Cathrine Broberg Vågbø

About

I have a PhD in molecular medicine and am affiliated with the Proteomics and Modomics Experimental Core facility (PROMEC), Department of Clinical and Molecular Medicine, NTNU.

My area of specialization is RNA epitranscriptomics and DNA epigenetics that regulate gene expression and through that most cellular processes. My primary aim is to enhance our understanding of how errors in these systems contribute to human diseases. I have 20 years of experience with analytical techniques such as chromatography and mass spectrometry, and the development of methods to characterize RNA- and DNA modifications has been central to my work. Today these methods are part of the PROMEC repertoire where they are used by a number of research groups nationally and internationally.

Publications

Published 38 articles (PubMed) in peer-reviewed international journals. Currently > 4000 citations and an h-index of 25 (Publons).

Statistics: Journal (impact factor, number of publications): Nature (43.1, 2), Cell (38.6, 1), Nat Neurosci (21.1, 1), Mol Cell (14.5, 2), Sci Adv (13.1, 1), Genes&Dev (12.6, 2), Nat Commun (11.9, 2), EMBO J (11.2, 2), Nucleic Acids Res (11.1, 6), J Cell Biol (9.6, 1), Am J Hum Genet (9.0, 1), Cell Rep (8.7, 2), Oncotarget (6.0, 1), J Transl Med (5.5, 1), Epigenet Chromatin (5.2, 1), DNA Rep (4.9, 5), J Biol Chem (4.6, 1), Cell Discov (4.5, 1), Sci Rep (4.5, 1), Mol Cell Biol (4.4, 1), Hum Genet (4.1, 1), PlosOne (3.5, 1), J Pharmacol Exp Ther (3.0, 1), F1000Res (1.7, 1), J Clin Pharm (1.7, 1).

Authored textbook chapter: Genomic Uracil: Evolution, Biology, Immunology and Disease, ISBN 9813233494, World Scientific publishing (2018).

Publications

2022

Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Vågbø, Cathrine Broberg; Skarpeteig, Veronica; Rye, Morten Beck. (2022) Prøv deg som en DNA-detektiv. Forskningstorget 2022 [Kunstnerisk og museal presentasjon] . NTNU Vitenskapsmuseet; Kalvskinnet, Trondheim. 2022-09-22 - 2022-09-23.
Other presentation

2021

Maddirevula, Sateesh; Alameer, Seham; Ewida, Nour; Sousa, Mirta; Bjørås, Magnar; Vågbø, Cathrine Broberg; Alkuraya, Fowzan S.. (2021) Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant. Human Genetics. volum 141.
Academic article
Mendel, Mateusz; Delaney, Kamila; Pandey, Radha Raman; Chen, Kuan-Ming; Wenda, Joanna M.; Vågbø, Cathrine Broberg; Steiner, Florian A.; Homolka, David; Pillai, Ramesh S.. (2021) Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing. Cell. volum 184 (12).
Academic article
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine. volum 19 (1).
Academic article

2020

Boeckemeier, L; Kraehenbuehl, R; Keszthelyi, A; Gasasira, MU; Vernon, EG; Beardmore, R; Vågbø, Cathrine Broberg; Chaplin, D; Gollins, S; Krokan, Hans Einar; Lambert, SAE; Paizs, B; Hartsuiker, Edgar. (2020) Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication. Science Advances. volum 6 (22).
Academic article
Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter; Vågbø, Cathrine; Suganthan, Rajikala; Segers, Filip; Holm, Sverre; Quiles-Jiménez, Ana M T; Gregersen, Ida; Fladeby, Cathrine; Aukrust, Pål; Bjørås, Magnar; Klungland, Arne; Halvorsen, Bente; Alseth, Ingrun. (2020) Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Research (NAR). volum 48 (8).
Academic article
Pandey, Radha Raman; Delfino, Elena; Homolka, David; Roithova, Adriana; Chen, Kuan-Ming; Li, Lingyun; Franco, Giulia; Vågbø, Cathrine Broberg; Taillebourg, Emmanuel; Fauvarque, Marie-Odile; Pillai, Ramesh S.. (2020) The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues. Cell reports. volum 32 (7).
Academic article
Schär, Primo; Schuermann, David; Schwarz, Simon D.; Grundbacher, Eliane; Hrovat, Alexandra M.; Xu, Jianming; Kusnierczyk, Anna; Vågbø, Cathrine Broberg. (2020) Inducible TDG knockout models to study epigenetic regulation. F1000. volum 9.
Academic article
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair. volum 95.
Academic article

