Marit Otterlei
About
Curriculum:
- 2010- CSO, APIM Therapeutics, Trondheim, Norway (part time)
- 2003- Professor, Faculty of Medicine and Health Sciences, Department of Clinical and Molecular medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway (main position).
- Visiting scientist at Centre de Rescherche en Cancerologies de Marseille (CRCM), France (spring) and Department of Biology, University of Copenhagen, Denmark (fall), 2019.
- Visiting scientist at Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, USA, 2003-2003.
- Researcher/group leader, Department of Cancer Research, NTNU, after receiving a carrier grant from RCN on the project “Replication associated DNA repair”, 2002-2006.
- Associated professor II, UNIGEN, Center for Molecular biology and Dept. of Cancer Research, University of Trondheim, UNIT (now NTNU), 1988-2002.
- Postdoctoral fellow in DNA repair at UNIGEN, Center for Molecular biology, UNIT (now NTNU), 1994-2001.
- PhD (Dr.ing) in innate immunity at Department of Biotechnology in collaborations with the Department of Cancer Research, The Norwegian Institute of Technology, NTH/UNIT (now NTNU), 1994.
- MSc (Siv.ing) from the Department of Biotechnology, NTH (now NTNU), 1988.
Proteins in the DNA sliding clamp family are structurally conserved essential proteins in all three kingdoms of life. Their role in DNA replication and repair is well known, but the recently discovered roles of the eukaryote DNA sliding clamp PCNA in regulation of cellular signaling, cellular metabolism and apoptosis indicate that this family of proteins has additional functions of importance for cellular stress responses. This highlights the clamp family as promising drug targets.
Based on the scientific discovery of the novel PCNA interaction motif, APIM, Otterlei founded the NTNU spin-off company APIM Therapeutics in 2009, and has since then been in charge of the development of a peptide drug containing the APIM sequence for use in cancer therapy as a part time CSO in APIM Therapeutics (https://www.apimtherapeutics.com/). Clinical phase I was finalized in 2021, and the drug, ATX-101, is well tolerated (Lemech et al, 2022 (PMID: 36564469) and show cancer stabilizing activity. Two Phase Ib/II studies are ongoing.
Central studies for understanding of the processes regulated by APIM-PCNA interactions and therefore important for understanding the mode of action of the APIM-peptide drug are:
- Basic research exploring the roles of the APIM – PCNA interactions in the regulation of DNA repair (Gilljam et al., 2009 (PMID 19736315) and 2012 (PMID 23152873)), DNA damage tolerance (Ræder et al., 2018 (PMID 30597836) and Seelinger and Otterlei, 2019 (PMID 31973093)) and cellular stress signaling (Olaisen et al, 2015 (PMID 25797046) and 2018 (PMID 29988559)
- In vivo anti-cancer effects (animal models) and cellular effects of targeting PCNA with peptides containing APIM (Gederaas et al., 2014 (PMID 25500092), Søgaard et al., 2018 (PMID 29545934) and (PMID 30197755), Søgaard et al., 2019 (PMID 31921382), Røst et al., 2022 (PMID: 36564470).
During studies of the peptide as an anti-cancer drug, an infection in one of the cell cultures lead to the discovery of the peptide’s antibacterial activity. This activity is shown to be linked its interaction with the beta-clamp (Nedal et al. 2020 (PMID 32347931). Recent experiments have shown that the peptide has anti-mutagenic activity, broad activity on multidrug resistant strains from all species on the ESCAPE list, is rapid bactericidal, has anti-biofilm activity, and is difficult to gain resistance against (Nepal et al, 2021 (PMID: 34899646), Sumabe et al, 2021 (PMID: 34198819), Ræder et al, 2021 (PMID: 33815313)).
The research group’s current focus is to further explore peptides targeting the bacterial DNA sliding clamp for anti-bacterial activities.
