Trond Peder Flaten

About

Research areas

A key word for my research activities and fields of interest is multidisciplinarity. Broadly speaking, the external environment's possible influences on human health is my main area. The biochemical, physiological, and toxicological roles of trace elements in medicine and biology, and their possible roles in disease, is a focus of study. A particular interest is the possible roles of metals and trace elements in neurodegenerative diseases; Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. In addition, drinking water and environmental toxins other than metals and trace elements, and other types of diseases, are studied. Also, studies related to the behaviour of trace elements in nature – air, water, soil and animals – are carried out. I am also doing epidemiological studies, currently in cooperation with the Department of Public Health and General Practice at NTNU, and have been editor for the journal Norsk Epidemiologi (Norwegian Journal of Epidemiology, http://www.ntnu.no/ojs/index.php/norepid) since 1995.

On my initiative, in the 3. wave of the Nord-Trøndelag health study (HUNT), 2006-2008, one of the 5 blood samples drawn from each participant is devoted to the analysis of trace elements and other compounds which may indicate environmental exposure. The first Ph.D. candidate under my supervision using these samples, will defend her thesis in 2016. The thesis consists of a large study of normal values of trace elements in the population, and 2 case-control studies of trace elements in type 2 diabetes. The main analytical tool in these and other studies is our Department's HR-ICP-MS instrument – the most powerful analytical technique currently available for multielement analysis at low concentrations.

Publications

2022

Flaten, Trond Peder; Larønningen, Siri; Grimsrud, Tom Kristian; Seglem, Ann Helen. (2022) Kreftregisteret 70 år. Temanummer av tidsskriftet Norsk Epidemiologi, 2022, Vol. 30, No. 1-2. 2022.
Report
Mosbacher, Jesper Bruun; Desforges, Jean-Pierre; Michelsen, Anders; Hansson, Sophia V.; Stelvig, Mikkel; Eulaers, Igor; Sonne, Christian; Dietz, Rune; Jenssen, Bjørn Munro; Ciesielski, Tomasz Maciej; Lierhagen, Syverin; Flaten, Trond Peder; Le Roux, Gael; Aggerbeck, Marie R.; Schmidt, Niels Martin. (2022) Hair mineral levels as indicator of wildlife demographics?—a pilot study of muskoxen. Polar Research. volum 41.
Academic article

2021

Aspli, Klaus Thanke; Holmøy, Trygve; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan. (2021) Skogholt’s disease—A tauopathy precipitated by iron and copper?. Journal of Trace Elements in Medicine and Biology. volum 70.
Academic article
Flaten, Trond Peder; Buajordet, Ingebjørg; Kildemoes, Helle Wallach; Selmer, Randi Marie; Waaseth, Marit. (2021) Farmakoepidemiologi. Temanummer av tidsskriftet Norsk Epidemiologi, 2021, Vol. 29, No. 1-2. 2021.
Report
Simic, Anica; Hansen, Ailin Falkmo; Syversen, Tore; Lierhagen, Syverin; Ciesielski, Tomasz Maciej; Romundstad, Pål Richard; Midthjell, Kristian; Åsvold, Bjørn Olav; Flaten, Trond Peder. (2021) Trace elements in whole blood in the general population in Trøndelag County, Norway: The HUNT3 Survey. Science of the Total Environment. volum 806.
Academic article

2020

Bruns, Tina Maria; Bandyopadhyay, Sulalit; Raghunathan, Karthik; Flaten, Trond Peder. (2020) Tracking Underlying Mechanisms and Yield of Anisotropic Gold Nanoparticles. Norges teknisk-naturvitenskapelige universitet. 2020.
Report
Mikalsen, Solveig Meyer; Aaseth, Jan; Flaten, Trond Peder; Whist, Jon Elling; Monsen, Anne Lise Bjørke. (2020) Essential trace elements in Norwegian obese patients before and 12 months after Roux-en-Y gastric bypass surgery: Copper, manganese, selenium and zinc. Journal of Trace Elements in Medicine and Biology. volum 62:126650.
Academic article
Syversen, Tore; Evje, Lars Gjermund; Wolf-Grosse, Susann; Flaten, Trond Peder; Lierhagen, Syverin; Simic, Anica. (2020) Trace Elements in the Large Population-Based HUNT3 Survey. Biological Trace Element Research. volum 199 (7).
Academic article

2019

Asheim, Johannes; Vike-Jonas, Kristine; Villa Gonzalez, Susana; Lierhagen, Syverin; Venkatraman, Vishwesh; Veivåg, Inga-Loise S.; Snilsberg, Brynhild; Flaten, Trond Peder; Asimakopoulos, Alexandros. (2019) Benzotriazoles, Benzothiazoles and Trace Elements in an Urban Road Setting in Trondheim, Norway: Re-Visiting the Chemical Markers of Traffic Pollution. Science of the Total Environment. volum 649.
Academic article
Flaten, Trond Peder; Hydle, Ida Marie; Kristofersen, Lars Bjarne; Sverdrup, Sidsel Muri. (2019) Ungdom, helse og velferd. Temanummer av tidsskriftet Norsk Epidemiologi, 2019, Vol. 28, No. 1-2. 2019.
Report
Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan. (2019) Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery. Journal of Trace Elements in Medicine and Biology. volum 54.
Academic article
Weggeberg, Hanne; Benden, Tonje Fagertun; Lierhagen, Syverin; Steinnes, Eiliv; Flaten, Trond Peder. (2019) Characterization and bioaccessibility assessment of elements in urban aerosols by extraction with simulated lung fluids. Environmental Chemistry and Ecotoxicology. volum 1.
Academic article
Weggeberg, Hanne; Benden, Tonje Fagertun; Steinnes, Eiliv; Flaten, Trond Peder. (2019) Element analysis and bioaccessibility assessment of ultrafine airborne particulate matter (PM0.1) using simulated lung fluid extraction (artificial lysosomal fluid and Gamble's solution). Environmental Chemistry and Ecotoxicology. volum 1.
Academic article

