Toril Holien
About
Research focus: TGF-β family signaling in cancer
Our research is focused on understanding the role of transforming growth factor (TGF)-ß family signaling pathways in multiple myeloma and other cancers. This includes ligands such as TGF-ß, activins, BMPs and GDFs. There is extensive redundancy in this family of ligands and receptors, and the effects of a given molecule will always depend on the context. Activation of the SMAD1/5 transcription factors by TGF-ß family ligands induces apoptosis in myeloma cells by downregulating the oncogene c-MYC. Potentiaion of SMAD1/5 activity represents therefore a possible treatment option for myeloma patients. We are also interested in the role of TGF-ß signaling in the context of the tumor microenvironment, particularly in relation to angiogenesis and dissemination.
We welcome students that want to study regulation of signaling in the TGF-ß family.
Our group, Fall 2020: Lu Bai (master student), Toril Holien (group leader, PhD), Ingrid Quist-Løkken (MSc, medical research student), Clara Andersson-Rusch (MSc, PhD candidate) and Megan Anne Vik (master student).
Medical Students' Research Programme: Ingrid Quist-Løkken
PhD student: Clara Andersson-Rusch
Master student: Bita Asghariastanehei
Post doctor (2020): Oddrun Elise Olsen
PhD (2017): Oddrun Elise Olsen
PhD (2020, Bjørkøy group, cosupervised): Camilla Wolowczyk
Molecular medicine (2020/21): Megan Anne Vik and Lu Bai
Biotechnology (2019/20, cosupervised): Jenny Malm Rasmussen
Pharmacy (2018/19): Martin Haugrud Kastnes, Nerissa Rae Booc
Pharmacy (2017/18): Thi Le, Fartun Hussein Ali
Molecular Medicine (2016/17): Samah Elsaadi, Fekadu Alemu Atire
Biotechnology (2013/15): Anette Skjærvik
Cell biology (2012/14): Kine Husteli Kristiansen
Biotechnology (2011/12): Oddrun Elise Olsen
Alexander Stockhammer (2018)
Marie-Thérèse Henke (2017)
Meenu Sankar (2015/16)
Sarah Nevens (2013/14)
Publications
2022
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Giliberto, Mariaserena;
Miranda Santana, Leonardo;
Holien, Toril;
Misund, Kristine;
Nakken, Sigve;
Vodak, Daniel;
Hovig, Eivind;
Meza, Leonardo Zepeda;
Coward, Eivind;
Waage, Anders;
Tasken, Kjetil;
Skånland, Sigrid S.
(2022)
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines.
Frontiers in Oncology.
volum 12.
Academic article
2021
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Christensen, Eidi;
Foss, Olav A.;
Quist-Paulsen, Petter;
Staur, Ingrid;
Pettersen, Frode;
Holien, Toril;
Juzenas, Petras;
Qian, Peng.
(2021)
Application of photodynamic therapy with 5-aminolevulinic acid to extracorporeal photopheresis in the treatment of patients with chronic graft-versus-host disease: A first-in-human study.
Pharmaceutics.
volum 13:1558 (10).
Academic article
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Kolos, Jürgen M;
Pomplun, Sebastian;
Jung, Sascha;
Rieß, Benedikt;
Purder, Patrick L;
Voll, Andreas M;
Merz, Stephanie;
Gnatzy, Monika;
Geiger, Thomas M;
Quist-Løkken, Ingrid;
Jatzlau, Jerome;
Knaus, Petra;
Holien, Toril;
Bracher, Andreas;
Meyners, Christian;
Czodrowski, Paul;
Krewald, Vera;
Hausch, Felix.
(2021)
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
Chemical Science.
Academic article
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Melvold, Katrine;
Giliberto, Mariaserena;
Karlsen, Linda;
Ayuda-Duran, Maria del Pilar;
Hanes, Robert;
Holien, Toril;
Enserink, Jorrit;
Brown, Jennifer R.;
Tjønnfjord, Geir Erland;
Tasken, Kjetil;
Skånland, Sigrid Strand.
(2021)
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies.
Molecular Oncology.
Academic article
2020
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Darvekar, Sagar;
Juzenas, Petras;
Oksvold, Morten Pedersen;
Kleinauskas, Andrius;
Holien, Toril;
Christensen, Eidi;
Stokke, Trond;
Sioud, Mouldy;
Qian, Peng.
(2020)
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis.
Cancers.
volum 12.
Academic article
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Ianevski, Aleksandr;
Kulesskiy, Evgeny;
Krpina, Klara;
Lou, Guofeng;
Aman, Yahyah;
Bugai, Andrii;
Aasumets, Koit;
Akimov, Yevhen;
Bulanova, Daria;
Gildemann, Kiira;
Arutyunyan, Albert F.;
Susova, Olga Yu.;
Zhuze, Alexei L.;
Ji, Ping;
Wang, Wei;
Holien, Toril;
Bugge, Marit;
Zusinaite, Eva;
Oksenych, Valentyn;
Lysvand, Hilde;
Gerhold, Joachim M.;
Bjørås, Magnar;
Johansen, Pål;
Waage, Anders;
Heckman, Caroline A.;
Fang, Fei;
Kainov, Denis.
(2020)
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis.
Cancers.
volum 12 (6).
Academic article
-
Martinez-Hackert, Erik;
Sundan, Anders;
Holien, Toril.
(2020)
Receptor binding competition: A paradigm for regulating TGF-β family action.
Cytokine & growth factor reviews.
Scientific translation/review
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Olsen, Oddrun Elise;
Hella, Hanne;
Elsaadi, Samah;
Jacobi, Carsten;
Martinez-Hackert, Erik;
Holien, Toril.
(2020)
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors.
