MOL8009 - Molecular Mechanisms of Inflammation


Examination arrangement

Examination arrangement: Aggregate score
Grade: Passed / Not Passed

Evaluation Weighting Duration Grade deviation Examination aids
Assignment 3/10
Home examination 7/10 3 hours

Course content

The course will give an overview of mechanisms and signaling pathways involved in inflammatory processes, mainly connected to activities at Centre of Molecular Inflammation Research (CEMIR, NTNU). This is inflammation related to infections, but also sterile inflammation (that can be observed during e.g. autoimmune diseases, heart infarction/failure and obesity). Innate and adaptive immune responses will be discussed, with an emphasis on innate immunity. Cell types that are involved include macrophages, monocytes, dendritic cells, neutrophils, dendritic cells, T cells, B cells, osteoblasts, osteoclasts. Recognition- and signaling mechanisms include complement, interactions between complement and other signals, phagocytosis, Toll-like receptors (TLRs), inflammasomes, RIG-I family and other helicases, cGAS, C-type lectin receptors, autophagy, responses to different types of bacteria, viruses, protozoan parasites and fungi, sterile inflammation, vaccines/adjuvants, inflammatory cytokines. Inflammatory signals will be discussed in relation to clinical situations such as infections, immunodeficiencies, inflammation during pregnancy, inflammatory bowel disease, heart failure and bone inflammation.

Learning outcome

After completing the course the student:

  • has insight into basal mechanisms of inflammation, much of this in relation to research conducted at Centre for Molecular Inflammation Research (CEMIR) and the Department of Clinical and Molecular Medicine.
  • will know how the body fight infection with many classes of pathogens, both with respect to different cell types involved and also recognition mechanisms and signaling pathways within those cells.
  • understand similarities between sterile inflammation and inflammation induced by infections.
  • know how innate immunity instructs adaptive immunity.
  • has increased understanding of the possibilities biological research on cell- and molecular level has on development of disease prevention and therapies.

Learning methods and activities

Lectures (mandatory), group discussions/group work (mandatory, 30 % of grade), self study.

Compulsory assignments

  • Attendance in lectures

Further on evaluation

Retake of the exam: The student must have completed the mandatory activities and assignments to take the exam. If the assignment is passed in a previous semester, it is sufficient to retake the written exam.

Specific conditions

Compulsory activities from previous semester may be approved by the department.

Required previous knowledge

Masters degree in biology, chemistry, physics. Medical Doctors degree. Or medical students at The Student Research Programme. Candidates with other or lower degree will be assessed individually.

Credit reductions

Course code Reduction From To
MOL8002 7.5 AUTUMN 2013
More on the course



Version: 1
Credits:  7.5 SP
Study level: Doctoral degree level


Term no.: 1
Teaching semester:  AUTUMN 2022

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Molecular Medicine
Contact information
Course coordinator: Lecturer(s):

Department with academic responsibility
Department of Clinical and Molecular Medicine


Examination arrangement: Aggregate score

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Autumn ORD Home examination 7/10





Room Building Number of candidates
Autumn ORD Assignment 3/10
Room Building Number of candidates
Spring ORD Home examination 7/10





Room Building Number of candidates
Spring ORD Assignment 3/10
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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