course-details-portlet

MOL8009 - Molecular Mechanisms of Inflammation

About

Examination arrangement

Examination arrangement: Home examination and Work
Grade: Passed/Failed

Evaluation form Weighting Duration Examination aids Grade deviation
Approved exercises 3/10 A
Home examination 7/10 3 hours D

Examination arrangement

Examination arrangement: Written examination and Work
Grade: Passed/Failed

Evaluation form Weighting Duration Examination aids Grade deviation
Approved exercises 3/10 ALLE
Written examination 7/10 3 hours D

Course content

The course will give an overview of mechanisms and signaling pathways involved in inflammatory processes, mainly connected to activities at Centre of Molecular Inflammation Research (CEMIR, NTNU). This is inflammation related to infections, but also sterile inflammation (that can be observed during e.g. autoimmune diseases, heart infarction/failure and obesity). Innate and adaptive immune responses will be discussed, with an emphasis on innate immunity. Cell types that are involved include macrophages, monocytes, dendritic cells, neutrophils, dendritic cells, T cells, B cells, osteoblasts, osteoclasts. Recognition- and signaling mechanisms include complement, interactions between complement and other signals, phagocytosis, Toll-like receptors (TLRs), inflammasomes, RIG-I family and other helicases, cGAS, C-type lectin receptors, autophagy, responses to different types of bacteria, viruses, protozoan parasites and fungi, sterile inflammation, vaccines/adjuvants, inflammatory cytokines. Inflammatory signals will be discussed in relation to clinical situations such as infections, immunodeficiencies, inflammation during pregnancy, inflammatory bowel disease, heart failure and bone inflammation.

Learning outcome

After completing the course the student:
• has insight into basal mechanisms of inflammation, much of this in relation to research conducted at Centre for Molecular Inflammation Research (CEMIR) and the Department of Cancer Research and Molecular Medicine.
• will know how the body fight infection with many classes of pathogens, both with respect to different cell types involved and also recognition mechanisms and signaling pathways within those cells.
• understand similarities between sterile inflammation and inflammation induced by infections.
• know how innate immunity instructs adaptive immunity.
• has increased understanding of the possibilities biological research on cell- and molecular level has on development of disease prevention and therapies.

Learning methods and activities

Lectures (mandatory), group discussions/group work (mandatory, 30 % of grade), self study.

Compulsory assignments

  • Attendance in lectures

Further on evaluation

Retake of the exam: The student must have completed the mandatory activities and assignments to take the exam. If the assignment is passed in a previous semester, it is sufficient to retake the written exam.

Specific conditions

Exam registration requires that class registration is approved in the same semester. Compulsory activities from previous semester may be approved by the department.

Required previous knowledge

Masters degree in biology, chemistry, physics. Medical Doctors degree. Or medical students at The Student Research Programme. Candidates with other or lower degree will be assessed individually.

Credit reductions

Course code Reduction From To
MOL8002 7.5 01.09.2013
More on the course

No

Facts

Version: 1
Credits:  7.5 SP
Study level: Doctoral degree level

Coursework

Term no.: 1
Teaching semester:  AUTUMN 2020

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Molecular Medicine
Contact information
Course coordinator: Lecturer(s):

Department with academic responsibility
Department of Clinical and Molecular Medicine

Phone:

Examination

Examination arrangement: Home examination and Work

Term Status code Evaluation form Weighting Examination aids Date Time Digital exam Room *
Autumn ORD Approved exercises 3/10 A
Room Building Number of candidates
Autumn ORD Home examination 7/10 D 2020-11-27

Release 2020-11-27

Submission 2020-11-27

09:00

Release 09:00

Submission 12:00

INSPERA
Room Building Number of candidates

Examination arrangement: Written examination and Work

Term Status code Evaluation form Weighting Examination aids Date Time Digital exam Room *
Spring ORD Approved exercises 3/10 ALLE
Room Building Number of candidates
Spring ORD Written examination 7/10 D INSPERA
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
Examination

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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