Applied Organic Chemistry

 

 

The research of Bård Helge Hoff is in the field of applied organic chemistry, working both with medicinal chemistry and energy/material related research. Currently, the main focus is on developing organic molecules for targeted cancer therapy by inhibition of kinases and dye-sensitized solar cells.

We also take on any organic chemistry challenge. So far these projects have involved asymmetric synthesis by non enzymatic and enzymatic methods, the chemistry of fluorinated molecules, heterocyclic chemistry, metal organic chemistry, carbohydrate chemistry and microwave chemistry.

Projects

  • Synthesis of kinase inhibitors for cancer therapy
  • Synthesis and characterisation of dyes for dye-sensitised solar cells
  • Asymmetric synthesis and resolution

 

Positions, Master studies and Erasmus students:

The labs

Medicinal chemistry

The group takes on medicinal chemistry projects. Past activity includes development of antifungal agents and inhibitors of the epidermal growth factor receptor (EGFR). Current work focus on inhibitors of the colony stimulating factor 1 receptor (CSF1R). Potent and selective inhibitors of this tyrosine kinase could offer treatment for several forms of cancer and inflammation diseases.

At the heart of our activity is the organic chemistry lab. These are well equipped for performing modern organic synthesis. Our aim is to develop scalable divergent routes giving access to a range of product. 

                 

Compounds are isolated and purified by conventional methods and characterised using HPLC, NMR (https://www.ntnu.edu/nmr), and mass spectroscopic methods (https://www.ntnu.edu/nv-mslab/).

        

Molecular docking, dynamics and Fragment-growth are used to provide working hypothesis and to explain the binding mode of our new ligands. Druglike properties are monitored by common metrics as Lipinski’s rule of five, LE, LLE, BEI, SEI and LELP. Kinase profiling is performed by CRO’s, while cell and ADME studies are done by both university collaborators and CRO’s.

          

 

 

Organic electronic materials

Dye-sensitized solar cells

A global challenge is that electricity is predominantly generated unsustainably. To improve on the situation, more of the electricity should be generated directly from sunlight by solar cells. Commercial solar cells based on crystalline silicon have increased their efficiencies over the years. However, their widespread global use is hampered by a high production cost. Alternative solar cell technologies are therefore of great interest and one of the most promising candidates is dye-sensitized solar cells (DSSCs), also termed Grätzel cells.

   

These cells are especially attractive under low-light conditions/in-door applications and as part of building design. The group currently have one project on the synthesis and characterisation of dye-sensitized solar cells. In the DSSC project we focus on phenothiazine based dyes, and aims to increase understanding of the structure-properties relationships. Hopefully, this will aid in the construction of more efficient and stable dyes. The synthesis of such dyes are quite funny as you can follow their colour change as degree of conjugation increase.

    

 

At Department of Chemistry (NTNU) we are currently building up a solar cell fabrication and characterisation lab. The dedicated equipment includes:

  • Special synthesis
    • Microwave, Initiator+ Microwave System w. Robot Eight EU, Biotage
    • Centrifuge, Labofuge 300, Heraeus
  • Fabrication
    • Spin coater, Laurell - WS-650-23B Spin Coater
    • Doctor blading, MSK-AFA III, MTI Corporation
    • Screen printer, Dyenamo AB
    • Programmable furnace, Nabertherm LT 9/11
  • Characterisation
    • Solar Simulator 300W, Sciencetech SF300B - ABA Class
    • Sourcemeter, Keithley 2450
    • Monochromator, CM110 Spectral products
    • Photoluminescence, Edinburgh Instruments FS5 Sprectrofluorometer
    • Potentiostat, Princeton Applied Research – Versastat 3-200
    • UV/Vis, U-1900 Spectrophotometer, Hitachi

  

Contact

Bård Helge Hoff - Leader Bioorganic Chemistry. Photo: Per Henning/NTNU

Bård Helge Hoff
Professor
E-mail: bard.h.hoff@ntnu.no
More contact information

Group members

Publications

Hoff, B. H.; Sundby, E. Bioorg. Chem. 2017, 74, 260-271.

Haghdani, S.; Hoff, B. H.; Koch, H.; Åstrand, P.-O. J. Phys. Chem. A 2017, 121, 4765-4777.

Bysting, F.; Bugge, S.; Sundby, E.; Hoff, B. H. RSC Adv. 2017, 7, 18569-18577.

