Ingrid Eftedal
Ingrid Eftedal
Senior scientist / research group leader
Department of Circulation and Medical Imaging Faculty of Medicine and Health SciencesBackground and activities
Senior researcher and research group leader in barophysiology / baromedicine at NTNU's Department of Circulation and Medical Imaging. I have previously worked as a postdoc at the Ecole Supérieure de Biotechnologie de Strasbourg, molecular biologist at Rigshospitalet København, head of the Department of Medical Genetics at St Olav’s Hospital and vice dean for research at the Faculty of Nursing and Health Sciences, Nord University and been a member of the Forensic Medicine Commission and the preimplantation genetic diagnosis (PGD) Committee.
Our research group focuses on physiological and pathophysiological responses to extreme environments. The goal is to contribute research-based knowledge that can prevent health damage to divers and others who stay in physically challenging environments and contribute to correct diagnosis and treatment when injury occurs. Our research also contributes to a better understanding of the complex processes that help determine how the human body responds to environmental changes in a broader sense.
A significant part of our research is linked to professional diving offshore, where Norway has an ambition to be a world leader in health, safety, and environments. Professional diving has been important in the oil and gas industry for many decades, and is just as important today when the activity turns towards renewable energy sources where divers are central in the establishment and maintenance of offshore facilities for e.g., wind and wave power.
Editor for "Survival in Extreme Environments - Adaptation or Decompensation?" Volumes 1 and 2, which addresses the biology of reactions to extreme environmental exposure, and "Women in Environmental Physiology", which highlights contributions of female researchers as well as studies of female physiology.
Some examples of societal benefits of baromedical research:
From AlphaGalileo (2021) Major breakthrough in research on decompression sickness
From BBC Future (2019) Can you survive if you run out of air?
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
Journal publications
- (2022) A Work Environment Under Pressure: Psychosocial Job Demands and Resources Among Saturation Divers. Frontiers In Public Health.
- (2022) Editorial: Survival in extreme environments – adaptation or decompensation. Frontiers in Physiology. vol. 13.
- (2021) The Assessment of Daily Energy Expenditure of Commercial Saturation Divers using Doubly Labelled Water. Frontiers in Physiology. vol. 12.
- (2021) Effects of Cold Decompression on Hemodynamic Function and Decompression Sickness Risk in a Dry Diving Rat Model. Frontiers in Physiology. vol. 12.
- (2021) Acute effects on the human peripheral blood transcriptome of decompression sickness secondary to scuba diving. Frontiers in Physiology. vol. 12.
- (2021) Functional profiling reveals altered metabolic activity in divers’ oral microbiota during commercial heliox saturation diving. Frontiers in Physiology. vol. 12.
- (2021) Shifts in the oral microbiota during a four-week commercial saturation dive to 200 meters. Frontiers in Physiology.
- (2021) Using salivary biomarkers for stress assessment in offshore saturation diving: A pilot study. Frontiers in Physiology. vol. 12.
- (2020) Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats. Scientific Reports. vol. 10.
- (2020) Extensive simulated diving aggravates endothelial dysfunction in male pro-atherosclerotic ApoE knockout rats. Frontiers in Physiology.
- (2020) Continuous Hemodynamic Monitoring in an Intact Rat Model of Simulated Diving. Frontiers in Physiology. vol. 10.
- (2019) A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females. Frontiers in Physiology. vol. 10.
- (2019) Commercial divers’ subjective evaluation of saturation. Frontiers in Psychology. vol. 9.
- (2019) Hemoglobin during and following a 4-week commercial saturation dive to 200 me. Frontiers in Physiology. vol. 10:1494.
- (2018) Immunity under pressure: Determining immune and inflammatory responses to the environments in diving. Cryobiology. vol. 81.
- (2018) Hemoglobin and Erythropoietin After Commercial Saturation Diving. Frontiers in Physiology. vol. 9.
- (2018) Blood gene expression and vascular function biomarkers in professional saturation diving. Frontiers in Physiology. vol. 9.
- (2017) Evolution of the plasma proteome of divers before and after a single SCUBA dive. PROTEOMICS - Clinical Applications. vol. 11 (9-10).
- (2017) Evolution of the plasma proteome of divers before and after a single SCUBA dive. PROTEOMICS - Clinical Applications. vol. 11 (9-10).
- (2016) Age, weight and decompression sickness in rats. Archives of Physiology and Biochemistry. vol. 122 (2).
- (2016) Diving into the rat plasma proteome to get to the bottom of decompression sickness. PROTEOMICS - Clinical Applications.
- (2016) Immune and inflammatory responses to freediving calculated from leukocyte gene expression profiles. Physiological Genomics. vol. 48 (11).
- (2015) The aging diver: endothelial biochemistry and its potential implications for cardiovascular health. Diving and Hyperbaric Medicine. vol. 45 (4).