2017

Farkas, Julia; Salaverria-Zabalegui, Iurgi Imanol; Styrishave, Bjarne; Stanková, Radka; Ciesielski, Tomasz Maciej; Olsen, Anders Johny; Posch, Wilfried; Flaten, Trond Peder; Krøkje, Åse; Salvenmoser, Willi; Jenssen, Bjørn Munro. (2017) Exposure of juvenile turbot (Scophthalmus maximus) to silver nanoparticles and 17α-ethinylestradiol mixtures: Implications for contaminant uptake and plasma steroid hormone levels. Environmental Pollution (1987). volum 220.
Academic article
Flaten, Trond Peder; Irgens, Lorentz M.; Næss, Truls Petter. (2017) Festskrift for Medisinsk fødselsregisters 50 års jubileum. Norsk Epidemiologi 2017, Vol. 27 No. 1-2. ISSN: 0803-2491.
Brochure
Hansen, Ailin Falkmo; Simic, Anica; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Syversen, Tore; Flaten, Trond Peder. (2017) Trace Elements in Early Phase Type 2 Diabetes Mellitus – a Population-based Study. The HUNT Study in Norway. Journal of Trace Elements in Medicine and Biology. volum 40.
Academic article
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Syversen, Tore; Flaten, Trond Peder. (2017) Trace element status in patients with type 2 diabetes in Norway: The HUNT3 Survey. Journal of Trace Elements in Medicine and Biology. volum 41.
Academic article

2016

Brzezicha-Cirocka, Justyna; Grembecka, Małgorzata; Ciesielski, Tomasz Maciej; Flaten, Trond Peder; Szefer, Piotr. (2016) Evaluation of Macro- and Microelement Levels in Black Tea in View of Its Geographical Origin. Biological Trace Element Research. volum 176.
Academic literature review
Weggeberg, Hanne; Føreland, Solveig; Buhagen, Morten; Hilt, Bjørn; Flaten, Trond Peder. (2016) Multi-element analysis of airborne particulate matter from different work tasks during subsea tunnel rehabilitation work. Journal of Occupational and Environmental Hygiene. volum 13 (10).
Academic article

2015

Aspli, Klaus Thanke; Flaten, Trond Peder; ROOS, PER; Holmøy, Trygve; Skogholt, Jon Henry; Aaseth, Jan. (2015) Iron and copper in progressive demyelination: New lessons from Skogholt’s disease. Journal of Trace Elements in Medicine and Biology. volum 31.
Academic article
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe Seppola; Forsen, Lisa; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2015) Population data on calcium in drinking water and hip fracture: An association may depend on other minerals in water. A NOREPOS study. Bone. volum 81.
Academic article
Dusek, Petr; ROOS, PER; Litwin, Tomasz; Schneider, Susanne A.; Flaten, Trond Peder; Aaseth, Jan. (2015) The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases. Journal of Trace Elements in Medicine and Biology. volum 31.
Academic literature review
Nordløkken, Marit; Berg, Torunn; Flaten, Trond Peder; Steinnes, Eiliv. (2015) Essential and non-essential elements in natural vegetation in southern Norway: Contribution from different sources. Science of the Total Environment. volum 502.
Academic article
Simic, Anica; Flaten, Trond Peder. (2015) Do trace elements play a role in type 2 diabetes?. Kjemi.
Academic literature review
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2015) Ca, Mg and Fe blood levels in diabetic patients differ with disease duration and glucose-lowering treatment. Journal of Trace Elements in Medicine and Biology. volum 32.
Abstract
Simic, Anica; Syversen, Tore; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Flaten, Trond Peder. (2015) Trace elements in whole blood in the general population in Nord-Trøndelag County, Norway – the HUNT3 Survey. Journal of Trace Elements in Medicine and Biology. volum 32.
Abstract

2014

Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe Seppola; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2014) Is copper in drinking water related to risk of hip fracture? And could a possible protective associationbetween calcium and hip fracture be modified by copper?. Norsk Epidemiologi. volum 24.
Abstract
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe S; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2014) Do cadmium, lead, and aluminum in drinking water increase the risk of hip fractures? A NOREPOS study. Biological Trace Element Research. volum 157 (1).
Academic article
Hansen, Ailin Falkmo; Simic, Anica; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Trace elements in undiagnosed type 2 diabetes mellitus (HUNT3). Toxicology Letters. volum 229.
Abstract
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Do trace element differences in diabetic patients persist with time? The HUNT3 Survey. Toxicology Letters. volum 229.
Abstract
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Trace elements and type 2 diabetes - two case-control studies in HUNT3. Norsk Epidemiologi, Supplement. volum 24.
Abstract

