2022

• Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen; Dalen, Knut Tomas; Nilsson, Per; Mollnes, Tom Eirik; Pischke, Soeren; Lien, Egil; Vaage, Ingvar Jarle; Yndestad, Arne; Stensløkken, Kåre-Olav. (2022) Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology. volum 13.
  Academic article

2021

• Zelic, Matija; Pontarelli, Fabrizio; Woodworth, Lisa; Zhu, Cheng; Mahan, Amy; Ren, Yi; LaMorte, Michael; Gruber, Ross; Keane, Aislinn; Loring, Pequita; Guo, Lilu; Xia, Tai-he; Zhang, Boyao; Ørning, Mathias Pontus; Lien, Egil; Degterev, Alexei; Hammond, Timothy; Ofengeim, Dimitry. (2021) RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis. Cell reports. volum 35 (6).
  Academic article

2020

• Choudhury, Asmita; Bullock, Daniel; Lim, Arlene; Argemi, Josepmaria; Ørning, Mathias Pontus; Lien, Egil; Bataller, Ramon; Mandrekar, Pranoti. (2020) Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury. Alcoholism: Clinical and Experimental Research. volum 44 (6).
  Academic article
• Shahini, Negar; Schjalm, Camilla; Nilsson, Per; Holt, Margrethe Flesvig; Øgaard, Jonas; Lien, Egil; Ahmed, Muhammad Shakil; Attramadal, Håvard; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom Eirik; Louwe, Maria Cornelia. (2020) Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. Biochemical and Biophysical Research Communications - BBRC. volum 523 (4).
  Academic article
• Tao, Liang; Yi, Yuguo; Chen, Yuxin; Zhang, Haibing; Ørning, Mathias Pontus; Lien, Egil; Jie, Jiapeng; Zhang, Weigao; Xu, Qian; Li, Yang; Ding, Zhao; Wu, Chao; Ding, Qiurong; Wang, Junsong; Zhang, Jianfa; Weng, Dan. (2020) RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. Cell Death and Differentiation.
  Academic article
• Ørning, Mathias Pontus; Lien, Egil. (2020) Multiple roles of caspase-8 in cell death, inflammation, and innate immunity. Journal of Leukocyte Biology.
  Scientific translation/review

2019

• Hancz, Dora; Westerlund, Elsa; Valfridsson, Christine; Aemero, Getachew Melkamu; Bastiat-Sempe, Benedicte; Ørning, Mathias Pontus; Lien, Egil; Wessels, Michael; Persson, Jenny. (2019) Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β. Journal of Innate Immunity.
  Academic article
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne. (2019) NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology. volum 10:1621 (JULY).
  Academic article
• Ørning, Mathias Pontus; Lien, Egil; Fitzgerald, Katherine A.. (2019) Gasdermins and their role in immunity and inflammation. Journal of Experimental Medicine (JEM). volum 216 (11).
  Scientific translation/review

2018

• Sokolova, Marina; Sahraoui, Afaf; Høyem, Merete; Øgaard, Jonas; Lien, Egil; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine; Scholz, Hanne. (2018) NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. American Journal of Physiology. Endocrinology and Metabolism. volum 315 (5).
  Academic article
• Ørning, Mathias Pontus Andreas; Flo, Trude Helen; Lien, Egil. (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe. volum 24 (4).
  Academic article
• Ørning, Mathias Pontus Andreas; Weng, Dan; Starheim, Kristian K.; Ratner, Dmitry; Best, Zachary; Lee, Bettina; Brooks, Alexandria; Xia, Shiyu; Wu, Hao; Kelliher, Michelle; Berger, Scott; Gough, Peter J.; Bertin, John; Proulx, Megan M.; Gougen, Jon D.; Kayagaki, Nobuhiko; Fitzgerald, Katherine A.; Lien, Egil. (2018) Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. volum 362 (6418).
  Academic article

2017

• Ratner, Dmitry; Ørning, Mathias Pontus; Lien, Egil. (2017) Bacterial secretion systems and regulation of inflammasome activation. Journal of Leukocyte Biology. volum 101 (1).
  Scientific translation/review
• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen; Attramadal, Håvard; Torp, May-Kristin; Fosshaug, Linn Elisabeth Lillerud; Rashidi, Azita; Lien, Egil; Finsen, Alexandra; Sandanger, Øystein; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne. (2017) Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. volum 1862 (2).
  Academic article

