Bård Helge Hoff
Background and activities
Research::
Home page: http://www.ntnu.edu/chemistry/research/organic/bioorganic-chemistry
Courses
- TKJ4130 - Organic Synthesis, Laboratory
- TKJ4155 - Organic Synthesis II
- TKJ4150 - Organic Synthesis I
- KJ2900 - Bachelor project in Chemistry
- TKJ4520 - Organic Chemistry, Specialization Project
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
Journal publications
- (2022) Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells. Journal of Photochemistry and Photobiology A: Chemistry. vol. 10.
- (2021) Effect of thiophene-based π-spacers on N-arylphenothiazine dyes for dye-sensitized solar cells. Dyes and pigments. vol. 185.
- (2021) Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents. European Journal of Organic Chemistry.
- (2021) Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors. ChemistrySelect. vol. 6 (45).
- (2021) SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging. Nuclear Medicine and Biology.
- (2021) Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma. Journal of Nuclear Medicine.
- (2021) Scalable Fabrication of Metallic Nanogaps at the Sub-10 nm Level. Advanced Science.
- (2021) Massively Parallel Arrays of Size-Controlled Metallic Nanogaps with Gap-Widths Down to the Sub-3-nm Level. Advanced Materials. vol. 33 (20).
- (2020) First Report of Chenodeoxycholic Acid–Substituted Dyes Improving the Dye Monolayer Quality in Dye-Sensitized Solar Cells. Solar RRL. vol. 4 (4).
- (2020) Synthesis of Novel 3,6-Dithienyl Diketopyrrolopyrrole Dyes by Direct C‒H Arylation. Molecules. vol. 25 (10).
- (2019) Effect of furan π-spacer and triethylene oxide methyl ether substituents on performance of phenothiazine sensitizers in dye-sensitized solar cells. New Journal of Chemistry. vol. 43 (24).
- (2019) Effect of Auxiliary Donors on 3,8-Phenothiazine Dyes for Dye-Sensitized Solar Cells. Molecules. vol. 24 (24).
- (2019) A comprehensive experimental study of five fundamental phenothiazine geometries increasing the diversity of the phenothiazine dye class for dye-sensitized solar cells. Dyes and pigments. vol. 169.
- (2019) Auxiliary donors for phenothiazine sensitizers for dye-sensitized solar cells – how important are they really?. Journal of Materials Chemistry A. vol. 7.
- (2019) Spontaneous Formation of Nanogap Electrodes by Self‐Peeling Adhesion Lithography. Advanced Materials Interfaces. vol. 6 (17).
- (2019) Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines. Bioorganic chemistry (Print). vol. 88.
- (2018) Effect of π-linkers on phenothiazine sensitizers for dye-sensitized solar cells. Dyes and pigments. vol. 151.
- (2018) Acetonitrile as a Building Block and Reactant. Synthesis (Stuttgart). vol. 50 (15).
- (2018) Identification of fused pyrimidines as interleukin 17 secretion inhibitors. European Journal of Medicinal Chemistry. vol. 155.
- (2017) Solvent Effects on Optical Rotation: On the Balance between Hydrogen Bonding and Shifts in Dihedral Angles. Journal of Physical Chemistry A. vol. 121 (5).
- (2017) Is literature data useful for identifying enzyme catalysts for new substrates? A case study on reduction of 1-aryl-2-alkanoates. Bioorganic chemistry (Print). vol. 74.
- (2017) Single-step microwave-assisted hot water extraction of hemicelluloses from selected lignocellulosic materials – A biorefinery approach. Bioresource Technology. vol. 241.
- (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief. vol. 12.
- (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry. vol. 107.
- (2016) Optical Rotation Calculations for Fluorinated Alcohols, Amines, Amides, and Esters. Journal of Physical Chemistry A. vol. 120 (40).
- (2016) Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry. vol. 124.
- (2016) Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors. European Journal of Medicinal Chemistry. vol. 119.
- (2015) Truncated structures used in search for new lead compounds and in a retrospective analysis of thienopyrimidine-based EGFR inhibitors. European Journal of Medicinal Chemistry. vol. 94.
- (2015) Extracting hemicelluloses from softwood and bagasse as oligosaccharides using pure water and microwave heating. Cellulose Chemistry and Technology. vol. 49 (2).