- (2015) Evaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric air. Physiological Reports. vol. 3:e12537 (6).
- (2014) Eccentric exercise 48 h prior to simulated diving has no effect on vascular bubble formation in rats. European Journal of Applied Physiology. vol. 115 (3).
- (2013) Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers. Physiological Genomics. vol. 45 (20).
- (2013) Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving. Physiological Reports. vol. 1 (6).
- (2013) Exercise-induced myofibrillar disruption with sarcolemmal integrity prior to simulated diving has no effect on vascular bubble formation in rats. European Journal of Applied Physiology. vol. 113 (5).
- (2012) Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional mutlicentre study. European Journal of Clinical Pharmacology. vol. 68 (1).
- (2012) Prior eccentric exercise modifies diving-induced inflammatory gene expression in rats. The FASEB Journal. vol. 26.
- (2012) Early genetic responses in rat vascular tissue after simulated diving. Physiological Genomics. vol. 44 (24).
- (2002) Diagnostikk av numeriske kromosomavvik ved hjelp av fluorescerende mikrosatelitt-analyser Detection of numerical abnormalities by fluorescent microsatellite analysis. Bioingeniøren.
- (2001) Embryonic stem cells and therapeutic cloning. Tidsskrift for Den norske legeforening. vol. 121 (20).
- (2001) Single intragenic microsatellite preimplantation genetic diagnosis for cystic fibrosis provides positive allele identification of all CFTR genotypes for informative couples. Molecular human reproduction. vol. 7 (3).
- (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics, Society and Policy.
- (1996) Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics. vol. 36.
- (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Biochemical and Biophysical Research Communications - BBRC.
- (1996) Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16. Biochemical and Biophysical Research Communications - BBRC. vol. 224.
- (1995) Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots. FEBS Letters. vol. 362.
- (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry. vol. 34.
- (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR). vol. 21 (9).
- (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry. vol. 211.
Books
- (2022) Survival in Extreme Environments - Adaptation or Decompensation?, Volume 1. Frontiers Media S.A.. 2022. ISBN 978-2-88974-590-6.
Report/dissertation
- (1993) Heterogeneity in the incorporation and excision of uracil in DNA. 1993. ISBN 82-7119-591-3. Doktor ingeniøravhandling (1993:12).
- (1989) Automatization of pressure chamber : Monitoring & control of hyperbaric environment for animalresearch. 1989.
Others
- (2022) Kristin holdt pusten i 5 minutter og 18 sekunder: - Tenker alltid på det samme. Budstikka [Avis]. 2022-04-10.
- (2022) Dette velkjente dykke-fjeset er helt unødvendig. Forskning.no [Internett]. 2022-04-26.
- (2021) Baromedisinsk forskning i Petromaks2 programmet: Hva vi får til når forskere, industrien og dykkerne samarbeider. Årsmøte Norsk Baromedisinsk Forening . Norsk Baromedisinsk Forening; Zoom. 2021-04-12.
- (2021) Bobler i blod og glass - populærvitenskap om trykkfallssyke. Dykkeklubben Draugen ; Trondheim. 2021-11-20.
- (2021) Foredrag med Ingrid Eftedal om dykkersyken og immunforsvaret. NTNUI Dykkergruppa . NTNUI Dykkergruppa; Gløshaugen. 2021-10-20.
- (2021) Update on research - NTNU Summary of "Long term project". Bergen International Diving Seminar 2021 . Norsk Undervannsintervensjon; Bergen. 2021-11-09 - 2021-11-10.
- (2021) NTNU-forsker med på stort gjennombrudd: Vet hvorfor dykkersyke oppstår. NRK Viten [Internett]. 2021-08-30.
- (2021) Skal forske på dykkersyke. NRK Trøndelag [Radio]. 2021-07-15.
- (2021) Gjennombrudd i forskning om dykkersyke. NRK Ekko [Radio]. 2021-09-22.
- (2021) Gjennombrudd i forskning på dykkersyke. Teknisk Ukeblad [Fagblad]. 2021-09-06.
- (2021) Stort gjennombrudd i forskning på dykkersyke. Forskning.no [Internett]. 2021-08-30.
- (2021) Forsker på dypvannsdykkere. NRK Trøndelag [Radio]. 2021-08-23.
- (2020) Gene Expression in Decompression Sickness secondary to Underwater Compressed Gas Diving. 2020 UHMS Annual Scientific Meeting . Underwater and Hyperbaric Medicine Society; San Diego. 2020-06-17 - 2020-06-20.
- (2019) Age associated endothelial function and cardiovascular health in divers: rat model. Årsmøte Norsk Baromedisinsk Forening . Norsk Baromedisinsk Forening; Haukeland Universitetssjukehus. 2019-04-05.