2013

Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe S; Flaten, Trond Peder; Krogh, Truls; Aamodt, Geir. (2013) Is the quality of drinking water a risk factor for self-reported forearm fractures? Cohort of Norway. Osteoporosis International. volum 24 (2).
Academic article
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe S; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2013) Nationwide data on municipal drinking water and hip fracture: Could calcium and magnesium be protective? A NOREPOS study. Bone. volum 57 (1).
Academic article
ROOS, PER; Vesterberg, Olof; Syversen, Tore; Flaten, Trond Peder; Nordberg, Monica. (2013) Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis. Biological Trace Element Research. volum 151 (2).
Academic article

2012

Flaten, Trond Peder; Aaseth, Jan Olav; Andersen, Ole; Kontoghiorghes, GJ. (2012) Iron mobilization using chelation and phlebotomy. Journal of Trace Elements in Medicine and Biology. volum 26 (2-3).
Academic article
Hjellvik, Vidar; Engedal, Knut Arne; Handal, Marte; Flaten, Trond Peder; Langballe, Ellen Melbye; Selmer, Randi; Strand, Bjørn Heine. (2012) Dementia in the National Cause of Death Registry in Norway 1969-2010. Norsk Epidemiologi. volum 22 (2).
Academic article
ROOS, PER; Lierhagen, Syverin; Flaten, Trond Peder; Syversen, Tore; Vesterberg, Olof; Nordberg, Monica. (2012) Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis. Experimental biology and medicine. volum 237 (7).
Academic article

2011

Roos, Per M.; Lierhagen, Syverin; Flaten, Trond Peder; Syversen, Tore; Bergström, Jakob; Vesterberg, Olof; Nordberg, Monica. (2011) Manganese in CSF and blood plasma from ALS patients. Journal of Trace Elements in Medicine and Biology. volum 26.
Abstract
Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe S; Flaten, Trond Peder; Krogh, Truls; Aamodt, Geir. (2011) Is the quality of drinking water a risk factor for forearm fractures?. Norsk Epidemiologi. volum 21.
Abstract
Flaten, Trond Peder; Aaseth, Jan Olav. (2011) Iron mobilization using chelation and phlebotomy. Journal of Trace Elements in Medicine and Biology. volum 26.
Abstract
Simic, Anica; Misic, S. Milicevic; Stojancov, S. Seskar; Ilic, G; Milosavljevic, B; Vujovic, M; Flaten, Trond Peder. (2011) Fatal pesticides-related self-poisonings in the southeastern region of Serbia-Alarming increase in suicides calls for restrictions. Toxicology Letters. volum 205.
Abstract

2009

Flaten, Trond Peder. (2009) Lead poisoning in China and Senegal. BMJ. British Medical Journal. volum 339.
Letter to the editor
Flaten, Trond Peder; Steinnes, Eiliv. (2009) Soil and fresh water. General and Applied Toxicology, 3rd Edition.
Academic chapter/article/Conference paper
Zachariassen, Karl Erik; Flaten, Trond Peder. (2009) Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?. Medical Hypotheses. volum 72 (5).
Academic article

2008

Flaten, Trond Peder; Andersen, Lars Haug; Holsen, Aase Marie Hersleth; Ottemo, Vivian Grønhaug; Pedersen, Hans Christian; Steinnes, Eiliv; Lierhagen, Syverin; Jenssen, Bjørn Munro. (2008) A nationwide survey of trace elements in lynx, wolverines, wolves, and brown bears in Norway. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Flaten, Trond Peder; Erikson, Keith M.; Aschner, M; Syversen, Tore. (2008) Leaching of trace elements from biological tissue by formalin fixation. Biological Trace Element Research. volum 121.
Academic article
Gellein, Kristin; Flaten, Trond Peder; Erikson, Keith M.; Aschner, Michael; Syversen, Tore. (2008) Effects of formalin fixation on trace element concentrations in biological tissue. Cell Biology and Toxicology. volum 24.
Abstract
Gellein, Kristin; Lierhagen, Syverin; Brevik, Per Steinar; Teigen, Marte; Kaur, Parvinder; Singh, Tajeshwar; Flaten, Trond Peder; Syversen, Tore. (2008) Trace element profiles in single strands of human hair determined by HR-ICP-MS. Biological Trace Element Research. volum 123 (1-3).
Academic article
Gellein, Kristin; Roos, Per M.; Evje, Lars Gjermund; Vesterberg, Olof; Flaten, Trond Peder; Nordberg, Monica; Syversen, Tore. (2008) Separation of proteins in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS. Cell Biology and Toxicology. volum 24.
Abstract
Gellein, Kristin; Skogholt, Jon H.; Aaseth, Jan; Thoresen, Gunnar B.; Lierhagen, Syverin; Steinnes, Eiliv; Syversen, Tore; Flaten, Trond Peder. (2008) Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and peripheral demyelinating disease. Journal of the Neurological Sciences. volum 266.
Academic article
Gellein, Kristin; Syversen, Tore; Steinnes, Eiliv; Nilsen, Tom Ivar Lund; Lierhagen, Syverin; Dahl, Ole Petter; Mitrovic, Sascha; Duraj, Dusan; Flaten, Trond Peder. (2008) Trace elements in serum from patients with Parkinson's disease – a prospective case-control study. Cell Biology and Toxicology. volum 24.
Abstract
Aaseth, Jan; Andersen, Ole; Flaten, Trond Peder; Gellein, Kristin. (2008) Iron and copper toxicity in hereditary diseases. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Skogholt, Jon Henry; Aaseth, Jan; Thoresen, Gunnar Børre; Lierhagen, Syverin; Syversen, Tore; Steinnes, Eiliv; Flaten, Trond Peder. (2008) Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and paripheral demyelinating disease. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Syversen, Tore; Steinnes, Eiliv; Nilsen, Tom Ivar Lund; Dahl, Ole Petter; Mitrovic, Sascha; Duraj, Dusan; Flaten, Trond Peder. (2008) Trace elements in serum from patients with Parkinson's disease – a prospective case-control study: The Nord-Trøndelag Health Study (HUNT). Brain Research. volum 1219.
Academic article

