhrin, Marita;
Standal, Therese.
(2019)
N-glykosylering av serumproteiner endres ved myelomatose.
Bestpractice Onkologi/Hematologi
Academic article
-
Børset, Magne;
Sundan, Anders;
Waage, Anders;
Standal, Therese.
(2019)
Why do myeloma patients have bone disease? A historical perspective.
Blood reviews
Academic literature review
2018
-
Standal, Therese.
(2018)
Myelomatose - bein i ubalanse.
Bestpractice Onkologi/Hematologi
Academic literature review
-
Holien, Toril;
Westhrin, Marita;
Moen, Siv Helen;
Zahoor, Muhammad;
Buene, Glenn;
Størdal, Berit Fladvad;
Hella, Hanne;
Yuan, Huipin;
Bruijn, Joost D de;
Martens, Anton.
(2018)
BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone.
Blood
Conference abstract
-
Westhrin, Marita;
Moen, Siv Helen;
Kristensen, Ida Bruun;
Buene, Glenn;
Mylin, Anne Kærsgaard;
Turesson, Ingemar;
Abildgaard, Niels;
Waage, Anders;
Standal, Therese.
(2018)
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes.
Biomarker Research
Academic article
-
Sponaas, Anne-Marit;
Yang, Rui;
Rustad, Even Holth;
Standal, Therese;
Thoresen, Aud;
Vo, Camilla Dao;
Waage, Anders;
Slørdahl, Tobias Schmidt;
Børset, Magne;
Sundan, Anders.
(2018)
PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.
OncoTarget
Academic article
2017
-
Rustad, Even Holth;
Coward, Eivind;
Skytøen, Emilie R;
Misund, Kristine;
Holien, Toril;
Standal, Therese;
Børset, Magne;
Beisvag, Vidar;
Myklebost, Ola;
Meza, Leonardo Zepeda.
(2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica
Academic article
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria;
Giliberto, Mariaserena;
Buene, Glenn;
Sundan, Anders;
Waage, Anders.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Academic article
2016
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad;
Sundan, Anders;
Nilsen, Nadra J.;
Sponaas, Anne-Marit;
Standal, Therese.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
2015
-
Westhrin, Marita;
Moen, Siv Helen;
Standal, Therese.
(2015)
GDF15 i beinsykdommen ved myelomatose.
Bestpractice Onkologi/Hematologi
Professional article
-
Sponaas, Anne-Marit;
Moen, Siv Helen;
Liabakk, Nina-Beate;
Feyzi, Emadoldin;
Holien, Toril;
Kvam, Solveig;
Grøseth, Lill Anny Gunnes;
Størdal, Berit Fladvad;
Buene, Glenn;
Espevik, Terje.
(2015)
The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma.
Immunity,Inflammation and Disease
Academic article
-
Sponaas, Anne-Marit;
Nejati Moharrami, Neda;
Feyzi, Emadoldin;
Standal, Therese;
Rustad, Even Holth;
Waage, Anders;
Sundan, Anders.
(2015)
PDL1 expression on plasma and dendritic cells in myeloma bone marrow suggests benefit of targeted anti PD1-PDL1 therapy.
PLOS ONE
Academic article
-
Westhrin, Marita;
Xie, Minli;
Olderøy, Magnus Ø.;
Sikorski, Pawel;
Strand, Berit Løkensgard;
Standal, Therese.
(2015)
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices.
PLOS ONE
Academic article
-
Westhrin, Marita;
Moen, Siv Helen;
Holien, Toril;
Mylin, Anne K.;
Heickendorff, Lene;
Olsen, Oddrun Elise;
Sundan, Anders;
Turesson, Ingemar;
Gimsing, Peter;
Waage, Anders.
(2015)
Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease.
Haematologica
Commentary
2014
-
Standal, Therese;
Johnson, Rachelle;
McGregor, Narelle;
Poulton, Ingrid;
Ho, Patricia W M;
Martin, T. John;
Sims, Natalie.
(2014)
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
Journal of Endocrinology
Academic article
-
Grandaunet, Berit Helen;
Standal, Therese;
Haugeberg, Glenn;
Sundan, Anders.
(2014)
Bone loss in rheumatoid arthritis: Possible roles for hepatocyte growth factor,syndecan-1 and dickkopf-1.
Norges teknisk-naturvitenskapelige universitet
Doctoral thesis
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Misund, Kristine;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Mylin, Anne K.;
Turesson, I;
Størdal, Berit Fladvad;
Moen, Siv Helen;
Standal, Therese.
(2014)
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Blood Cancer Journal
Academic article
-
Johnson, Rachelle;
Brennan, Holly;
Vrahnas, Christina;
Poulton, Ingrid;
McGregor, Narelle;
Standal, Therese;
Walker, Emma;
Koh, T;
Nguyen, H.;
Walsh, Nicole.
(2014)
The Primary Function of gp130 Signaling in Osteoblasts is to Maintain bone Formation and Strength, Rather than Promote Osteoclast Formation.
Journal of Bone and Mineral Research
Academic article
2013
-
Slørdahl, Tobias Schmidt;
Denayer, Tinneke;
Moen, Siv Helen;
Standal, Therese;
Børset, Magne;
Ververken, Cedric;
Rø, Torstein Baade.
(2013)
Anti-c-MET Nanobody® – a new potential drug in multiple myeloma treatment.
European Journal of Haematology
Academic article
-
Grandaunet, Berit Helen Jensen;
Syversen, Silje Watterdal;
Hoff, Mari;
Haugeberg, Glenn;
Hejde, Désirée Van der;
Kvien, Tore Kristian;
Standal, Therese.
(2013)
Dickkopf-1 is associated with periarticular bone loss in patients with rheumatoid arthritis.
Open Journal of Rheumatology and Autoimmune Diseases
Academic article
2012
-
Jönsson, Sofia;
Hjorth-Hansen, Henrik;
Olsson, Bob;
Wadenvik, H;
Sundan, Anders;
Standal, Therese.
(2012)
Imatinib inhibits proliferation of human mesenchymal stem cells and promotes early but not late osteoblast differentiation in vitro.
Journal of Bone and Mineral Metabolism
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes;
Rekvig, Magne;
Børset, Magne;
Standal, Therese;
Waage, Anders.