2016

• Martinez, Núria; Ketheesan, Natkunam; Martens, Gregory W; West, Kim; Lien, Egil; Kornfeld, Hardy. (2016) Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes and infection. volum 18 (10).
  Academic article
• Marty-Roix, Robyn; Vladimer, Gregory; Pouliot, Kimberly; Weng, Dan; Buglione-Corbett, Rachel; West, Kim; MacMicking, John; Chee, Jonathan; Wang, Shixia; Lu, Shan; Lien, Egil. (2016) Identification of QS-21 as an inflammasome-activating molecular component of saponin adjuvants. Journal of Biological Chemistry. volum 291 (3).
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Proulx, MK; Wang, Donghai; Gavrilin, Mikhail; Wewers, Mark; Alnemri, Emad; Johnson, Peter; Lee, Bettina; Mecsas, Joan; Kayagaki, Nobuhiko; Goguen, JD; Lien, Egil. (2016) The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathogens. volum 12 (12).
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Starheim, Kristian K.; Marty-Roix, Robyn; Proulx, MK; Goguen, JD; Lien, Egil. (2016) Manipulation of IL-1β and IL-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence. Journal of Biological Chemistry. volum 291 (19).
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Starheim, Kristian Kobbenes; Marty-Roix, Robyn; Proulx, MK; Goguen, JD; Lien, Egil. (2016) Manipulation of interleukin-1β and interleukin-18 production by yersinia pestis effectors YopJ and YopM and redundant impact on virulence. Journal of Biological Chemistry. volum 291 (19).
  Academic article

2015

• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto; Skjønsberg, Ole Henning. (2015) Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. volum 309 (4).
  Academic article
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto; Skjønsberg, Ole Henning. (2015) Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. volum 309.
  Academic article
• Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil. (2015) A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. Journal of Biological Chemistry. volum 290 (6).
  Academic article
• Wilks, Jessica; Lien, Egil; Jacobson, Amy N; Fischbach, Michael A.; Qureshi, Nilofer; Chervonsky, Alexander V; Golovkina, Tatyana V. (2015) Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host and Microbe. volum 18 (4).
  Academic article
• Ystgaard, Martin Bogale; Sejersted, Yngve; Løberg, Else Marit; Lien, Egil; Yndestad, Arne; Saugstad, Ola Didrik. (2015) Early upregulation of NLRP3 in the brain of neonatal mice exposed to hypoxia-ischemia: No early neuroprotective effects of NLRP3 deficiency. Neonatology. volum 108.
  Academic article

2014

• Pouliot, K; Buglione-Corbett, R; Marty-Roix, R; Montminy-Paquette, S; West, K; Wang, S; Lu, S; Lien, Egil. (2014) Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine. Vaccine. volum 32 (39).
  Academic article
• Weng, D; Marty-Roix, R; Ganesan, S; Proulx, MK; Vladimer, G; Kaiser, WJ; Mocarski, ES; Pouliot, K; Chan, FK-M; Kelliher, MA; Harris, PA; Bertin, J; Gough, PJ; Shayakhmetov, DM; Goguen, JD; Fitzgerald, Katherine A.; Silverman, N; Lien, Egil. (2014) Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proceedings of the National Academy of Sciences of the United States of America. volum 111 (20).
  Academic article

2013

• Lien, Egil. (2013) Pest og plager - kva er samanhengen mellom pest og overvekt?.
  Web pages (information material)
• Lien, Egil. (2013) Plagues and illness – what’s the connection between the plague and being overweight?.
  Web pages (information material)
• Marty-Roix, Robyn; Lien, Egil. (2013) De-oiling inflammasomes. Immunity. volum 38.
  Short communication
• Sandanger, Øystein; Ranheim, Trine; Vinge, Leif Erik; Bliksøen, Marte; Alfsnes, Katrine; Finsen, Alexandra; Dahl, Christen Peder; Askevold, Erik Tandberg; Florholmen, Geir; Christensen, Geir Arve; Fitzgerald, Katherine A.; Lien, Egil; Valen, Guro; Espevik, Terje; Aukrust, Pål; Yndestad, Arne. (2013) The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovascular Research (CVR). volum 99 (1).
  Academic article
• Vladimer, G; Marty-Roix, R; Ghosh, S; Weng, D; Lien, Egil. (2013) Inflammasomes and host defenses against bacterial infections. Current Opinion in Microbiology. volum 16 (1).
  Scientific translation/review

