Background and activities

Group leader, Integrative Neuroscience Group, Department of Neuromedicine and Movement Science, NTNU

https://www.ntnu.edu/web/inb/sandvig#/view/about

Secretary General and President-Elect of the Norwegian Neuroscience Society (NNS) 

Member: Federation of European Neuroscience Societies (FENS); Society for Neuroscience (SfN); ALBA Network; Translational Neuroscience Clinical-Academic Group for Alzheimer´s Disease 

Research interests

The main research interest of our group is the study and elucidation of neuroplasticity mechanisms in the context of CNS damage and repair. Specifically, we model and investigate dynamic structure-function relationships in neuronal assemblies in healthy and perturbed conditions with the goal of identifying and engaging key aspects of complex neural network behaviour that determine adaptive or maladaptive neuroplasticity in the lesioned CNS, including injury and neurodegenerative disease.

Ongoing research activities focus on CNS lesion modelling through the integration of advanced theoretical concepts and interdisciplinary methods and tools. Apart from in vivo models, we work with in vitro and computational models that recapitulate and exploit fundamental attributes of biological neural networks, including self-organization over time into assemblies of increasing structural complexity, with concomitant emergence of complex functional dynamics.

Our working hypotheses are based on the relevance of specific identifiable network topologies as well as patterns of synaptic transmission for the functional capacity of a network in terms of plasticity, learning, and adaptability and, by the same token, for the initiation and spread of lesion-related pathologies in vivo and in vitro.

These research activities  are coupled to clinical research by our group investigating dynamic neuroplasticity using connectomics and transcriptional analyses. 

Selected publications 2018-date

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

2021

2020

2019

2018