(2012)
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.
Leukemia
Academic article
-
Jönsson, Sofia;
Standal, Therese;
Olsson, Bob;
Mellström, Dan;
Wadenvik, H.
(2012)
Secondary hyperparathyroidism but stable bone-mineral density in patients with chronic myeloid leukemia treated with imatinib.
American Journal of Hematology
Commentary
-
Olderøy, Magnus Østgård;
Westhrin, Marita;
Andreassen, Jens-Petter;
Zhang, Zhibing;
Strand, Berit Løkensgard;
Standal, Therese;
Sikorski, Pawel.
(2012)
Properties and cell compatibility of mineralized alginate hydrogel beads.
European Cells and Materials
Conference abstract
-
Olderøy, Magnus Østgård;
Westhrin, Marita;
Ehnert, Sabrina;
Xie, Minli;
Andreassen, Jens-Petter;
Strand, Berit Løkensgard;
Standal, Therese;
Nussler, Andreas K;
Sikorski, Pawel.
(2012)
Investigation of mineralized alginate gels as a scaffold material for stem cell based bone tissue engineering.
Journal of Tissue Engineering and Regenerative Medicine
Conference abstract
2011
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes;
Rekvig, Magne;
Børset, Magne;
Standal, Therese;
Waage, Anders.
(2011)
BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC.
Haematologica
Conference abstract
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jönsson, S;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders;
Standal, Therese.
(2011)
CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis.
Bone
Conference abstract
-
Grandaunet, Berit Helen;
Syversen, Silje Watterdal;
Hoff, Mari;
Sundan, Anders;
Haugeberg, Glenn;
Heijde, Desiree van der;
Kvien, Tore Kristian;
Standal, Therese.
(2011)
Association Between High Plasma Levels of Hepatocyte Growth Factor and Progression of Radiographic Damage in the Joints of Patients With Rheumatoid Arthritis.
Arthritis and Rheumatism
Academic article
2010
-
Grandaunet, Berit Helen;
Syversen, Silje;
Hoff, Mari;
Haugeberg, Glenn;
Heijde, Desire van der;
Kvien, Tore;
Standal, Therese.
(2010)
DKK1, AN INHIBITOR OF BONE FORMATION IS AN INDEPENDENT PREDICTOR OF HAND BONE LOSS IN RHEUMATOID ARTHRITIS.
Scandinavian Journal of Rheumatology
Conference abstract
-
Jönsson, S;
Hjorth-Hansen, Henrik;
Olsson, B;
Wadenvik, H;
Sundan, Anders;
Standal, Therese.
(2010)
Second-generation TKI dasatinib inhibits proliferation of mesenchymal stem cells and osteoblast differentiation in vitro.
Leukemia
Commentary
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jonsson, Sofia;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders;
Standal, Therese.
(2010)
CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis.
Journal of Immunology
Academic article
2009
-
Standal, Therese;
Norgaard, NN;
Bohnhorst, J;
Espevik, T;
Waage, A;
Sundan, A.
(2009)
Does Toll-like Receptor 9 Signaling Play a Role in Myeloma Disease Progression?.
Clinical Lymphoma & Myeloma
Conference abstract
-
Mylin, AK;
Andersen, NF;
Johansen, JS;
Abildgaard, N;
Heickendorff, L;
Standal, Therese;
Gimsing, P;
Knudsen, LM.
(2009)
Serum YKL-40 and bone marrow angiogenesis in multiple myeloma.
International Journal of Cancer
Commentary
2008
-
Mylin, AK;
Abildgaard, N;
Johansen, JS;
Andersen, NF;
Heickendorff, L;
Standal, Therese;
Gimsing, P;
Knudsen, LM.
(2008)
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients.
European Journal of Haematology
Academic article
-
Børset, Magne;
Standal, Therese;
Waage, Anders;
Sundan, Anders.
(2008)
Hepatocyte growth factor (HGF) in the pathogenesis of multiple myeloma.
Cellular Therapy and Transplantation
Academic literature review
2007
-
Standal, Therese;
Abildgaard, N;
Fagerli, Unn-Merete;
Stordal, B;
Hjertner, ¯yvind;
Børset, Magne;
Sundan, Anders.
(2007)
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma.
Blood
Academic article
2006
-
Standal, Therese.
(2006)
The interplay between malignant plasma cells and the bone marrow microenvironment.
NTNU
Doctoral thesis
-
Standal, Therese.
(2006)
HGF inhibits BMP-2 induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma.
Blood
Conference abstract
-
Hjertner, ¯yvind;
Standal, Therese;
Børset, Magne;
Sundan, Anders;
Waage, Anders.
(2006)
Bone disease in multiple myeloma.
Medical Oncology (MO)
Academic literature review
-
Standal, Therese;
Abildgaard, Niels;
Fagerli, Unn-merete;
Størdal, Berit Fladvad;
Hjertner, Øyvind;
Børset, Magne;
Sundan, Anders.
(2006)
HGF Inhibits BMP-Induced Osteoblastogenesis: Implications for the Bone Disease in Multiple Myeloma.
Blood
Conference abstract
2005
-
Andersen, NF;
Standal, Therese;
Nielsen, JL;
Heickendorff, L;
Børset, Magne;
Sorensen, FB;
Abildgaard, N.
(2005)
Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival.
British Journal of Haematology
Academic article
-
Hjertner, Øyvind;
Standal, Therese;
Børset, Magne;
Sundan, Anders;
Waage, Anders.
(2005)
Identification of new targets for therapy of osteolytic bone disease in multiple myelomas.
Current Drug Targets
Academic literature review
2004
-
Standal, Therese;
Børset, Magne;
Sundan, Anders.
(2004)
Role of osteopontin in adhesion, migration, cell survival and bone remodeling.
Experimental Oncology
Academic article
2002
-
Standal, Therese;
Seidel, Carina;
Hjertner, ¯yvind;
Plesner, Torben;
Sanderson, Ralph D.;
Waage, Anders;
Børset, Magne;
Sundan, Anders.
(2002)
Osteoprotegerin is Bound, Internalized and Degraded by Multiple Myeloma Cells.
Blood
Academic article
-
Standal, Therese;
Børset, Magne;
Lenhoff, S.;
Wisløff, Finn;
Størdal, Berit Fladval;
Sundan, Anders;
Waage, Anders;
Seidel, Carina.
