OptimEx - Optimizing Exercise Training in the Prevention and Treatment of Diastolic Heart Failure - is one of the largest projects in the group. Diastolic heart failure is the only cardiovascular disease with increasing prevalence. Despite several attempts, no medical treatment has been found to be effective in diastolic heart failure. The purpose of the OptimEx study is therefore to find out whether exercise can be a medicine for this patients. Furthermore, we want to find out how much exercise and what intensity is most appropriate. You can read more about the study on the website of OptimEx.
The OptimEx study is a collaboration of five European Universities: Antwerp University Hospital, the University of Leipzig, the Technical University of Munich, the University of Graz and the Norwegian University of Science and Technology (NTNU). The EU has funded the study, which started October 2013 and is planned finished in 2017.
Generasjon100 is a clinical study on elderly and exercise with over 1500 participants aged 70-77 years in Trondheim. The study is unique as it has never previously been undertaken similar projects among older people in such a large scale. Through random selection of different types of exercise through a total of three years. Our population is getting older, and the goal of this study is to determine whether exercise can give elderly people better health and quality of life.
MET-EX is a multicenter study coordinated by researcher Arnt Erik Tjønna at CERG with fokus on VO2max in exercise with high intensity for patients at risk of developing metabolic syndrome. Typical risk factors are obesity, impaired glucose intolerance, type 2 diabetes and hypertention. Through supervised training for 16 weeks and a total of three years follow-up, we want to find out if training with high intensity is more effective in terms of reversal of risk factors for metabolic syndrome than moderate intensity. Furthermore, an important goal is to find out how little exercise you get away with - a group will therefore test interval training for 1x4 method: only four minutes of intensive training during each session. We hope to include 750 patients, and inclusion is still ongoing.
SMARTEX-HF is a multicenter study coordinated by CERG and NTNU, with collaborating centers nine different places in Europe. Through 12 weeks of training with different intensity and duration and follow-up of 1 year, we investigate the effect of training on the various functions of the heart in a total of 209 patients with heart failure. Our hypothesis is that training with high intensity is more effective than previous recommendations for moderate intensity. We have no results to present yet, but details of the study design and purpose are described here.