Background and activities
Main areas of research: Pain and palliation in advanced cancer, with the emphasis on genetics. Lung cancer, with the emphasis on genetic risk factors, biomarkers for early detection, effect from therapy and early detection of disease relapse. Areas of teaching: Human genetics.
Professor I, medicine (molecular biologi)
Main areas of research:
Pain and symptom control in patients with advanced cancer disease (palliation); cohort-based studies of genetic variation and response to opioids, including dose requirements, pain relief, adverse effects, and genetics and morphine metabolism. Molecular mechanisms for cancer cachexia.
Lung cancer; genetic risk factors for lung cancer, biomarkers for early detection, tumor heterogeneity and biomarkers for prognosis and effect of therapy, biomarkers for early detection of disease relapse after surgery. Genetics and nicotine dependence.
Has also worked on cellular mechanisms of DNA repair, genetics and diabetes (LADA), genetics and non-malignant pain, etc.
Main areas of teaching:
Human genetics, with the emphasis on population genetics, genetics and disease, gene mapping, gene regulation, methods in genetic diagnostics.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2017) The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. Osteoarthritis and Cartilage. vol. 25 (6).
- (2017) Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling. Scientific Reports. vol. 7 (1).
- (2017) Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports. vol. 7:2224.
- (2017) Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks. BMC Research Notes.
- (2017) Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. BMJ Open. vol. 7 (e017256).
- (2016) Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Brain and Behavior. vol. 6 (7).
- (2016) The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses. Acta Anaesthesiologica Scandinavica. vol. 60 (8).
- (2015) Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis. vol. 36 (11).
- (2015) Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids. Clinical and Translational Gastroenterology. vol. 6:e90.
- (2015) Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study. BMJ Open Diabetes Research & Care. vol. 3 (1).
- (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics. vol. 46 (4).
- (2014) No large-effect low-frequency coding variation found for myocardial infarction. Human Molecular Genetics. vol. 23 (17).
- (2014) Clinical and genetic factors related to cancer-induced bone pain and bone pain relief. The Oncologist. vol. 19 (12).
- (2014) Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open. vol. 4 (10).
- (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature Genetics. vol. 46 (7).
- (2014) Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway. International Journal of Epidemiology. vol. 43 (5).
- (2013) The N-Terminally Truncated mu 3 and mu 3-Like Opioid Receptors Are Transcribed from a Novel Promoter Upstream of Exon 2 in the Human OPRM1 Gene. PLoS ONE. vol. 8 (8).
- (2013) The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. Psychological Medicine. vol. 43 (4).
- (2013) Variability in UDP-glucuronosyltransferase genes and morphine metabolism. Observations from a cross-sectional multicenter study in advanced cancer patients with pain. Pharmacogenetics & Genomics. vol. 23 (3).
- (2013) Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway. European Journal of Human Genetics. vol. 21 (11).