Background and activities
Main areas of research: Pain and palliation in advanced cancer, with the emphasis on genetics. Lung cancer, with the emphasis on genetic risk factors, biomarkers for early detection, effect from therapy and early detection of disease relapse. Areas of teaching: Human genetics.
Professor I, medicine (molecular biologi)
Main areas of research:
Pain and symptom control in patients with advanced cancer disease (palliation); cohort-based studies of genetic variation and response to opioids, including dose requirements, pain relief, adverse effects, and genetics and morphine metabolism. Molecular mechanisms for cancer cachexia.
Lung cancer; genetic risk factors for lung cancer, biomarkers for early detection, tumor heterogeneity and biomarkers for prognosis and effect of therapy, biomarkers for early detection of disease relapse after surgery. Genetics and nicotine dependence.
Has also worked on cellular mechanisms of DNA repair, genetics and diabetes (LADA), genetics and non-malignant pain, etc.
Main areas of teaching:
Human genetics, with the emphasis on population genetics, genetics and disease, gene mapping, gene regulation, methods in genetic diagnostics.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2021) Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study. International Journal of Epidemiology.
- (2020) Power comparisons and clinical meaning of outcome measures in assessing treatment effect in cancer cachexia: secondary analysis from a randomised pilot multimodal intervention trial. Frontiers in Nutrition. vol. 7:602775.
- (2020) Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients. Scientific Reports. vol. 10 (1).
- (2020) DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples. International Journal of Colorectal Disease.
- (2020) The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients. Experimental and molecular pathology (Print). vol. 112C:104347.
- (2018) Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning. BMC Research Notes. vol. 11 (78).
- (2018) The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study. European Journal of Neurology. vol. 25 (9).
- (2018) Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study. European Respiratory Journal. vol. 51 (6).
- (2017) The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. Osteoarthritis and Cartilage. vol. 25 (6).
- (2017) Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling. Scientific Reports. vol. 7 (1).
- (2017) Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports. vol. 7:2224.
- (2017) Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks. BMC Research Notes. vol. 10 (136).
- (2017) Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. BMJ Open. vol. 7 (6).
- (2017) Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study. European Journal of Epidemiology (EJE). vol. 33 (1).
- (2016) Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Brain and Behavior. vol. 6 (7).
- (2016) The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses. Acta Anaesthesiologica Scandinavica. vol. 60 (8).
- (2015) Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis. vol. 36 (11).
- (2015) Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids. Clinical and Translational Gastroenterology. vol. 6:e90.
- (2015) Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study. BMJ Open Diabetes Research & Care. vol. 3 (1).
- (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature Genetics. vol. 46 (7).