Christian Schulz
+4773413148
Kjemi 3, 3.061, Gløshaugen, Sem Sælandsvei 6/8
About
I am working in Almaas Lab on genome-scale metabolic modelling to analyze the cell’s systems response to local changes, as for example knock-outs.
My main project is an Digital Life Norway project called BedPan. The project aims to produce palladium-nanoparticles with E. coli. For the project I perform the genome-scale modelling.
Additionally, I am working on an initiative to determine organisms’ macromolecular content, specifically, the biomass composition such as the rations of DNA, RNA, protein, carbohydrates, lipids, and others.
To achieve high-quality measurements in the laboratory, we generate micro-organism biomass in defined culturing conditions using fermenters and chemostat setups. This biomass is analyzed with various methods such as MS and NMR, to generate high-quality data for the given environments. The data is stored in a database to increase the genome-scale metabolic modeling precision, and to be used for machine learning techniques to predict organism behavior.
For the future we plan to include higher organisms such as the salmon, plants, and human samples (e.g. cancer cells vs. healthy cells) as well.
Knowledge for a better world.
Publications
2023
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Karlsen, Emil;
Gylseth, Marianne;
Schulz, Christian;
Almaas, Eivind.
(2023)
A study of a diauxic growth experiment using an expanded dynamic flux balance framework.
PLOS ONE.
Academic article
2022
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Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bruheim, Per;
Almaas, Eivind.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE.
volum 17 (1).
Academic article
2021
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Joudeh, Nadeem;
Saragliadis, Athanasios;
Schulz, Christian;
Voigt, Andre;
Almaas, Eivind;
Linke, Dirk.
(2021)
Transcriptomic Response Analysis of Escherichia coli to Palladium Stress.
Frontiers in Microbiology.
volum 12.
Academic article
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Schulz, Christian;
Kumelj, Tjasa;
Karlsen, Emil;
Almaas, Eivind.
(2021)
Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition.
PLoS Computational Biology.
volum 17 (5).
Academic article
2020
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Schulz, Christian;
Almaas, Eivind.
(2020)
Genome-scale reconstructions to assess metabolic phylogeny and organism clustering.
PLOS ONE.
Academic article
2018
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Karlsen, Emil;
Schulz, Christian;
Almaas, Eivind.
(2018)
Automated generation of genome-scale metabolic draft reconstructions based on KEGG.
BMC Bioinformatics.
volum 19 (467).
Academic article
Scientific articles
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Karlsen, Emil;
Gylseth, Marianne;
Schulz, Christian;
Almaas, Eivind.
(2023)
A study of a diauxic growth experiment using an expanded dynamic flux balance framework.
PLOS ONE.
Academic article
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bruheim, Per;
Almaas, Eivind.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE.
volum 17 (1).
Academic article
-
Joudeh, Nadeem;
Saragliadis, Athanasios;
Schulz, Christian;
Voigt, Andre;
Almaas, Eivind;
Linke, Dirk.
(2021)
Transcriptomic Response Analysis of Escherichia coli to Palladium Stress.
Frontiers in Microbiology.
volum 12.
Academic article
-
Schulz, Christian;
Kumelj, Tjasa;
Karlsen, Emil;
Almaas, Eivind.
(2021)
Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition.
PLoS Computational Biology.
volum 17 (5).
Academic article
-
Schulz, Christian;
Almaas, Eivind.
(2020)
Genome-scale reconstructions to assess metabolic phylogeny and organism clustering.
PLOS ONE.
Academic article
-
Karlsen, Emil;
Schulz, Christian;
Almaas, Eivind.
(2018)
Automated generation of genome-scale metabolic draft reconstructions based on KEGG.
BMC Bioinformatics.
volum 19 (467).
Academic article
Teaching
Courses
Media
2022
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PosterKarlsen, Emil; Gylseth, Marianne; Schulz, Christian; Almaas, Eivind. (2022) Investigating Diauxic Growth Using Dynamic Enzyme-Constrained Flux Balance Analysis. 8th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2022) | AIChE ; Galway. 2022-09-28 - 2022-09-30.
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PosterSchulz, Christian; Simensen, Vetle; Karlsen, Emil; Almaas, Eivind. (2022) Analyzing the Biomass for an organism. DLN conference ; Trondheim. 2022-10-20 - 2022-10-21.
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PosterSchulz, Christian; Simensen, Vetle; Karlsen, Emil; Almaas, Eivind. (2022) Analyzing the Biomass for an organism. Cobra conference ; Galway. 2022-09-28 - 2022-09-30.
2020
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Programme participationJevne, Lone Sunniva; Schulz, Christian; Røe, Ingeborg Treu; Vethe, Daniel; Johansen, Børge Andreas Heggen; Lindholm, Håvard Takle; Osman, Mogahid; Sæter, Gunn-Berit; Hagen, Inger Berge; Grendal, Ola Gjønnes. (2020) Forsker Grand Prix 2019, Trondheim. NRK2 [TV]. 2020-01-25.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2020) Beer in the NMR - Who left Fingerprints?. NORBIS anual conference ; 2020-11-03 - 2020-11-03.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2020) Combining Theory and Praxis: Measuring (Microbial) Biomass Composition for Genome-Scale Metabolic Modelling. NBS contact meeting ; 2020-01-23 - 2020-01-26.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2020) First project meeting presentation. BedPan project meeting ; 2020-03-04 - 2020-03-05.
2019
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Academic lectureSchulz, Christian. (2019) Beer'omics. PhD retreat IBT ; 2019-10-21.