2019

Li, Xiang; Zhao, Qiongyi; Wei, Wei; Lin, Quan; Magnan, Christophe; Emami, Michael R; Wearick-Silva, Luis E; Viola, Thiago; Marshall, Paul R; Yin, Jiayu; Madugalle, Sachithrani U; Wang, Ziqi; Nainar, Sarah; Vågbø, Cathrine Broberg; Leighton, Laura J; Zajaczkowski, Esmi L; Ke, Ke; Grassi-Oliveira, Rodrigo; Bjørås, Magnar; Baldi, Pierre F; Spitale, Robert C; Bredy, Timothy W. (2019) The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience. volum 22 (4).
Academic article
Monies, Dorota; Vågbø, Cathrine Broberg; Al-Owain, Mohammad; Alhomaidi, Suzan; Alkuraya, Fowzan S.. (2019) Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification. American Journal of Human Genetics. volum 104 (6).
Academic article
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn; Olsen, Jesper V; Gleizes, Pierre-Emmanuel; Vermeulen, Michiel; Leidel, Sebastian A.; Slupphaug, Geir; Falnes, Pål Øystein. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). volum 48 (2).
Academic article
Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Maiken Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian. (2019) 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication. Scientific Reports. volum 9.
Academic article

2017

Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse; Byrum, Andrea K; Zhao, Yu; Corbett, Mark A.; Gècz, Jozef; Field, Michael; Vindigni, Alessandro; Slupphaug, Geir; Wolberger, Cynthia; Mosammaparast, Nima. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. volum 551 (7680).
Academic article
Ke, Shengdong; Pandya-Jones, Amy; Saito, Yuhki; Fak, John J.; Vågbø, Cathrine Broberg; Geula, Shay; Hanna, Jakob; Black, Douglas L; Darnell, James E.; Darnell, Robert B.. (2017) m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Genes & Development. volum 31 (10).
Academic article
Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus; Klungland, Arne. (2017) Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discovery. volum 3.
Academic article
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget. volum 8 (12).
Academic article

2016

Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne. (2016) DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports. volum 6.
Academic article
Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne; Staerk, Judith. (2016) Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin. volum 9.
Academic article
Weber, Alain R.; Krawczyk, Claudia; Robertson, Adam Brian; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Schürmann, David; Klungland, Arne; Schär, Primo. (2016) Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nature Communications. volum 7.
Academic article

2015

Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports. volum 13 (12).
Academic article
Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J.; Mele, Aldo; Haripal, Bhagwattie; Zucker-Scharff, Ilana; Moore, Michael J.; Park, Christopher Y.; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Klungland, Arne; Darnell, James E.; Darnell, Robert B.. (2015) A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development. volum 29 (19).
Academic article

2014

Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin; Falnes, Pål. (2014) Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE. volum 9 (6).
Academic article

2013

Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair. volum 12 (9).
Academic article
Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg; Bjørås, Magnar; Nilsen, Hilde. (2013) The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell. volum 49 (2).
Academic article
Vågbø, Cathrine Broberg; Svaasand, Eva Kathrine; Aas, Per Arne; Krokan, Hans Einar. (2013) Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA Repair. volum 12 (3).
Academic article
Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui; Lu, Zhike; Bosmans, Ralph P. G.; Dai, Qing; Hao, Ya-Juan; Yang, Xin; Zhao, Wen-Ming; Tong, Wei-Min; Wang, Xiu-Jie; Bogdan, Florian; Furu, Kari; Fu, Ye; Jia, Guifang; Zhao, Xu; Liu, Jun; Krokan, Hans Einar; Klungland, Arne; Yang, Yun-Gui; He, Chuan. (2013) ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell. volum 49 (1).
Academic article

2012

Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål. (2012) The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR). volum 40 (14).
Academic article

2011

Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar; Klungland, Arne. (2011) A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research (NAR). volum 39 (8).
Academic article
Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål. (2011) Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research (NAR). volum 39 (17).
Academic article
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR). volum 39 (19).
Academic article
Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne; Falnes, Pål. (2011) ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications. volum 2.
Academic article

2010

Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO; Klungland, A. (2010) Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology. volum 30 (7).
Academic article

2009

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
Academic article

2008

Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair. volum 7 (11).
Academic article
Vågbø, Cathrine Broberg. (2008) Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases. 2008. ISBN 978-82-471-1154-3.
Doctoral dissertation
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
Academic article