2007

Gellein, Kristin; Roos, Per M.; Evje, Lars Gjermund; Vesterberg, Olof; Flaten, Trond Peder; Nordberg, Monica; Syversen, Tore. (2007) Separation of proteins including metallothionein in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS. Brain Research. volum 1174.
Academic article
Aaseth, J; Flaten, Trond Peder; Andersen, O. (2007) Hereditary iron and copper deposition: Diagnostics, pathogenesis and therapeutics. Scandinavian Journal of Gastroenterology. volum 42.
Academic literature review

2006

Grotmol, Tom; Bernhoft, Aksel; Eriksen, Gunnar Sundstøl; Flaten, Trond Peder. (2006) Endocrine Disrupters. Proceedings from a symposium held at The Norwegian Academy of Science and Letters, Oslo, 13-14 October 2005. Novus Forlag. 2006. ISBN 978-82-7099-437-3.
Academic anthology/Conference proceedings

2003

Garmo, Øyvind Aaberg; Røyset, Oddvar; Steinnes, Eiliv; Flaten, Trond Peder. (2003) Performance study of diffusive gradients in thin films for 55 elements. Analytical Chemistry. volum 75.
Academic article
Gellein, Kristin; Garruto, Ralph; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2003) Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam determined by high-resolution ICP-MS. Biological Trace Element Research. volum 96 (1-3).
Academic article
Gellein, Kristin; Garruto, RM; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2003) Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam determined by high-resolution ICP-MS. Biological Trace Element Research. volum 96.
Academic article
Melø, Torun Margareta; Larsen, Cecilie; White, Linda; Aasly, Jan; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder; Sonnewald, Ursula; Syversen, Tore. (2003) Manganese, Copper, and Zinc in Cerebrospinal Fluid from Patients with Multiple Sclerosis. Biological Trace Element Research. volum 93.
Academic article

2002

Flaten, Trond Peder. (2002) Aluminium in tea � concentrations, speciation and bioavailability. Coordination chemistry reviews. volum 228 (2).
Academic article
Røyset, Oddvar; Garmo, Øyvind Aaberg; Steinnes, Eiliv; Flaten, Trond Peder. (2002) Performance study of diffusive gradients in thin films (DGT) for 55 elements. 2002. ISBN 82-577-4264-3.
Report

2001

Flaten, Trond Peder. (2001) Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Research Bulletin. volum 55 (2).
Academic literature review

2000

Melø, Torun Margareta; Larsen, Cecilie; White, Linda; Aasly, Jan; Sonnewald, Ursula; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2000) Manganese, copper, iron and zinc in cerebrospinal fluid from multiple sclerosis patients and controls. Journal of Alzheimer's Disease. volum 2 (3-4).
Academic article

1999

Flaten, Trond Peder. (1999) Avfallsforbrenning, dioksiner og kreft. Adresseavisen.
Feature article
Flaten, Trond Peder; Steinnes, Eiliv. (1999) Soil and fresh waters. General and applied toxicology. Volume 2, 2nd edition.
Academic chapter/article/Conference paper

1998

Flaten, Trond Peder. (1998) Drikkevann og helse. Tidsskrift for Den norske legeforening. volum 118 (30).
Feature article
Flaten, Trond Peder. (1998) Kjemisk sammensetning av norsk drikkevann. Norsk Veterinærtidsskrift. volum 110 (10).
Academic article

1997

Bølviken, Bjørn; Flaten, Trond Peder; Zheng, Chunjiang. (1997) Relations between nasopharyngeal carcinoma and magnesium and other alkaline earth elements in soils in China. Medical Hypotheses. volum 48 (1).
Academic article
Flaten, Trond Peder; Alfrey, Allen C.; Birchall, J. Derek; Savory, John; Yokel, Robert A.. (1997) Status and future concerns of clinical and environmental aluminum toxicology. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper
Harris, Wesley R.; Berthon, Guy; Day, J. Philip; Exley, Christopher; Flaten, Trond Peder; Forbes, William F.; Kiss, Tamas; Orvig, Chris; Zatta, Paolo F.. (1997) Speciation of aluminum in biological systems. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper
Yokel, Robert A.; Ackrill, Peter; Burgess, Ellen; Day, J. Philip; Domingo, José L.; Flaten, Trond Peder; Savory, John. (1997) Prevention and treatment of aluminum toxicity including chelation therapy: Status and research needs. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper

