Mara Martin Alonso
+4773598448
Kunnskapssenteret, Øya, Olav Kyrres Gate 10
About
Now hiring!
https://www.nature.com/naturecareers/job/postdoctoral-fellow-in-intestinal-biology-and-colorectal-cancer-norwegian-university-of-science-and-technology-ntnu-767619
About the lab:
Our main scientific goal is to understand how diseases in mucosal surfaces such as the gut are started and develop in time including processes such as intestinal repair and tumorigenesis.
Our laboratory consists of an international team of enthusiastic biologists, with an exciting and extremely good work environment.
https://www.ntnu.edu/cemir/regeneration
About me:
I am currently a Group leader at CEMIR, at the Department of Clinical and Molecular Medicine (IKOM) at NTNU. I did a Bachelor's in Science, Biology, (2009) at the Universidad Complutense de Madrid, and a Master Degree in Molecular Biomedicine (2010) at the Universidad Autonoma de Madrid. After finishing my PhD in 2016 at CNIC (National Center for Cardiovascular Research, Spain) under the supervision of Alicia G.Arroyo, I moved to Norway to work as a postdoc at Menno's Oudhoff group. Here I obtained a Marie Skłodowska-Curie Action Individual Fellowship (MSCA-IF) to study the interplay between the intestinal muscle and stem cells. In 2021, I was awarded the Young Researcher Talent grant, allowing me to start my own group. Our group has recently received funding from the Norwegian Cancer Society.
Lecturing:
MOL3005. Barrier immunity
MOL8009. Barrier tissues immunity, inflammation and regeneration.
Highlighted Journal Articles:
- Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage. Mara Martín-Alonso*, Sharif Iqbal, Pia M. Vornewald, Håvard T. Lindholm, Mirjam J. Damen, Fernando Martínez, Sigrid Hoel, Alberto Díez-Sánchez, Maarten Altelaar, Pekka Katajisto, Alicia G. Arroyo & Menno J. Oudhoff*. Nat Commun 12, 6741 (2021).*Corresponding authors.
- Intestinal-epithelial LSD1 controls goblet cell differentiation and effector responses required for gut immunity to bacterial and helminth infection. Naveen Parmar; Kyle Burrows; Pia Vornewald; Håvard T. Lindholm; Rosalie T. Zwiggelaar; Alberto Díez-Sanchez; Mara Martín-Alonso; Madeleine Fosslie; Bruce Vallance; John Arne Dahl; Colby Zaph; Menno Johannes Oudhoff. PlosPathogens. 2021 March31.
- Il4ra -independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology following HSV-2 infection. Alisha Chetty; Matthew G Darby; Pia M Vornewald; Mara Martín-Alonso; Anna Filz; Manuel Ritter; Henry J McSorley; Lindi Masson; Katherine Smith; Frank Brombacher; Matthew K O'Shea; Adam F Cunningham; Bernhard Ryffel; Menno J Oudhoff; Benjamin G Dewals; Laura E Layland; William Horsnell. Cell Host and microbe. 2021. April, 21; 29(4)
- LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium. Rosalie Zwiggelaar*, Håvard Lindholm*, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Diez-Sanchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno J. Oudhoff. *Authors with equal contribution. Sci Adv. 2020 Sep 11;6(37).
- MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote & Arroyo AG. Nat Commun 2018 March 9, 910.
- E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine. Gómez-Escudero J,* Moreno V,*, Martín-Alonso M, Feinberg T, Hernández de Riquer MV, Colmenar A, Calvo E, Camafeita E, Martínez F, Oudhoff MJ, Weiss SJ, and Arroyo AG. J Cell Sci. 2017 Dec 1;130(23):4013-4027. *Authors with equal contribution.
This work resulted in a Cover picture of the issue, taken by me, of an organoid knockdown for MT2-MMP (MMP15). https://jcs.biologists.org/content/130/23.cover-expansion
- Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice. Martín- Alonso M, García-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Méndez-Barbero N, Pollán Á, Sánchez-Camacho C, Denhardt DT, Seiki M, Vázquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG. Circ Res. 2015 Jul 3;117(2):e13-26.
Publications
2021
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando;
Hoel, Sigrid;
Sanchez, Alberto Diez;
Altelaar, Maarten;
Katajisto, Pekka;
Arroyo, Alicia G.;
Oudhoff, Menno.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications.
volum 12 (1).
