Cathrine Broberg Vågbø
Cathrine Broberg Vågbø
cathrine.b.vagbo@ntnu.no
About
I have a PhD in molecular medicine and am affiliated with the Proteomics and Modomics Experimental Core facility (PROMEC), Department of Clinical and Molecular Medicine, NTNU.
My area of specialization is RNA epitranscriptomics and DNA epigenetics that regulate gene expression and through that most cellular processes. My primary aim is to enhance our understanding of how errors in these systems contribute to human diseases. I have 20 years of experience with analytical techniques such as chromatography and mass spectrometry, and the development of methods to characterize RNA- and DNA modifications has been central to my work. Today these methods are part of the PROMEC repertoire where they are used by a number of research groups nationally and internationally.
Publications
Published 41 articles (PubMed) in peer-reviewed international journals, >5000 citations, h-index 27 (Publons).
Statistics: Journal (impact factor, number of publications): Nature (69.5, 3), Cell (41.6, 1), Nat Neurosci (28.1, 1), Mol Cell (19.3, 2), Nucleic Acids Res (19.1, 6), Sci Adv (14.1, 1), Genes&Dev (12.9, 2), Nat Commun (17.7, 2), EMBO J (13.8, 2), Am J Hum Genet (11.0, 1), Cell Rep (10.0, 2), J Cell Biol (8.1, 1), Oncotarget (6.0, 1), J Transl Med (5.5, 1), Epigenet Chromatin (5.2, 1), DNA Rep (4.9, 5), J Biol Chem (4.6, 1), Cell Discov (4.5, 1), Sci Rep (4.5, 1), Mol Cell Biol (4.4, 1), Hum Genet (5.2, 1), PlosOne (3.5, 1), J Pharmacol Exp Ther (3.0, 1), F1000Res (1.7, 1), J Clin Pharm (1.7, 1).
Authored textbook chapter: Genomic Uracil: Evolution, Biology, Immunology and Disease, ISBN 9813233494, World Scientific publishing (2018).
Publications
2023
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Academic article
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Academic article
2022
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Other presentation
2021
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Academic article
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Academic article
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Academic article
2020
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Academic article
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Academic article
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Academic article
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Academic article
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Academic article
2019
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Academic article
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Academic article
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Academic article
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Academic article
2017
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Academic article
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Academic article
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Academic article
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Academic article
2016
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Academic article
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Academic article
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Academic article
2015
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Academic article
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Academic article
2014
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Academic article
2013
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Academic article
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Academic article
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Academic article
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Academic article
2012
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Academic article
2011
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Academic article
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Academic article
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Academic article
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Academic article
2010
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Academic article
2009
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Academic article
2008
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doctoral dissertation
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Academic article
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Academic article
2007
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Academic literature review
2006
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Academic article
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Academic article
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Academic literature review
2003
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Academic article
2001
-
Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Academic article
Journal publications
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Academic article
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Academic article
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Academic article
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Academic article
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Academic article
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Academic article
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Academic article
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Academic article
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Academic article
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Academic article
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Academic article
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Academic article
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Academic article
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Academic article
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Academic article
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Academic article
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Academic article
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Academic article
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Academic article
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Academic article
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Academic article
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Academic article
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Academic article
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Academic article
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Academic article
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Academic article
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Academic article
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Academic article
