Anna Marie Holand
Background and activities
I am a postdoc at the Department of Mathematical Sciences, NTNU and associated to the Centre of Excellence, Centre for Biodiversity Dynamics at NTNU.
In my research I focus on questions in the intersection between genetics, evolution and statistics.
My broad interest is to understand, disentangle and quantify the contribution of genes and environmental effects caused by differences between individuals in complex traits. In addition, identifiability issues are of interest. To explore these important scientific questions I use advanced statistical methods and models, and application of new methodology in statistical inference and genetic/genomic data.
The main study system has been the house sparrow populations along the coast of mid-and northern Norway. I have used this study system to model and estimate genetic differentiation for quantitative traits (Qst) and neutral marker loci (Fst) (with Associate Prof. Henrik Jensen at Dept. of Biology and Prof. Jarle Tufto), and additive genetic variation (using pedigree-based models) (Henrik Jensen and Prof. Ingelin Steinsland at Dept. of Mathematical Sciences, NTNU). I have been evolved in collaboration with people at the INLA-group at Dept. of Mathematical Sciences, NTNU (Integrated Nested Laplace Approximation (INLA), Håvard Rue, Dept. of Mathematical Sciences, NTNU and Sara Martino, SINTEF) developing an R-package using the INLA methodology as inference method for pedigree-based models. In addition, I have been working with the modeling and estimation of sex-linked genetic variance in the study system of barn owls in Switzerland (Prof. Alex Roulin, Lausanne University), modeling multivariate models for agricultural data (with Boby Mathew, Institute of Crop Science and Resource Conservation, University of Bonn).
Ongoing projects is to perform genomic prediction of complex traits in the house sparrow populations using high density single-nucleotide polymorphisms (SNPs) (with Henrik Jensen and Ingelin Steinsland) and indentifiability issues. I recently started a collaboration with Kirsti Kvaløy and Bjørn Olav Åsvold (Helseundersøkelsen i Nord-Trøndelag (HUNT), Institutt for samfunnsmedisin, NTNU) on estimating different aspects of genetic and environmental influences in BMI and diabetes using pedigree, SNP and phenotypic data from the HUNT study.
I finished my PhD in 2013: “Statistical methods for estimating intra- and inter-population variation in genetic diversity” (main supervisor: Bernt Erik Sæther at Dept. of Biology, CBD, NTNU, co-supervisor: Ingelin Steinsland and Henrik Jensen). During my PhD I visited Ingelin Steinsland at Statistical and Applied Mathematical Sciences Institute (SAMSI), North Carolina. In 2013 I started as postdoc at the Dept. of Mathematical Sciences, NTNU.
I teach in TMA4255: Applied Statistics
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2016) Is my study system good enough? A case study for identifying maternal effects. Ecology and Evolution. vol. 6 (11).
- (2016) Reparametrization-based estimation of genetic parameters in multi-trait animal model using Integrated Nested Laplace Approximation. Theoretical and Applied Genetics. vol. 129 (2).
- (2014) On estimation and identifiability issues of sex-linked inheritance with a case study of pigmentation in Swiss barn owl (Tyto alba). Ecology and Evolution. vol. 4 (9).
- (2013) Animal Models and Integrated Nested Laplace Approximations. G3: Genes, Genomes, Genetics. vol. 3 (8).
- (2013) Genetic variation and structure of house sparrow populations: is there an island effect?. Molecular Ecology. vol. 22 (7).
- (2011) Does selection or genetic drift explain geographic differentiation of morphological characters in house sparrows Passer domesticus?. Genetics Research. vol. 93 (5).
- (2013) Statistical methods for estimating intra- and inter-population variation in genetic diversity. Norges teknisk-naturvitenskapelige universitet. 2013. ISBN 978-82-471-4599-9.