Media and publications - OptimEx
Media and publications
As the OptimEx study goes on, selected media appearances and publications outgoing from the study will be published here.
Press inquieries can be sent to email@example.com
- Seiler M, Bowen TS, Rolim N, Dieterlen MT, Werner S, Hoshi T, Fischer T, Mangner N, Linke A, Schuler G, Halle M, Wisloff U, Adams V. (2016) Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines? Circ Heart Fail. 2016 Sep;9(9). pii: e003027.
"A greater understanding of the different underlying mechanisms between patients with heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction is urgently needed to better direct future treatment. However, although skeletal muscle impairments, potentially mediated by inflammatory cytokines, are common in both HFrEF and HFpEF, the underlying cellular and molecular alterations that exist between groups are yet to be systematically evaluated. The present study, therefore, used established animal models to compare whether alterations in skeletal muscle (limb and respiratory) were different between HFrEF and HFpEF, while further characterizing inflammatory cytokines."
- Adams V, Alves M, Fischer T, Rolim N, Werner S, Schütt N, Bowen TS, Linke A, Schuler G, Wisloff U (2015). High-intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction. Journal of Applied Physiology (1985). 15;119(6):745-52.
"Heart failure patients with preserved left ventricular ejection fraction (HFpEF) have endothelial dysfunction, but the underlying molecular mechanisms remain unknown. In addition, whether exercise training improves endothelial function in HFpEF is still controversial. The present study therefore aimed to determine the functional and molecular alterations in the endothelium associated with HFpEF, while further assessing the effects of high-intensity interval training (HIT)"
- Rolim N, Skårdal K, Høydal M, Sousa MM, Malmo V, Kaurstad G, Ingul CB, Hansen HE, Alves MN, Thuen M, Haraldseth O, Brum PC, Slupphaug G, Loennechen JP, Stølen T, Wisløff U. Aerobic interval training reduces inducible ventricular arrhythmias in diabetic mice after myocardial infarction. Basic Res Cardiol. 2015;110(4):44.
"Diabetes mellitus (DM) increases the risk of heart failure after myocardial infarction (MI), and aggravates ventricular arrhythmias in heart failure patients. Although exercise training improves cardiac function in heart failure, it is still unclear how it benefits the diabetic heart after MI."
- Bowen, T. S., Rolim, N. P., Fischer, T., Bækkerud, F. H., Medeiros, A., Werner, S., ... & Adams, V. (2015). Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle. European journal of heart failure, 17(3), 263-272.
"Our findings are the first to demonstrate that diastolic heart failure induces significant molecular, mitochondrial, histological, and functional alterations in the diaphragm and soleus, which were attenuated by exercise training. These data therefore reveal novel mechanisms and potential therapeutic treatments of exercise intolerance in diastolic heart failure."
- Suchy C, Massen L, Rognmo O, Van Craenenbroeck EM, Beckers P, Kraigher-Krainer E, Linke A, Adams V6, Wisløff U, Pieske B, Halle M. (2014) Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. European Journal og Preventive Cardiology, 21(2 Suppl):18-25.
"Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to improve pathophysiology and deprived exercise-tolerance in HFpEF patients seems to be exercise training, but the optimal approach and dose of exercise is still unknown."