Guglielmo Genovese
About
Guglielmo Genovese, PhD, is a tenure-track faculty at the department of Neuromedicine and Movement Science (INB, Norwegian University of Science and Technology, Trondheim), which he very recently joined (October 2023). Previously, he spent four years of post-doctoral training at the Center for Magnetic Resonance Research (CMRR, University of Minnesota). In 2019, he completed his PhD in neuroscience at the Sorbonne University working at the Brain Institute under the supervision of Prof. Stephane Lehericy.
During his PhD, he investigated microstructural alterations in the human brain and in experimental models with magnetic resonance spectroscopy (MRS), and with diffusion weighted- (DW-)MRS at high (3 T) and ultra-high field (11.7 T). Major achievements of this work were a histological validation of DW-MRS markers for detecting inflammation, and a promising application of DW-MRS for monitoring inflammation in cerebral ischemia.
Currently, he is focused on characterizing the impairment of GABAergic and glutamatergic metabolisms in major depressive disorder and migraine at ultra-high field (7 T). Additionally, his research involves the characterization of macromolecular changes linked to aging and Alzheimer’s disease.
Publications
Longitudinal Monitoring of Microstructural Alterations in Cerebral Ischemia with in Vivo Diffusion-weighted MR Spectroscopy
Inflammation-driven glial alterations in the cuprizone mouse model probed with diffusion-weighted magnetic resonance spectroscopy at 11.7 T
Quantification of GABA concentration measured noninvasively in the human posterior cingulate cortex with 7 T ultra-short-TE MR spectroscopy
Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling
2025
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Şimşek, Kadir;
Gallea, Cécile;
Genovese, Guglielmo;
Lehéricy, Stephane;
Branzoli, Francesca;
Palombo, Marco.
(2025)
Age-Trajectories of Higher-Order Diffusion Properties of Major Brain Metabolites in Cerebral and Cerebellar Gray Matter Using In Vivo Diffusion-Weighted MR Spectroscopy at 3T.
Aging Cell
Academic article
Journal publications
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Şimşek, Kadir;
Gallea, Cécile;
Genovese, Guglielmo;
Lehéricy, Stephane;
Branzoli, Francesca;
Palombo, Marco.
(2025)
Age-Trajectories of Higher-Order Diffusion Properties of Major Brain Metabolites in Cerebral and Cerebellar Gray Matter Using In Vivo Diffusion-Weighted MR Spectroscopy at 3T.
Aging Cell
Academic article
Outreach
2024
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Popular scientific lectureGenovese, Guglielmo. (2024) Unlocking the Brain: How MR Can Help Treat Migraines. Hodepine Norge Hodepineaften , Trondheim, St. Olavs hospital 2024-09-05 -
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PosterNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A personalized in vitro metabolic model of preclincal Alzheimer's disease. Trondheim fMRI group, MiDT national research centre, St. Olav's Hospital, and Department of Neuromedicine and Movement Science, NTNU The Aging Brain Conference , Union Hotel Geiranger 2024-06-12 - 2024-06-14
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Academic lectureNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A Personalized in vitro Metabolic Model of Preclinical Alzheimer’s Disease. ICBEM 15th International Conference on Brain Energy Metabolism (ICBEM) , Grand Hotel Union in Ljubljana, Slovenia 2024-09-17 - 2024-09-21