- (2019) Current Baromedical Research at NTNU. Årsmøte Norsk Baromedisinsk Forening . Norsk Baromedisinsk Forening; Haukeland Universitetssjukehus. 2019-04-05.
- (2019) Research for saturation diving - European universities in Collaboration with Equinor and TechnipFMC. Bergen International Diving Seminar . Norsk Undervannsintervensjon; Bergen. 2019-11-13 - 2019-11-14.
- (2019) Can you survive if you run out of air?. BBC Future [Internett]. 2019-04-23.
- (2019) Proteomics applied to decompression sickness: finding a new biomarker of DCS early development. Annual Meeting of the EUBS . European Underwater and Baromedical Society; Tel Aviv. 2019-09-09 - 2019-09-13.
- (2019) Hemoglobin status during and after commercial saturation diving. Årsmøte Norsk Baromedisinsk Forening . Norsk Baromedisinsk Forening; Haukeland Universitetssjukehus. 2019-04-05.
- (2019) Investigation of oral microbiome in commercial saturation diving. Annual Meeting of the EUBS . European Underwater and Baromedical Society; Tel Aviv. 2019-09-09 - 2019-09-13.
- (2018) Endothelial function and cardiovascular stress markers in ApoE knockout rats after a single simulated heliox dive. 2nd Tricontinental Scientific Conference on Diving and Hyperbaric Medicine . EUBS, SPUMS, SAUHMA and the Scott Haldane Foundation; Durban. 2018-09-23 - 2018-09-29.
- (2018) Scuba Diving and Life Expectancy. The Alert Diver, Expert Opinions [Internett]. 2018-07-31.
- (2018) Grunnleggende biologiske mekanismer i akklimatisering til dykking. Yrkesdykkerkonferansen 2018 . Norsk Undervannsintervensjon; Bergen. 2018-11-13 - 2018-11-14.
- (2018) Metningsdykkere har mye å lære oss om miljøtilpassing.
- (2018) EFFECTS OF A COMMERCIAL SATURATION DIVE ON HEMOGLOBIN AND ERYTHROPOIETIN LEVELS. 2nd Tricontinental Scientific Conference on Diving and Hyperbaric Medicine . EUBS, SPUMS, SAUHMA and the Scott Haldane Foundation; Durban. 2018-09-23 - 2018-09-29.
- (2017) Endothelial function and cardiovascular stress markers after a single dive in aging rats (ApoE knockout rats). NORDIC PhD SUMMIT "Health Sciences Across Borders" . NorDoc - Nordic Doctoral Training in Health Sciences; Karolinska Institutet, Stockholm. 2017-08-21 - 2017-08-22.
- (2017) 2016 DAN/R.W. “Bill” Hamilton Memorial Dive Medicine Research Grant. Ingrid Eftedal Braves the North Seas for Blood Studies.
- (2017) IMMUNITY UNDER PRESSURE: determining immune and inflammatory responses to the environments in diving. The Global Summit on Organ Banking through Converging Technologies ; Harvard Medical School, Boston. 2017-08-03 - 2017-08-06.
- (2017) Modelling immune and inflammatory responses in human diving. Norsk Fysiologisk Forening - The Winter Meeting 2017 . Norsk Fysiologisk Forening; Hafjell. 2017-02-04.
- (2017) 5 spørsmål om DNA. Teknisk Ukeblad [Fagblad]. 2017-09-19.
- (2017) The outcome of saturation diving on endothelial function and biomarkers of vascular health in professional offshore divers (2017). 43rd Annual Meeting of the European Underwater and Baromedical Society . The European Underwater and Baromedical Society; Ravenna. 2017-09-13 - 2017-09-17.
- (2017) Asking the Right Questions: Ingrid Eftedal researcher profile. Alert Diver Magazine [Fagblad]. 2017-03-01.
- (2016) Dykkeforskning på NTNUs medisinske fakultet: Internasjonal forskningsfront og sentrale emner for videre forskning innen HMS i dagens offshoredykking. Dialogmøte for HMS-forskning i Petromaks . Norges Forskningsråd; Oslo. 2016-04-20.
- (2016) Dykking endrer immunforsvaret. Observasjoner og tanker om konsekvenser. Norsk Baromedisinsk Forening, Julemøte 2016 . Norsk Baromedisinsk Forening; Bergen. 2016-12-02.
- (2016) Dykking og immunforsvaret. Hva Skjer'a - ISBs interne seminarserie . Institutt for sirkulasjon og bildediagnostikk, NTNU; NTNU Trondheim. 2016-12-13.
- (2016) Hjerte- og karhelse hos nordsjødykkere. Norges Forskningsråd / Petromaks2 "HMS til frokost" . Norges Forskningsråd; Clarion Energy Hotel / Offshore North Sea (ONS) Stavavanger. 2016-08-31.