Journal publications

Mosbacher, Jesper Bruun; Desforges, Jean-Pierre; Michelsen, Anders; Hansson, Sophia V.; Stelvig, Mikkel; Eulaers, Igor; Sonne, Christian; Dietz, Rune; Jenssen, Bjørn Munro; Ciesielski, Tomasz Maciej; Lierhagen, Syverin; Flaten, Trond Peder; Le Roux, Gael; Aggerbeck, Marie R.; Schmidt, Niels Martin. (2022) Hair mineral levels as indicator of wildlife demographics?—a pilot study of muskoxen. Polar Research. volum 41.
Academic article
Aspli, Klaus Thanke; Holmøy, Trygve; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan. (2021) Skogholt’s disease—A tauopathy precipitated by iron and copper?. Journal of Trace Elements in Medicine and Biology. volum 70.
Academic article
Simic, Anica; Hansen, Ailin Falkmo; Syversen, Tore; Lierhagen, Syverin; Ciesielski, Tomasz Maciej; Romundstad, Pål Richard; Midthjell, Kristian; Åsvold, Bjørn Olav; Flaten, Trond Peder. (2021) Trace elements in whole blood in the general population in Trøndelag County, Norway: The HUNT3 Survey. Science of the Total Environment. volum 806.
Academic article
Mikalsen, Solveig Meyer; Aaseth, Jan; Flaten, Trond Peder; Whist, Jon Elling; Monsen, Anne Lise Bjørke. (2020) Essential trace elements in Norwegian obese patients before and 12 months after Roux-en-Y gastric bypass surgery: Copper, manganese, selenium and zinc. Journal of Trace Elements in Medicine and Biology. volum 62:126650.
Academic article
Syversen, Tore; Evje, Lars Gjermund; Wolf-Grosse, Susann; Flaten, Trond Peder; Lierhagen, Syverin; Simic, Anica. (2020) Trace Elements in the Large Population-Based HUNT3 Survey. Biological Trace Element Research. volum 199 (7).
Academic article
Asheim, Johannes; Vike-Jonas, Kristine; Villa Gonzalez, Susana; Lierhagen, Syverin; Venkatraman, Vishwesh; Veivåg, Inga-Loise S.; Snilsberg, Brynhild; Flaten, Trond Peder; Asimakopoulos, Alexandros. (2019) Benzotriazoles, Benzothiazoles and Trace Elements in an Urban Road Setting in Trondheim, Norway: Re-Visiting the Chemical Markers of Traffic Pollution. Science of the Total Environment. volum 649.
Academic article
Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan. (2019) Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery. Journal of Trace Elements in Medicine and Biology. volum 54.
Academic article
Weggeberg, Hanne; Benden, Tonje Fagertun; Lierhagen, Syverin; Steinnes, Eiliv; Flaten, Trond Peder. (2019) Characterization and bioaccessibility assessment of elements in urban aerosols by extraction with simulated lung fluids. Environmental Chemistry and Ecotoxicology. volum 1.
Academic article
Weggeberg, Hanne; Benden, Tonje Fagertun; Steinnes, Eiliv; Flaten, Trond Peder. (2019) Element analysis and bioaccessibility assessment of ultrafine airborne particulate matter (PM0.1) using simulated lung fluid extraction (artificial lysosomal fluid and Gamble's solution). Environmental Chemistry and Ecotoxicology. volum 1.
Academic article
Farkas, Julia; Salaverria-Zabalegui, Iurgi Imanol; Styrishave, Bjarne; Stanková, Radka; Ciesielski, Tomasz Maciej; Olsen, Anders Johny; Posch, Wilfried; Flaten, Trond Peder; Krøkje, Åse; Salvenmoser, Willi; Jenssen, Bjørn Munro. (2017) Exposure of juvenile turbot (Scophthalmus maximus) to silver nanoparticles and 17α-ethinylestradiol mixtures: Implications for contaminant uptake and plasma steroid hormone levels. Environmental Pollution (1987). volum 220.
Academic article
Hansen, Ailin Falkmo; Simic, Anica; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Syversen, Tore; Flaten, Trond Peder. (2017) Trace Elements in Early Phase Type 2 Diabetes Mellitus – a Population-based Study. The HUNT Study in Norway. Journal of Trace Elements in Medicine and Biology. volum 40.
Academic article
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Syversen, Tore; Flaten, Trond Peder. (2017) Trace element status in patients with type 2 diabetes in Norway: The HUNT3 Survey. Journal of Trace Elements in Medicine and Biology. volum 41.
Academic article
Brzezicha-Cirocka, Justyna; Grembecka, Małgorzata; Ciesielski, Tomasz Maciej; Flaten, Trond Peder; Szefer, Piotr. (2016) Evaluation of Macro- and Microelement Levels in Black Tea in View of Its Geographical Origin. Biological Trace Element Research. volum 176.
Academic literature review
Weggeberg, Hanne; Føreland, Solveig; Buhagen, Morten; Hilt, Bjørn; Flaten, Trond Peder. (2016) Multi-element analysis of airborne particulate matter from different work tasks during subsea tunnel rehabilitation work. Journal of Occupational and Environmental Hygiene. volum 13 (10).
Academic article
Aspli, Klaus Thanke; Flaten, Trond Peder; ROOS, PER; Holmøy, Trygve; Skogholt, Jon Henry; Aaseth, Jan. (2015) Iron and copper in progressive demyelination: New lessons from Skogholt’s disease. Journal of Trace Elements in Medicine and Biology. volum 31.
Academic article
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe Seppola; Forsen, Lisa; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2015) Population data on calcium in drinking water and hip fracture: An association may depend on other minerals in water. A NOREPOS study. Bone. volum 81.
Academic article
Dusek, Petr; ROOS, PER; Litwin, Tomasz; Schneider, Susanne A.; Flaten, Trond Peder; Aaseth, Jan. (2015) The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases. Journal of Trace Elements in Medicine and Biology. volum 31.