(2002)
Serum insulin-like growth factor is not increased in patients with multiple myelomna but is still a prognostic factor.
Blood
Academic article
-
Seidel, Carina;
Lenhoff, S.;
Brabrand, Sigmund;
Anderson, G;
Standal, Therese;
Nielsen, Johan Lanng;
Turesson, I;
Børset, Magne;
Waage, Anders.
(2002)
Hepatocyte growth factor in myeloma patients treated with high-dose chemotherapy.
British Journal of Haematology
Academic article
Journal publications
-
Roseth, Ingrid Aass;
Hatscher, Lukas;
Schiller, Chiara;
Johnstuen, Håkon Skjalg Selland;
Slørdahl, Tobias Schmidt;
Hov, Håkon;
Schapiro, Denis;
Standal, Therese.
(2025)
Multiplexed Imaging Reveals Immune-Metabolic Niches in Multiple Myeloma Linked to Progression and Bone Disease.
Blood Cancer Discovery
Academic article
-
Emma, Busarello,;
Giulia, Biancon,;
Ilaria, Cimignolo,;
Vittorio, Bontempi,;
Giorgia, Bucciarelli,;
Marianna, Ciuffreda,;
Zuhairia, Ibnat,;
Fabio, Lauria,;
Paolo, Macchi,;
Maria, Marino, Stefano.
(2025)
Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease | Nature Communications.
Nature Communications
Academic article
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma.
Scientific Reports
Academic article
-
Rustad, Even Holth;
Coward, Eivind;
Skytøen, Emilie R;
Misund, Kristine;
Holien, Toril;
Standal, Therese;
Børset, Magne;
Beisvag, Vidar;
Myklebost, Ola;
Meza, Leonardo Zepeda.
(2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica
Academic article
-
Sponaas, Anne-Marit;
Waage, Anders;
Vandsemb, Esten;
Misund, Kristine;
Børset, Magne;
Sundan, Anders;
Slørdahl, Tobias Schmidt;
Standal, Therese.
(2021)
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?.
Frontiers in Immunology
Academic literature review
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya;
Standal, Therese.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Academic article
-
Zhang, Zejian;
Westhrin, Marita;
Bondt, Albert;
Wuhrer, Manfred;
Standal, Therese;
Holst, Stephanie.
(2019)
Serum protein N-glycosylation changes in multiple myeloma.
Biochimica et Biophysica Acta - General Subjects
Academic article
-
Standal, Therese;
Johnson, Rachelle;
McGregor, Narelle;
Poulton, Ingrid;
Ho, Patricia W M;
Martin, T. John;
Sims, Natalie.
(2014)
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
Journal of Endocrinology
Academic article
-
Moen, Ingrid Nyhus;
Westhrin, Marita;
Håland, Erling;
Haug, Markus;
Nonstad, Unni;
Klaharn, Merisa;
Standal, Therese;
Starheim, Kristian K..
(2021)
Smac-mimetics reduce numbers and viability of human osteoclasts.
Cell death discovery
Academic article
-
Westhrin, Marita;
Moen, Siv Helen;
Standal, Therese.
(2015)
GDF15 i beinsykdommen ved myelomatose.
Bestpractice Onkologi/Hematologi
Professional article
-
Ma, Qianli;
Rubenis, Kristaps;
Sigurjonsson, Olafur E.;
Hildebrand, Torben;
Standal, Therese;
Zemjane, Signe;
Locs, Janis;
Loca, Dagnija;
Haugen, Håvard Jostein.
(2023)
Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model.
Smart Materials in Medicine
Academic article
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo;
Hella, Hanne;
Sponaas, Anne Marit;
Standal, Therese.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Academic article
-
Westhrin, Marita;
Holien, Toril;
Zahoor, Muhammad;
Moen, Siv Helen;
Buene, Glenn;
Størdal, Berit Fladvad;
Hella, Hanne;
Yuan, Huipin;
Bruijn, Joost D de;
Martens, Anton.
(2020)
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone.
JBMR Plus
Academic article
-
Standal, Therese;
Abildgaard, N;
Fagerli, Unn-Merete;
Stordal, B;
Hjertner, ¯yvind;
Børset, Magne;
Sundan, Anders.
(2007)
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma.
Blood
Academic article
-
Andersen, NF;
Standal, Therese;
Nielsen, JL;
Heickendorff, L;
Børset, Magne;
Sorensen, FB;
Abildgaard, N.
(2005)
Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival.
British Journal of Haematology
Academic article
-
Aass, Kristin Roseth;
Kastnes, Martin;
Standal, Therese.
(2020)
Molecular interactions and functions of IL-32.
Journal of Leukocyte Biology
Academic article
-
Jönsson, Sofia;
Hjorth-Hansen, Henrik;
Olsson, Bob;
Wadenvik, H;
Sundan, Anders;
Standal, Therese.
(2012)
Imatinib inhibits proliferation of human mesenchymal stem cells and promotes early but not late osteoblast differentiation in vitro.
Journal of Bone and Mineral Metabolism
Academic article
-
Standal, Therese;
Norgaard, NN;
Bohnhorst, J;
Espevik, T;
Waage, A;
Sundan, A.
(2009)
Does Toll-like Receptor 9 Signaling Play a Role in Myeloma Disease Progression?.
Clinical Lymphoma & Myeloma
Conference abstract
-
Mylin, AK;
Abildgaard, N;
Johansen, JS;
Andersen, NF;
Heickendorff, L;
Standal, Therese;
Gimsing, P;
Knudsen, LM.
(2008)
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients.
European Journal of Haematology
Academic article
-
Yang, Rui;
Elsaadi, Samah;
Misund, Kristine;
Abdollahi, Pegah;
Vandsemb, Esten;
Moen, Siv Helen;
Kusnierczyk, Anna;
Slupphaug, Geir;
Standal, Therese;
Waage, Anders.
(2020)
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade.
Journal for ImmunoTherapy of Cancer (JITC)
Academic article
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad;
Sundan, Anders;
Nilsen, Nadra J.;
Sponaas, Anne-Marit;
Standal, Therese.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
-
Grandaunet, Berit Helen;
Syversen, Silje;
Hoff, Mari;
Haugeberg, Glenn;
Heijde, Desire van der;
Kvien, Tore;
Standal, Therese.