- (2016) Ongoing Research in baromedicine at NTNU. Faggruppemøte Aarhus Universitetet . Aarhus Univ, Inst for Klinisk Medicin - Comparative Medicine; Aarhus. 2016-09-01.
- (2016) The peripheral blood transcriptome reflects leukocyte fractions and activity: applications in diving. 42nd Annual Scientific Meeting of the EUBS . European Underwater & Baromedical Society; Geneva. 2016-09-13 - 2016-09-16.
- (2016) What the immune system is up to while you’re holding your breath.
- (2016) The outcome of saturation diving on endothelial function and biomarkers of vascular health in professional offshore divers. 42nd Annual Scientific Meeting of the EUBS . European Underwater & Baromedical Society; Geneva. 2016-09-13 - 2016-09-16.
- (2015) Fitness to dive. NUI International Diving Seminar . Norsk Undervannsintervensjon; Bergen. 2015-11-25 - 2015-11-26.
- (2015) Decompression sickness after a chamber dive to 18 msw for 100 min. UHMS . UHMS; Montreal. 2015-06-18 - 2015-06-20.
- (2014) Acclimation to SCUBA diving. Fagmøte barofysiologi ; Université de Bretagne Occidentale. 2014-10-23 - 2014-10-24.
- (2014) Keynote Lecture: Diving physiology and acclimation to decompression stress. Canadian Chapter of the Undersea and Hyperbaric Medical Society Annual Symposium . Canadian Chapter of the Undersea and Hyperbaric Medical Soci; Quebec City. 2014-10-17 - 2014-10-18.
- (2014) Blodmålinger fra trykkammerstudie. Oppsummeringsmøte for studien Gjentatte dykk: effekter på hjerte- karsystemet . NTNU gruppe for barofysiologi; NTNU Vitenskapsmuseet. 2014-05-13 - 2014-05-13.
- (2013) Bruk av genomverktøy i barofysiologisk forskning. Høstmøte Norsk Baromedisinsk Forening . Norsk Baromedisinsk Forening; Ullevål Sykehus, Oslo. 2013-10-04 - 2013-10-04.
- (2013) Fitness to dive. Fellesmøte Pingvin Sportsdykkerklubb og Statoil BIL . Pingvin Sportsdykkerklubb; Trondheim. 2013-11-05 - 2013-11-05.
- (2013) Fitness to dive - a translational approach to physiological challenges in the hyperbaric working environment. Presentasjon av nye prosjekter for HMS-kompetansegruppen i PETROMAKS 2 . Norges forskningsråd; Stavanger. 2013-10-16 - 2013-10-16.
- (2013) Fitness to dive: A physiological research project into the health of underwater workers. NUI international diving seminar 2013 . Norwegian Underwater Intervention; Bergen. 2013-11-20 - 2013-11-21.
- (2013) Taking the plunge. International Innovation [Internett]. 2013-03-01.
- (2013) Applying genomics tools in studies of barophysiology. Tricontinental meeting on diving and hyperbaric medicine . European Underwater and Baromedical Society; Ile de la Reunion. 2013-09-23 - 2013-09-28.
- (2013) Vil komme til bunns i dykkersykemysteriet. NRK Viten [Internett]. 2013-08-30.
- (2012) Anvendt fysiologi i ekstreme miljøer: genuttrykksstudier av vaskulære effekter av dykking. Årlig molekylærmedisinseminar St. Olavs Hospital . Avdeling for patologi og medisinsk genetikk; St. Olavs Hospital. 2012-01-25 - 2012-01-25.
- (2012) Dykkermedisinske erfaringer fra PETROMAKS-prosjektene ved NTNU. HMS-forskning i petroleumsindustrien . Norges forskningsråd; Stavanger. 2012-03-15 - 2012-03-15.
- (2012) Fra frø til baby. Salaby /Gyldendal Norsk Forlag [Internett]. 2012-02-03.
- (2010) Plasminogen activator inhibitor protein is a biomarker of decompression stress in rats. 36th Annual Meeting of the European Underwater and Baromedical Society . European Underwater and Baromedical Society; Istanbul. 2010-09-14 - 2010-09-18.
- (2010) HYPERBARIC OXYGEN PREBREATHING DOES NOT REDUCE VASCULAR BUBBLE FORMATION IN DECOMPRESSED RATS. 36th Annual Meeting of the European Underwater and Baromedical Society . the European Underwater and Baromedical Society; Istanbul. 2010-09-14 - 2010-09-18.
- (1996) Inactivation of the mouse 3-methyladenine DNA glycosylase gene by homologous recombination. Annual Meeting of the Norwegian Biochemical Society, annual meeting ; Geilo, Norway. 1996-01-01.