- Select a clinical indication for further development
- Explore the beta-clamp’s role outside DNA replication, i.e. elucidate the involvement in regulation of cellular signaling and metabolism
- Explore the interaction between the APIM-peptide and its target.
Increase the understanding of the complex roles of the DNA clamp in prokaryotes is important for development of drugs targeting the beta-clamp.
The project “Targeting AMR by inhibition of bacterial stress responses”, TAMiR, (https://www.ntnu.edu/ikom/tamir#/view/about) is one out of four AMR related projects in Norway funded by the Trond Mohn Foundation (TMS) (see: https://mohnfoundation.no/amr-prosjekter/).
Publications
2025
-
Simonsen, Signe;
Larsen, Fia B.;
Søgaard, Caroline Krogh;
Jonsson, Nicolas;
Lindorff-Larsen, Kresten;
Bruheim, Per.
(2025)
Extreme multivalency and a composite short linear motif facilitate PCNA-binding, localisation and abundance of p21 (CDKN1A).
The FEBS Journal
Academic article
2024
-
Singleton, Amanda Holstad;
Otterlei, Marit.
(2024)
Nytt verktøy i jakten på nye antibiotikakandidater.
Bioingeniøren
Popular scientific article
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Mancini, Andrea;
Rossetti, Alessandra;
Martellucci, Stefano;
Ventura, Luca.
(2024)
Correction to: ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma (Cancers, (2022), 14, 2, (289), 10.3390/cancers14020289).
Cancers
Errata
-
Otterlei, Marit;
Haugan, Maria Schei;
Bjørås, Magnar;
Müller, Fredrik.
(2024)
Hva bør Norge bidra med for å redusere antibiotikaresistens-krisen?.
Dagens medisin
Reader opinion piece
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2024)
tRNA-Derived Fragments as Biomarkers in Bladder Cancer.
Cancers
Academic article
-
Simonsen, Signe;
Søgaard, Caroline Krogh;
Olsen, Johan G.;
Otterlei, Marit;
Kragelund, Birthe B..
(2024)
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery.
Cellular and Molecular Life Sciences (CMLS)
Academic literature review
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Academic article
-
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2024)
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy.
Advances in Pharmacology
Academic article
-
Olaisen, Camilla;
Røst, Lisa M.;
Sharma, Animesh;
Søgaard, Caroline Krogh;
Khong, Tiffany;
Berg, Sigrid Ravn.
(2024)
Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.
Cancers
Academic article
-
Otterlei, Marit;
Huse, Kanutte;
Rye, Inga Hansine.
(2024)
The Tumor Immune Microenvironment in Breast Cancer Progression.
Acta Oncologica
Academic literature review
2023
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Academic article
-
Hestvik, Ingebjørg;
Singleton, Amanda Holstad;
Otterlei, Marit.
(2023)
Ny metode baner vei for nye antibiotika.
Gemini.no
Interview Journal
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Academic article
2022
-
Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene
Academic article
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Academic article
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Academic article
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
.
Cancers
Academic article
2021
-
Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy Nucleic Acids
Academic article
-
Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology
Academic article
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Academic article
-
Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology
Academic article
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology
Academic article
-
Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
.
European Journal of Organic Chemistry
Academic article
2020
-
Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3
Ubiquitin Ligase SHPRH Confer DNA Damage
Tolerance through Direct Interactions
with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences
Academic article
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
-
Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim.
(2020)
Peptides containing the PCNA interacting motif APIM
bind to the beta-clamp and inhibit bacterial growth and
mutagenesis.
Nucleic Acids Research (NAR)
Academic article
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules
Academic article
2019
-
Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S..