(2010)
DKK1, AN INHIBITOR OF BONE FORMATION IS AN INDEPENDENT PREDICTOR OF HAND BONE LOSS IN RHEUMATOID ARTHRITIS.
Scandinavian Journal of Rheumatology
Conference abstract
-
Standal, Therese.
(2018)
Myelomatose - bein i ubalanse.
Bestpractice Onkologi/Hematologi
Academic literature review
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne;
Standal, Therese.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Academic article
-
Sponaas, Anne-Marit;
Moen, Siv Helen;
Liabakk, Nina-Beate;
Feyzi, Emadoldin;
Holien, Toril;
Kvam, Solveig;
Grøseth, Lill Anny Gunnes;
Størdal, Berit Fladvad;
Buene, Glenn;
Espevik, Terje.
(2015)
The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma.
Immunity,Inflammation and Disease
Academic article
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine;
Standal, Therese.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Academic article
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria;
Giliberto, Mariaserena;
Buene, Glenn;
Sundan, Anders;
Waage, Anders.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Academic article
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
van den Brink, Luca Mare;
Roseth, Ingrid Aass;
Westhrin, Marita;
Zahoor, Muhammad;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Academic article
-
Hjertner, Øyvind;
Standal, Therese;
Børset, Magne;
Sundan, Anders;
Waage, Anders.
(2005)
Identification of new targets for therapy of osteolytic bone disease in multiple myelomas.
Current Drug Targets
Academic literature review
-
Slørdahl, Tobias Schmidt;
Denayer, Tinneke;
Moen, Siv Helen;
Standal, Therese;
Børset, Magne;
Ververken, Cedric;
Rø, Torstein Baade.
(2013)
Anti-c-MET Nanobody® – a new potential drug in multiple myeloma treatment.
European Journal of Haematology
Academic article
-
Westhrin, Marita;
Kovcic, Vlado;
Zejian, Zhang;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene;
Bondt, Albert;
Holst, Stephanie;
Misund, Kristine;
Buene, Glenn;
Sundan, Anders.
(2020)
Monoclonal immunoglobulins promote bone loss in multiple myeloma.
Blood
Academic article
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Misund, Kristine;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Mylin, Anne K.;
Turesson, I;
Størdal, Berit Fladvad;
Moen, Siv Helen;
Standal, Therese.
(2014)
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Blood Cancer Journal
Academic article
-
Mylin, AK;
Andersen, NF;
Johansen, JS;
Abildgaard, N;
Heickendorff, L;
Standal, Therese;
Gimsing, P;
Knudsen, LM.
(2009)
Serum YKL-40 and bone marrow angiogenesis in multiple myeloma.
International Journal of Cancer
Commentary
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes;
Rekvig, Magne;
Børset, Magne;
Standal, Therese;
Waage, Anders.
(2011)
BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC.
Haematologica
Conference abstract
-
Sponaas, Anne-Marit;
Nejati Moharrami, Neda;
Feyzi, Emadoldin;
Standal, Therese;
Rustad, Even Holth;
Waage, Anders;
Sundan, Anders.
(2015)
PDL1 expression on plasma and dendritic cells in myeloma bone marrow suggests benefit of targeted anti PD1-PDL1 therapy.
PLOS ONE
Academic article
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel;
Hella, Hanne;
Ryan, Liv;
Standal, Therese;
Espevik, Terje.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
-
Holien, Toril;
Westhrin, Marita;
Standal, Therese.
(2019)
BMP4-genterapi hemmer vekst av myelomceller, men har også hemmende effekt på trabekulært ben i mus.
Bestpractice Onkologi/Hematologi
Professional article
-
Holien, Toril;
Westhrin, Marita;
Moen, Siv Helen;
Zahoor, Muhammad;
Buene, Glenn;
Størdal, Berit Fladvad;
Hella, Hanne;
Yuan, Huipin;
Bruijn, Joost D de;
Martens, Anton.
(2018)
BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone.
Blood
Conference abstract
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes;
Rekvig, Magne;
Børset, Magne;
Standal, Therese;
Waage, Anders.
(2012)
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.
Leukemia
Academic article
-
Jönsson, Sofia;
Standal, Therese;
Olsson, Bob;
Mellström, Dan;
Wadenvik, H.
(2012)
Secondary hyperparathyroidism but stable bone-mineral density in patients with chronic myeloid leukemia treated with imatinib.
American Journal of Hematology
Commentary
-
Jönsson, S;
Hjorth-Hansen, Henrik;
Olsson, B;
Wadenvik, H;
Sundan, Anders;
Standal, Therese.
(2010)
Second-generation TKI dasatinib inhibits proliferation of mesenchymal stem cells and osteoblast differentiation in vitro.
Leukemia
Commentary
-
Westhrin, Marita;
Xie, Minli;
Olderøy, Magnus Ø.;
Sikorski, Pawel;
Strand, Berit Løkensgard;
Standal, Therese.
(2015)
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices.
PLOS ONE
Academic article
-
Kohtala, Sampsa;
Nedal, Tonje Marie Vikene;
Kriesi, Carlo Rene;
Moen, Siv Helen;
Ma, Qianli;
Ødegaard, Kristin Sirnes;
Standal, Therese;
Steinert, Martin.
(2022)
Automated Quantification of Human Osteoclasts Using Object Detection.
Frontiers in Cell and Developmental Biology
Academic article
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jonsson, Sofia;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders;
Standal, Therese.
(2010)
CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis.
Journal of Immunology
Academic article
-
Standal, Therese;
Børset, Magne;
Sundan, Anders.
(2004)
Role of osteopontin in adhesion, migration, cell survival and bone remodeling.
Experimental Oncology
Academic article
-
Westhrin, Marita;
Moen, Siv Helen;
Kristensen, Ida Bruun;
Buene, Glenn;
Mylin, Anne Kærsgaard;
Turesson, Ingemar;
Abildgaard, Niels;
Waage, Anders;
Standal, Therese.
(2018)
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes.