Mihiretu, G. T.; Brodin, M.; Chimphango, A. F.; Øyaas, K.; Hoff, B. H.; Görgens, J. F. Bioresour. Technol. 2017, 242, 669-680.

Petrovic, V.; Olaisen, C.; Sharma, A.; Nepal, A.; Bugge, S.; Sundby, E.; Hoff, B. H.; Slupphaug, G.; Otterlei, M. Anal. Biochem. 2017, 523, 10-16.

Petrovic, V.; Olaisen, C.; Sharma, A.; Nepal, A.; Bugge, S.; Sundby, E.; Hoff, B. H.; Slupphaug, G.; Otterlei, M. Data in Brief 2017, 12, 18-21.

Han, J.; Kaspersen, S. J.; Nervik, S.; Nørsett, K. G.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2016, 119, 278-299.

Han, J.; Henriksen, S.; Nørsett, K. G.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2016, 124, 583-607.

Haghdani, S.; Hoff, B. H.; Koch, H.; Åstrand, P.-O. J. Phys. Chem. A 2016, 120, 7973-7986.

Bugge, S.; Buene, A. F.; Jurisch-Yaksi, N.; Moen, I. U.; Skjønsfjell, E. M.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2016, 107, 255-274.

Sundby, E.; Han, J.; Kaspersen, S. J.; Hoff, B. H. Eur. J. Pharm. Sci. 2015, 80, 56-65.

Karlsen, M.; Liu, H.; Johansen, J. E.; Hoff, B. H. Molecules 2015, 20, 5329-5345.

Hoff, B.; Kaspersen, S.; Bugge, S.; Sundby, E.; Han, J.; Norwegian University of Science and Technology NTNU , Norway . 2015; WO2015000959A1.

Gulbrandsen, T. A.; Johnsen, I. A.; Opedal, M. T.; Toven, K.; Øyaas, K.; Pranovich, A.; Mikkola, J.-P.; Hoff, B. H. Cellul. Chem. Technol. 2015, 49, 117-126.

Bugge, S.; Moen, I. U.; Kragseth Sylte, K.-O.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2015, 94, 175-194.

Kaspersen, S. J.; Han, J.; Nørsett, K. G.; Rydsa, L.; Kjøbli, E.; Bugge, S.; Bjørkøy, G.; Sundby, E.; Hoff, B. H. Eur. J. Pharm. Sci. 2014, 59, 69-82.

Karlsen, M.; Liu, H. L.; Berg, T.; Johansen, J. E.; Hoff, B. H. J. Labelled Compd. Radiopharm. 2014, 57, 378-387.

Karlsen, M.; Liu, H.; Johansen, J. E.; Hoff, B. H. Molecules 2014, 19, 13526-13540.

Bugge, S.; Skjønsfjell, E. M.; Willumsen, F. B.; Sundby, E.; Hoff, B. H. Chem. Heterocycl. Compd. 2014, 50, 1177-1187.

Bugge, S.; Kaspersen, S. J.; Larsen, S.; Nonstad, U.; Bjørkøy, G.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2014, 75, 354-374.

Rodionova, G.; Hoff, B. H.; Lenes, M.; Eriksen, O.; Gregersen, O. Cellulose 2013, 20, 1167-1174.

Krane Thvedt, T. H.; Kaasa, K.; Sundby, E.; Charnock, C.; Hoff, B. H. Eur. J. Med. Chem. 2013, 68, 482-496.

Hoff, B. H.; Sundby, E. Bioorg. Chem. 2013, 51, 31-47.

Han, J.; Sundby, E.; Hoff, B. H. J. Fluorine Chem. 2013, 153, 82-88.

Kaspersen, S. J.; Sundby, E.; Charnock, C.; Hoff, B. H. Bioorg. Chem. 2012, 44, 35-41.

Esmurziev, A. M.; Reimers, A.; Andreassen, T.; Simic, N.; Sundby, E.; Hoff, B. H. Molecules 2012, 17, 820-35.

Bugge, S.; Kaspersen, S. J.; Sundby, E.; Hoff, B. H. Tetrahedron 2012, 68, 9226-9233.

Slungård, S. V.; Krakeli, T.-A.; Thvedt, T. H. K.; Fuglseth, E.; Sundby, E.; Hoff, B. H. Tetrahedron 2011, 67, 5642-5650.

Krane Thvedt, T. H.; Kristensen, T. E.; Sundby, E.; Hansen, T.; Hoff, B. H. Tetrahedron: Asymmetry 2011, 22, 2172-2178.