2007

Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
Academic literature review

2006

Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate; Bjørk, Alexandra; Doughty, Richard William; Falnes, Pål Ø.; Krokan, Hans Einar; Klungland, Arne. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal. volum 25.
Academic article
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal. volum 25.
Academic article

2004

Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
Academic literature review

2003

Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
Academic article

2001

Chatton, Jean-Yves; Idle, Jefrrey R.; Vågbø, Cathrine; Magistretti, Pierre. (2001) Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons. Journal of Pharmacology and Experimental Therapeutics. volum 299.
Academic article

Journal publications

Maddirevula, Sateesh; Alameer, Seham; Ewida, Nour; Sousa, Mirta; Bjørås, Magnar; Vågbø, Cathrine Broberg; Alkuraya, Fowzan S.. (2021) Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant. Human Genetics. volum 141.
Academic article
Mendel, Mateusz; Delaney, Kamila; Pandey, Radha Raman; Chen, Kuan-Ming; Wenda, Joanna M.; Vågbø, Cathrine Broberg; Steiner, Florian A.; Homolka, David; Pillai, Ramesh S.. (2021) Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing. Cell. volum 184 (12).
Academic article
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine. volum 19 (1).
Academic article
Boeckemeier, L; Kraehenbuehl, R; Keszthelyi, A; Gasasira, MU; Vernon, EG; Beardmore, R; Vågbø, Cathrine Broberg; Chaplin, D; Gollins, S; Krokan, Hans Einar; Lambert, SAE; Paizs, B; Hartsuiker, Edgar. (2020) Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication. Science Advances. volum 6 (22).
Academic article
Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter; Vågbø, Cathrine; Suganthan, Rajikala; Segers, Filip; Holm, Sverre; Quiles-Jiménez, Ana M T; Gregersen, Ida; Fladeby, Cathrine; Aukrust, Pål; Bjørås, Magnar; Klungland, Arne; Halvorsen, Bente; Alseth, Ingrun. (2020) Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Research (NAR). volum 48 (8).
Academic article
Pandey, Radha Raman; Delfino, Elena; Homolka, David; Roithova, Adriana; Chen, Kuan-Ming; Li, Lingyun; Franco, Giulia; Vågbø, Cathrine Broberg; Taillebourg, Emmanuel; Fauvarque, Marie-Odile; Pillai, Ramesh S.. (2020) The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues. Cell reports. volum 32 (7).
Academic article
Schär, Primo; Schuermann, David; Schwarz, Simon D.; Grundbacher, Eliane; Hrovat, Alexandra M.; Xu, Jianming; Kusnierczyk, Anna; Vågbø, Cathrine Broberg. (2020) Inducible TDG knockout models to study epigenetic regulation. F1000. volum 9.
Academic article
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair. volum 95.
Academic article
Li, Xiang; Zhao, Qiongyi; Wei, Wei; Lin, Quan; Magnan, Christophe; Emami, Michael R; Wearick-Silva, Luis E; Viola, Thiago; Marshall, Paul R; Yin, Jiayu; Madugalle, Sachithrani U; Wang, Ziqi; Nainar, Sarah; Vågbø, Cathrine Broberg; Leighton, Laura J; Zajaczkowski, Esmi L; Ke, Ke; Grassi-Oliveira, Rodrigo; Bjørås, Magnar; Baldi, Pierre F; Spitale, Robert C; Bredy, Timothy W. (2019) The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience. volum 22 (4).
Academic article
Monies, Dorota; Vågbø, Cathrine Broberg; Al-Owain, Mohammad; Alhomaidi, Suzan; Alkuraya, Fowzan S.. (2019) Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification. American Journal of Human Genetics. volum 104 (6).
Academic article
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn; Olsen, Jesper V; Gleizes, Pierre-Emmanuel; Vermeulen, Michiel; Leidel, Sebastian A.; Slupphaug, Geir; Falnes, Pål Øystein. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). volum 48 (2).
Academic article
Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Maiken Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian. (2019) 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication. Scientific Reports. volum 9.
Academic article
Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse; Byrum, Andrea K; Zhao, Yu; Corbett, Mark A.; Gècz, Jozef; Field, Michael; Vindigni, Alessandro; Slupphaug, Geir; Wolberger, Cynthia; Mosammaparast, Nima. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. volum 551 (7680).
Academic article
Ke, Shengdong; Pandya-Jones, Amy; Saito, Yuhki; Fak, John J.; Vågbø, Cathrine Broberg; Geula, Shay; Hanna, Jakob; Black, Douglas L; Darnell, James E.; Darnell, Robert B.. (2017) m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Genes & Development. volum 31 (10).
Academic article
Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus; Klungland, Arne. (2017) Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discovery. volum 3.
Academic article
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget. volum 8 (12).
Academic article
Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne. (2016) DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports. volum 6.
Academic article
Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne; Staerk, Judith. (2016) Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin. volum 9.
Academic article
Weber, Alain R.; Krawczyk, Claudia; Robertson, Adam Brian; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Schürmann, David; Klungland, Arne; Schär, Primo. (2016) Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nature Communications. volum 7.
Academic article
Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports. volum 13 (12).
Academic article
Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J.; Mele, Aldo; Haripal, Bhagwattie; Zucker-Scharff, Ilana; Moore, Michael J.; Park, Christopher Y.; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Klungland, Arne; Darnell, James E.; Darnell, Robert B.. (2015) A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development. volum 29 (19).
Academic article
Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin; Falnes, Pål. (2014) Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE. volum 9 (6).
Academic article
Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair. volum 12 (9).
Academic article
Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg; Bjørås, Magnar; Nilsen, Hilde. (2013) The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell. volum 49 (2).
Academic article
Vågbø, Cathrine Broberg; Svaasand, Eva Kathrine; Aas, Per Arne; Krokan, Hans Einar. (2013) Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA Repair. volum 12 (3).
Academic article
Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui; Lu, Zhike; Bosmans, Ralph P. G.; Dai, Qing; Hao, Ya-Juan; Yang, Xin; Zhao, Wen-Ming; Tong, Wei-Min; Wang, Xiu-Jie; Bogdan, Florian; Furu, Kari; Fu, Ye; Jia, Guifang; Zhao, Xu; Liu, Jun; Krokan, Hans Einar; Klungland, Arne; Yang, Yun-Gui; He, Chuan. (2013) ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell. volum 49 (1).
Academic article
Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål. (2012) The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR). volum 40 (14).
Academic article
Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar; Klungland, Arne. (2011) A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research (NAR). volum 39 (8).
Academic article
Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål. (2011) Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research (NAR). volum 39 (17).
Academic article
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR). volum 39 (19).
Academic article
Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne; Falnes, Pål. (2011) ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications. volum 2.
Academic article
Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO; Klungland, A. (2010) Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology. volum 30 (7).
Academic article
Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
Academic article
Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair. volum 7 (11).
Academic article
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
Academic article
Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
Academic literature review
Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate; Bjørk, Alexandra; Doughty, Richard William; Falnes, Pål Ø.; Krokan, Hans Einar; Klungland, Arne. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal. volum 25.
Academic article
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal. volum 25.
Academic article
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
Academic literature review
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
Academic article
Chatton, Jean-Yves; Idle, Jefrrey R.; Vågbø, Cathrine; Magistretti, Pierre. (2001) Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons. Journal of Pharmacology and Experimental Therapeutics. volum 299.
Academic article