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Academic article
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Academic article
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Academic article
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Academic article
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Academic article
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Academic article
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Academic article
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Academic article
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Academic article
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Academic literature review
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Academic article
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Academic article
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Academic literature review
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Academic article
-
Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Academic article
Report
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doctoral dissertation
UTSTILLING
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Other presentation
Media
2022
-
Academic lectureSlupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. Proteomass Scientific Society 8th International Caparica Conference on Analytical Proteomics 2022 , Carparica, Portugal 2022-07-18 - 2022-07-21
-
Academic lectureEldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. Societe Francaise de Virologie XXIVème Journées Francophones de Virologie , Strasbourg 2022-04-11 - 2022-04-12
2018
-
Academic lectureVågbø, Cathrine Broberg. (2018) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Melhus Bibliotek 2018-11-03 - 2018-11-03
-
PosterVågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
-
PosterSlupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
2017
-
Academic lectureVågbø, Cathrine Broberg. (2017) Mass spectrometry based analysis of modified DNA and RNA. Matriks Seminar massespektrometri , Oslo 2017-11-02 - 2017-11-02
-
Academic lectureVågbø, Cathrine Broberg. (2017) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Trondheim Folkebibliotek 2021-04-07 - 2021-04-07
2016
-
Academic lectureSlupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3 . The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
-
PosterSharma, Animesh; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir. (2016) PROMEC: Services within Proteomics and DNA/RNA-modomics. NTNU - Faculty of Medicine Seminar for staff at the future Faculty of Medicine and Health Sciences , Scandic Lerkendal Hotel, Trondheim 2016-11-10 - 2016-11-11
2014
-
PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2014) Epigenetically modified cytosines in the honey bee genome. The Ecology of Food Perception Unconventional Model Animals in Food & Health , Oslo 2014-03-20 - 2014-03-21
2013
-
PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2013) Presence of modified cytosines in the honey bee genome. Insect Nutritional Homeostasis , Bonn 2013-05-01 - 2013-05-04
2011
-
PosterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. UiO 4th EU-USA conference on DNA base damage and repair , Holmenkollen Park Hotell 2011-05-18 - 2011-05-22
2010
-
Academic lectureMeza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland. (2010) The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage. 9th Norwegian Arabidopsis Meeting , Oslo 2010-11-11 - 2010-11-11
-
Academic lectureGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
-
Academic lectureVågbø, Cathrine Broberg. (2010) Biological applications of mass spectrometry in the analysis of DNA and RNA modifications. The 6th Norwegian Proteomics Conference 2010-12-09 - 2010-12-10
2009
-
Academic lectureGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
-
PosterHenrik Sahlin, Pettersen; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair , Ålesund og Geiranger 2009-06-20 - 2009-06-25
2008
-
Academic lectureVågbø, Cathrine Broberg. (2008) RNA repair by AlkB proteins - fact or fiction?. Inst. for Kreftforskning og Molekylær Medisin Faglig seminar Inst. for Kreftforskning og Molekylær Medisin 2008-11-11 - 2008-11-11
-
Academic lectureSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
-
Academic lectureVågbø, Cathrine Broberg. (2008) ALKB mediert RNA reparasjon. IKM Tirsdagsmøter ved Institutt for kreftforskning og molekylær medisin , Trondheim 2008-11-11 -
2007
-
Academic lectureVågbø, Cathrine Broberg. (2007) Repair of RNA alkylation damage - in vivo?. Avd. for Kreftforskning og Molekylær Medisin, NTNU Fagmøte på Avd. for Kreftforskning og Molekylær Medisin , Laboratoriesenteret, NTNU 2007-09-10 - 2007-09-10
2006
-
Academic lectureVågbø, Cathrine Broberg. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA (oral presentation). EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
-
Academic lectureVågbø, Cathrine Broberg. (2006) The in vivo role of mouse AlkB homologue 2 and 3 assessed through LC/MS/MS. Institutt for Kreftforskning og Molekylær Medisin, NTNU Tirsdagsseminar Institutt for Kreftforskning og Molekylær Medisin , Trondheim 2006-10-24 - 2006-10-24
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
-
PosterSousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair , Bodø og Hennigsvær 2006-05-28 - 2006-06-02
-
PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
-
PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. Universitet i Oslo Erling Seeberg Symposium on DNA repair , Henningsvær, Lofoten 2006-05-28 - 2006-06-02
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. Norwegian Biochemical Society (NBS) The Norwegian Biochemical Society 42. Contact Meeting , Storefjell, Storefjell Hotell 2006-01-19 - 2006-01-22
2005
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease 2005-09-06 -
2004
-
Academic lectureHagen, Lars; Vågbø, Cathrine Broberg. (2004) Mass spectrometry applications at Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim. Norsk selskap for massespektrometri Møte i Norsk selskap for massespektrometri , Bergen 2004-05-10 -
2002
-
PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) To BER or not to BER - is that the question?. Norsk Biokjemisk Selskaps Vintermøte , Røros, Norge 2002-01-20 -
-
PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) The signifisance of variation of uracil DNA.glycosylase activity on uracil initiated base exicion repair. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
1999
-
Popular scientific lectureVågbø, Cathrine Broberg; Brunsvik, Anders; Zahlsen, Kolbjørn; Hadidi, Hakam; Idle, Jeffrey R.. (1999) Phenotypic and excessive 3-hydroxylation of coumarin, a ubiquitous environmental contaminant. 35. Biokjemiske kontaktmøte NBS , Tromsø, 21 - 24. januar 1999
1998
-
PosterVågbø, Cathrine B.; Haidid, Hakam; Idle, Jeffrey. (1998) Thiodiglycolic acid a novel endogenous urinary metabolite in humans. Biokjemisk kontaktmøte , Lillehammer