2012

• Johnsen, Ingvild Bjellmo; Nguyen, Thuy Thi Thu; Bergstrøm, Bjarte; Lien, Egil; Anthonsen, Marit Walbye. (2012) Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA. Cytokine. volum 57 (3).
  Academic article
• Vladimer, G; Weng, D; Paquette, SWM; Vanaja, SK; Rathinam, VAK; Aune, Marie Hjelmseth; Conlon, JE; Burbage, JJ; Proulx, MK; Liu, Q; Reed, George; Mecsas, JC; Iwakura, Y; Bertin, J; Goguen, JD; Fitzgerald, KA; Lien, Egil. (2012) The NLRP12 Inflammasome Recognizes Yersinia pestis. Immunity. volum 37 (1).
  Academic article

2010

• Duewell, P; Kono, H; Rayner, KJ; Sirois, CM; Vladimer, G; Bauernfeind, FG; Abela, GS; Franchi, L; Nunez, G; Schnurr, M; Espevik, Terje; Lien, E; Fitzgerald, KA; Rock, KL; Moore, KJ; Wright, SD; Hornung, V; Latz, Eicke. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. volum 464 (7293).
  Academic article
• Husebye, Harald; Aune, Marie Hjelmseth; Stenvik, Jørgen; Samstad, Eivind Ottersen; Skjeldal, Frode Miltzow; Halaas, Øyvind; Nilsen, Nadra; Stenmark, Harald Alfred; Latz, Eicke; Lien, Egil; Mollnes, Tom Eirik; Bakke, Oddmund; Espevik, Terje. (2010) The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity. volum 33 (4).
  Academic article
• Nguyen, Thuy Tranh; Johnsen, Ingvild Bjellmo; Knetter, CF; Drabløs, Finn; Fitzgerald, KA; Lien, E; Anthonsen, Marit Walbye. (2010) Differential Gene Expression Downstream of Toll-like Receptors (TLRs) ROLE OF c-Src AND ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3). Journal of Biological Chemistry. volum 285 (22).
  Academic article

2009

• Damås, Jan Kristian; Davi, Giovanni; Jensenius, M; Santilli, F; Otterdal, K; Ueland, T; Flo, Trude Helen; Lien, E; Espevik, Terje; Frøland, Stig S; Vitale, G; Raoult, D; Aukrust, P. (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection. volum 58 (1).
  Academic article

2008

• Nilsen, Nadra; Deininger, S; Nonstad, Unni; Skjeldal, F; Husebye, Harald; Rodionov, D; von Aulock, S; Hartung, T; Lien, E; Lien, E; Bakke, O; Espevik, Terje. (2008) Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. Journal of Leukocyte Biology. volum 84.
  Academic article

2006

• Espevik, Terje; Lien, Egil. (2006) Vaksine mot svartedauen. Gemini.
  Popular scientific article
• Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Ringdal, Monika; Tryggestad, AM; Bakke, Oddmund; Lien, Egil; Espevik, Terje; Anthonsen, Marit Walbye. (2006) Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO Journal. volum 26 (25).
  Academic article
• Montminy, Sara W; Khan, Naseema; McGrath, Sara; Walkowicz, Mitchell J; Sharp, Fiona; Conlon, Joseph; Fukase, Koichi; Kusumoto, Shoichi; Sweet, Charles; Miyake, Kensuke; Akira, Shizuo; Cotter, Robert J; Goguen, JD; Lien, Egil. (2006) Virulence Factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nature Immunology. volum 7.
  Academic article