Academic literature review
Nordløkken, Marit; Berg, Torunn; Flaten, Trond Peder; Steinnes, Eiliv. (2015) Essential and non-essential elements in natural vegetation in southern Norway: Contribution from different sources. Science of the Total Environment. volum 502.
Academic article
Simic, Anica; Flaten, Trond Peder. (2015) Do trace elements play a role in type 2 diabetes?. Kjemi.
Academic literature review
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2015) Ca, Mg and Fe blood levels in diabetic patients differ with disease duration and glucose-lowering treatment. Journal of Trace Elements in Medicine and Biology. volum 32.
Abstract
Simic, Anica; Syversen, Tore; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Midthjell, Kristian; Flaten, Trond Peder. (2015) Trace elements in whole blood in the general population in Nord-Trøndelag County, Norway – the HUNT3 Survey. Journal of Trace Elements in Medicine and Biology. volum 32.
Abstract
Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe Seppola; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2014) Is copper in drinking water related to risk of hip fracture? And could a possible protective associationbetween calcium and hip fracture be modified by copper?. Norsk Epidemiologi. volum 24.
Abstract
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe S; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2014) Do cadmium, lead, and aluminum in drinking water increase the risk of hip fractures? A NOREPOS study. Biological Trace Element Research. volum 157 (1).
Academic article
Hansen, Ailin Falkmo; Simic, Anica; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Trace elements in undiagnosed type 2 diabetes mellitus (HUNT3). Toxicology Letters. volum 229.
Abstract
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Do trace element differences in diabetic patients persist with time? The HUNT3 Survey. Toxicology Letters. volum 229.
Abstract
Simic, Anica; Hansen, Ailin Falkmo; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Syversen, Tore; Midthjell, Kristian; Flaten, Trond Peder. (2014) Trace elements and type 2 diabetes - two case-control studies in HUNT3. Norsk Epidemiologi, Supplement. volum 24.
Abstract
Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe S; Flaten, Trond Peder; Krogh, Truls; Aamodt, Geir. (2013) Is the quality of drinking water a risk factor for self-reported forearm fractures? Cohort of Norway. Osteoporosis International. volum 24 (2).
Academic article
Dahl, Cecilie; Søgaard, Anne-Johanne; Tell, Grethe S; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Aamodt, Geir. (2013) Nationwide data on municipal drinking water and hip fracture: Could calcium and magnesium be protective? A NOREPOS study. Bone. volum 57 (1).
Academic article
ROOS, PER; Vesterberg, Olof; Syversen, Tore; Flaten, Trond Peder; Nordberg, Monica. (2013) Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis. Biological Trace Element Research. volum 151 (2).
Academic article
Flaten, Trond Peder; Aaseth, Jan Olav; Andersen, Ole; Kontoghiorghes, GJ. (2012) Iron mobilization using chelation and phlebotomy. Journal of Trace Elements in Medicine and Biology. volum 26 (2-3).
Academic article
Hjellvik, Vidar; Engedal, Knut Arne; Handal, Marte; Flaten, Trond Peder; Langballe, Ellen Melbye; Selmer, Randi; Strand, Bjørn Heine. (2012) Dementia in the National Cause of Death Registry in Norway 1969-2010. Norsk Epidemiologi. volum 22 (2).
Academic article
ROOS, PER; Lierhagen, Syverin; Flaten, Trond Peder; Syversen, Tore; Vesterberg, Olof; Nordberg, Monica. (2012) Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis. Experimental biology and medicine. volum 237 (7).
Academic article
Roos, Per M.; Lierhagen, Syverin; Flaten, Trond Peder; Syversen, Tore; Bergström, Jakob; Vesterberg, Olof; Nordberg, Monica. (2011) Manganese in CSF and blood plasma from ALS patients. Journal of Trace Elements in Medicine and Biology. volum 26.
Abstract
Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe S; Flaten, Trond Peder; Krogh, Truls; Aamodt, Geir. (2011) Is the quality of drinking water a risk factor for forearm fractures?. Norsk Epidemiologi. volum 21.
Abstract
Flaten, Trond Peder; Aaseth, Jan Olav. (2011) Iron mobilization using chelation and phlebotomy. Journal of Trace Elements in Medicine and Biology. volum 26.
Abstract
Simic, Anica; Misic, S. Milicevic; Stojancov, S. Seskar; Ilic, G; Milosavljevic, B; Vujovic, M; Flaten, Trond Peder. (2011) Fatal pesticides-related self-poisonings in the southeastern region of Serbia-Alarming increase in suicides calls for restrictions. Toxicology Letters. volum 205.
Abstract
Flaten, Trond Peder. (2009) Lead poisoning in China and Senegal. BMJ. British Medical Journal. volum 339.
Letter to the editor
Zachariassen, Karl Erik; Flaten, Trond Peder. (2009) Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?. Medical Hypotheses. volum 72 (5).
Academic article
