Guglielmo Genovese
About
Guglielmo Genovese, PhD, is an Associate Professor at NTNU, affiliated with Norwegian Centre for Headache Research (NorHEAD). He holds a background in physics, which he has applied to neuroscience through advanced imaging and spectroscopy. He earned his PhD in neuroscience from Sorbonne University, conducting research at the Paris Brain Institute. He then completed a four-year postdoctoral fellowship at the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota, a global leader in ultra-high-field MR imaging and spectroscopy.
His research focuses on the development and application of advanced magnetic resonance spectroscopy (MRS) techniques, with a particular emphasis on uncovering neurochemical mechanisms underlying neurological conditions, including primary headache disorders. He is currently building a multidisciplinary research group dedicated to advancing non-invasive neurochemical imaging for clinical and translational neuroscience.
He has authored over 10 peer-reviewed publications in the fields of neuroimaging, neurometabolism, and MRS methodology. Notable works include:
-
Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7T
-
Quantification of GABA concentration measured noninvasively in the human posterior cingulate cortex with 7T ultra-short-TE MR spectroscopy
-
Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling
He is a recipient of the prestigious Onsager Fellowship and a member of NTNU’s Outstanding Academic Fellow Programme. He also serves on the board of HUMANI as Infrastructure Strategy Lead, contributing to the development of integrated research infrastructure at the intersection of healthcare, neuroscience, and artificial intelligence.
His work bridges clinical neuroscience, advanced imaging technology, and translational medicine to foster biomarker discovery and precision treatment in neurology.
Research
Guglielmo Genovese leads and contributes to several collaborative research projects:
-
CGRP-mAb Project (NorHEAD): Investigating hypothalamic neurochemical signatures associated with treatment response to CGRP-monoclonal antibodies in chronic migraine using 7T MRS.
-
Hyperexcitability in Chronic Migraine (NorHEAD): Exploring cortical excitatory/inhibitory balance and its role in migraine chronicization.
-
MACROMAP: Developing multimodal imaging and machine learning pipelines to analyze brain macrostructure, aiming to identify neurodegenerative patterns relevant to dementia and aging.
-
Metabolic Platform for Brain Disease Research (Trønderbrain): Utilizing MRS and patient-derived organoids to investigate metabolic and epigenetic changes in neurodegenerative diseases such as Alzheimer’s.
Publications
A Maiuro, M Palombo, E Macaluso, G Genovese, M Bozzali, F Giove, S Capuani; New functional MRI experiments based on fractional diffusion representation show independent and complementary contrast to diffusion-weighted and blood-oxygen-level-dependent functional MRI; Applied Sciences (2025); doi: 10.3390/app15094930.
L Hingerl, B Strasser, S Schmidt, K Eckstein, G Genovese, E Auerbach, A Grant, M Waks, P Lazen, A Sadeghi-Tarakameh, G Hangel, F Niess, Y Eryaman, G Adriany, G Metzger, W Bogner, M Marjańska, “Exploring In Vivo Human Brain Metabolism at 10.5 T: Initial Insights from MR Spectroscopic Imaging”, NeuroImage (2025); doi: 10.1016/j.neuroimage.2025.121015.
G Genovese, M Terpstra, P Filip, S Mangia, J McCarten, L Hemmy, and M Marjańska; Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7 T; Magnetic Resonance in Medicine (2024); doi: 10.1002/mrm.30061.
C Ligneul, C Najac, A Döring, F Branzoli, W Clarke, C Cudalbu, G Genovese, S Jbabdi, I Jelescu, R Kreis, H Lundell, M Marjańska, H Moeller, J Mosso, E Mougel, S Ruschke, K Simsek, F Szczepankiewicz, G Oeltzschner, M Palombo, I Ronen, J Valette, “Diffusion-weighted MR spectroscopy: consensus, recommendations and resources from acquisition to modelling”, Magnetic Resonance in Medicine (2024); doi: 10.1002/mrm.29877.
K Şimşek, C Gallea, G Genovese, S Lehéricy, F Branzoli, M Palombo; Age-trajectories of higher-order diffusion properties of major brain metabolites in cerebral and cerebellar grey matter using in vivo diffusion-weighted MR spectroscopy at 3T; Aging Cell (2024); doi: 10.1111/acel.14477.
A Jain, A Rørnes, A Farestveit, M Grinde, A Nyman, B Sitter, E Tronvik, T Meisingset, G Genovese; Higher thalamic myo-Inositol measured at 7T using 1H-MR spectroscopy suggests novel mechanisms in chronic cluster headaches; Abstract from the 18th European Headache Congress (2024)
C Özütemiz, M White, W Elvendhal, Y Eryaman, G Metzger, R Patriat, N Harel, M Marjańska, J Kulesa, A Grant, G Genovese, Z Cyaci; Clinical Neuroradiology Applications of 7T MRI: Indications, Sequence Parameters, Pitfalls, and Solutions. A Single-Center Clinical Experience; American Journal of Roentgenology (2023); doi:10.2214/AJR.23.29342.