Biomolecules.
volum 10 (4).
Academic article
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Westhrin, Marita;
Holien, Toril;
Zahoor, Muhammad;
Moen, Siv Helen;
Buene, Glenn;
Størdal, Berit Fladvad;
Hella, Hanne;
Yuan, Huipin;
de Bruijn, Joost D;
Martens, Anton;
Groen, Richard WJ;
Bosch, Fátima;
Smith, Ulf;
Sponaas, Anne-Marit;
Sundan, Anders;
Standal, Therese.
(2020)
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone.
JBMR Plus.
volum 4 (1).
Academic article
2019
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Neckmann, Ulrike;
Wolowczyk, Camilla;
Hall, Martina;
Almaas, Eivind;
Ren, Jiang;
Zhao, Sen;
Johannessen, Bjarne;
Skotheim, Rolf I.;
Bjørkøy, Geir;
Dijke, Peter Ten;
Holien, Toril.
(2019)
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients.
Cell Communication and Signaling.
volum 17.
Academic article
2018
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Holien, Toril;
Gederaas, Odrun Arna;
Darvekar, Sagar;
Christensen, Eidi;
Qian, Peng.
(2018)
Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo.
Lasers in Surgery and Medicine.
volum 50 (5).
Academic article
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Olsen, Oddrun Elise;
Sankar, Meenu;
Elsaadi, Samah;
Hella, Hanne;
Buene, Glenn;
Darvekar, Sagar;
Misund, Kristine;
Katagiri, Takenobu;
Knaus, Petra;
Holien, Toril.
(2018)
BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
Journal of Cell Science.
volum 131 (11).
Academic article
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Våtsveen, Thea Kristin;
Myhre, Marit Renee;
Steen, Chloe Beate;
Wälchli, Sébastien;
Lingjærde, Ole Christian;
Bai, Baoyan;
Dillard, Pierre;
Theodossiou, Theodossis;
Holien, Toril;
Sundan, Anders;
Inderberg, Else Marit;
Smeland, Erlend B;
Myklebust, June;
Oksvold, Morten Pedersen.
(2018)
Artesunate shows potent anti-tumor activity in B-cell lymphoma.
Journal of Hematology & Oncology.
volum 11:23.
Academic article
2017
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Olsen, Oddrun Elise;
Skjærvik, Anette;
Størdal, Berit Fladvad;
Sundan, Anders;
Holien, Toril.
(2017)
TGF-β contamination of purified recombinant GDF15.
PLOS ONE.
volum 12:e0187349 (11).
Academic article
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Rustad, Even Holth;
Coward, Eivind;
Skytøen, Emilie R;
Misund, Kristine;
Holien, Toril;
Standal, Therese;
Børset, Magne;
Beisvag, Vidar;
Myklebost, Ola;
Meza, Leonardo Zepeda;
Hong, Yan Dai;
Sundan, Anders;
Waage, Anders.
(2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica.
volum 102 (7).
Academic article
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Tangen, Jon-Magnus;
Holien, Toril;
Mirlashari, Mohammad Reza;
Misund, Kristine;
Hetland, Geir.
(2017)
Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™.
BioMed Research International.
volum 2017.
Academic article
2016
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Abdollahi, Pegah;
Vandsemb, Esten Nymoen;
Hjort, Magnus Aassved;
Misund, Kristine;
Holien, Toril;
Sponaas, Anne-Marit;
Rø, Torstein Baade;
Slørdahl, Tobias Schmidt;
Børset, Magne.
(2016)
Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3.
Molecular Cancer Research.
volum 15 (1).
Academic article
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Baranowska, Katarzyna Anna;
Misund, Kristine;
Starheim, Kristian K.;
Holien, Toril;
Johansson, Ida;
Darvekar, Sagar;
Buene, Glenn;
Waage, Anders;
Bjørkøy, Geir;
Sundan, Anders.
(2016)
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
OncoTarget.
volum 7 (43).
Academic article
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Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit;
Hella, Hanne;
Buene, Glenn;
Waage, Anders;
Sundan, Anders;
Bjørkøy, Geir.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal.
Academic article
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Våtsveen, Thea Kristin;
Børset, Magne;
Dikic, Aida;
Tian, Erming;
Micci, Francesca;
Lid, Ana Barragan;
Meza-Zepeda, Leonardo A.;
Coward, Eivind;
Waage, Anders;
Sundan, Anders;
Kuehl, W. Michael;
Holien, Toril.
(2016)
VOLIN and KJON—Two novel hyperdiploid myeloma cell lines.
Genes, Chromosomes and Cancer.
volum 55 (11).
Academic article
2015
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Holien, Toril;
Misund, Kristine;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Buene, Glenn;
Børset, Magne;
Waage, Anders;
Sundan, Anders.
(2015)
MYC amplifications in myeloma cell lines: Correlation with MYC-inhibitor efficacy.
OncoTarget.
volum 6 (26).
Academic article
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Jung, Kwan-Young;
Wang, Huabo;
Teriete, Peter;
Yap, Jeremy L;
Chen, Lijia;
Lanning, Maryanna E;
Hu, Angela;
Lambert, Lester J;
Holien, Toril;
Sundan, Anders;
Cosford, Nicholas D P;
Prochownik, Edward V;
Fletcher, Steven.
(2015)
Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics.
Journal of Medicinal Chemistry.
volum 58 (7).
Academic article
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Starheim, Kristian K.;
Johansson, Ida;
Buene, Glenn;
Waage, Anders;
Bjørkøy, Geir;
Sundan, Anders.
(2015)
Chloroquine potentiates Carfilzomib but not Bortezomib effects on myeloma cells.
Cancer Research.
Summary/Abstract
- Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne K.;