Background and activities
Prof Magnar Bjørås is a Principle Investigator of the research group of Cellular responses to DNA damage at Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim and at Oslo University Hospital/University of Oslo. Bjørås is an expert on genome dynamics with particular emphasis on oxidative stress, DNA base lesion repair and maintenance of epigenetic DNA methylation (epigenome stability).
Cellular genomes are continuously challenged by physical, chemical and biological agents that introduce changes of the chemical structure of the DNA. Intracellular reactive metabolites such as reactive oxygen species and alkylating compounds are important inducers of such changes. Nevertheless, mutation frequencies are low because of very efficient pathways for DNA repair and DNA recombination, which remove DNA damage and conserve at least one functional copy of the genome.
The main focus of the Bjørås group has been on repair of endogenous DNA base lesion repair mechanisms and genome stability. He has made major contributions to characterization of many new DNA repair enzymes from bacteria, yeast and mammalian (i.e. EMBO, 1990; Nature 1992; PNAS 1996; EMBO 1997; MCB 1997; NAR 2002; Nature 2002; JBC 2004; NAR 2005; Mol Micro 2006). He spent two years (2002-2004) in Professor John Tainer’s lab at Scripps Research Institute, California. His research group has solved the atomic structure (3D) of many DNA-protein complexes revealing several new mechanisms of DNA base damage recognition and catalysis (i.e. EMBO 2008; NSMB 2008; NSMB 2009; Cell Structure 2011; Cell Structure 2012; J Struct. Biol 2014). The last 10 years he has established research on the role of DNA base lesion repair in neurodegeneration, cognition and behavior, which is a new direction in the DNA repair field revealing novel functions beyond canonical DNA repair (i.e. Nature 2007; BMC Neurosci 2009; DNA repair 2008; Pediatric Res 2009; Brain Res 2010; Stem Cells 2010; J Neurosci 2011; PNAS 2011; Hum Mol Gen 2012; Cell Reports 2012; Cell Reports 2015). Bjørås has established collaborations with clinicians to study the impact of DNA base lesion repair on diseases such as infections (i.e Blood 2005; Virology 2006; JMB 2008 NAR 2008; PLoSOne 2010; PLoSGen, 2013, Int J Antimic Agents 2015), heart failure (Mutation Res 2009; J Mol Cell Card 2014; DNA repair 2015) metabolic diseases (Mol Genet Metab 2010; J Inherited Met Disease 2012 and 2013, Am J Hum Genet. 2014; Metabolism 2014) and cancer (Carcinogenesis 2009; Blood 2010; Blood 2012; DNA repair 2012).
Molecular mechanisms of DNA base lesion repair (Project leader: Magnar Bjørås)
Role of oxidative DNA base lesion repair in cancer (Project leader: Magnar Bjørås)
Impact of oxidative DNA base lesion repair and epigenetics on brain function (cognition, behavior and neurogenesis) (Project leaders: Magnar Bjørås and Katja Scheffler).
Small peptides in biological responses to DNA damage (Project leaders: Magnar Bjørås and James Booth).
Impact of Oxidation resistance gene 1 (Oxr1) in stress signaling (Project leader: Magnar Bjørås).
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases. vol. 93.
- (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers. vol. 12 (6).
- (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. Viruses.
- (2020) IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity. Computational and Structural Biotechnology Journal. vol. 18.
- (2020) Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis. Nucleic Acids Research.
- (2020) DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease. Free Radical Biology & Medicine.
- (2020) High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting. Catalysis Today.
- (2020) OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. Cell reports. vol. 30 (12).
- (2019) Additive manufacturing of laminar flow cells for single-molecule experiments. Scientific Reports. vol. 9 (1).
- (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses. vol. 11 (10).
- (2019) Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform. PLOS ONE. vol. 14 (11).
- (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology. vol. 10.
- (2019) Generation of a mouse model lacking the non-homologous end-joining factor Mri/Cyren. Biomolecules. vol. 9:798 (12).
- (2019) Expanding the activity spectrum of antiviral agents. Drug Discovery Today. vol. 24 (5).
- (2019) The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience. vol. 22 (4).
- (2019) Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. vol. 10 (1).
- (2019) Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation. Journal of Perinatal Medicine. vol. 47 (1).
- (2019) Diverse functions of DNA glycosylases processing oxidative base lesions in brain. DNA Repair. vol. 81.
- (2019) Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy. Neonatology. vol. 115 (4).
- (2019) Histone methylations define neural stem/progenitor cell subtypes in the mouse subventricular zone. Molecular Neurobiology.