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget
Academic article
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Academic article
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Academic article
-
Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS)
Academic article
2018
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Academic article
-
Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences
Academic article
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Academic article
2017
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Academic article
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief
Academic article
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Academic article
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry
Academic article
2016
-
Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal
Academic article
2015
-
Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling
Academic article
2014
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Academic article
-
Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International
Academic article
2013
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Academic article
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Academic article
2012
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair
Academic article
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Academic article
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology
Abstract
-
Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE
Academic article
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences
Academic literature review
-
Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE
Academic article
2011
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Academic article
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Academic article
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology
Abstract
2010
-
Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology
Academic article
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Academic article
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Abstract
2009
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Academic article
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Academic article
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Academic article
-
Müller, Rebekka;
Otterlei, Marit.
(2009)
APIM's mechanisms of action.
Norwegian University of Science and Technology, Faculty of Medicine
Masters thesis
2008
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Academic article
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Academic article
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Academic article
2007
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Academic literature review
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Abstract
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Academic article
-
Sterten, Heidi;
Krøkje, Åse;
Otterlei, Marit;
Slupphaug, Geir.
(2007)
Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA).
NTNU
Thesis at a second degree level
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Academic article
2006
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Academic literature review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Abstract
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Academic article
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Academic article
-
Pettersen, Grete Klippenvåg;
Otterlei, Marit.
(2006)
DNA repair complexes.
Privat
Masters thesis
2005
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Academic article
-
Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology
Academic article
-
Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR)
Academic article
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Academic literature review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Academic article
-
Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR)
Academic article
-
Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell
Academic article
-
Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell
Academic article
2003
-
Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
von Kobbe, Cayetano;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press
Academic article
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Academic article
-
Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry
Academic article
2002
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Academic article
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Academic article
2000
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Academic article
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Academic article
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Academic article
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Academic article
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Academic article
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Academic article
1999
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Academic article
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Academic article
1998
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Academic article
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Academic article
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Non-fiction book
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
[Mangler utgivernavn]
Report
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
[Mangler utgivernavn]
Report
-
Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
[Mangler utgivernavn]
Thesis at a second degree level
1997
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Academic article
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Academic article
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Academic chapter/article/Conference paper
1995
-
Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
US-Patent 5459 054, Oct. 1995
Report
Journal publications
-
Simonsen, Signe;
Larsen, Fia B.;
Søgaard, Caroline Krogh;
Jonsson, Nicolas;
Lindorff-Larsen, Kresten;
Bruheim, Per.
(2025)
Extreme multivalency and a composite short linear motif facilitate PCNA-binding, localisation and abundance of p21 (CDKN1A).
The FEBS Journal
Academic article
-
Singleton, Amanda Holstad;
Otterlei, Marit.
(2024)
Nytt verktøy i jakten på nye antibiotikakandidater.
Bioingeniøren
Popular scientific article
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Mancini, Andrea;
Rossetti, Alessandra;
Martellucci, Stefano;
Ventura, Luca.
(2024)
Correction to: ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma (Cancers, (2022), 14, 2, (289), 10.3390/cancers14020289).
Cancers
Errata
-
Otterlei, Marit;
Haugan, Maria Schei;
Bjørås, Magnar;
Müller, Fredrik.
(2024)
Hva bør Norge bidra med for å redusere antibiotikaresistens-krisen?.
Dagens medisin
Reader opinion piece
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2024)
tRNA-Derived Fragments as Biomarkers in Bladder Cancer.
Cancers
Academic article
-
Simonsen, Signe;
Søgaard, Caroline Krogh;
Olsen, Johan G.;
Otterlei, Marit;
Kragelund, Birthe B..
(2024)
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery.
Cellular and Molecular Life Sciences (CMLS)
Academic literature review
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Academic article
-
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2024)
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy.
Advances in Pharmacology
Academic article
-
Olaisen, Camilla;
Røst, Lisa M.;
Sharma, Animesh;
Søgaard, Caroline Krogh;
Khong, Tiffany;
Berg, Sigrid Ravn.
(2024)
Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.
Cancers
Academic article
-
Otterlei, Marit;
Huse, Kanutte;
Rye, Inga Hansine.
