Laurent Thomas

Researcher

Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences

laurent.thomas@ntnu.no

Laboratoriesenteret, 231.05.033, Øya

laurent.thomas@ntnu.no

Researcher at the Unit for Molecular Biology, in the group for Bioinformatics and Gene Regulation, and in the K.G. Jebsen Center for Genetic Epidemiology.

Received a Ph.D. in bioinformatics and trained as a postdoctoral scientist at the Norwegian University of Science and Technology (NTNU), Trondheim. His research interests focus on gene regulation, particularly on single nucleotide polymorphisms, alternative polyadenylation and non-coding RNAs such as microRNAs and circular RNAs, but also genetic variants such as Single Nucleotide Polymorphisms (SNP), particulary SNP funcitonal changes, Genome-wide association studies (GWAS) and genotype quality control (QC).

Scientific, academic and artistic work

A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

Journal publications

Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria. (2021) Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell. vol. 184.
Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik K S; Drange, Ole Kristian; Martinsen, Amy E.; Skogholt, Anne Heidi; Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; Nielsen, Jonas Bille; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Meisingset, Tore Wergeland; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Sealock, Julia; Davis, Lea K.; Pedersen, Nancy L.; Reynolds, Chandra A.; Karlsson, Ida K.; Magnusson, Sigurdur; Stefansson, Hreinn; Thordardottir, Steinunn; Jónsson, Pálmi V.; Snædal, Jon; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Waern, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John Anker Henrik; Athanasiu, Lavinia; Selnes, Per; Saltvedt, Ingvild; Sando, Sigrid Botne; Ulstein, Ingun; Djurovic, Srdjan; Fladby, Tormod; Aarsland, Dag; Selbæk, Geir; Ripke, Stephan; Stefánsson, Kári; Andreassen, Ole; Posthuma, Danielle. (2021) A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics.
Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S. (2020) Mitochondrial genome-wide association study of migraine – the HUNT Study. Cephalalgia. vol. 40 (6).
Johnsen, Marianne Bakke; Magnusson, Karin; Børte, Sigrid; Gabrielsen, Maiken Elvestad; Winsvold, Bendik K S; Skogholt, Anne Heidi; Thomas, Laurent; Storheim, Kjersti; Hveem, Kristian; Zwart, John-Anker. (2020) Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study. Osteoarthritis and Cartilage. vol. 28 (7).
Klarin, Derek; Verma, Shefali Setia; Judy, Renae; Dikilitas, Ozan; Wolford, Brooke N.; Paranjpe, Ishan; Levin, Michael G.; Pan, Cuiping; Tcheandjieu, Catherine; Spin, Joshua M.; Lynch, Julie; Assimes, Themistocles L; Nyrønning, Linn Ålstedt; Mattsson, Erney; Edwards, Todd L.; Denny, Josh C.; Larson, Eric B.; Lee, Ming Ta Michael; Carrell, David S.; Zhang, Yanfei; Jarvik, Gail P.; Gharavi, Ali G.; Harley, John B.; Mentch, Frank D.; Pacheco, Jennifer A.; Hakonarson, Hakon; Skogholt, Anne Heidi; Thomas, Laurent; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Nielsen, Jonas Bille; Zhou, Wei; Fritsche, Lars; Huang, Jie; Natarajan, Pradeep; Sun, Yan V.; DuVall, Scott L.; Rader, Daniel J.; Cho, Kelly; Chang, Kyong-Mi; Wilson, Peter W.F.; O'Donnell, Christopher J.; Kathiresan, Sekar; Scali, Salvatore; Berceli, Scott A.; Willer, Cristen J.; Jones, Gregory T.; Bown, Matthew J.; Nadkarni, Girish; Kullo, Iftikhar J.; Ritchie, Marylyn D.; Damrauer, Scott M.; Tsao, Philip S.. (2020) Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. vol. 142 (17).
Løset, Mari; Thomas, Laurent; Brumpton, Ben Michael; Wolford, Brooke N.; Holmen, Oddgeir; Luetge, Almut; Skogholt, Anne Heidi; Modalsli, Ellen Heilmann; Solvin, Åshild Øksnevad; Fritsche, Lars; Nielsen, Jonas Bille; Zhou, Wei; Gabrielsen, Maiken Elvestad; Saunes, Marit; Willer, Cristen; Hveem, Kristian. (2019) Genome-wide association study of psoriasis suggests a new risk locus on chromosome 10: The HUNT Study. Forum for Nordic Dermato-Venereology. vol. 24 (2).
Stracquadanio, Giovanni; Wang, Xuting; Wallace, Marsha D; Grawenda, Anna M.; Zhang, Ping; Hewitt, Juliet; Zeron-Medina, Jorge; Castro-Giner, Francesc; Tomlinson, Ian P; Goding, Colin R.; Cygan, Kamil J; Fairbrother, William G; Thomas, Laurent; Sætrom, Pål; Gemignani, Federica; Landi, Stefano; Schuster-Böckler, Benjamin; Bell, Douglas A; Bond, Gareth L.. (2016) The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nature Reviews Cancer. vol. 16 (4).
Razick, Sabry; Mocnik, Rok; Thomas, Laurent; Ryeng, Einar; Drabløs, Finn; Sætrom, Pål. (2014) The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences. Database: The Journal of Biological Databases and Curation.
Thomas, Laurent; Sætrom, Pål. (2014) Circular RNAs are depleted of polymorphisms at microRNA binding sites. Bioinformatics. vol. 30 (16).
Thomas, Laurent; Sætrom, Pål. (2012) Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation. PLoS Computational Biology. vol. 8 (8).
Thomas, Laurent; Saito, Takaya; Sætrom, Pål. (2011) Inferring causative variants in microRNA target sites. Nucleic Acids Research (NAR). vol. 39 (16).
Sætrom, Pål; Biesinger, Jacob; Li, Sierra M.; Smith, David; Thomas, Laurent Francois; Majzoub, Karim; Rivas, Guillermo E.; Alluin, Jessica; Rossi, John J.; Krontiris, Theodore G.; Weitzel, Jeffrey; Daly, Mary B.; Benson, Al B.; Kirkwood, John M.; O'Dwyer, Peter J.; Sutphen, Rebecca; Stewart, James A.; Johnson, David; Larson, Garrett P.. (2009) A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated with Breast Cancer Pathogenesis. Cancer Research. vol. 69 (18).

Report/dissertation

Thomas, Laurent. (2012) Effects of single-nucleotide polymorphisms on microRNA-based gene regulation and their association with disease. 2012. ISBN 978-82-471-3932-5. Doktoravhandlinger ved NTNU (2012:307).

Språkvelger

Laurent Thomas

Background and activities

Scientific, academic and artistic work

Journal publications

Report/dissertation

Links