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Christian Schulz

Christian Schulz

Postdoctoral Fellow
Department of Biotechnology and Food Science
Faculty of Natural Sciences

christian.schulz@ntnu.no
+4773413148 Kjemi 3, 3.061, Gløshaugen, Sem Sælandsvei 6/8
ORCID
About Publications Teaching Media

About

I am working in Almaas Lab on genome-scale metabolic modelling to analyze the cell’s systems response to local changes, as for example knock-outs.

My main project is an Digital Life Norway project called BedPan. The project aims to produce palladium-nanoparticles with E. coli. For the project I perform the genome-scale modelling.

Additionally, I am working on an initiative to determine organisms’ macromolecular content, specifically, the biomass composition such as the rations of DNA, RNA, protein, carbohydrates, lipids, and others.

To achieve high-quality measurements in the laboratory, we generate micro-organism biomass in defined culturing conditions using fermenters and chemostat setups. This biomass is analyzed with various methods such as MS and NMR, to generate high-quality data for the given environments. The data is stored in a database to increase the genome-scale metabolic modeling precision, and to be used for machine learning techniques to predict organism behavior.

For the future we plan to include higher organisms such as the salmon, plants, and human samples (e.g. cancer cells vs. healthy cells) as well.

Knowledge for a better world.

 

Competencies

  • Biochemistry
  • Bioinformatics
  • Cell biology
  • Knowledge-based systems
  • Mathematic modelling and numerical methods
  • Simulation, visualisation, signal processing, image analysis
  • Theoretical computer science, programming science and theory

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2023

  • Karlsen, Emil; Gylseth, Marianne; Schulz, Christian; Almaas, Eivind. (2023) A study of a diauxic growth experiment using an expanded dynamic flux balance framework. PLOS ONE.
    Academic article

2022

  • Simensen, Vetle; Schulz, Christian; Karlsen, Emil; Bråtelund, Signe; Burgos, Idun Maria Tokvam; Thorfinnsdottir, Lilja Brekke; Garcia Calvo, Laura; Bruheim, Per; Almaas, Eivind. (2022) Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling. PLOS ONE. volum 17 (1).
    Academic article

2021

  • Joudeh, Nadeem; Saragliadis, Athanasios; Schulz, Christian; Voigt, Andre; Almaas, Eivind; Linke, Dirk. (2021) Transcriptomic Response Analysis of Escherichia coli to Palladium Stress. Frontiers in Microbiology. volum 12.
    Academic article
  • Schulz, Christian; Kumelj, Tjasa; Karlsen, Emil; Almaas, Eivind. (2021) Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition. PLoS Computational Biology. volum 17 (5).
    Academic article

2020

  • Schulz, Christian; Almaas, Eivind. (2020) Genome-scale reconstructions to assess metabolic phylogeny and organism clustering. PLOS ONE.
    Academic article

2018

  • Karlsen, Emil; Schulz, Christian; Almaas, Eivind. (2018) Automated generation of genome-scale metabolic draft reconstructions based on KEGG. BMC Bioinformatics. volum 19 (467).
    Academic article

Scientific articles

  • Karlsen, Emil; Gylseth, Marianne; Schulz, Christian; Almaas, Eivind. (2023) A study of a diauxic growth experiment using an expanded dynamic flux balance framework. PLOS ONE.
    Academic article
  • Simensen, Vetle; Schulz, Christian; Karlsen, Emil; Bråtelund, Signe; Burgos, Idun Maria Tokvam; Thorfinnsdottir, Lilja Brekke; Garcia Calvo, Laura; Bruheim, Per; Almaas, Eivind. (2022) Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling. PLOS ONE. volum 17 (1).
    Academic article
  • Joudeh, Nadeem; Saragliadis, Athanasios; Schulz, Christian; Voigt, Andre; Almaas, Eivind; Linke, Dirk. (2021) Transcriptomic Response Analysis of Escherichia coli to Palladium Stress. Frontiers in Microbiology. volum 12.
    Academic article
  • Schulz, Christian; Kumelj, Tjasa; Karlsen, Emil; Almaas, Eivind. (2021) Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition. PLoS Computational Biology. volum 17 (5).
    Academic article
  • Schulz, Christian; Almaas, Eivind. (2020) Genome-scale reconstructions to assess metabolic phylogeny and organism clustering. PLOS ONE.
    Academic article
  • Karlsen, Emil; Schulz, Christian; Almaas, Eivind. (2018) Automated generation of genome-scale metabolic draft reconstructions based on KEGG. BMC Bioinformatics. volum 19 (467).
    Academic article

