course-details-portlet

MOL8009

Molecular Mechanisms of Inflammation

Assessments and mandatory activities may be changed until September 20th.

Credits 7.5
Level Doctoral degree level
Course start Spring 2026
Duration 1 semester
Language of instruction English
Location Trondheim
Examination arrangement Aggregate score

About

About the course

Course content

The advanced immunology course will give an overview of mechanisms and signaling pathways involved in inflammatory processes, in topics mainly connected to activities at the Department of Clinical and Molecular Medicine (IKOM). This is inflammation related to infections, but also sterile inflammation (that can be observed during e.g. autoimmune diseases, heart infarction/failure, and obesity). Although the main focus will be on innate immunity, both innate and adaptive immune responses will be discussed. Cell types involved include macrophages, monocytes, dendritic cells, neutrophils, T cells, B cells, osteoblasts, osteoclasts, and epithelial cells on mucosal surfaces. Recognition- and signaling mechanisms include complement, phagocytosis, Toll-like receptors (TLRs), inflammasomes, RIG-I family and other helicases, cGAS, C-type lectin receptors, responses to different types of bacteria, viruses, protozoan parasites and fungi, sterile inflammation, vaccines/adjuvants, inflammatory cytokines and cell death. Inflammatory signals will be discussed in relation to cell biology, molecular trafficking, immunometabolism, and immune activation and evasion by microbial pathogens. We will link the events to clinical situations such as infections, immunodeficiencies, inflammation during pregnancy, inflammatory bowel disease, heart failure, cancer, and bone inflammation.

Learning outcome

Knowledge

After completing the course, the candidate:

  • has insight into basic mechanisms of inflammation, much of this in relation to research conducted at IKOM
  • has advanced knowledge of how the body fights infection with many classes of pathogens, both concerning different cell types involved and recognition mechanisms and signaling pathways within those cells.
  • can evaluate similarities and differences between sterile inflammation and inflammation induced by infections.
  • has increased understanding of how research on molecular inflammation can contribute to the development of vaccines, therapies, and disease prevention.

Skills

After the course, the candidate can:

  • identify and critically assess key signals of inflammation
  • has advanced knowledge of central signaling pathways of innate immunity
  • outline, evaluate and interpret how certain ligands and signals are associated with specific classes of microbial pathogens, diseases, and inflammatory conditions.
  • Has an advanced understanding of the processes how innate immunity shapes and directs the development and outcome of adaptive immune responses

General proficiency

After the course, the candidate can:

  • Comprehend and interpret how inflammatory signals can be both beneficial and harmful for the body, depending on the circumstances, such as the nature of acute vs chronic inflammation.
  • Discuss and compare differences and similarities between different types of inflammation and innate immune signals
  • Interpret and critically evaluate scientific literature on topics of inflammation, innate immunity and the relationship to disease

Learning methods and activities

Lectures, group discussions/group work, self study.

Compulsory assignments

  • Attendance in lectures/group work

Further on evaluation

Compulsory assignments: Attendance in lectures (minimum 80% must be attended)

Evaluation will be on a short paper, written in English, on topics related to the course (70% of grade). Group work and presentation (30% of grade).

Retake of the exam: Students with legitimate leave of absence at the final examination and students who receive the grade "not passed" may retake the exam the following semester. Completion of the compulsory assignments in a previous semester may be approved by the department. The student can choose which part of the examination to retake. The examination form of the group presentation can be changed when retaking the exam.

Required previous knowledge

Masters degree in biology, chemistry, physics or similar. Knowledge about immunology similar to a basic course, such as MOL3005. Medical Doctors degree, or medical students participating in The Student Research track Programme.

Course materials

Suggested textbooks for background reading:

Janeway`s Immunobiology (10th edition, ISBN 9781315533247).

Kuby Immunology (8th edition, ISBN 9781319114701) is a comparable alternative.

Specific background literature related to different lectures and sessions will be distributed before and during the course.

Credit reductions

Course code Reduction From
MOL8002 7.5 sp Autumn 2013
MOL3025 7.5 sp Autumn 2025
This course has academic overlap with the courses in the table above. If you take overlapping courses, you will receive a credit reduction in the course where you have the lowest grade. If the grades are the same, the reduction will be applied to the course completed most recently.

Subject areas

  • Molecular Medicine

Contact information

Course coordinator

Department with academic responsibility

Department of Clinical and Molecular Medicine

Examination

Examination

Examination arrangement: Aggregate score
Grade: Passed / Not Passed

Ordinary examination - Spring 2026

Written paper
Weighting 7/10 Exam system Inspera Assessment
Oral presentation in groups
Weighting 3/10 Examination aids Code A Duration 1 days