Biomarker Research
Academic article
-
Ødegaard, Kristin Sirnes;
Westhrin, Marita;
Bin Afif, Abdulla Shaikh Abdul Qader;
Ma, Qianli;
Mela, Petra;
Standal, Therese;
Elverum, Christer Westum;
Torgersen, Jan.
(2023)
The effects of surface treatments on electron beam melted Ti-6Al-4V disks on osteogenesis of human mesenchymal stromal cells.
Biomaterials Advances
Academic article
-
Standal, Therese;
Seidel, Carina;
Hjertner, ¯yvind;
Plesner, Torben;
Sanderson, Ralph D.;
Waage, Anders;
Børset, Magne;
Sundan, Anders.
(2002)
Osteoprotegerin is Bound, Internalized and Degraded by Multiple Myeloma Cells.
Blood
Academic article
-
Standal, Therese;
Børset, Magne;
Lenhoff, S.;
Wisløff, Finn;
Størdal, Berit Fladval;
Sundan, Anders;
Waage, Anders;
Seidel, Carina.
(2002)
Serum insulin-like growth factor is not increased in patients with multiple myelomna but is still a prognostic factor.
Blood
Academic article
-
Seidel, Carina;
Lenhoff, S.;
Brabrand, Sigmund;
Anderson, G;
Standal, Therese;
Nielsen, Johan Lanng;
Turesson, I;
Børset, Magne;
Waage, Anders.
(2002)
Hepatocyte growth factor in myeloma patients treated with high-dose chemotherapy.
British Journal of Haematology
Academic article
-
Westhrin, Marita;
Standal, Therese.
(2019)
N-glykosylering av serumproteiner endres ved myelomatose.
Bestpractice Onkologi/Hematologi
Academic article
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Bouma, Siri Anshushaug;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival.
British Journal of Cancer
Academic article
-
Standal, Therese.
(2006)
HGF inhibits BMP-2 induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma.
Blood
Conference abstract
-
Olderøy, Magnus Østgård;
Westhrin, Marita;
Andreassen, Jens-Petter;
Zhang, Zhibing;
Strand, Berit Løkensgard;
Standal, Therese;
Sikorski, Pawel.
(2012)
Properties and cell compatibility of mineralized alginate hydrogel beads.
European Cells and Materials
Conference abstract
-
Olderøy, Magnus Østgård;
Westhrin, Marita;
Ehnert, Sabrina;
Xie, Minli;
Andreassen, Jens-Petter;
Strand, Berit Løkensgard;
Standal, Therese;
Nussler, Andreas K;
Sikorski, Pawel.
(2012)
Investigation of mineralized alginate gels as a scaffold material for stem cell based bone tissue engineering.
Journal of Tissue Engineering and Regenerative Medicine
Conference abstract
-
Sponaas, Anne-Marit;
Yang, Rui;
Rustad, Even Holth;
Standal, Therese;
Thoresen, Aud;
Vo, Camilla Dao;
Waage, Anders;
Slørdahl, Tobias Schmidt;
Børset, Magne;
Sundan, Anders.
(2018)
PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.
OncoTarget
Academic article
-
Hjertner, ¯yvind;
Standal, Therese;
Børset, Magne;
Sundan, Anders;
Waage, Anders.
(2006)
Bone disease in multiple myeloma.
Medical Oncology (MO)
Academic literature review
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jönsson, S;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders;
Standal, Therese.
(2011)
CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis.
Bone
Conference abstract
-
Børset, Magne;
Standal, Therese;
Waage, Anders;
Sundan, Anders.
(2008)
Hepatocyte growth factor (HGF) in the pathogenesis of multiple myeloma.
Cellular Therapy and Transplantation
Academic literature review
-
Ødegaard, Kristin Sirnes;
Ouyang, Lingzi;
Ma, Qianli;
Buene, Glenn;
Wan, Di;
Elverum, Christer Westum;
Torgersen, Jan;
Standal, Therese;
Westhrin, Marita.
(2021)
Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells.
Journal of Materials Science: Materials in Medicine
Academic article
-
Standal, Therese;
Abildgaard, Niels;
Fagerli, Unn-merete;
Størdal, Berit Fladvad;
Hjertner, Øyvind;
Børset, Magne;
Sundan, Anders.
(2006)
HGF Inhibits BMP-Induced Osteoblastogenesis: Implications for the Bone Disease in Multiple Myeloma.
Blood
Conference abstract
-
Grandaunet, Berit Helen;
Syversen, Silje Watterdal;
Hoff, Mari;
Sundan, Anders;
Haugeberg, Glenn;
Heijde, Desiree van der;
Kvien, Tore Kristian;
Standal, Therese.
(2011)
Association Between High Plasma Levels of Hepatocyte Growth Factor and Progression of Radiographic Damage in the Joints of Patients With Rheumatoid Arthritis.
Arthritis and Rheumatism
Academic article
-
Johnson, Rachelle;
Brennan, Holly;
Vrahnas, Christina;
Poulton, Ingrid;
McGregor, Narelle;
Standal, Therese;
Walker, Emma;
Koh, T;
Nguyen, H.;
Walsh, Nicole.
(2014)
The Primary Function of gp130 Signaling in Osteoblasts is to Maintain bone Formation and Strength, Rather than Promote Osteoclast Formation.
Journal of Bone and Mineral Research
Academic article
-
Grandaunet, Berit Helen Jensen;
Syversen, Silje Watterdal;
Hoff, Mari;
Haugeberg, Glenn;
Hejde, Désirée Van der;
Kvien, Tore Kristian;
Standal, Therese.
(2013)
Dickkopf-1 is associated with periarticular bone loss in patients with rheumatoid arthritis.
Open Journal of Rheumatology and Autoimmune Diseases
Academic article
-
Børset, Magne;
Sundan, Anders;
Waage, Anders;
Standal, Therese.
(2019)
Why do myeloma patients have bone disease? A historical perspective.
Blood reviews
Academic literature review
-
Westhrin, Marita;
Moen, Siv Helen;
Holien, Toril;
Mylin, Anne K.;
Heickendorff, Lene;
Olsen, Oddrun Elise;
Sundan, Anders;
Turesson, Ingemar;
Gimsing, Peter;
Waage, Anders.
(2015)
Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease.
Haematologica
Commentary
Student thesis or dissertation
-
Standal, Therese.
