Wannan Tang
About
Wannan Tang a neuroscientist with background in clinical medicine. Her research profiles are in a broad neuroscience research range, such as in cellular and molecular neurobiology, two-photon imaging, electrophysiology and rAAV-mediated gene therapy development. She has completed her Master and PhD degrees at the Department of Molecular Neurobiology in Max Plank Institute for Medical Research Heidelberg, Germany, with the late Prof. Peter Seeburg and Dr. Rolf Sprengel as supervisors. Her PhD focused on cellular and molecular technologies to study neural circuits, including gene-manipulated mouse lines and virus mediated gene transfer in neurons. After her PhD, she started her research on glial cells, particularly on brain astrocytes. During year 2012-2020, she has designed and applied various molecular sensors and tools via rAAV gene transfer methods to study brain astrocytes in physiological and disease conditions using two-photon imaging in acute brain slices and in awake behaving animals. In 2017, she received Young Research Talents grant from Research Council of Norway and established her own research group. Since 2021 she has joined Norwegian University of Science and Technology (NTNU), and her research interests were extended to roles of brain astrocytes in neurodegenerative diseases and aging. She is currently focusing on astrocytic functions in brain aging, neurodegeneration and metabolism using combination of various molecular tools, two-photon in vivo imaging and transcriptome studies. In addition, to expend her research competence in translational medicine, with her long-term expertise in rAAV engineering, she carries out projects on developing rAAV-mediated gene therapy treatments for various rare genetic disorders.
Publications
2024
-
Kirchhoff, Frank;
Tang, Wannan.
(2024)
Analysis of Functional NMDA Receptors in Astrocytes.
Methods in molecular biology
Academic article
2023
-
Bordoni, Luca;
Thorén, Anna Elisabeth;
Gutiérrez-Jiménez, Eugenio;
Åbjørsbråten, Knut Sindre;
Bjørnstad, Daniel Marelius;
Tang, Wannan.
(2023)
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia
Academic article
-
Hjukse, Jarand Berg;
Puebla, Mario Fernández de la;
Vindedal, Gry Fluge;
Sprengel, Rolf;
Jensen, Vidar;
Nagelhus, Erlend Arnulf.
(2023)
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses.
Glia
Academic article
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
2022
-
Åbjørsbråten, Knut Sindre;
Skaaraas, Gry Helen Enger Syverstad;
Cunen, Celine Marie Løken;
Bjørnstad, Daniel Marelius;
Binder, Kristin Maria Gullestad;
Bojarskaite, Laura.
(2022)
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice.
eLIFE
Academic article
2020
-
Bojarskaite, Laura;
Bjørnstad, Daniel Marelius;
Pettersen, Klas Henning;
Cunen, Celine;
Hermansen, Gudmund Horn;
Åbjørsbråten, Knut Sindre.
(2020)
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep.
Nature Communications
Academic article
-
Tang, Wannan;
Zillmann, Uwe;
Sprengel, Rolf.
(2020)
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults.
Frontiers in Behavioral Neuroscience
Academic article
2019
-
Rosic, Brana;
Dukefoss, Didrik Bakke;
Åbjørsbråten, Knut Sindre;
Tang, Wannan;
Jensen, Vidar;
Ottersen, Ole Petter.
(2019)
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.
Glia
Academic article
-
Eilert-Olsen, Martine;
Hjukse, Jarand Berg;
Thoren, Anna;
Tang, Wannan;
Enger, Rune;
Jensen, Vidar.
(2019)
Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions.
Glia
Academic article
2018
-
Heuser, Kjell;
Nome, Cecilie;
Pettersen, Klas;
Åbjørsbråten, Knut Sindre;
Jensen, Vidar;
Tang, Wannan.
(2018)
Ca2+ signals in astrocytes facilitate spread of epileptiform activity.
Cerebral Cortex
Academic article
2017
-
Tan, Linette Liqi;
Pelzer, Patric;
Heinl, Céline;
Tang, Wannan;
Gangadharan, Vijayan;
Flor, Herta.
(2017)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.
Nature Neuroscience
Academic article
2016
-
Enger, Rune;
Dukefoss, Didrik Bakke;
Tang, Wannan;
Pettersen, Klas;
Bjørnstad, Daniel Marelius;
Helm, Paul Johannes.
(2016)
Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice.
Cerebral Cortex
Academic article
-
Obenhaus, Horst-Andreas Gustav Wilhelm;
Rozov, Andrei;
Bertocchi, Ilaria;
Tang, Wannan;
Kirsch, Joachim;
Betz, Heinrich.
(2016)
Causal interrogation of neuronal networks and behavior through virally transduced ivermectin receptors.
Frontiers in Molecular Neuroscience
Academic article
2015
-
Szokol, Karolina;
Heuser, Kjell;
Tang, Wannan;
Jensen, Vidar;
Enger, Rune;
Bedner, Peter.
