Background and activities

I am currently working as a post-doc in the department of Biology at NTNU as part of a collaboration with Coegin Pharma to develop treatments for chronic inflammatory diseases.   After completing a Ph.D. in Cell and Molecular Biology in the Physiology department at the University of Liverpool, UK, I worked at Baylor College of Medicine, Houston, Texas, where I completed my post-doctoral fellowship in the department of Molecular and Cell Biology establishing high-content imaging approaches to identify and characterize environmental estrogens.

My research has spanned several fields of cell biology but with the common goal of understanding how signaling events are coordinated to control cell fate decisions in human health and disease. I am particularly interested in the development of cell-based assays to enable improved characterization of complex cell behaviors in response to endogenous and exogenous perturbations, while reducing the use of experimental animals.

Research projects

My current research concerns understanding the cellular and molecular mechanisms that regulate inflammation. Ongoing projects include...

  • Investigating cytosolic phospholipase A2α (cPLA2α) as a druggable target for treating  psoriasis.
  • Studying the regulation of macrophage fate by lipid signaling mediators.
  • Investigating the pro-inflammatory effects of nano and microplastics at the cell and molecular level.
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    Publications

    Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA. Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol. 2014 Jun 19;21(6):743-53

    Ashcroft FJ, Newberg JY, Jones ED, Mikic I, Mancini MA. High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes. Gene. 2011 May 15;477(1-2):42-52

    Chao WT, Ashcroft F, Daquinag AC, Vadakkan T, Wei Z, Zhang P, Dickinson ME, Kunz J. Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol. 2010 Sep;30(18):4463-79

    Chao WT, Daquinag AC, Ashcroft F, Kunz J. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol. 2010 Jul 26;190(2):247-62. Erratum in: J Cell Biol. 2010 Aug 9;190(3):479

    Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12;37(3):321-32

    Nedjadi T, Kitteringham N, Campbell F, Jenkins RE, Park BK, Navarro P, Ashcroft F, Tepikin A, Neoptolemos JP, Costello E. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer. 2009 Oct 6;101(7):1145-54

    Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E. Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut. 2007 Jan;56(1):95-106

    Ashcroft FJ, Varro A, Dimaline R, Dockray GJ. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochem J ;381:397-403

    Pagliocca A, Wroblewski LE, Ashcroft FJ, Noble, PJ, Dockray, GJ, & Varro A. (2002). Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. Am.J.Physiol Gastrointest.Liver Physiol 283, G292-G299