TKJ4155 - Organic Synthesis II


Examination arrangement

Examination arrangement: School exam
Grade: Letter grades

Evaluation Weighting Duration Grade deviation Examination aids
School exam 100/100 4 hours D

Course content

A broad introduction to modern synthetic organic chemistry will be given: preparation and reactions with organometallic compounds (Mg, Li), reactions involving transition metals (organo-Cu, -Pd, -Ru), C-C bond formation reactions from organoboron and organotin compounds, oxidation reactions (alcohols, C=C bonds), reactions via electron deficient intermediates: cations, carbenes and metallocarbenes, nitrenes, radical chemistry with alkenes and alkynes, functionalisation of aromatic structures by electrophilic aromatic substitution, via aryl diazonium ions, nucleophilic aromatic substitution and palladium/cupper catalysed nuleophilic aromatic substitution. An introduction to retrosynthesis will be given.

Learning outcome

The course covers the theoretical basis for the chemical reactions that are important in the synthesis of organic compounds, particularly organometallic chemistry, including transition metals, C-C bond formation of organoboranes and -stannanes, carbene chemistry, aromatic substitutions and oxidations.

After the course the students are supposed to be able to: - plan syntheses of organic molecules by proper choice of starting materials, reagents and reaction conditions, - predict competing reactions and potential by-products, - know how functional groups affect the electron density, the properties and, in particular, the reactivity of organic compounds, - show reaction mechanisms for the reactions, - plan synthetic routes based on retrosynthetic synthesis strategy. The students will learn how to focus on sustainable use of organometallic compounds (such as Sn, Pd, Cr, Os), including the concept of using nontoxic co-oxidants and metal-free methods.

Learning methods and activities

Lectures and exercises.

Expected work load in the course is 200-225 hours.

Further on evaluation

If there is a re-sit examination, the examination form may be changed from written to oral.

Required previous knowledge

Basic course in organic chemistry: TKJ4102/TKJ4100 or KJ1020/KJ1021 or similar courses from other universities.

Intermediate course in organic chemistry: TKJ4150 Organic synthesis I, or similar courses from other universities.

Course materials

1) F. A. Carey and R. J. Sundberg: "Advanced Organic Chemistry. Part B, Reactions and Synthesis", 5. Ed., Springer, 2007.

2) Course compendiums

3) Exercises

Credit reductions

Course code Reduction From To
TKJ4135 4.0 AUTUMN 2012
TKJ4111 3.5 AUTUMN 2013
More on the course



Version: 1
Credits:  7.5 SP
Study level: Second degree level


Term no.: 1
Teaching semester:  AUTUMN 2024

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Organic Chemistry
  • Chemistry
  • Technological subjects
Contact information
Course coordinator:

Department with academic responsibility
Department of Chemistry


Examination arrangement: School exam

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Autumn ORD School exam 100/100 D INSPERA
Room Building Number of candidates
Summer UTS School exam 100/100 D INSPERA
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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