Background and activities
Head of the Department of Geriatrics, St Olav hospital and associate professor, Department of Neuroscience, Norwegian, University of Science and Technology (NTNU).
I completed medical studies in 1987 and specialties in internal medicine and geriatric medicine in 2000. My thesis "Treatment of acutely sick, frail elderly patient in a geriatric evaluation and management unit. Results from a prospective randomised study" was defended in 2006.
I have comprehensive experience in clinical work with hospitalised geriatric patients and assessment of outclinic geriatric patients.
For many years, I have been teaching medical students at NTNU and I have also been teaching other students, health care professionals and public groups.
My thesis was a randomised study showing that acutely sick geriatric patients had benefit from treatment in an acute geriatric ward as compared to medical wards. Later we have also shown that home-dwelling hip fracture patients had benefit from treatment in a geriatric ward as compared to an orthopaedic ward, and that the treatment was cost-efficient. These results were published in the Lancet.
The main research focus now is on elderly patients with cognitive impairment:
In PADR (Progression of Alzheimers disase and use of Rescources) factors of importance for disease progression among patients with dementia and Alzheimers disease is studied, about 400 patients are followed 2 years after diagnostic work-up. PADR is conducted in collaboration with Department of Geriatrics, St Olavs hospital, Memory clinics at the Oslo university hospital and Old age psychiatry at Innlandet hospital trust. Two phd and three postdoc students are working on the study. Our main focus will be vascular aspects of disease progression.
Nor-COAST (Norwegian Cognitive Impairment After Stroke Study) is a multi centre study funded by the National Health association A total of 828 stroke patients are included at 6 different hospitals and cognitive function will be assessed up to 18 months after a stroke. Patient recruitment was completed spring 2017. I initiated the study, and I am principal investigator. There are 4 phd-students, 2 postdoc students, 1 reseracher and several masterstudents working on Nor-COAST.
I am also collaborating in other studies: i) association between delirium and movement in the DeMo (Delirium and Movement) study ii) in the DYNAMICS study focusing on physical activity among persons with cognitive impairment, iii) epidemiologic studies on mechanisms for developing dementia in the HUNT study iv)genetic aspects of dementia in the DemGene study v) in the EU study PreventIT focusing on an app aiming at increasing level of physical activity
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2019) Delirium og kognitiv svikt blant eldre i norske akuttmottak. Tidsskrift for Den norske legeforening. vol. 139 (6).
- (2019) Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics. vol. 51 (3).
- (2018) Cortisol levels among older people with and without depression and dementia. International psychogeriatrics.
- (2018) Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics. BMC Geriatrics. vol. 18:120.
- (2018) Environmental factors and risk of delirium in geriatric patients: An observational study. BMC Geriatrics. vol. 18 (1).
- (2018) The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway. Immunity & Ageing. vol. 15 (4).
- (2018) The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study. BMC Neurology. vol. 18:193.
- (2018) Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. vol. 8.
- (2017) Trajectories of depressive symptoms and their relationship to the progression of dementia. Journal of Affective Disorders. vol. 222.
- (2017) Progression of Alzheimer's disease: A longitudinal study in Norwegian memory clinics. Journal of Alzheimer's Disease. vol. 61 (3).
- (2017) Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database of Systematic Reviews. vol. 2017 (9).
- (2017) Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study. Alzheimer's Research & Therapy. vol. 9 (1).
- (2017) Patterns of drug prescriptions in an orthogeriatric ward as compared to orthopaedic ward: results from the Trondheim Hip Fracture Trial?a randomised clinical trial. European Journal of Clinical Pharmacology. vol. 73 (8).
- (2017) Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients. BMC Geriatrics. vol. 17 (210).
- (2017) Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. vol. 44 (1-2).
- (2017) MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis. PLoS ONE. vol. 12 (10).
- (2016) One-year health and care costs after hip fracture for home-dwelling elderly patients in Norway: Results from the Trondheim Hip Fracture Trial. Scandinavian Journal of Public Health. vol. 44 (8).
- (2016) Who benefits from orthogeriatric treatment? Results from the Trondheim hip-fracture trial. BMC Geriatrics. vol. 16:49 (1).
- (2016) The long-term effect of comprehensive geriatric care on gait after hip fracture: the Trondheim Hip Fracture Trial—a randomised controlled trial. Osteoporosis International. vol. 27 (3).
- (2015) Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway. European Journal of Epidemiology. vol. 30 (9).