Christiana Bjørkli
About
Postdoctoral Researcher
The Sandvig Integrative Neuroscience Group, Department of Neuromedicine and Movement Science, NTNU
My research background revolves around advanced preclinical Alzheimer's disease (AD) modeling and neuropharmacological interventions.
Competencies
Research
During my Ph.D. work, I focused on developing fundamental research concepts and methodologies in advanced preclinical AD modeling. This involved gaining expertise in various aspects of AD preclinical research, including pathological staining techniques, sampling and analysis of cerebrospinal fluid (CSF) biomarkers, drug research, viral vector delivery systems, and cognitive behavioral assays. Through these experiences, I have acquired a deep understanding of the intricacies of AD pathology and the evaluation of therapeutic interventions.
Currently, my research is primarily focused on AD neuropharmacology, building upon recent breakthrough findings. These findings have demonstrated the efficacy of combinatorial treatment with two repurposed drugs in significantly attenuating AD pathology and improving memory function in preclinical models of AD. This has led to the first ever drug repurposing project at NTNU. By expanding on these discoveries, I aim to further investigate the underlying mechanisms of this combinatorial treatment approach and explore its potential translational applications in human AD patients.
Publications
2022
-
Bjørkli, Christiana;
Ebbesen, Nora Cecilie;
Julian, Joshua Benjamin;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna.
(2022)
Manipulation of neuronal activity in the entorhinal-hippocampal circuit affects intraneuronal amyloid-β levels.
bioRxiv.
Academic article
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford;
Gouras, Gunnar K;
Witter, Menno.
(2022)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
bioRxiv.
Academic article
2021
-
Bjorkli, Christiana;
Louet, Claire;
Flo, Trude Helen;
Hemler, Mary Elizabeth;
Sandvig, Axel;
Sandvig, Ioanna.
(2021)
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology.
Journal of Alzheimer's Disease.
volum 84 (4).
Academic article
2020
-
Bjorkli, Christiana;
Sandvig, Axel;
Sandvig, Ioanna.
(2020)
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients.
Frontiers in Aging Neuroscience.
volum 12.
Academic literature review
Journal publications
-
Bjørkli, Christiana;
Ebbesen, Nora Cecilie;
Julian, Joshua Benjamin;
Witter, Menno;
Sandvig, Axel;
Sandvig, Ioanna.
(2022)
Manipulation of neuronal activity in the entorhinal-hippocampal circuit affects intraneuronal amyloid-β levels.
bioRxiv.
Academic article
-
Kobro-Flatmoen, Asgeir;
Battistin, Claudia;
Raveendran Nair, Rajeevkumar;
Bjorkli, Christiana;
Skender, Belma;
Kentros, Clifford;
Gouras, Gunnar K;
Witter, Menno.
(2022)
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.
bioRxiv.
Academic article
-
Bjorkli, Christiana;
Louet, Claire;
Flo, Trude Helen;
Hemler, Mary Elizabeth;
Sandvig, Axel;
Sandvig, Ioanna.
(2021)
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology.
Journal of Alzheimer's Disease.
volum 84 (4).
Academic article
-
Bjorkli, Christiana;
Sandvig, Axel;
Sandvig, Ioanna.
(2020)
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients.
Frontiers in Aging Neuroscience.
volum 12.
Academic literature review
Teaching
Courses
Media
2022
-
InterviewBrandslet, Steinar; Bjorkli, Christiana. (2022) Forsøksdyr hjelper oss til å forstå Alzheimers. Gemini.no [Internett]. 2022-01-03.