Teaching

Courses

  • TBT4165 - System Biology and Biological Networks

Media

2022

  • Poster
    Karlsen, Emil; Gylseth, Marianne; Schulz, Christian; Almaas, Eivind. (2022) Investigating Diauxic Growth Using Dynamic Enzyme-Constrained Flux Balance Analysis. 8th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2022) | AIChE ; Galway. 2022-09-28 - 2022-09-30.
  • Poster
    Schulz, Christian; Simensen, Vetle; Karlsen, Emil; Almaas, Eivind. (2022) Analyzing the Biomass for an organism. DLN conference ; Trondheim. 2022-10-20 - 2022-10-21.
  • Poster
    Schulz, Christian; Simensen, Vetle; Karlsen, Emil; Almaas, Eivind. (2022) Analyzing the Biomass for an organism. Cobra conference ; Galway. 2022-09-28 - 2022-09-30.

2020

  • Programme participation
    Jevne, Lone Sunniva; Schulz, Christian; Røe, Ingeborg Treu; Vethe, Daniel; Johansen, Børge Andreas Heggen; Lindholm, Håvard Takle; Osman, Mogahid; Sæter, Gunn-Berit; Hagen, Inger Berge; Grendal, Ola Gjønnes. (2020) Forsker Grand Prix 2019, Trondheim. NRK2 [TV]. 2020-01-25.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2020) Beer in the NMR - Who left Fingerprints?. NORBIS anual conference ; 2020-11-03 - 2020-11-03.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2020) Combining Theory and Praxis: Measuring (Microbial) Biomass Composition for Genome-Scale Metabolic Modelling. NBS contact meeting ; 2020-01-23 - 2020-01-26.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2020) First project meeting presentation. BedPan project meeting ; 2020-03-04 - 2020-03-05.

2019

  • Academic lecture
    Schulz, Christian. (2019) Beer'omics. PhD retreat IBT ; 2019-10-21.
  • Lecture
    Schulz, Christian. (2019) Beer’omics – Kveik for Christmas. IBT's weekly Department lunch . IBT; IBT's lunch room, NV Faculty, NTNU, Gløshaugen. 2019-12-18.
  • Popular scientific lecture
    Schulz, Christian. (2019) GenomeScale metabolic modelling for Nylon production. PhD Grand Prix NV faculty NTNU ; 2019-03-20 - 2019-03-20.
  • Popular scientific lecture
    Schulz, Christian. (2019) Producing more plastic to save the world. Forsker Grand Prix 2019 Trondheim ; 2019-09-26 - 2019-09-26.
  • Interview
    Schulz, Christian. (2019) Urnorsk gjær lager øl superraskt. https://gemini.no/2019/12/urnorsk-gjaer-lager-ol-superraskt/ [Fagblad]. 2019-12-18.
  • Lecture
    Schulz, Christian. (2019) What I've learned from Forsker GrandPrix - Presentation techniques. PhD retreat IBT ; 2019-10-21 - 2019-10-22.
  • Lecture
    Schulz, Christian; Almaas, Eivind. (2019) Beer'omics - Kveik for Christmas. IBT department Seminar ; 2019-12-18 - 2019-12-18.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2019) Combining Genome-Scale modelling with HUNT. Jebsen Center meeting ; 2019-10-25 - 2019-10-25.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2019) Genome-Scale modelling - No4. Bianual project meeting ; 2019-10-30 - 2019-10-30.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic modeling: Metabolic engineering to increase production of nylon precursors in Pseudomonas. NBS meeting 2019 . NBS; 2019-01-24 - 2019-01-27.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic modelling 3. Bianual project meeting ; 2019-03-11 - 2019-03-11.
  • Poster
    Schulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic reconstructions for phylogeny?. Fish under stress - Systems biology and mathematical modelling ; 2019-05-24 - 2019-05-28.
  • Poster
    Schulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic reconstructions for phylogeny?. Multivariate analysis of omics data with special emphasis on metabolomics Summerschool ; 2019-05-17 - 2019-05-21.
  • Academic lecture
    Schulz, Christian; Diab, Joseph. (2019) ForskerGrandPrix: Experiences, Talks, and what we have learned. NORBIS anual conference . NORBIS; Oslo. 2019-09-30 - 2019-10-02.
  • Poster
    Schulz, Christian; Karlsen, Emil; Kumar, Kanhaiya; Bartosova, Zdenka; Schmid, Jochen; Bruheim, Per; Almaas, Eivind. (2019) Measuring Biomass Composition for Modelling. DLN anual conference ; 2019-09-05 - 2019-09-06.