(2024)
The Tumor Immune Microenvironment in Breast Cancer Progression.
Acta Oncologica
Academic literature review
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Academic article
-
Hestvik, Ingebjørg;
Singleton, Amanda Holstad;
Otterlei, Marit.
(2023)
Ny metode baner vei for nye antibiotika.
Gemini.no
Interview Journal
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Academic article
-
Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene
Academic article
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Academic article
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Academic article
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
.
Cancers
Academic article
-
Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy Nucleic Acids
Academic article
-
Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology
Academic article
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Academic article
-
Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology
Academic article
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology
Academic article
-
Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
.
European Journal of Organic Chemistry
Academic article
-
Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3
Ubiquitin Ligase SHPRH Confer DNA Damage
Tolerance through Direct Interactions
with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences
Academic article
-
Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim.
(2020)
Peptides containing the PCNA interacting motif APIM
bind to the beta-clamp and inhibit bacterial growth and
mutagenesis.
Nucleic Acids Research (NAR)
Academic article
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules
Academic article
-
Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S..
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget
Academic article
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Academic article
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Academic article
-
Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS)
Academic article
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Academic article
-
Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences
Academic article
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Academic article
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Academic article
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief
Academic article
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Academic article
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry
Academic article
-
Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal
Academic article
-
Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling
Academic article
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Academic article
-
Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International
Academic article
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Academic article
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Academic article
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair
Academic article
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Academic article
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology
Abstract
-
Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE
Academic article
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences
Academic literature review
-
Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE
Academic article
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Academic article
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Academic article
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology
Abstract
-
Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology
Academic article
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Academic article
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Abstract
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Academic article
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Academic article
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Academic article
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Academic article
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Academic article
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Academic article
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Academic literature review
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Abstract
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Academic article
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Academic article
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Academic literature review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Abstract
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Academic article
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Academic article
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Academic article
-
Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology
Academic article
-
Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR)
Academic article
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Academic literature review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Academic article
-
Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR)
Academic article
-
Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell
Academic article
-
Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell
Academic article
-
Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
von Kobbe, Cayetano;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press
Academic article
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Academic article
-
Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry
Academic article
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Academic article
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Academic article
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Academic article
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Academic article
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Academic article
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Academic article
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Academic article
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Academic article
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Academic article
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Academic article
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Academic article
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Academic article
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Academic article
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Academic article
Books
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Non-fiction book
Part of book/report
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Academic chapter/article/Conference paper
Report
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
-
Müller, Rebekka;
Otterlei, Marit.
(2009)
APIM's mechanisms of action.
Norwegian University of Science and Technology, Faculty of Medicine
Masters thesis
-
Sterten, Heidi;
Krøkje, Åse;
Otterlei, Marit;
Slupphaug, Geir.
(2007)
Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA).
NTNU
Thesis at a second degree level
-
Pettersen, Grete Klippenvåg;
Otterlei, Marit.
(2006)
DNA repair complexes.