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LectureSchulz, Christian. (2019) Beer’omics – Kveik for Christmas. IBT's weekly Department lunch . IBT; IBT's lunch room, NV Faculty, NTNU, Gløshaugen. 2019-12-18.
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Popular scientific lectureSchulz, Christian. (2019) GenomeScale metabolic modelling for Nylon production. PhD Grand Prix NV faculty NTNU ; 2019-03-20 - 2019-03-20.
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Popular scientific lectureSchulz, Christian. (2019) Producing more plastic to save the world. Forsker Grand Prix 2019 Trondheim ; 2019-09-26 - 2019-09-26.
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InterviewSchulz, Christian. (2019) Urnorsk gjær lager øl superraskt. https://gemini.no/2019/12/urnorsk-gjaer-lager-ol-superraskt/ [Fagblad]. 2019-12-18.
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LectureSchulz, Christian. (2019) What I've learned from Forsker GrandPrix - Presentation techniques. PhD retreat IBT ; 2019-10-21 - 2019-10-22.
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LectureSchulz, Christian; Almaas, Eivind. (2019) Beer'omics - Kveik for Christmas. IBT department Seminar ; 2019-12-18 - 2019-12-18.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2019) Combining Genome-Scale modelling with HUNT. Jebsen Center meeting ; 2019-10-25 - 2019-10-25.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2019) Genome-Scale modelling - No4. Bianual project meeting ; 2019-10-30 - 2019-10-30.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic modeling: Metabolic engineering to increase production of nylon precursors in Pseudomonas. NBS meeting 2019 . NBS; 2019-01-24 - 2019-01-27.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic modelling 3. Bianual project meeting ; 2019-03-11 - 2019-03-11.
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PosterSchulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic reconstructions for phylogeny?. Fish under stress - Systems biology and mathematical modelling ; 2019-05-24 - 2019-05-28.
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PosterSchulz, Christian; Almaas, Eivind. (2019) Genome-scale metabolic reconstructions for phylogeny?. Multivariate analysis of omics data with special emphasis on metabolomics Summerschool ; 2019-05-17 - 2019-05-21.
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Academic lectureSchulz, Christian; Diab, Joseph. (2019) ForskerGrandPrix: Experiences, Talks, and what we have learned. NORBIS anual conference . NORBIS; Oslo. 2019-09-30 - 2019-10-02.
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PosterSchulz, Christian; Karlsen, Emil; Kumar, Kanhaiya; Bartosova, Zdenka; Schmid, Jochen; Bruheim, Per; Almaas, Eivind. (2019) Measuring Biomass Composition for Modelling. DLN anual conference ; 2019-09-05 - 2019-09-06.
2018
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Academic lectureAlmaas, Eivind; Karlsen, Emil; Schulz, Christian; Martyushenko, Nikolay. (2018) Dynamic FBA with Global Constraints on Cellular Protein Fraction. 5th Conference on Constraint-Based Reconstruction and Analysis ; Seattle. 2018-10-14 - 2018-10-16.
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Academic lectureKarlsen, Emil; Schulz, Christian; Almaas, Eivind. (2018) Automatic assembly of genome-scale metabolic draft reconstructions from KEGG data. NORBIS Annual Conference 2018 . NORBIS; Voss. 2018-10-17 - 2018-10-19.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Combining phylogeny with genome-scale metabolic networks: Another tree of life and infinite engineering possibilities?. Micobial Biotechnology Division meeting ; 2018-06-22 - 2018-06-22.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Cross-organism-wide network comparison to identify conserved gene functions. Digital Life Annual PhD School meeting ; 2018-05-30 - 2018-06-01.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Discovery of conserved functions within cross-organism-wide genes using reaction networks. BioCat annual conference ; 2018-06-03 - 2018-06-06.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) From Zero to Hero: The Story of Modeling Pseudomonas. Department meeting IBT and Food Science ; 2018-05-16 - 2018-05-16.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Genome-Scale Metabolic Modeling for Biotechnology: What We Need to Conduct Our Magic. Micobial Biotechnology Division meeting ; 2018-03-09 - 2018-03-09.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Genome-Scale metabolic modelling. Bianual PolyBugs project meeting ; Trondheim. 2018-08-13 - 2018-08-13.
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PosterSchulz, Christian; Almaas, Eivind. (2018) Genome-scale metabolic reconstructions for phylogeny?. COBRA conference 2018 ; Seattle, WA. 2018-10-14 - 2018-10-16.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) PolyBugs – WP2 Genome-Scale Metabolic Modelling. Project meeting ; 2018-01-16 - 2018-01-17.
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PosterSchulz, Christian; Almaas, Eivind. (2018) Using reaction networks to identify cross-organism-wide genes with conserved functions. Summer School Systems and Synthetic Biology ; Sienna. 2018-07-24 - 2018-07-30.
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Academic lectureSchulz, Christian; Almaas, Eivind. (2018) Using reactions networks to identify cross organism-wide genes with conserved functions. NetSci 2018 Conference Paris ; 2018-06-11 - 2018-06-15.
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PosterSchulz, Christian; Almaas, Eivind. (2018) Virtual biological cell engineering: Differences and similarities in genome-scale metabolic models shown for the Pseudomonas case. DigitalLife anual conference ; 2018-03-20 - 2018-03-21.
2017
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PosterSchulz, Christian; Almaas, Eivind. (2017) Comparison of publicly available Pseudomonas genome scale metabolic models. Norbis anual Conference ; 2017-11-08 - 2017-11-10.