G Genovese, D Deelchand, M Terpstra, M Marjańska; Quantification of GABA concentration in human brain from 7-T ultra-short-TE MR spectra; Magnetic Resonance in Medicine (2023); doi:10.1002/mrm.29514
G Genovese, B Diaz-Fernandez, F Lejeune, I Ronen, M Marjańska, L Cherif, S Lehericy, F Branzoli, C Rosso; Longitudinal monitoring of microstructural alterations in cerebral ischemia by in vivo diffusion-weighted magnetic resonance spectroscopy; Radiology (2022); doi: 10.1148/radiol.220430.
G Genovese, M Palombo, M Santin, J Valette, C Ligneul, M Aigrot, N Abdoulkader, D Langui, A Millecamps, A Baron-Van Evercooren, B Stankoff, S Lehericy, A Petier, F Branzoli; Inflammation-driven glial alterations in the cuprizone mouse probed with diffusion-weighted magnetic resonance spectroscopy at 11.7 T; NMR in Biomedicine (2021); doi: 10.1002/nbm.4480.
G Genovese, M Marjańska, E J Auerbach, L Yahia Cherif, I Ronen, S Lehéricy, F Branzoli; In vivo diffusion-weighted MRS using semi-LASER in the human brain at 3 T: methodological aspects and clinical feasibility; NMR in Biomedicine (2021); doi: 10.1002/nbm.4206.
2025
-
Maiuro, Alessandra;
Palombo, Marco;
Macaluso, Emiliano;
Genovese, Guglielmo;
Bozzali, Marco;
Giove, Federico.
(2025)
New Functional MRI Experiments Based on Fractional Diffusion Representation Show Independent and Complementary Contrast to Diffusion-Weighted and Blood-Oxygen-Level-Dependent Functional MRI.
Applied Sciences
Academic article
Journal publications
-
Maiuro, Alessandra;
Palombo, Marco;
Macaluso, Emiliano;
Genovese, Guglielmo;
Bozzali, Marco;
Giove, Federico.
(2025)
New Functional MRI Experiments Based on Fractional Diffusion Representation Show Independent and Complementary Contrast to Diffusion-Weighted and Blood-Oxygen-Level-Dependent Functional MRI.
Applied Sciences
Academic article
Teaching
MEDT8011/FY8408 - Introduction to MR Imaging - Guest Lecturer
FIS/07 - Medical imaging techniques: principles and applications - Guest Lecturer (Università degli Studi di Verona; Italy)
Supervision
Guglielmo Genovese, PhD, is currently main supervisor for 1 PhD student at PHMEDT (Medical Technology)
He is also main supervisor for 1 Master's student MSMOLMED (Molecular Medicine) and 2 Erasmus Master's students.
Outreach
2024
-
Popular scientific lectureGenovese, Guglielmo. (2024) Unlocking the Brain: How MR Can Help Treat Migraines. Hodepine Norge Hodepineaften , Trondheim, St. Olavs hospital 2024-09-05 -
-
PosterNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A personalized in vitro metabolic model of preclincal Alzheimer's disease. Trondheim fMRI group, MiDT national research centre, St. Olav's Hospital, and Department of Neuromedicine and Movement Science, NTNU The Aging Brain Conference , Union Hotel Geiranger 2024-06-12 - 2024-06-14
-
Academic lectureNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A Personalized in vitro Metabolic Model of Preclinical Alzheimer’s Disease. ICBEM 15th International Conference on Brain Energy Metabolism (ICBEM) , Grand Hotel Union in Ljubljana, Slovenia 2024-09-17 - 2024-09-21
-
Academic lectureJain, Avneesh; Rørnes, Anna Xiu; Farestveit, Anne; Grinde, Maria; Nyman, Axel Karl Gottfrid; Sitter, Beathe. (2024) Higher thalamic myo-Inositol measured at 7Tesla suggests novel mechanisms in chronic cluster headaches. European Society for Magnetic Resonance in Medicine and Biology 40th Annual Scientific Meeting 2024-10-02 - 2024-10-05
-
PosterJain, Avneesh; Rørnes, Anna Xiu; Farestveit, Anne; Grinde, Maria; Nyman, Axel Karl Gottfrid; Sitter, Beathe. (2024) Higher thalamic myo-Inositol measured at 7T using 1H-MR spectroscopy suggests novel mechanisms in chronic cluster headaches. 18th European Headache Concgress 2024-12-04 - 2024-12-07