Privat
Masters thesis
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
[Mangler utgivernavn]
Report
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
[Mangler utgivernavn]
Report
-
Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
[Mangler utgivernavn]
Thesis at a second degree level
-
Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
US-Patent 5459 054, Oct. 1995
Report
Teaching
Courses
Outreach
2019
-
PosterRøst, Lisa Marie; Løkken, Erle Gustavsen; Otterlei, Marit; Bruheim, Per. (2019) Glioblastoma cells respond to hypoxia by increased cell growth and altered TCA-cycle progression. Norsk Biokjemisk Selskap Trondheim NBS Vintermøte , Røros 2019-01-24 - 2019-01-27
2018
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PosterKim, Jana; Søgaard, Caroline Krogh; Kim, Eugene; Bathen, Tone Frost; Otterlei, Marit; Moestue, Siver Andreas. (2018) Diffusion weighted MRI simplifies therapy monitoring in TRAMP mice . Joint Annual Meeting ISMRM-ESMRMB , Paris 2018-06-16 - 2018-06-21
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PosterOlaisen, Camilla; Røst, Lisa Marie; Nedal, Aina; Petrovic, Voin; Kvitvang, Hans Fredrik Nyvold; Bruheim, Per. (2018) Proliferating Cell Nuclear Antigen (PCNA) has a Central Role in Regulation of the Glycolysis in Haematological Cancer Cells. American Association of Cancer Research Metabolism and Cancer , Marriott New York Brooklyn Bridge 2018-09-28 - 2018-10-01
2016
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PosterRøst, Lisa Marie; Olaisen, Camilla; Petrovic, Voin; Otterlei, Marit; Bruheim, Per. (2016) Blocking the Stress-specific APIM-PCNA Interaction in Multiple Myeloma Cells Cause Significant Changes in Central Carbon Metabolism. International Society of Cancer Metabolism ISCaM 2016: Metabolic Networks in Cancer , Brussel 2016-10-26 - 2016-10-29
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PosterSøgaard, Caroline Danielsen; Petrovic, Voin; Blindheim, Augun; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Otterlei, Marit. (2016) PCNA-targeting APIM-peptide alters response to DNA damage in human bladder cancer cells on a signaling level. EMBO 2nd EMBO Cellular Signalling & Cancer Therapy Conference , Cavtat 2016-05-27 - 2016-05-31
2012
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Academic lectureOtterlei, Marit. (2012) APIM-peptides targeting PCNA induce apoptosis in cancer cells. The 3rd Erling Seeberg Symposium on DNA Repair , Trondheim 2012-07-19 - 2012-07-23
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PosterArum, Carl-Jørgen; Gederaas, Odrun; Bachke, Siri; Viset, Trond; Otterlei, Marit. (2012) Targeting DNA repair mechanisms increases efficiency of intravesical chemotherapy in an orthotopic rat bladder model. EAU, AUA info kommer , info kommer 2012-11-30 - 2012-11-30
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Academic lectureGederaas, Odrun; Bachke, Siri; Sørgaard, Caroline Danielsen; Viset, Trond; Arum, Carl-Jørgen; Otterlei, Marit. (2012) Increased efficacy of intravesical chemotherapy in an orthotopic rat bladder cancer model by targeting PCNA with the novel synthetic peptide drug ATX-101. Congress, USA. Urology (korrekt navn blir supplert) 2012-11-30 - 2012-11-30
2011
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PosterBaglo, Yan; Müller, Rebekka; Otterlei, Marit; Gederaas, Odrun Arna. (2011) Analysis of stress responses induced by hexylaminolevulinate-mediated photodynamic treatment. University of Geneva and ESP 14th Congress of the European Society for Photobiology , Geneva 2011-09-01 - 2011-09-06
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Academic lectureMüller, Rebekka; Giljam, Karin Margaretha; Liabakk, Nina-Beate; Otterlei, Marit. (2011) Efficient repair of UV-induced DNA damage during replication depends on direct XPA-PCNA interaction. Cold Spring Harbor Laboratory Eukaryotic DNA Replication & Genome Maintenance , Cold Spring Harbor 2011-09-06 - 2011-09-10
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PosterMüller, Rebekka; Jacob, Havjin; Bachke, Siri; Giljam, Karin Margaretha; Otterlei, Marit. (2011) Inhibition of the NF-kappaB pathway by the APIM-peptide. Responses to DNA damage: from molecular mechanism to human disease , Egmond aan Zee 2011-04-03 - 2011-04-08
2010
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Academic lectureGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
2009
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Academic lectureSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair , Ålesund/Geiranger 2009-06-20 - 2009-06-25