Kaspersen, S. J.; Sørum, C.; Willassen, V.; Fuglseth, E.; Kjøbli, E.; Bjørkøy, G.; Sundby, E.; Hoff, B. H. Eur. J. Med. Chem. 2011, 46, 6002-6014.

Thvedt, T. H. K.; Fuglseth, E.; Sundby, E.; Hoff, B. H. Tetrahedron 2010, 66, 6733-6743.

Sørum, C.; Simic, N.; Sundby, E.; Hoff, B. H. Magn. Reson. Chem. 2010, 48, 244-248.

Lystvet, S. M.; Hoff, B. H.; Anthonsen, T.; Jacobsen, E. E. Biocatal. Biotransform. 2010, 28, 272-278.

Esmurziev, A. M.; Simic, N.; Hoff, B. H.; Sundby, E. J. Carbohydr. Chem. 2010, 29, 348-367.

Krane Thvedt, T. H.; Fuglseth, E.; Sundby, E.; Helge Hoff, B. Tetrahedron 2009, 65, 9550-9556.

Fuglseth, E.; Sundby, E.; Hoff, B. H. J. Fluorine Chem. 2009, 130, 600-603.

Fuglseth, E.; Sundby, E.; Bruheim, P.; Hoff, B. H. Tetrahedron: Asymmetry 2009, 20, 130.

Fuglseth, E.; Otterholt, E.; Hoegmoen, H.; Sundby, E.; Charnock, C.; Hoff, B. H. Tetrahedron 2009, 65, 9807-9813.

Esmurziev, A.; Sundby, E.; Hoff, B. H. Eur. J. Org. Chem. 2009, 1592-1597.

Esmurziev, A.; Simic, N.; Sundby, E.; Hoff, B. H. Magn. Reson. Chem. 2009, 47, 449-452.

Fuglseth, E.; Thvedt, T. H. K.; Møll, M. F.; Hoff, B. H. Tetrahedron 2008, 64, 7318-7323.

Fuglseth, E.; Sundby, E.; Bruheim, P.; Hoff, B. H. Tetrahedron: Asymmetry 2008, 19, 1941-1946.

Fuglseth, E.; Anthonsen, T.; Hoff, B. H. Tetrahedron: Asymmetry 2006, 17, 1290-1295.

Moen, A. R.; Hoff, B. H.; Hansen, L. K.; Anthonsen, T.; Jacobsen, E. E. Tetrahedron: Asymmetry 2004, 15, 1551-1554.

Jacobsen, E. E.; Hoff, B. H.; Moen, A. R.; Anthonsen, T. J. Mol. Catal. B: Enzym. 2003, 21, 55-58.

Sundby, E.; Andersen, M. M.; Hoff, B. H.; Anthonsen, T. ARKIVOC 2001, 76-84.

Liu, H.-L.; Hoff, B. H.; Berg, T. C.; Anthonsen, T. Chirality 2001, 13, 135-139.

Liu, H.-L.; Hoff, B. H.; Anthonsen, T. Perkin 1 2000, 1767-1769.

Liu, H.; Hoff, B. H.; Anthonsen, T. Chirality 2000, 12, 26-29.

Jacobsen, E. E.; Hoff, B. H.; Anthonsen, T. Chirality 2000, 12, 654-659

Hoff, B. H.; Ljones, L.; Ronstad, A.; Anthonsen, T. J. Mol. Catal. B: Enzym. 2000, 8, 51-60

Hoff, B. H.; Anthonsen, T. Tetrahedron: Asymmetry 1999, 10, 1401-1412

Hoff, B. H.; Anthonsen, T. Chirality 1999, 11, 760-767.

Anthonsen, T.; Hoff, B. H.; Hofsløkken, N. U.; Skattebøl, L.; Sundby, E. Acta Chem. Scand. 1999, 53, 360-365.

Anthonsen, T.; Hoff, B. H. Chem. Phys. Lipids 1998, 93, 199-207.

Hoff, B. H.; Waagen, V.; Anthonsen, T. Tetrahedron: Asymmetry 1996, 7, 3181-3186.

Hoff, B. H.; Anthonsen, H. W.; Anthonsen, T. Tetrahedron: Asymmetry 1996, 7, 3187-3192.

Anthonsen, H. W.; Hoff, B. H.; Anthonsen, T. Tetrahedron: Asymmetry 1996, 7, 2633-2638.

Anthonsen, H. W.; Hoff, B. H.; Anthonsen, T. Tetrahedron: Asymmetry 1995, 6, 3015-22.