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Toril Holien

Toril Holien

Professor
Department of Biomedical Laboratory Science
Faculty of Natural Sciences

toril.holien@ntnu.no
+4792421162 Øya
ResearchGate Google Scholar TGF-β family signaling in multiple myeloma Publons
About Publications Teaching Media

About

Research focus: TGF-β family signaling in cancer

Our research is focused on understanding the role of transforming growth factor (TGF)-ß family signaling pathways in multiple myeloma and other cancers. This includes ligands such as TGF-ß, activins, BMPs and GDFs. There is extensive redundancy in this family of ligands and receptors, and the effects of a given molecule will always depend on the context. Activation of the SMAD1/5 transcription factors by TGF-ß family ligands induces apoptosis in myeloma cells by downregulating the oncogene c-MYC. Potentiaion of SMAD1/5 activity represents therefore a possible treatment option for myeloma patients. We are also interested in the role of TGF-ß signaling in the context of the tumor microenvironment, particularly in relation to angiogenesis and dissemination. 

We welcome students that want to study regulation of signaling in the TGF-ß family.

 

Our group, Fall 2020: Lu Bai (master student), Toril Holien (group leader, PhD), Ingrid Quist-Løkken (MSc, medical research student), Clara Andersson-Rusch (MSc, PhD candidate) and Megan Anne Vik (master student).

 

Students
Medical Students' Research Programme: Ingrid Quist-Løkken
PhD student: Clara Andersson-Rusch
Master student: Bita Asghariastanehei
 
Former students and coworkers
Post doctor (2020): Oddrun Elise Olsen
PhD (2017): Oddrun Elise Olsen
PhD (2020, Bjørkøy group, cosupervised): Camilla Wolowczyk
 
Master level:
Molecular medicine (2020/21): Megan Anne Vik and Lu Bai
Biotechnology (2019/20, cosupervised): Jenny Malm Rasmussen
Pharmacy (2018/19): Martin Haugrud Kastnes, Nerissa Rae Booc
Pharmacy (2017/18): Thi Le, Fartun Hussein Ali
Molecular Medicine (2016/17): Samah Elsaadi, Fekadu Alemu Atire
Biotechnology (2013/15): Anette Skjærvik
Cell biology (2012/14): Kine Husteli Kristiansen
Biotechnology (2011/12): Oddrun Elise Olsen
 
Erasmus trainee students:
Alexander Stockhammer (2018)
Marie-Thérèse Henke (2017)
Meenu Sankar (2015/16)
Sarah Nevens (2013/14)

 

Pubmed

 

Competencies

  • Basic Medical Sciences
  • Cancer research
  • Cell Biology
  • Immunologic Techniques
  • Immunology
  • Medical biochemistry
  • Medical immunology
  • Medical molecular biology
  • Medical research
  • Molecular medicine
  • Multiple myeloma
  • Translational cancer research

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2022

  • Giliberto, Mariaserena; Miranda Santana, Leonardo; Holien, Toril; Misund, Kristine; Nakken, Sigve; Vodak, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Coward, Eivind; Waage, Anders; Tasken, Kjetil; Skånland, Sigrid S. (2022) Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines. Frontiers in Oncology. volum 12.
    Academic article

2021

  • Christensen, Eidi; Foss, Olav A.; Quist-Paulsen, Petter; Staur, Ingrid; Pettersen, Frode; Holien, Toril; Juzenas, Petras; Qian, Peng. (2021) Application of photodynamic therapy with 5-aminolevulinic acid to extracorporeal photopheresis in the treatment of patients with chronic graft-versus-host disease: A first-in-human study. Pharmaceutics. volum 13:1558 (10).
    Academic article
  • Kolos, Jürgen M; Pomplun, Sebastian; Jung, Sascha; Rieß, Benedikt; Purder, Patrick L; Voll, Andreas M; Merz, Stephanie; Gnatzy, Monika; Geiger, Thomas M; Quist-Løkken, Ingrid; Jatzlau, Jerome; Knaus, Petra; Holien, Toril; Bracher, Andreas; Meyners, Christian; Czodrowski, Paul; Krewald, Vera; Hausch, Felix. (2021) Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chemical Science.
    Academic article
  • Melvold, Katrine; Giliberto, Mariaserena; Karlsen, Linda; Ayuda-Duran, Maria del Pilar; Hanes, Robert; Holien, Toril; Enserink, Jorrit; Brown, Jennifer R.; Tjønnfjord, Geir Erland; Tasken, Kjetil; Skånland, Sigrid Strand. (2021) Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies. Molecular Oncology.
    Academic article