2004

• Heggelund, L; Flo, Trude Helen; Berg, K.; Lien, E; Espevik, Terje. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 3 (18).
  Academic article
• Heggelund, L; Muller, F; Lien, E; Yndestad, A; Ueland, T; Kristiansen, KI; Espevik, Terje; Aukrust, P; Frøland, Stig Sophus; Froland, SS. (2004) Increased expression of Toll-like receptor 2 on monocytes in HIV infection: Possible roles in inflammation and viral replication. Clinical Infectious Diseases. volum 39.
  Academic article
• Heggelund, L; Damas, JK; Damås, Jan Kristian; Yndestad, A; Holm, AM; Muller, F; Lien, E; Lien, E; Espevik, Terje; Aukrust, P; Froland, SS; Frøland, Stig Sophus. (2004) Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences. Clinical and Experimental Immunology. volum 138 (1).
  Academic article
• Latz, E; Schoenemeyer, A; Visintin, A; Fitzgerald, KA; Monks, BG; Knetter, Cathrine; Lien, E; Nilsen, Nadra; Espevik, Terje; Golenbock, DT. (2004) TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature Immunology. volum 5.
  Academic article
• Nilsen, N; Nonstad, U; Khan, N; Knetter, Cathrine; Akira, S; Sundan, Anders; Espevik, Terje; Lien, E. (2004) Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. Journal of Biological Chemistry. volum 279.
  Academic article
• Nilsen, Nadra; Nonstad, Unni; Kahn, Naseema; Knetter, Cathrine; Akira, Shizuo; Sundan, Anders; Espevik, Terje; Lien, Egil. (2004) Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88. Journal of Biological Chemistry.
  Academic article

2003

• Espevik, Terje; Latz, Eicke; Lien, Egil; Monks, Brian G.. (2003) Cell distribution and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scandinavian Journal of Infectious Diseases. volum 35 (9).
  Academic article
• Latz, E; Visintin, A; Lien, E; Fitzgerald, KA; Espevik, Terje; Golenbock, DT. (2003) The LPS receptor generates inflammatory signals from the cell surface. Journal of Endotoxin Research. volum 9.
  Academic article
• Mori, Y; Yoshimura, A; Ukai, T; Lien, Egil; Espevik, Terje; Hara, Y. (2003) Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis. Oral Microbiology and Immunology. volum 18 (1).
  Academic article
• Nordøy, Ingvild; Rollag, Halvor; Lien, Egil; Sindre, Hilde; Degre, Miklos; Aukrust, Pål; Frøland, Stig Sophus; Muller, Fredrik. (2003) Cytomegalovirus infection induces production of human interleukin-10 in macrophages. European Journal of Clinical Microbiology and Infectious Diseases. volum 22.
  Academic article

2002

• Dybdahl, Brit; Lien, Egil; Flo, Trude Helen; Espevik, Terje; Sundan, Anders; Wahba, Alexander; Sellevold, Olav F Münter. (2002) Heat Shock Proteins and Endotoxin Combined as a Trigger for Inflammatory Cytokine Release During Cardiopulmonary Bypass: A Possible Third Way? Letter til artikkel. Circulation. volum 106.
  Academic article
• Dybdahl, Brit; Wahba, Alexander; Lien, Egil; Flo, Trude Helen; Waage, Anders; Sellevold, Olav F Münter; Espevik, Terje; Sundan, Anders; Qureshi, Nilofer. (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. volum 105 (6).
  Academic article
• Flo, Trude Helen; Ryan, Liv; Latz, Eicke; Takeuchi, Osamu; Monks, Brian G.; Lien, Egil; Halaas, Øyvind; Akira, Shizuo; Skjåk-Bræk, Gudmund; Golenbock, Douglas T.; Espevik, Terje. (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry. volum 277 (38).
  Academic article
• Kristo, C.; Godang, Kristin; Ueland, Thor; Lien, Egil; Aukrust, Pål; Frøland, Stig Sophus; Bollerslev, Jens. (2002) Raised serum levels of interleukin (IL)-8 and IL-18 in relation to bone metabolism in endogenous Cushing's syndrome. European Journal of Endocrinology (EJE). volum 146.
  Academic article
• Latz, Eicke; Visintin, A; Lien, Egil; Fitzgerald, KA; Monks, Brian G.; Kurt-Jones, EA; Golenbock, Douglas T.; Espevik, Terje. (2002) Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the Toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. Journal of Biological Chemistry. volum 277 (49).
  Academic article

