Background and activities
I am Head of the Department of Geriatrics, St Olav hospital and professor at the Department of Neuromedicine and movement science, Norwegian, University of Science and Technology (NTNU).
I completed medical studies in 1987 and specialties within internal medicine and geriatric medicine in 2000. My thesis "Treatment of acutely sick, frail elderly patient in a geriatric evaluation and management unit. Results from a prospective randomised study" was defended in 2006 at NTNU.
I have comprehensive experience in clinical work with geriatric patients referred to the hospital.
For many years, I have been teaching medical students at NTNU and I have also been teaching other students, health care professionals and public groups.
My research has focused mainly on comprehensive geriatric assessment and cognitive impairment (dementia and delirum) in the elderly. My thesis was a randomised study showing that acutely sick geriatric patients had benefit from treatment in an acute geriatric ward as compared to medical wards. Later we have also shown that home-dwelling hip fracture patients had benefit from treatment in a geriatric ward as compared to an orthopaedic ward, and that the treatment was cost-efficient. These results were published in the Lancet. We have now one ongoing study in collaboration with Innlandet hospital trust (PI is professor Marit Slaaen Jordhøy). In the cluster-randomised pilot study we investigate elderly cancer patients who get radiotherapy. In the LAST-long study we study follow-up of stroke patients and if functional decline can be prevented by offering geriatric assessment and a personilsed follow-up (PI is professor Torunn Askim).
In my research on elderly patients with cognitive impairment I have been involved in studies on progression of Alzheimers disease, acute delirium, risk factors for dementia and the association between cognition and motoric function. We are also part of the NorKOG network and recruiting patients being assessed for cognitive impairment and thereby also in the DemGene study that is focusing on genetics and dementia.
I am principal investigator of the Nor-COAST (Norwegian Cognitive Impairment After Stroke Study) is a multi centre study funded by the National Health association A total of 815 stroke patients are included at 5 different hospitals and are folllowed for three years, data collection will be finished in March 2020. 2017. There are several phd-students and postdocs and we expect several papers published in peer reviewed journals.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2022) New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics. vol. 54 (4).
- (2022) Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: the updated SMART2 algorithm. European Heart Journal.
- (2022) Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease. Translational Psychiatry. vol. 12.
- (2022) Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke?. BMC Geriatrics. vol. 22 (1).
- (2022) Associations between Measured and Patient-Reported Physical Function. Healthcare. vol. 10 (5).
- (2021) The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study. Frontiers in Neurology. vol. 12.
- (2021) Predicting the Emergence of Major Neurocognitive Disorder Within Three Months After a Stroke. Frontiers in Aging Neuroscience. vol. 13.
- (2021) Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study. BMC Neurology. vol. 21 (1).
- (2021) Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC Neurology. vol. 21 (1).
- (2021) Orthogeriatrics prevents functional decline in hip fracture patients: report from two randomized controlled trials. BMC Geriatrics. vol. 21 (208).
- (2021) Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications. vol. 12.
- (2021) Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Molecular Psychiatry. vol. 26.
- (2021) Associations between post-stroke motor and cognitive function: a cross-sectional study. BMC Geriatrics. vol. 21.
- (2021) The delirium screening tool 4AT in routine clinical practice: prediction of mortality, sensitivity and specificity. European Geriatric Medicine. vol. 12.
- (2021) Risk Stratification in Patients with Ischemic Stroke and Residual Cardiovascular Risk with Current Secondary Prevention. Clinical Epidemiology. vol. 13.
- (2021) The human brain representation of odor identification in amnestic mild cognitive impairment and Alzheimer's dementia of mild degree. Frontiers in Neurology. vol. 11.
- (2021) Geriatric assessment with management for older patients with cancer receiving radiotherapy. Protocol of a Norwegian cluster-randomised controlled pilot study. Journal of Geriatric Oncology.
- (2021) Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study. BMC Neurology. vol. 21 (1).
- (2021) Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatrics. vol. 21:362.
- (2021) Gait, physical function, and physical activity in three groups of home-dwelling older adults with different severity of cognitive impairment - a cross-sectional study. BMC Geriatrics. vol. 21 (1).