2020

  • Darvekar, Sagar; Juzenas, Petras; Oksvold, Morten Pedersen; Kleinauskas, Andrius; Holien, Toril; Christensen, Eidi; Stokke, Trond; Sioud, Mouldy; Qian, Peng. (2020) Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis. Cancers. volum 12.
    Academic article
  • Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Fei; Kainov, Denis. (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers. volum 12 (6).
    Academic article
  • Martinez-Hackert, Erik; Sundan, Anders; Holien, Toril. (2020) Receptor binding competition: A paradigm for regulating TGF-β family action. Cytokine & growth factor reviews.
    Scientific translation/review
  • Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril. (2020) Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors. Biomolecules. volum 10 (4).
    Academic article
  • Westhrin, Marita; Holien, Toril; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sponaas, Anne-Marit; Sundan, Anders; Standal, Therese. (2020) Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone. JBMR Plus. volum 4 (1).
    Academic article

2019

  • Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril. (2019) GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients. Cell Communication and Signaling. volum 17.
    Academic article

2018

  • Holien, Toril; Gederaas, Odrun Arna; Darvekar, Sagar; Christensen, Eidi; Qian, Peng. (2018) Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo. Lasers in Surgery and Medicine. volum 50 (5).
    Academic article
  • Olsen, Oddrun Elise; Sankar, Meenu; Elsaadi, Samah; Hella, Hanne; Buene, Glenn; Darvekar, Sagar; Misund, Kristine; Katagiri, Takenobu; Knaus, Petra; Holien, Toril. (2018) BMPR2 inhibits activin and BMP signaling via wild-type ALK2. Journal of Cell Science. volum 131 (11).
    Academic article
  • Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian; Bai, Baoyan; Dillard, Pierre; Theodossiou, Theodossis; Holien, Toril; Sundan, Anders; Inderberg, Else Marit; Smeland, Erlend B; Myklebust, June; Oksvold, Morten Pedersen. (2018) Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. volum 11:23.
    Academic article

2017

  • Olsen, Oddrun Elise; Skjærvik, Anette; Størdal, Berit Fladvad; Sundan, Anders; Holien, Toril. (2017) TGF-β contamination of purified recombinant GDF15. PLOS ONE. volum 12:e0187349 (11).
    Academic article
  • Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders. (2017) Monitoring multiple myeloma by quantification of recurrent mutations in serum. Haematologica. volum 102 (7).
    Academic article
  • Tangen, Jon-Magnus; Holien, Toril; Mirlashari, Mohammad Reza; Misund, Kristine; Hetland, Geir. (2017) Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. BioMed Research International. volum 2017.
    Academic article

2016

  • Abdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Holien, Toril; Sponaas, Anne-Marit; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Børset, Magne. (2016) Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3. Molecular Cancer Research. volum 15 (1).
    Academic article
  • Baranowska, Katarzyna Anna; Misund, Kristine; Starheim, Kristian K.; Holien, Toril; Johansson, Ida; Darvekar, Sagar; Buene, Glenn; Waage, Anders; Bjørkøy, Geir; Sundan, Anders. (2016) Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells. OncoTarget. volum 7 (43).
    Academic article
  • Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir. (2016) Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells. Blood Cancer Journal.
    Academic article
  • Våtsveen, Thea Kristin; Børset, Magne; Dikic, Aida; Tian, Erming; Micci, Francesca; Lid, Ana Barragan; Meza-Zepeda, Leonardo A.; Coward, Eivind; Waage, Anders; Sundan, Anders; Kuehl, W. Michael; Holien, Toril. (2016) VOLIN and KJON—Two novel hyperdiploid myeloma cell lines. Genes, Chromosomes and Cancer. volum 55 (11).
    Academic article

2015

  • Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders. (2015) MYC amplifications in myeloma cell lines: Correlation with MYC-inhibitor efficacy. OncoTarget. volum 6 (26).
    Academic article
  • Jung, Kwan-Young; Wang, Huabo; Teriete, Peter; Yap, Jeremy L; Chen, Lijia; Lanning, Maryanna E; Hu, Angela; Lambert, Lester J; Holien, Toril; Sundan, Anders; Cosford, Nicholas D P; Prochownik, Edward V; Fletcher, Steven. (2015) Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics. Journal of Medicinal Chemistry. volum 58 (7).
    Academic article
  • Misund, Kristine; Baranowska, Katarzyna Anna; Holien, Toril; Starheim, Kristian K.; Johansson, Ida; Buene, Glenn; Waage, Anders; Bjørkøy, Geir; Sundan, Anders. (2015) Chloroquine potentiates Carfilzomib but not Bortezomib effects on myeloma cells. Cancer Research.
    Summary/Abstract
  • Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne K.;