2001

• Aukrust, Pål; Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Nitter-Hauge, Sigurd L; Ueland, Thor; Frøland, Stig Sophus; Lien, Egil. (2001) Increase in anti-inflammatory cytokine levels in chronic heart failure: a measure of treatment success or failure? (Reply to a letter to the editor). Circulation. volum 104.
  Academic article
• Flo, Trude Helen; Halaas, Øyvind; Torp, Sverre Helge; Ryan, Liv; Lien, Egil; Dybdahl, Brit; Sundan, Anders; Espevik, Terje. (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology. volum 69.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Wikeby, Lisbeth; Nitter-Hauge, Sigurd L; Fjeld, Jan Gunnar; Lien, Egil; Ueland, Thor; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunglobulin. Tidsskrift for Den norske legeforening.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Wikeby, Lisbeth; Nitter-Hauge, Sigurd L; Fjeld, Jan Gunnar; Lien, Egil; Ueland, Thor; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunmodulerende behandling ved avansert hjertesvikt: effekt av intravenøs immunglobulin. Tidsskrift for Den norske legeforening. volum 121.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Wikeby, Lisbeth; Nitter-Hauge, Sigurd L; Fjeld, Jan Gunnar; Ueland, Thor; Lien, Egil; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunglobin. Tidsskrift for Den norske legeforening. volum 121.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Nitter-Hauge, Sigurd L; Ueland, Thor; Lien, Egil; Frøland, Stig Sophus; Aukrust, Pål. (2001) An increase in anti-inflammatory cytokine leves in chronic heart failure: a measure of treatment success or failure?. Circulation. volum 104.
  Letter to the editor
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Nitter-Hauge, Sigurd L; Ueland, Thor; Lien, Egil; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure. Circulation. volum 103.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Nitter-Hauge, Sigurd L; Ueland, Thor; Lien, Egil; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation. volum 103.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Nitter-Hauge, Sigurd L; Ueland, Thor; Lien, Egil; Frøland, Stig Sophus; Aukrust, Pål. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation. volum 103.
  Academic article
• Gullestad, Lars; Aass, Halfdan; Lien, Egil. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunoglobulin. Tidsskrift for Den norske legeforening. volum 16 (121).
  Academic article
• Gullestad, Lars; Fjeld, Jan G.; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John; Lien, Egil. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation. volum 103.
  Academic article
• Ingalls, Robin; Lien, Egil; Golenbock, D. (2001) Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through Toll-like receptor 2. Infection and Immunity. volum 69 (4).
  Academic article
• Lien, Egil; Chow, Jesse C.; Hawkins, Lynn D.; McGuinness, Pamela D.; Miyake, Kensuke; Espevik, Terje; Gusovsky, Fabian; Golenbock, Douglas T.. (2001) A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/Toll-like receptor 4 signaling pathway. Journal of Biological Chemistry.
  Academic article
• Lien, Egil; Ingalls, Robin. (2001) Toll receptors. Critical Care Medicine. volum 30 (1s1).
  Academic article
• Medvedev, Andrei; Henneke, Philipp; Schromm, Andra; Lien, Egil; Ingalls, Robin; et, al.. (2001) Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4. Journal of Immunology. volum 167.
  Academic article
• Schromm, Andra; Lien, Egil; Henneke, Philipp; Chow, Jesse C; et, al.. (2001) Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. Journal of Experimental Medicine (JEM). volum 194 (1).
  Academic article
• Liabakk, Nina-Beate; Waage, Anders; Lien, Egil; Stenvik, Jørgen; Espevik, Terje. (2001) Cytokine bioassays. Methods in Molecular Medicine. volum 67.
  Academic article