Flaten, Trond Peder; Andersen, Lars Haug; Holsen, Aase Marie Hersleth; Ottemo, Vivian Grønhaug; Pedersen, Hans Christian; Steinnes, Eiliv; Lierhagen, Syverin; Jenssen, Bjørn Munro. (2008) A nationwide survey of trace elements in lynx, wolverines, wolves, and brown bears in Norway. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Flaten, Trond Peder; Erikson, Keith M.; Aschner, M; Syversen, Tore. (2008) Leaching of trace elements from biological tissue by formalin fixation. Biological Trace Element Research. volum 121.
Academic article
Gellein, Kristin; Flaten, Trond Peder; Erikson, Keith M.; Aschner, Michael; Syversen, Tore. (2008) Effects of formalin fixation on trace element concentrations in biological tissue. Cell Biology and Toxicology. volum 24.
Abstract
Gellein, Kristin; Lierhagen, Syverin; Brevik, Per Steinar; Teigen, Marte; Kaur, Parvinder; Singh, Tajeshwar; Flaten, Trond Peder; Syversen, Tore. (2008) Trace element profiles in single strands of human hair determined by HR-ICP-MS. Biological Trace Element Research. volum 123 (1-3).
Academic article
Gellein, Kristin; Roos, Per M.; Evje, Lars Gjermund; Vesterberg, Olof; Flaten, Trond Peder; Nordberg, Monica; Syversen, Tore. (2008) Separation of proteins in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS. Cell Biology and Toxicology. volum 24.
Abstract
Gellein, Kristin; Skogholt, Jon H.; Aaseth, Jan; Thoresen, Gunnar B.; Lierhagen, Syverin; Steinnes, Eiliv; Syversen, Tore; Flaten, Trond Peder. (2008) Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and peripheral demyelinating disease. Journal of the Neurological Sciences. volum 266.
Academic article
Gellein, Kristin; Syversen, Tore; Steinnes, Eiliv; Nilsen, Tom Ivar Lund; Lierhagen, Syverin; Dahl, Ole Petter; Mitrovic, Sascha; Duraj, Dusan; Flaten, Trond Peder. (2008) Trace elements in serum from patients with Parkinson's disease – a prospective case-control study. Cell Biology and Toxicology. volum 24.
Abstract
Aaseth, Jan; Andersen, Ole; Flaten, Trond Peder; Gellein, Kristin. (2008) Iron and copper toxicity in hereditary diseases. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Skogholt, Jon Henry; Aaseth, Jan; Thoresen, Gunnar Børre; Lierhagen, Syverin; Syversen, Tore; Steinnes, Eiliv; Flaten, Trond Peder. (2008) Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and paripheral demyelinating disease. Cell Biology and Toxicology. volum 24 (Supplement 1).
Abstract
Gellein, Kristin; Syversen, Tore; Steinnes, Eiliv; Nilsen, Tom Ivar Lund; Dahl, Ole Petter; Mitrovic, Sascha; Duraj, Dusan; Flaten, Trond Peder. (2008) Trace elements in serum from patients with Parkinson's disease – a prospective case-control study: The Nord-Trøndelag Health Study (HUNT). Brain Research. volum 1219.
Academic article
Gellein, Kristin; Roos, Per M.; Evje, Lars Gjermund; Vesterberg, Olof; Flaten, Trond Peder; Nordberg, Monica; Syversen, Tore. (2007) Separation of proteins including metallothionein in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS. Brain Research. volum 1174.
Academic article
Aaseth, J; Flaten, Trond Peder; Andersen, O. (2007) Hereditary iron and copper deposition: Diagnostics, pathogenesis and therapeutics. Scandinavian Journal of Gastroenterology. volum 42.
Academic literature review
Garmo, Øyvind Aaberg; Røyset, Oddvar; Steinnes, Eiliv; Flaten, Trond Peder. (2003) Performance study of diffusive gradients in thin films for 55 elements. Analytical Chemistry. volum 75.
Academic article
Gellein, Kristin; Garruto, Ralph; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2003) Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam determined by high-resolution ICP-MS. Biological Trace Element Research. volum 96 (1-3).
Academic article
Gellein, Kristin; Garruto, RM; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2003) Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam determined by high-resolution ICP-MS. Biological Trace Element Research. volum 96.
Academic article
Melø, Torun Margareta; Larsen, Cecilie; White, Linda; Aasly, Jan; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder; Sonnewald, Ursula; Syversen, Tore. (2003) Manganese, Copper, and Zinc in Cerebrospinal Fluid from Patients with Multiple Sclerosis. Biological Trace Element Research. volum 93.
Academic article
Flaten, Trond Peder. (2002) Aluminium in tea � concentrations, speciation and bioavailability. Coordination chemistry reviews. volum 228 (2).
Academic article
Flaten, Trond Peder. (2001) Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Research Bulletin. volum 55 (2).
Academic literature review
Melø, Torun Margareta; Larsen, Cecilie; White, Linda; Aasly, Jan; Sonnewald, Ursula; Syversen, Tore; Sjøbakk, Torill Eidhammer; Flaten, Trond Peder. (2000) Manganese, copper, iron and zinc in cerebrospinal fluid from multiple sclerosis patients and controls. Journal of Alzheimer's Disease. volum 2 (3-4).
Academic article
Flaten, Trond Peder. (1999) Avfallsforbrenning, dioksiner og kreft. Adresseavisen.
Feature article
Flaten, Trond Peder. (1998) Drikkevann og helse. Tidsskrift for Den norske legeforening. volum 118 (30).
Feature article
Flaten, Trond Peder. (1998) Kjemisk sammensetning av norsk drikkevann. Norsk Veterinærtidsskrift. volum 110 (10).
Academic article
Bølviken, Bjørn; Flaten, Trond Peder; Zheng, Chunjiang. (1997) Relations between nasopharyngeal carcinoma and magnesium and other alkaline earth elements in soils in China. Medical Hypotheses. volum 48 (1).
Academic article