- (2015) Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products. Molecules. vol. 20 (4).
- (2015) In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib. European Journal of Pharmaceutical Sciences. vol. 80.
- (2014) Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor. European Journal of Medicinal Chemistry. vol. 75.
- (2014) Improved and Scalable Preparation of 6-Bromo-4-Chlorothieno[2,3-d]Pyrimidine. Chemistry of Heterocyclic Compounds. vol. 50 (8).
- (2014) Synthesis of [13C6]-labelled phenethylamine derivatives for drug quantification in biological samples. Journal of labelled compounds & radiopharmaceuticals. vol. 57 (5).
- (2014) Synthesis of [13C4]-labeled ∆9-tetrahydrocannabinol and 11-nor-9-carboxy-∆9-tetrahydrocannabinol as internal standards for reducing ion supressing/alteration effects in LC/MS-MS quantification. Molecules. vol. 19 (9).
- (2014) Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4- amines as highly potent EGFR-TK inhibitors with Src-family activity. European Journal of Pharmaceutical Sciences. vol. 59 (1).
- (2013) Solvent selection in synthesis of 4-(1-arylfluoroethoxy)quinazolines and thienopyrimidines. Journal of fluorine chemistry. vol. 153.
- (2013) Preparation of pharmaceutical important fluorinated 1-arylethanols using isolated enzymes. Bioorganic chemistry (Print). vol. 51C.
- (2013) Gas-phase esterification of microfibrillated cellulose (MFC) films. Cellulose. vol. 20 (3).
- (2013) Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. European Journal of Medicinal Chemistry. vol. 68.
- (2012) Route selection in the synthesis of C-4 and C-6 substituted thienopyrimidines. Tetrahedron. vol. 68 (45).
- (2012) Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine. Molecules. vol. 17 (1).
- (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorganic chemistry (Print). vol. 44.
- (2011) Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines. European Journal of Medicinal Chemistry. vol. 46 (12).
- (2011) Investigation into the enantioselection mechanism of ruthenium-arene-diamine transfer hydrogenation catalysts using fluorinated substrates. Tetrahedron. vol. 67 (31).
- (2011) Enantioselectivity, swelling and stability of 4-hydroxyprolinol containing acrylic polymer beads in the asymmetric reduction of ketones. Tetrahedron: asymmetry. vol. 22 (24).
- (2010) Synthesis and Structure Elucidation of Benzoylated Deoxyfluoropyranosides. Journal of carbohydrate chemistry. vol. 29 (7).
- (2010) Chemoenzymatic synthesis of enantiopure 1-phenyl-2-haloethanols and their esters. Biocatalysis and Biotransformation. vol. 28 (4).
- (2010) 1H,13C and 19F NMR data of N-substituted 6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amines in DMSO-d6. Magnetic Resonance in Chemistry. vol. 48 (3).
- (2010) Enantioenriched 1-aryl-2-fluoroethylamines. Efficient lipase-catalysed resolution and limitations to the Mitsunobu inversion protocol. Tetrahedron. vol. 66 (34).
- (2009) H-1 and C-13 NMR data of methyl tetra-O-benzoyl-D-pyranosides in acetone-d(6). Magnetic Resonance in Chemistry. vol. 47 (5).
- (2009) 1H and 13C NMR data of methyl tetra-O-benzoyl-D-pyranosides in acetone-d6. Magnetic Resonance in Chemistry. vol. 47 (5).
- (2009) Regioselective C-6 Hydrolysis of Methyl O-Benzoyl-pyranosides Catalysed by Candida Rugosa Lipase. European Journal of Organic Chemistry.
- (2009) Regioselective C-6 Hydrolysis of Methyl O-Benzoyl-pyranosides Catalysed by Candida Rugosa Lipase. European Journal of Organic Chemistry. vol. 10.
- (2009) Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity. Tetrahedron. vol. 65 (47).
- (2009) Ruthenium-catalysed asymmetric transfer hydrogenation of para-substituted alpha-fluoroacetophenones. Journal of fluorine chemistry. vol. 130 (6).