2018

  • Academic lecture
    Almaas, Eivind; Karlsen, Emil; Schulz, Christian; Martyushenko, Nikolay. (2018) Dynamic FBA with Global Constraints on Cellular Protein Fraction. 5th Conference on Constraint-Based Reconstruction and Analysis ; Seattle. 2018-10-14 - 2018-10-16.
  • Academic lecture
    Karlsen, Emil; Schulz, Christian; Almaas, Eivind. (2018) Automatic assembly of genome-scale metabolic draft reconstructions from KEGG data. NORBIS Annual Conference 2018 . NORBIS; Voss. 2018-10-17 - 2018-10-19.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Combining phylogeny with genome-scale metabolic networks: Another tree of life and infinite engineering possibilities?. Micobial Biotechnology Division meeting ; 2018-06-22 - 2018-06-22.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Cross-organism-wide network comparison to identify conserved gene functions. Digital Life Annual PhD School meeting ; 2018-05-30 - 2018-06-01.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Discovery of conserved functions within cross-organism-wide genes using reaction networks. BioCat annual conference ; 2018-06-03 - 2018-06-06.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) From Zero to Hero: The Story of Modeling Pseudomonas. Department meeting IBT and Food Science ; 2018-05-16 - 2018-05-16.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Genome-Scale Metabolic Modeling for Biotechnology: What We Need to Conduct Our Magic. Micobial Biotechnology Division meeting ; 2018-03-09 - 2018-03-09.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Genome-Scale metabolic modelling. Bianual PolyBugs project meeting ; Trondheim. 2018-08-13 - 2018-08-13.
  • Poster
    Schulz, Christian; Almaas, Eivind. (2018) Genome-scale metabolic reconstructions for phylogeny?. COBRA conference 2018 ; Seattle, WA. 2018-10-14 - 2018-10-16.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) PolyBugs – WP2 Genome-Scale Metabolic Modelling. Project meeting ; 2018-01-16 - 2018-01-17.
  • Poster
    Schulz, Christian; Almaas, Eivind. (2018) Using reaction networks to identify cross-organism-wide genes with conserved functions. Summer School Systems and Synthetic Biology ; Sienna. 2018-07-24 - 2018-07-30.
  • Academic lecture
    Schulz, Christian; Almaas, Eivind. (2018) Using reactions networks to identify cross organism-wide genes with conserved functions. NetSci 2018 Conference Paris ; 2018-06-11 - 2018-06-15.
  • Poster
    Schulz, Christian; Almaas, Eivind. (2018) Virtual biological cell engineering: Differences and similarities in genome-scale metabolic models shown for the Pseudomonas case. DigitalLife anual conference ; 2018-03-20 - 2018-03-21.

2017

  • Poster
    Schulz, Christian; Almaas, Eivind. (2017) Comparison of publicly available Pseudomonas genome scale metabolic models. Norbis anual Conference ; 2017-11-08 - 2017-11-10.
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