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Academic lectureGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
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Academic lectureKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete. (2009) Uracil in DNA and its processing. E. Dogliotti, H. Krokan, T. Stevnsner, S. Mitra, S.H. Wilson 3rd US-EU Conference- Repair of Endogenous Genome Damage , Moody Gardens Hotel, Galveston, Texas 2009-02-21 - 2009-02-25
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Academic lectureOtterlei, Marit. (2009) A New PCNA Binding Motif which Sensitizes Cancer Cells to Chemotherapy. NTNU Symposium on trends and needs in medical technology and health care 2009-11-05 - 2009-11-06
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Academic lectureOtterlei, Marit. (2009) A new PCNA binding motif with possible implication in chemotherapy. Inger Sandlie, UiO Torsdagseminar, IMBV, UiO , UiO 2009-09-03 -
-
Academic lectureOtterlei, Marit. (2009) APIM Therapeutics, improving chemotherapy for cancer patients. Norsk Biokjemisk Selskap avd. Midt Norge Selbu møte 2009 2009-10-05 - 2009-10-06
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Academic lectureOtterlei, Marit. (2009) Identification of a novel and widespread PCNA interacting motif with potential use in chemotherapy. Tirsdagseminar, IBT, NTNU , IBT, NTNU 2009-11-25 -
-
PosterPsonka-Antonczyk, Katarzyna Maria; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar; Stokke, Bjørn Torger. (2009) Uracil-DNA glycosylase (UNG) interacting with mismatched DNA – a single molecule approach. European Biophysical Societies' Association European Biophysics Congress , Genoa 2009-07-11 - 2009-07-15
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" , Egmond aan Zee 2009-03-30 - 2009-04-01
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Popular scientific lectureOtterlei, Marit. (2009) GFP, the "Nobel" protein. Norsk Kjemisk Selskap, NTNU Medlemsmøte NKS 2009-02-10 -
2008
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Academic lectureSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
2007
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Academic lectureSæten, Christina; Misund, Kristine; Steigedal, Tonje; Otterlei, Marit; Lægreid, Astrid; Thommesen, Liv. (2007) Complex functional studies in mammalian cells using transfected cell arrays. Norsk Biokjemisk Selskap (NBS) The Norwegian Bichemical Society 43. Contact Meeting , Lillehammer 2007-02-01 - 2007-02-04
2006
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PosterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
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PosterHanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Krokan, Hans Einar; Otterlei, Marit. (2006) Functional analysis of XRCC1 associated repair complexes containing the XRCC1 polymorphisms Arg194Trp, Arg280His, and Arg399Gln. EU IP "DNA Damage Response and Repair Mechanisms" DNA repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
2005
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PosterDiaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting 2005-11-29 - 2005-12-03
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PosterKavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. Instituto Superiore di Sanita/EMBO 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes , Erice, Sicily 2005-11-28 - 2005-12-03
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PosterOtterlei, Marit; Akbari, Mansour; Hanssen-Bauer, Audun; Garten, Karin; Wilson III, David; Andersen, Sonja Benedikte. (2005) Base Excision Repair and Single Strand Break Repair proficient XRCC1 complexes. DNA repair meeting , Sicily 2005-11-28 - 2005-12-03
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PosterBruland, Torunn; Sæten, Christina; Strømmen, Tonje; Bergum, Hallgeir; Otterlei, Marit; Thommesen, Liv. (2005) High-throughput characterisation of gene function using cell microarray. ESF The2nd ESF Functional Genomic Conference, Oslo , Oslo 2005-09-06 - 2005-09-10
2004
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Academic lectureBruland, Torunn; Bergum, Hallgeir; Steigedal, Tonje; Otterlei, Marit; Thommesen, Liv; Lægreid, Astrid. (2004) Array based screening og gene function and cell-biological application of transfected-cell microarrays. NBS NBS Kontaktmøte , Hafjell 2004-01-15 - 2004-01-18
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PosterKavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis , Bermuda 2004-11-14 - 2004-11-20