Report

Vågbø, Cathrine Broberg. (2008) Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases. 2008. ISBN 978-82-471-1154-3.
Doctoral dissertation

UTSTILLING

Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Vågbø, Cathrine Broberg; Skarpeteig, Veronica; Rye, Morten Beck. (2022) Prøv deg som en DNA-detektiv. Forskningstorget 2022 [Kunstnerisk og museal presentasjon] . NTNU Vitenskapsmuseet; Kalvskinnet, Trondheim. 2022-09-22 - 2022-09-23.
Other presentation

Media

2022

Academic lecture

Eldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. XXIVème Journées Francophones de Virologie . Societe Francaise de Virologie; Strasbourg. 2022-04-11 - 2022-04-12.
Academic lecture

Slupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. 8th International Caparica Conference on Analytical Proteomics 2022 . Proteomass Scientific Society; Carparica, Portugal. 2022-07-18 - 2022-07-21.

2018

Poster

Slupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vuk, Palibrk; Bjørås, Magnar; Mosammaparast, Nima; Fonseca, Davi de Miranda; Vågbø, Cathrine Broberg. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice . EMBO; Capri. 2018-10-14 - 2018-10-17.
Academic lecture

Vågbø, Cathrine Broberg. (2018) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet: DNA – livets oppskrift! . Barneuniversitetet/ Kunnskapsbyen Trondheim.; Melhus Bibliotek. 2018-11-03 - 2018-11-03.
Poster

Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice . EMBO; Capri. 2018-10-14 - 2018-10-17.