Course - New Concepts in Organic Synthesis - KJ8107
New Concepts in Organic Synthesis
Lessons are not given in the academic year 2013/2014
About
About the course
Course content
In supramolecular chemistry the focus is on how molecules assembles and interacts, and how these interactions can be used in future technologies such as chemical sensor, molecular switches and machines, energy converting technologies, or artificial intelligent. The course will have an organic chemistry perspective.
The subject will first give an introduction to key concepts and definitions in the field, and describe which kind of interactions is used in the design of supramolecular complexes, and how these can be analysed and characterised. It will further be focused how different molecular entities can be prepared by classical methods, high dilution synthesis combined with more sophisticated template synthesis.
Using both biological and synthetically examples it will be shown how multicomponent complexes have been constructed. Key questions would be: what kind of binding forces are acting between the molecular entities, what kind of energy contributions play a role in driving the reaction towards this particular complex, and what structural changes can be done to alter interactions and the thereby the application. Principals and concepts for design of molecular complexes will be focused throughout the course.
Learning outcome
After completing the coarse the student should: be able to describe and define key concepts in the field of supramolecular chemistry; be able to analyse which binding forces are involved in complex formation, and how these forces change in response to structural variations in the components and by variation of the reaction medium; be able to design and describe by schematic drawings synthetic methods for preparation of corands, cryptands, calixarenes, catenands, rotaxanes and metal containing organic complexes with and without templates; from structural information be able to suggest binding partner(s) for various molecules and complexes; be able to design complex molecules for targeting specific organic molecules and inorganic ions; be able to qualitatively analyse contribution to binding strength of complexes in terms of enthalpy and entropy; know weaknesses and strengths of analytical techniques used in investigation of suparmolecular complexes; from structural information be able to rationalize the field of use of various molecular complexes.
Learning methods and activities
The course is held every second year, next time autumn 2014. Learning activities will include a combination of individual reading, problem solving, lectures (3 h/week) and student presentations. The learning activities might be modified depending on the number of students.
Recommended previous knowledge
Background in organic chemistry; TKJ4111/TKJ4150, TKJ4135/TKJ4150 and TKJ4180 Physical organic chemistry or comparable courses.
Course materials
Steed, J. W, Atwood, J. L, Supramolecular Chemistry, 2. ed.,Wiley.
Subject areas
- Chemistry
- Organic Chemistry