(2006)
The interplay between malignant plasma cells and the bone marrow microenvironment.
NTNU
Doctoral thesis
-
Grandaunet, Berit Helen;
Standal, Therese;
Haugeberg, Glenn;
Sundan, Anders.
(2014)
Bone loss in rheumatoid arthritis: Possible roles for hepatocyte growth factor,syndecan-1 and dickkopf-1.
Norges teknisk-naturvitenskapelige universitet
Doctoral thesis
-
Standal, Therese;
Aass, Kristin Roseth.
(2020)
The role IL-32 in multiple myeloma.
NTNU Open
Doctoral thesis
-
Standal, Therese;
Kovcic, Vlado.
(2020)
New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma.
Norges teknisk-naturvitenskapelige universitet
Doctoral thesis
Outreach
2024
-
Conference posterMestvedt, Ingvild Bergdal; Yurchenko, Maria; Espevik, Terje; Standal, Therese; Wolowczyk, Camilla Izabel; Rasheed, Kashif; Misund, Kristine; Slørdahl, Tobias Schmidt; Hella, Hanne; Ryan, Liv. (2024) Exploring peptide derived from Signaling Lymphocytic Activation Molecule Family 1 as novel treatment for multiple myeloma. ENA 2024 Symposium on molecular targets and cancer therapeutics
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Conference lectureRoseth, Ingrid Aass; Behsen, Alenka Djarmila; Moen, Siv Helen; Sponaas, Anne Marit; Aass, Kristin Roseth; Tryggestad, Synne Stokke; Hella, Hanne; Størdal, Berit Fladvad; Nedal, Tonje Marie Vikene; Standal, Therese. (2024) Mass cytometry of murine immune cell populations upon diet induced obesity and early stages of myeloma. Norwegian Flow Cytometry Meeting 2024
2023
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Lecture
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Conference lectureRoseth, Ingrid Aass; Hov, Håkon; Johnstuen, Håkon Skjalg Selland; Standal, Therese. (2023) Spatial interactions between cells in the multiple myeloma bone marrow. Mutiple Myeloma Medical Education Symposium
2022
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Conference lectureRoseth, Ingrid Aass; Hov, Håkon; Johnstuen, Håkon Skjalg Selland; Standal, Therese. (2022) Imaging Mass Cytometry: Spatial relationships between cells in the multiple myeloma bone marrow . Norwegian Myeloma Workshop
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Conference lectureTryggestad, Synne Stokke; Aass, Kristin Roseth; Buene, Glenn; Standal, Therese. (2022) Infections may render myeloma cells less sensitive to common myeloma drugs. 3rd Norwegian myeloma workshop
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Conference lectureRoseth, Ingrid Aass; Johnstuen, Håkon Skjalg Selland; Hov, Håkon; Standal, Therese. (2022) Imaging mass cytometry: spatial relationships between cells in the multiple myeloma bone marrow. Nordic Myeloma Study Group Meeting
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LectureStandal, Therese. (2022) Immunterapi mot kreft: kan immunforsvaret vårt kurere kreft?. Forelesningsserie Kunnskapsbyen Trondheim
2021
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Conference posterKastnes, Martin Haugrud; Standal, Therese; Aass, Kristin Roseth; Sponaas, Anne-Marit; Tryggestad, Synne Stokke. (2021) Investigating the role of IL-32 in T cells. British Society for Immunology Congress 2021
2020
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Interview
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Interview
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Interview
2019
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Conference lectureHolien, Toril; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; Bruijn, Joost D de; Martens, Anton. (2019) BMP4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone. The TGF-β Superfamily: Signaling in Development and disease.
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Conference posterAass, Kristin Roseth; Mjelle, Robin; Westhrin, Marita; Zahoor, Muhammad; Yurchenko, Mariya; Buene, Glenn; Slørdahl, Tobias Schmidt; Hella, Hanne; Waage, Anders; Standal, Therese. (2019) IL-32 is a novel growth factor and metabolic regulator in multiple myeloma cells. The Second Conference on Molecular Mechanisms of Inflammation in Trondheim June 3-6, 2019.
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Conference lectureWesthrin, Marita; Kovcic, Vlado; Bondt, Albert; Wuhrer, Manfred; Holst, Stephanie; Zhang, Zejian; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese. (2019) A role for immunoglobulins in the osteolytic bone disease of multiple myeloma. Herbert Fleisch workshop
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Conference lectureWesthrin, Marita; Kovcic, Vlado; Bondt, Albert; Holst, Stephanie; Zhang, Zejian; Sundan, Anders; Slørdahl, Tobias Schmidt; Waage, Anders; Wuhrer, Manfred; Standal, Therese. (2019) Glycosylation of immunoglobulins determine bone loss in multiple myeloma. American association for bone and mineral research annual meeting
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Conference posterAass, Kristin Roseth; Mjelle, Robin; Zahoor, Muhammad; Yurchenko, Mariya; Westhrin, Marita; Buene, Glenn; Hella, Hanne; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese. (2019) IL-32 is a novel growth factor and metabolic regulator for multiple myeloma cells. Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment.
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Conference lectureStandal, Therese; Westhrin, Marita; Kovcic, Vlado; Zhang, Zejian; Bondt, Albert; Slørdahl, Tobias Schmidt; Waage, Anders; Holst, Stephanie; Wuhrer, Manfred. (2019) Multiple myeloma bone disease. Do immunoglobulins play a role?. International Conference on Molecular Mechanisms of Inflammation
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Conference lectureHolien, Toril; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; Bruijn, Joost D de; Martens, Anton. (2019) BMP4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone. BMP Signalling in Cancer II
2018
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Conference posterHolien, Toril; Westhrin, Marita; Moen, Siv Helen; Buene, Glenn; Groen, Richard WJ; Martens, Anton; Sundan, Anders; Standal, Therese. (2018) BMP4 gene therapy inhibits myeloma tumor growth, but has a negative impact on bone. 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult?
