Marit Walbye Anthonsen
Background and activities
Viruses may cause severe acute or chronic diseases such as pneumonia and hepatitis. In doing so, viruses evade the immune system and may also suppress immune responses to facilitate detrimental superinfections by bacteria or other viruses. Our research is focused on understanding our innate immune response to virus infections, and studying the interactions between the virus and the host that govern viral replication and the infection outcome, hence determining disease development.
The group also contributes to the Childhood Airway Infections Research Group (CAIR).
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses. vol. 11 (10).
- (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology. vol. 10.
- (2019) Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection. Mediators of Inflammation. vol. 2019.
- (2018) Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection. Scientific Reports. vol. 8.
- (2017) Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proceedings of the National Academy of Sciences of the United States of America. vol. 114 (17).
- (2016) Cytokine profiles in human metapneumovirus infected children: Identification of genes involved in the antiviral response and pathogenesis. PLOS ONE. vol. 11:e0155484 (5).
- (2013) Inducible cAMP early repressor (ICER) is a novel regulator of RIG-I mediated IFN-beta production. Cellular Signalling. vol. 25 (9).
- (2012) Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA. Cytokine. vol. 57 (3).
- (2011) LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids.
- (2010) Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3). Journal of Biological Chemistry. vol. 285 (32).
- (2010) Differential Gene Expression Downstream of Toll-like Receptors (TLRs) ROLE OF c-Src AND ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3). Journal of Biological Chemistry. vol. 285 (22).
- (2009) The Tyrosine Kinase c-Src Enhances RIG-I (Retinoic Acid-inducible Gene I)-elicited Antiviral Signaling. Journal of Biological Chemistry. vol. 284 (28).
- (2006) Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO Journal. vol. 26 (25).
- (2005) Macrophage-specific overexpression of group IIa sPLA2 results in increased atherosclerotic lesion size and enhanced collagen deposition. Journal of Lipid Research. vol. 46.
- (2004) Group IIa phospholipase A2 regulated collagen accumulation determine plaque and lesion size in atherosclerosis. Circulation. vol. 110.
- (2004) The role of lysoPC in monocyte proinflammatory activation. The FASEB Journal. vol. 18.
- (2004) Modification of LDL with human secretory phospholipase A(2) or sphingomyelinase promotes its arachidonic acid-releasing propensity. Journal of Lipid Research. vol. 45.
- (2003) Role of secretory and cytosolic phospholipase A2 enzymes in lysophosphatidylcholine stimulated monocyte arachidonic acid release. FEBS Letters. vol. 555 (2).
- (2003) Role of secretory and cytosolic phospholipase A2 in lysophosphatidylcholine stimulated monocyte arachidonic acid release. FEBS Letters. vol. 555.
- (2001) Atypical l/i PKC conveys 5-LO/LTB4-mediated cross-talk between PLA2s and NF-kB activation in response to TNF-a and IL-1b. Journal of Biological Chemistry. vol. 276.