2000

• Flo, Trude Helen; Halaas, Øyvind; Lien, Egil; Ryan, Liv; Teti, Guiseppe; Golenbock, Douglas T.; Sundan, Anders; Espevik, Terje. (2000) Human Toll-like Receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. Journal of Immunology. volum 164.
  Academic article
• Ingalls, Robin; Lien, Egil; Golenbock, D. (2000) Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of neisseria meningitidis. Journal of Endotoxin Research. volum 6 (5).
  Academic article
• Lien, E.; Espevik, Terje. (2000) Toll-lignende reseptorer - kroppens sensorer for infeksjon. NBS-nytt.
  Popular scientific article
• Lien, Egil; Means, Terry K; Heine, Holger; Yoshimura, Atsutoshi; Kusumoto, Shoichi; Fukase, Koichi; Fenton, Matthew J; Oikawa, Masato; Qureshi, Nilofer; Monks, Brian; Finberg, Robert W; Ingalls, Robin R. (2000) Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. The Journal of Clinical Investigation. volum 105 (4).
  Academic article
• Nordøy, I.; Müller, F.; Nordal, K.P.; Rollag, H.; Lien, E.; Aukrust, P.; Frøland, S.S.. (2000) The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. Journal of Infectious Diseases. volum 181.
  Academic article
• Nordøy, Ingvild; Muller, Fredrik; Nordal, Knut P.; Rollag, Halvor; Lien, Egil; Aukrust, Pål; Frøland, Stig Sophus. (2000) The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. Journal of Infectious Diseases. volum 181.
  Academic article

1999

• Aukrust, Pål; Haug, Charlotte J.; Ueland, Thor; Lien, Egil; Muller, Fredrik; Espevik, T; Bollerslev, Jens; Frøland, Stig Sophus. (1999) Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone-remodeling process during highly active antiretroviral therapy. Journal of Clinical Endocrinology and Metabolism (JCEM). volum 84 (1).
  Academic article
• Aukrust, Pål; Haug, Charlotte J.; Ueland, Thor; Lien, Egil; Müller, Fredrik; Espevik, Terje; Bollerslev, Jens; Frøland, Stig S.. (1999) Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: Indication of normalization of the bone-remodeling process during highly active antiretroviral therapy. Journal of Clinical Endocrinology and Metabolism (JCEM). volum 84 (1).
  Academic article
• Aukrust, Pål; Müller, Fredrik; Lien, Egil; Nordøy, Ingvild; Liabakk, Nina-Beate; Kvale, Dag; Espevik, Terje; Frøland, Stig S.. (1999) Tumor necrosis factor (TNF) system levels in human immunodificiency virus-infected patients during highly active antiretroviral therapy: Perisistent TNF activation is associated with virologic and immunologic treatment failure. Journal of Infectious Diseases. volum 179.
  Academic article
• Heine, Holger; Kirschning, Carsten J.; Lien, Egil; Monks, Brian G.; Rothe, Mike; Golenbock, Douglas T.. (1999) Cutting edge : cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. Journal of Immunology. volum 162.
  Academic article
• Ingalls, Robin R.; Heine, Holger; Lien, Egil; Yoshimura, Atsutoshi; Golenbock, Douglas. (1999) Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors. Infectious Disease Clinics of North America. volum 13 (2).
  Academic article
• Lien, Egil; Heine, H.; Golenbock, Douglas T.. (1999) LPS receptors. Update in intensive care and emergency medicine. 31 Immune Response in the Critically Ill.
  Academic chapter/article
• Lien, Egil; Sellati, Timothy J.; Yoshimura, Atsutosi; Flo, Trude Helen; Rawadi, Georges; Finberg, Robert W.; Caroll, J.David; Espevik, Terje; Ingalls, Robin R; Radolf, Justin D.; Golenbock, Douglas T.. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry. volum 274 (47).
  Academic article
• Lønning, P.Ø.; Lien, Egil; Tveter, Kjell; Christoffersen, Thoralf. (1999) Cytostatika Medikamentell kreftbehandling kap. 18 Hormoner og hormonantagonister. 1999. Cytostatika -Medikamentell kreftbehandling.
  Nonfiction book
• Means, Terry K.; Lien, Egil; Yoshimura, Atsutoshi; Wang, Shuyan; Golenbock, Douglas T.; Fenton, Matthew J.. (1999) The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for toll-like receptors. Journal of Immunology. volum 163.
  Academic article
• Means, Terry K.; Wang, Shuyan; Lien, Egil; Yoshimura, Atsutoshi; Golenbock, Douglas T.; Fenton, Matthew J.. (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. Journal of Immunology. volum 163.
  Academic article
• Nordøy, Ingvild; Müller, Fredrik; Nordahl, Knut P; Rollag, Halvor; Lien, Egil; Aukrust, Pål; Frøland, Stig S. (1999) Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients. Journal of Infectious Diseases. volum 180.
  Academic article
• Nordøy, Ingvild; Muller, Fredrik; Nordal, Knut P.; Rollag, Halvor; Lien, Egil; Aukrust, Pål; Frøland, Stig Sophus. (1999) Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients. Journal of Infectious Diseases. volum 180 (1).
  Academic article
• Yoshimura, Atsutoshi; Lien, Egil; Ingalls, Robin R.; Tuomanen, Elaine; Dziarski, Roman; Golenbock, Douglas. (1999) Cutting edge : recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. Journal of Immunology. volum 163.
  Academic article
• Aukrust, Pål; Muller, Fredrik; Lien, Egil; Nordøy, Ingvild; Liabakk, Nina-Beate; Kvale, Dag; Espevik, T; Frøland, Stig Sophus. (1999) Tumor necrosis factor (TNF) system in human immunodeficiency virus-infected patients during highly active antiretroviral therapy (HAART): Persistent TNF activation is associated with virologic and immunologic treatment failure. Journal of Infectious Diseases. volum 179 (1).
  Academic article
• Aukrust, Pål; Ueland, Thor; Lien, Egil; Bendtzen, Klaus; Muller, Fredrik; Andreassen, Arne K.; Nordøy, Ingvild; Aass, Halfdan; Espevik, T; Simonsen, Svein; Frøland, Stig Sophus; Gullestad, Lars. (1999) Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology. volum 83.
  Academic article