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Conference lectureWesthrin, Marita; Kovcic, Vlado; Buene, Glenn; Sundan, Anders; Slørdahl, Tobias Schmidt; Waage, Anders; Wuhrer, Manfred; Standal, Therese. (2018) Do immunoglobulins promote bone loss in multiple myeloma?. 1st Norwegian Myeloma Workshop
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LectureStandal, Therese. (2018) Beintap ved myelomatose/Erfaringer med brukermedvirkning i forskning. Blodkreftforeningens myelomatoseseminar
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Conference posterHolien, Toril; Westhrin, Marita; Moen, Siv Helen; Zahoor, Muhammad; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Sundan, Anders; Standal, Therese. (2018) BMP4 gene therapy inhibits myeloma tumor growth, but has a negative impact on bone. 12th International BMP Conference
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Conference posterMoen, Ingrid Nyhus; Westhrin, Marita; Quinsgaard, Ellen Marie; Lien, Egil; Bjørkøy, Geir; Standal, Therese; Starheim, Kristian K.. (2018) TAK1- and IAP-inhibitors re-direct osteoclastogenesis to cell death. International NTNU Symposium on Clinical Biomarkers of Cancer
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Conference posterStandal, Therese; Westhrin, Marita; Kovcic, Vlado; Bondt, Albert; Holst, Stephanie; Zhang, Zejian; Buene, Glenn; Sundan, Anders; Slørdahl, Tobias Schmidt; Waage, Anders. (2018) A role for immunoglobulins in the osteolytic bone disease of multiple myeloma. American association for bone and mineral research annual meeting
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Conference lectureWesthrin, Marita; Kovcic, Vlado; Bondt, Albert; Holst, Stephanie; Zhang, Zejian; Buene, Glenn; Sundan, Anders; Slørdahl, Tobias Schmidt; Waage, Anders; Wuhrer, Manfred. (2018) A role for immunoglobulins in the osteolytic bone disease of multiple myeloma. 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer
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Conference posterHolien, Toril; Westhrin, Marita; Moen, Siv Helen; Zahoor, Muhammad; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; Bruijn, Joost D de; Martens, Anton. (2018) BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone. ASH 2018
2017
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Lecture
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Conference lectureStandal, Therese. (2017) Newer aspects of the bone disease in multiple myeloma. Nordic Myeloma Study Group Plenary Autumn Meeting
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Lecture
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Conference lectureStandal, Therese; Westhrin, Marita; Zahoor, Muhammad; Aass, Kristin Roseth; Moen, Siv Helen. (2017) IL-32 in multiple myeloma. Department seminar
2016
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Conference posterStandal, Therese; Zahoor, Muhammad; Westhrin, Marita; Moen, Siv Helen. (2016) IL-32 is produced by myeloma cells in response to hypoxia: potential role for exosomal IL-32 in multiple myeloma bone disease. American Association for Bone and Mineral Research annual meeting
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Conference posterRustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Dai, Hong Yan; Sundan, Anders; Waage, Anders. (2016) Circulating Tumor DNA in Multiple Myeloma. European Hematology Association 21th Congress
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Interview
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Conference posterZahoor, Muhammad; Westhrin, Marita; Moen, Siv Helen; Standal, Therese. (2016) IL-32 is produced by myeloma cells in response to hypoxia: potential role for exosomal IL-32in multiple myeloma bone disease. 1st. International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer
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Conference posterMoen, Siv Helen; Westhrin, Marita; Zahoor, Muhammad; Standal, Therese. (2016) Caspase-8 regulates the expresion of pro- and anti-inflammatory cytokines in human bone marrow-dervied mesenchymal stromal cells. CEMIR 2016 Conference on Molecular Mechanisms of Inflammation
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Conference posterZahoor, Muhammad; Westhrin, Marita; Moen, Siv Helen; Standal, Therese. (2016) Myeloma cells secrete IL-32 in response to hypoxia: a potential role for exosomal IL-32in multiple myeloma bone disease. CEMIR 2016 Conference on Molecular Mechanisms of Inflammation
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Conference posterZahoor, Muhammad; Westhrin, Marita; Moen, Siv Helen; Standal, Therese. (2016) IL-32 is produced by myeloma cells in response to hypoxia: potential role for exosomal IL-32in multiple myeloma bone disease. Herbert Fleisch Workshop
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LectureZahoor, Muhammad; Westhrin, Marita; Moen, Siv Helen; Standal, Therese. (2016) IL-32 is produced by myeloma cells in response to hypoxia: potential role for exosomal IL-32in multiple myeloma bone disease (Oral presentation). Herbert Fleisch Workshop
2015
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Conference lecture
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Conference lectureWesthrin, Marita; Moen, Siv Helen; Holien, Toril; Olsen, Oddrun Elise; Sundan, Anders; Waage, Anders; Standal, Therese. (2015) Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease. 15th international myeloma workshop
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Interview
2014
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LectureHolien, Toril; Grøseth, Lill Anny Gunnes; Standal, Therese; Misund, Kristine; Bruvoll, Ingrid; Nordrum, Ivar Skjåk; Sundan, Anders. (2014) Hvordan jobber en kreftforsker + Besøk i medisinsk museum i Kunnskapssenteret. Klassebesøk, 5. trinn barneskole
2013
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Interview
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Interview
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LectureHolien, Toril; Sponaas, Anne-Marit; Misund, Kristine; Rø, Torstein Baade; Brede, Gaute; Standal, Therese; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Starheim, Kristian Kobbenes; Feyzi, Emadoldin. (2013) "Ta livet av kreftcellene" Stand i samarbeid med Kreftforeningen. Forskningstorget
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Conference posterOlsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Størdal, Berit Fladvad; Moen, Siv Helen; Standal, Therese; Waage, Anders; Sundan, Anders. (2013) Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. TGF-B Superfamily: Signaling in Development and Disease
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LectureStandal, Therese; Johnson, Rachelle; McGregor, Narelle; Poulton, Ingrid; Martin, T. John; Sims, Natalie. (2013) Deletion of gp130 in Osteocytes Blocks PTH Anabolic Effect. American association of bone and mineral resarch annual meeting 2013