- (2009) Ruthenium-catalysed asymmetric transfer hydrogenation of para-substituted alpha-fluoroacetophenones. Journal of fluorine chemistry. vol. 130 (6).
- (2009) Microwave assisted fluorination: an improved method for side chain fluorination of substituted 1-arylethanones. Tetrahedron. vol. 65 (46).
- (2008) Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols. Tetrahedron: asymmetry. vol. 19 (16).
- (2008) Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols. Tetrahedron: asymmetry. vol. 19.
- (2008) Electrophilic and nucleophilic side chain fluorination of para-substituted acetophenones. Tetrahedron. vol. 64.
- (2006) New chiral building blocks from acetovanillone using lipase A and B from Candida antarctica. Tetrahedron: asymmetry. vol. 17 (8).
- (2004) Absolute configurations of monoesters produced by enzyme catalyzed hydrolysis of diethyl 3-hydroxyglutarate. Tetrahedron: asymmetry. vol. 15.
- (2003) Enantioselective enzymatic preparation of chiral glutaric monocarboxylic acids and amides. Journal of Molecular Catalysis B: Enzymatic. vol. 21.
- (2002) Lipase catalysed resolution and microbial reduction for obtaining enantiopure 1-(2-thienyl)alkanols. ARKIVOC.
- (2001) Synthesis of the anti-stroke drug Lubeluzole and its enantiomer. Lipase catalyzed resolution of chiral building block. Chirality. vol. 13.
- (2000) Enantiopure derivatives of 1,2-alkanediols. Substrate requirements for lipase B from Candida antarctica. Chirality. vol. 12.
- (2000) Influence of Substituents on Enantiomeric Ratio in Transesterification of Racemic C-3 Synthons using Lipase B from Candida antarctica. Journal of Molecular Catalysis B: Enzymatic. vol. 8.
- (2000) Enantiopure derivatives of 1,2-alkanediols: Substrate requirements of lipase B from Candida antarctica. Chirality. vol. 12.
- (2000) Chemoenzymatic synthesis of the antidepressant Duloxetine and its enantiomer. Chirality. vol. 12.
- (2000) Chemo-enzymatic synthesis of both enantiomers of the non-tricyclic antidepressants Fluoxetine, Nisoxetine and Tomoxetine. Journal of the Chemical Society. Perkin transactions 1.
- (1999) Gas Chromatographic enantiomer separation of C-3 and C-4 synthons. Combination with enzymatic resolution to determine absolute configuration. Chirality. vol. 11.
- (1999) Synthesis of 1,3-dithianes and 1,3-dithiolanes. Baker´s yeast reduction and lipase-catalyzed resolution for synthesis of enantiopure derivatives. Acta Chemica Scandinavica. vol. 53.
- (1999) Lipase catalyzed resolution of esters of 4-chloro-3-hydroxybutanoic acid. Effect of alkoxy group and solvent on enantiomeric ratio. Tetrahedron: asymmetry. vol. 10.
- (1999) Synthesis of 1,3-Dithianes and 1,3-Dithiolanes. Baker's Yeast reduction and Lipase-Catalyzed resolution for synthesis of Enantiopure derivatives. Acta Chemica Scandinavica. vol. 53.
- (1998) Resolution of Derivatives of 1,2-Propanediol with Lipase B from Candida antarctica. Effect of Substrate Structure, Medium, Water Activity and Acyl on Enantiomeric Ratio. Chemistry and Physics of Lipids. vol. 93 (xx).
- (1996) Calculation of enantiomer ratio and equilibrium constants in biocatalytic ping-pong bi-bi resolutions. Tetrahedron: asymmetry. vol. 7.
- (1996) The enantiomer ratio strongly depends on the alkyl part of the acyl donor in transesterification with lipase B from Candida antarctica. Tetrahedron: asymmetry. vol. 7.
- (1996) Resolution of 1-phenoxy-, 1-phenylmethoxy- and 1-(2-phenylethoxy)-2-propanol and their butanoates by hydrolysis with lipase B from Candida antarctica. Tetrahedron: asymmetry. vol. 7.
Others
- (2017) Synthetic strategies towards substituted pyrrolopyridines. Organisk Kjemisk Vintermøte OKV32 . University of Oslo; Skeikampen. 2017-01-12 - 2017-01-15.