1998

• Aukrust, Pål; Ueland, Thor; Lien, Egil. (1998) The cytokine network in congstive heart failure-dysbalance between inflammatory and anti-inflammatory mediators. European Heart Journal. volum 19.
  Academic article
• Døllner, H; Arntzen, K.J; Lien, E; Hæreid, P.E; Brubakk, A.M; Aag, S.; Austgulen, Rigmor. (1998) Increased serum concentrations of soluble tumor necrosis factor receptors p55 and p75 in early onset neonatal sepsis. Early Human Development.
  Academic article
• Lien, E; Sundan, A; Aukrust, P; Frøland, S; Espevik, Terje. (1998) Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood.
  Academic article
• Lien, Egil; Aukrust, Pål; Sundan, Andreas; Muller, Fredrik; Frøland, Stig Sophus; Espevik, T. (1998) Elevated levels of serum-soluble CD14 in human immonudeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood. volum 92 (6).
  Academic article
• Muller, Fredrik; Aukrust, Pål; Lien, Egil; Haug, Charlotte J.; Frøland, Stig Sophus. (1998) Enhanced interleukin-10 production in response to Mycobacterium avium products in mononuclear cells from patients with human immunodeficiency virus infection. Journal of Infectious Diseases. volum 177 (3).
  Academic article

1997

• Arntzen, Knut Jørgen; Lien, Egil; Austgulen, Rigmor. (1997) Maternal serum levels of interleukin-6 and clinical characteristics of normal delivery at term. Acta Obstetricia et Gynecologica Scandinavica. volum 76.
  Academic article
• Aukrust, Pål; Hestad, Kjetil; Lien, Egil; Bjerkeli, Vigdis; Nordøy, Ingvild; Espevik, T; Muller, Fredrik; Frøland, Stig Sophus. (1997) Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-_a activity in human immunodeficiency virus type 1 infection. Journal of Infectious Diseases. volum 176 (4).
  Academic article
• Aukrust, Pål; Hestdal, Ketil; Lien, Egil; Bjerkeli, Vigdis; Nordøy, Ingvild; Espevik, Terje; Myller, Stig; Frøland, S.. (1997) Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-alpha activity in human immunodeficiency virus type 1 infection. Journal of Infectious Diseases. volum 176.
  Academic article
• Austgulen, Rigmor; Lien, E; Vince, G; Redman, CWG. (1997) Increased levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in serum from women with pre-eclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology. volum 71.
  Academic article
• Austgulen, Rigmor; Lien, Egil; Vince, Gill; Redman, Chris W.G.. (1997) Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology. volum 71.
  Academic article
• Hestad, Kjetil; Aukrust, Pål; Muller, Fredrik; Lien, Egil; Bjerkeli, Vigdis; Espevik, T; Frøland, Stig Sophus. (1997) Dysregulation of membrane-bound tumor necrosis factor-_a and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1  infection: Low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load. Blood. volum 90 (7).
  Academic article
• Hestdal, Kjetil; Aukrust, Pål; Müller, Fredrik; Lien, Egil; Bjerkeli, Vigdis; Espevik, Terje; Frøland, Stig S.. (1997) Dysregulation of membrane-bound tumor necrosis factor-_a and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection : low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load. Blood. volum 90 (7).
  Academic article
• Jackson, A.M.; Lien, Egil; Alexandroff, A.B.; Espevik, Terje; James, K.; Selby, P.J.; Sundan, Anders. (1997) Soluble urinary CD14 after intravesical bacille Calmette-Guérin immunotherapy for carcinoma in situ. British Journal of Urology. volum 80.
  Academic article