(2015)
Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Frontiers in Cellular Neuroscience
Academic article
-
Enger, Rune;
Tang, Wannan;
Vindedal, Gry Fluge;
Jensen, Vidar;
Helm, Paul Johannes;
Sprengel, Rolf.
(2015)
Dynamics of ionic shifts in cortical spreading depression.
Cerebral Cortex
Academic article
-
Tang, Wannan;
Szokol, Karolina;
Jensen, Vidar;
Enger, Rune;
Trivedi, Chintan A.;
Hvalby, Øyvind Christian dødsbo.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Journal of Neuroscience
Academic article
2014
-
Engin, Elif;
Bakhurin, Konstantin I.;
Smith, Kiersten S,;
Hines, Rochelle M.;
Reynolds, Lauren M.;
Tang, Wannan.
(2014)
Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens.
Neuropsychopharmacology
Academic article
Journal publications
-
Kirchhoff, Frank;
Tang, Wannan.
(2024)
Analysis of Functional NMDA Receptors in Astrocytes.
Methods in molecular biology
Academic article
-
Bordoni, Luca;
Thorén, Anna Elisabeth;
Gutiérrez-Jiménez, Eugenio;
Åbjørsbråten, Knut Sindre;
Bjørnstad, Daniel Marelius;
Tang, Wannan.
(2023)
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia
Academic article
-
Hjukse, Jarand Berg;
Puebla, Mario Fernández de la;
Vindedal, Gry Fluge;
Sprengel, Rolf;
Jensen, Vidar;
Nagelhus, Erlend Arnulf.
(2023)
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses.
Glia
Academic article
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
-
Åbjørsbråten, Knut Sindre;
Skaaraas, Gry Helen Enger Syverstad;
Cunen, Celine Marie Løken;
Bjørnstad, Daniel Marelius;
Binder, Kristin Maria Gullestad;
Bojarskaite, Laura.
(2022)
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice.
eLIFE
Academic article
-
Bojarskaite, Laura;
Bjørnstad, Daniel Marelius;
Pettersen, Klas Henning;
Cunen, Celine;
Hermansen, Gudmund Horn;
Åbjørsbråten, Knut Sindre.
(2020)
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep.
Nature Communications
Academic article
-
Tang, Wannan;
Zillmann, Uwe;
Sprengel, Rolf.
(2020)
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults.
Frontiers in Behavioral Neuroscience
Academic article
-
Rosic, Brana;
Dukefoss, Didrik Bakke;
Åbjørsbråten, Knut Sindre;
Tang, Wannan;
Jensen, Vidar;
Ottersen, Ole Petter.
(2019)
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.
Glia
Academic article
-
Eilert-Olsen, Martine;
Hjukse, Jarand Berg;
Thoren, Anna;
Tang, Wannan;
Enger, Rune;
Jensen, Vidar.
(2019)
Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions.
Glia
Academic article
-
Heuser, Kjell;
Nome, Cecilie;
Pettersen, Klas;
Åbjørsbråten, Knut Sindre;
Jensen, Vidar;
Tang, Wannan.
(2018)
Ca2+ signals in astrocytes facilitate spread of epileptiform activity.
Cerebral Cortex
Academic article
-
Tan, Linette Liqi;
Pelzer, Patric;
Heinl, Céline;
Tang, Wannan;
Gangadharan, Vijayan;
Flor, Herta.
(2017)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.
Nature Neuroscience
Academic article
-
Enger, Rune;
Dukefoss, Didrik Bakke;
Tang, Wannan;
Pettersen, Klas;
Bjørnstad, Daniel Marelius;
Helm, Paul Johannes.
(2016)
Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice.
Cerebral Cortex
Academic article
-
Obenhaus, Horst-Andreas Gustav Wilhelm;
Rozov, Andrei;
Bertocchi, Ilaria;
Tang, Wannan;
Kirsch, Joachim;
Betz, Heinrich.
(2016)
Causal interrogation of neuronal networks and behavior through virally transduced ivermectin receptors.
Frontiers in Molecular Neuroscience
Academic article
-
Szokol, Karolina;
Heuser, Kjell;
Tang, Wannan;
Jensen, Vidar;
Enger, Rune;
Bedner, Peter.
(2015)
Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Frontiers in Cellular Neuroscience
Academic article
-
Enger, Rune;
Tang, Wannan;
Vindedal, Gry Fluge;
Jensen, Vidar;
Helm, Paul Johannes;
Sprengel, Rolf.
(2015)
Dynamics of ionic shifts in cortical spreading depression.
Cerebral Cortex
Academic article
-
Tang, Wannan;
Szokol, Karolina;
Jensen, Vidar;
Enger, Rune;
Trivedi, Chintan A.;
Hvalby, Øyvind Christian dødsbo.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Journal of Neuroscience
Academic article
-
Engin, Elif;
Bakhurin, Konstantin I.;
Smith, Kiersten S,;
Hines, Rochelle M.;
Reynolds, Lauren M.;
Tang, Wannan.
(2014)
Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens.
Neuropsychopharmacology
Academic article