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel;
McSorley, Henry;
Masson, Lindi;
Smith, Katherine;
Brombacher, Frank;
O'Shea, Matthew;
Cunningham, Adam;
Ryffel, Bernhard;
Oudhoff, Menno;
Dewals, Benjamin;
Layland, Laura;
Horsnell, WG.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe.
Academic article
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez;
Alonso, Mara Martin;
Fosslie, Madeleine Lystad;
Vallance, Bruce A.;
Dahl, John Arne;
Zaph, Colby;
Oudhoff, Menno.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens.
volum 17 (3).
Academic article
2020
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez;
Martin Alonso, Mara;
Ostrop, Jenny;
Matano, Mami;
Parmar, Naveen;
Kvaløy, Emilie;
Spanjers, Roos;
Nazmi, Kamran;
Rye, Morten Beck;
Drabløs, Finn;
Arrowsmith, Cheryl H;
Dahl, John Arne;
Jensen, Kim B.;
Sato, Toshiro;
Oudhoff, Menno.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances.
volum 6 (37).
Academic article
2017
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel;
Calvo, Enrique;
Camfeita, Emilio;
Martinez, Fernando;
Oudhoff, Menno;
Weiss, Stephen J.;
Arrayo, Alicia G..
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
Journal of Cell Science.
volum 130 (23).
Academic article
Scientific articles
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando;
Hoel, Sigrid;
Sanchez, Alberto Diez;
Altelaar, Maarten;
Katajisto, Pekka;
Arroyo, Alicia G.;
Oudhoff, Menno.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications.
volum 12 (1).
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel;
McSorley, Henry;
Masson, Lindi;
Smith, Katherine;
Brombacher, Frank;
O'Shea, Matthew;
Cunningham, Adam;
Ryffel, Bernhard;
Oudhoff, Menno;
Dewals, Benjamin;
Layland, Laura;
Horsnell, WG.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe.
Academic article
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez;
Alonso, Mara Martin;
Fosslie, Madeleine Lystad;
Vallance, Bruce A.;
Dahl, John Arne;
Zaph, Colby;
Oudhoff, Menno.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens.
volum 17 (3).
Academic article
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez;
Martin Alonso, Mara;
Ostrop, Jenny;
Matano, Mami;
Parmar, Naveen;
Kvaløy, Emilie;
Spanjers, Roos;
Nazmi, Kamran;
Rye, Morten Beck;
Drabløs, Finn;
Arrowsmith, Cheryl H;
Dahl, John Arne;
Jensen, Kim B.;
Sato, Toshiro;
Oudhoff, Menno.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances.
volum 6 (37).
Academic article
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel;
Calvo, Enrique;
Camfeita, Emilio;
Martinez, Fernando;
Oudhoff, Menno;
Weiss, Stephen J.;
Arrayo, Alicia G..
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
Journal of Cell Science.
volum 130 (23).
Academic article
Media
2019
-
PosterOstrop, Jenny; Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Martin Alonso, Mara; Sanchez, Alberto Diez; Nonstad, Unni; Radetzki, Silke; T. Pedersen, Marianne; Arrowsmith, Cheryl H; Oudhoff, Menno. (2019) Development of a semi-automated intestinal organoid screening method. Conference on Molecular Mechanisms of Inflammation 2019 ; 2019-06-03 - 2019-06-05.
2018
-
PosterMartin Alonso, Mara; Oudhoff, Menno. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. EMBO meeting on Tissue Regeneration ; 2018-09-15 - 2018-09-19.
-
Academic lectureMartin Alonso, Mara; Oudhoff, Menno; Garcia Arroyo, Alicia. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. Gordon's Research Conference Stem Cells ; 2018-08-16 - 2018-08-21.
-
PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Nonstad, Unni; Spanjers, Roos; Arrowsmith, Cheryl H; Oudhoff, Menno. (2018) Development of a semi-automated intestinal organoid screening method. Network of European Bioimage Analysts Conference . NEUBIAS; Szeged. 2018-01-30 - 2018-02-02.
-
PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. European Light Microscopy Initiative (ELMI) ; Dublin. 2018-06-05 - 2018-06-08.
-
PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. Focus on Microscopy ; 2018-03-25 - 2018-03-28.
2017
-
PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Spanjers, Roos; Arrowsmith, Cheryl H; Oudhoff, Menno. (2017) Semi-automated screening of organoid cultures to test effects of potential therapeutics on antimicrobial functions and tissue regeneration in the intestine. Annual Meeting of German Society for Immunology . German Society for Immunology; Erlangen. 2017-09-12 - 2017-09-15.