1996

• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne K.; Müller, Fredrik; Haug, Charlotte J.; Espevik, Terje; Frøland, Stig S.. (1996) Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency : possible immunologic and clinical consequences. Blood. volum 87 (2).
  Academic article
• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne Karin; Muller, Fredrik; Haug, Charlotte J.; Espevik, T; Frøland, Stig Sophus. (1996) Persistant Activation of The Tumor Nevcrosis Factor System in a Subgroup of Patients With Common Varable Immunodeficincy - Possible Immunological and Clinical and Consequences. Blood. volum 87.
  Academic article
• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne Karin; Muller, Fredrik; Haug, Charlotte J.; Espevik, T; Frøland, Stig Sophus. (1996) Persistent activation of tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency - Possible immunologic and clinical concensus. Blood. volum 87 (2).
  Academic article
• Børset, Magne; Lien, Egil; Espevik, Terje; Helseth, Eirik; Waage, Anders; Sundan, Anders. (1996) Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. Journal of Biological Chemistry. volum 271 (40).
  Academic article
• Haug, Charlotte J.; Aukrust, Pål; Lien, Egil; Muller, Fredrik; Espevik, T; Frøland, Stig Sophus. (1996) Disseminated Mycobacterium avium complex (MAC) infection in AIDS: Immunopathogenic significance of an activated tumor necrosis factor (TNF) system and depressed serum levels of 1,25-dihydroxyvitamin D. Journal of Infectious Diseases. volum 173.
  Academic article
• Haug, Charlotte J.; Aukrust, Pål; Lien, Egil; Müller, Fredrik; Espevik, Terje; Frøland, Stig S.. (1996) Disseminated Mycobacterium avium complex infection in AIDS : immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D. Journal of Infectious Diseases. volum 173.
  Academic article
• Lien, Egil; Liabakk, Nina-Beate; Austgulen, Rigmor. (1996) Detection of soluble receptors for tumor necrosis factor, interleukin-2 and interleukin-6 in retroplacental serum from normal pregnant women. Gynecologic and Obstetric Investigation. volum 41.
  Academic article

1995

• Lien, Egil; Liabakk, Nina-Beate; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Nonstad, Unni; Sundan, Anders; Espevik, Terje. (1995) Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells. European Journal of Immunology. volum 25.
  Academic article

1994

• Austgulen, Rigmor; Lien, E; Liabakk, N-B; Jacobsen, G.; Arntzen, KJ. (1994) Increased levels of cytokine activity modifiers in normal pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology. volum 57.
  Academic article

1993

• Austgulen, Rigmor; Liabakk, N-B; Lien, E; Espevik, Terje. (1993) Increased levels of soluble TNF-alpha receptors in serum from pregnant women, and in serum and urine samples from newborns. Pediatric Research. volum 33.
  Academic article
• Liabakk, N-B; Lien, E; Sundan, A; Sunde, A; Austgulen, Rigmor; Espevik, Terje. (1993) High concentrations of the soluble p55 tumor necrosis factor receptor in human seminal plasma. Human Reproduction. volum 8.
  Academic article