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LectureStandal, Therese; Johnson, Rachelle; McGregor, Narelle; Poulton, Ingrid; Martin, T. John; Sims, Natalie. (2013) Deletion of gp130 in Osteocytes Blocks PTH Anabolic Effect. Norsk Beinsymposium
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LectureStandal, Therese. (2013) Cells down under the bone. Seminar at the Department of Cancer Research and Molecular Medicine
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Conference posterSlørdahl, Tobias Schmidt; Denayer, Tinneke; Moen, Siv Helen; Standal, Therese; Børset, Magne; Ververken, Cedric; Rø, Torstein Baade. (2013) Anti-c-Met Nanobody. A potential new drug in cancer treatment. AACR 104th Annual conference
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Conference posterSlørdahl, Tobias Schmidt; Denayer, Tinneke; Moen, Siv Helen; Standal, Therese; Børset, Magne; Ververken, Cedric; Rø, Torstein Baade. (2013) Anti-c-Met Nanobody. A new potential drug in multiple myeloma treatment. The 14th International Myeloma Workshop
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Conference posterMoen, Siv Helen; Nørgaard, Nikolai Nordberg; Westhrin, Marita; Størdal, Berit Fladvad; Hella, Hanne; Sundan, Anders; Standal, Therese. (2013) TLR agonists induce expression of cytokines in mesenchymal stem cells and pre-osteoblasts promoting osteoclast activation and MM-cell growth. International Myeloma Workshop 2013
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LectureOlsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Størdal, Berit Fladvad; Moen, Siv Helen; Standal, Therese; Waage, Anders; Sundan, Anders. (2013) Membrane bound and soluble endoglin protects myeloma cells from bone morphogenetic protein 9 induced apoptosis. NBS vintermøte
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Conference posterWesthrin, Marita; Xie, Minli; Olderøy, Magnus Ø.; Sikorski, Pawel; Strand, Berit Løkensgard; Standal, Therese. (2013) Human mesenchymal stem cells in mineralized alginate beads: A potential new tool to study interactions between osteocytes and myeloma cells. International Myeloma Workshop
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LectureStandal, Therese. (2013) Hepatocyte growth factor in multiple myeloma; the influence on the bone marrow microenvironment, inflammation and differentiation of osteoblasts and osteoclast. Cell biology guest lecture
2011
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Conference posterHolien, Toril; Våtsveen, Thea Kristin; Hella, Hanne; Rampa, Christoph Samuel; Brede, Gaute; Grøseth, Lill Anny Gunnes; Rekvig, Magne; Børset, Magne; Standal, Therese; Waage, Anders. (2011) BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC. 13th Interntional Myeloma Workshop
2010
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Conference posterXie, Minli; Olderøy, Magnus Østgård; Strand, Berit Løkensgard; Standal, Therese; Zhang, Zhibing; Andreassen, Jens-Petter; Sikorski, Pawel. (2010) Bio-inspired mineralization of alginate hydrogels with hydroxyapatite for new composite materials in tissue engineering. Gordon Research Conference: Biomineralization
2009
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Interview
2008
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Conference lectureStandal, Therese; Nørgaard, Nikolai Nordberg. (2008) Is there a role for toll-like receptor 9 in multiple myeloma?. Norwegian Center for Stem Cell Research Annual Meeting
2007
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Conference lectureStandal, Therese; Sundan, Anders; Børset, Magne. (2007) Impediment of Mesenchymal Stem Cell Differentiation Consequence for the Bone Disease in Multiple Myeloma. Hemopoietic Stem Cell Transplantation - International meeting dedicated to the memory of Raisa Gorbachova.
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Conference lectureStandal, Therese; Nørgaard, Nikolai Nordberg; Sundan, Anders. (2007) Mesenchymal stem cells express toll like receptors. BMP and toll makes tull...?. Norwegian Stem Cell Networking Meeting
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Conference lectureStandal, Therese; Abildgaard, Niels; Fagerli, Unn-Merete; Hjertner, ¯yvind; Størdal, Berit Fladvad; Børset, Magne; Sundan, Anders. (2007) Beinsykdommen ved myelomatose. Er HGF skurken?. Norsk Beinsymposium: Osteoporose og beinforskning i Norge
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Conference lectureStandal, Therese; Abildgaard, Niels; Fagerli, Unn-Merete; Størdal, Berit Fladvad; Hjertner, ¯yvind; Børset, Magne; Sundan, Anders. (2007) HGF:perpetrator of myeloma bone disease?. Polsk-norsk uke
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Conference lectureStandal, Therese; Nørgaard, Nikolai Nordberg; Sundan, Anders. (2007) Fra mesenchymal stamcelle til osteoblast. BMP og toll blir tull?. Tirsdagsmøte, Institutt for kreftforskning og molekylær medisin
2006
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Conference lectureStandal, Therese. (2006) HGF inhibits BMP-2 induced osteoblastogenesis:possible implications for the bone disease of multiple myeloma. 6th International Conference on Bone Morphogenetic Proteins 2006
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Conference lecture
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Conference posterStandal, Therese. (2006) HGF inhibits BMP-2 induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. American Society for Hematology Annual Meeting 2006
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Conference posterStandal, Therese. (2006) HGF inhibits BMP-2 induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. 1st International Conference in Osteoimmunolgy
2003
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Conference posterStandal, Therese; Hjorth-Hansen, Henrik; Dahl, Ivar M.; Brenne, Anne Tove; Waage, Anders; Børset, Magne; Sundan, Anders; Hjertner, ¯yvind. (2003) Elevated plasma OPN in multiple myeloma patients. Multiple Myeloma 9th International Workshop
2002
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Conference posterStandal, Therese; Waage, Anders; Seidel, Carina; Hjertner, ¯yvind; Plesner, Torben; Sanderson, Ralph D.; Børset, Magne; Sundan, Anders. (2002) Increased clearance of osteoprotegerin (OPG) in multiple myeloma: OPG is internalized and degraded by myeloma cells. Nordisk forening for hematologis vårmøte
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Conference lecture
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Conference lectureStandal, Therese; Seidel, Carina; Hjertner, ¯yvind; Plesner, Torben; Waage, Anders; Børset, Magne; Sundan, Anders. (2002) Osteoprotegerin is bound, internalized and degraded by multiple myeloma cells. 18th UICC International Cancer Congress
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Conference lectureStandal, Therese; Børset, Magne; Lenhoff, S.; Wisløff, Finn; Størdal, Berit Fladval; Sundan, Anders; Waage, Anders; Seidel, Carina. (2002) Serum Insulin-Like Growth Factor Is Not Elevated in Patients with Multiple Myeloma but Is Still a Prognostic Factor. American Society of Hematology Forty-fourth annual meeting