Books

Grotmol, Tom; Bernhoft, Aksel; Eriksen, Gunnar Sundstøl; Flaten, Trond Peder. (2006) Endocrine Disrupters. Proceedings from a symposium held at The Norwegian Academy of Science and Letters, Oslo, 13-14 October 2005. Novus Forlag. 2006. ISBN 978-82-7099-437-3.
Academic anthology/Conference proceedings

Part of book/report

Flaten, Trond Peder; Steinnes, Eiliv. (2009) Soil and fresh water. General and Applied Toxicology, 3rd Edition.
Academic chapter/article/Conference paper
Flaten, Trond Peder; Steinnes, Eiliv. (1999) Soil and fresh waters. General and applied toxicology. Volume 2, 2nd edition.
Academic chapter/article/Conference paper
Flaten, Trond Peder; Alfrey, Allen C.; Birchall, J. Derek; Savory, John; Yokel, Robert A.. (1997) Status and future concerns of clinical and environmental aluminum toxicology. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper
Harris, Wesley R.; Berthon, Guy; Day, J. Philip; Exley, Christopher; Flaten, Trond Peder; Forbes, William F.; Kiss, Tamas; Orvig, Chris; Zatta, Paolo F.. (1997) Speciation of aluminum in biological systems. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper
Yokel, Robert A.; Ackrill, Peter; Burgess, Ellen; Day, J. Philip; Domingo, José L.; Flaten, Trond Peder; Savory, John. (1997) Prevention and treatment of aluminum toxicity including chelation therapy: Status and research needs. Research Issues in Aluminum Toxicity.
Academic chapter/article/Conference paper

Report

Flaten, Trond Peder; Larønningen, Siri; Grimsrud, Tom Kristian; Seglem, Ann Helen. (2022) Kreftregisteret 70 år. Temanummer av tidsskriftet Norsk Epidemiologi, 2022, Vol. 30, No. 1-2. 2022.
Report
Flaten, Trond Peder; Buajordet, Ingebjørg; Kildemoes, Helle Wallach; Selmer, Randi Marie; Waaseth, Marit. (2021) Farmakoepidemiologi. Temanummer av tidsskriftet Norsk Epidemiologi, 2021, Vol. 29, No. 1-2. 2021.
Report
Bruns, Tina Maria; Bandyopadhyay, Sulalit; Raghunathan, Karthik; Flaten, Trond Peder. (2020) Tracking Underlying Mechanisms and Yield of Anisotropic Gold Nanoparticles. Norges teknisk-naturvitenskapelige universitet. 2020.
Report
Flaten, Trond Peder; Hydle, Ida Marie; Kristofersen, Lars Bjarne; Sverdrup, Sidsel Muri. (2019) Ungdom, helse og velferd. Temanummer av tidsskriftet Norsk Epidemiologi, 2019, Vol. 28, No. 1-2. 2019.
Report
Røyset, Oddvar; Garmo, Øyvind Aaberg; Steinnes, Eiliv; Flaten, Trond Peder. (2002) Performance study of diffusive gradients in thin films (DGT) for 55 elements. 2002. ISBN 82-577-4264-3.
Report

INFORMASJONSMATR

Flaten, Trond Peder; Irgens, Lorentz M.; Næss, Truls Petter. (2017) Festskrift for Medisinsk fødselsregisters 50 års jubileum. Norsk Epidemiologi 2017, Vol. 27 No. 1-2. ISSN: 0803-2491.
Brochure

Teaching

Courses

Media