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PosterAkbari, Mansour; Monterotti, Bruno; Krokan, Hans Einar; Otterlei, Marit. (2004) XRCC1-Associated repair complexes (ARC). DNA-repair and mutagenesis: From molecular structure to biological consequences 2004-11-14 - 2004-11-20
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PosterOtterlei, Marit. (2004) Biochemical and Genetic Characterization og the interaction between Werner Syndrome protein and Fen-1 suggests their mechanism of action in vivo. DNA Repair and mutagenesis: From molecular structure to biological consequences 2004-11-14 - 2004-11-20
2003
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Academic lectureOtterlei, Marit; Bruheim, Per; Byungchan, Ahn; Baynton, Kathy; Opresko, Patricia; Seeberg, E.. (2003) DNA damage causing replication arrest leads to a relocation of WRN hekicase to complexes containing proteins from the RAD52 epistasis group: RAD52, RAD51, RAD54 and RAD54B. Possible role for WRN in regulation of HR. International Workshop on Werner Syndrome , Lansdowne 2003-05-31 -
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PosterLuna, Luisa; Rolseth, Veslemøy; Otterlei, Marit; Hildestrand, Gunn; Seeberg, Erling Christen. (2003) Subnuclear localisation of hOgg1 in dependent on phosphorylation of serine 36 and is disrupted in the polymorphic hOgg1-Cys326 allele. The Norwegian Biochemical Society Vintermøte , Geilo 2003-01-23 - 2003-01-26
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Popular scientific lectureOtterlei, Marit. (2003) Involvement of WRN in homologous recombination. "Tirsdagsmøte" , Trondheim, Norge 2003-09-30 -
2002
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InterviewSundan, Anders; Otterlei, Marit; Krokan, Hans Einar. (2002) Det gode liv på Øya: Rapport fra et vinnermiljø. [Newspaper] 2002-06-13
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Academic lectureAas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life , Røros 2002-01-20 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
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PosterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference , Ventura, California, USA 2002-03-08 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders , Warsaw. Poland 2002-09-07 -
2001
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PosterSundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules. , Como, Italy 2001-05-17 -
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PosterSlupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch.; Otterlei, Marit. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair: Interplay with other cellular processes , Noordwijkerhout, The Netherlands, February 25 - March 2, 2001
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Popular scientific lectureOtterlei, Marit. (2001) "....om gfp, yfp, cfp, kofokal og FRET...". Oppdalsmøte 2001 , Oppdal, 21.- 22. mars 2001
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Academic lectureLuna, L.; Morland, I.; Rolseth, V.; Bjørås, M.; Otterlei, Marit; Seeberg, E.. (2001) Cell cycle dependent expression and intracellular sorting characteristics of the human Ogg1 DNA glycosylase and its mutant form S236C. Workshop on DNA repair: interplay with other cellular processes. , Noordwijkerhout, Nederland 2001-03-25 -
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Popular scientific lectureOtterlei, Marit. (2001) Interaction between replication and repair proteins. "Tirsdagsmøte" populærvitenskapelig foredrag. , Medisinsk Teknisk Senter 2001-12-11 -
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Popular scientific lectureOtterlei, Marit. (2001) DNA skader og reparasjon. Foredrag for doktorgradsstudenter "Gentoksikologi" , Inst. for bioteknologi, Fakultet for kjemi, NTNU 2001-10-02 -
2000
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Popular scientific lectureNilsen, Hilde; Roswell, Ian; Robins, Peter; Slupphaug, Geir; Steinsbekk, Kristin; Otterlei, Marit. (2000) Characterisation Of The Major Murine Uracil-DNA Glycosylase And Expression Patterns And Generation of ung/-Knockout Mice. DNA Base Excision Repair Workshop (BER 2000 Workshop) , Galveston, Texas, USA March 10 - 13, 2000
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Popular scientific lectureKrokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP) , Galveston, Texas, March 10 - 13, 2000
1999
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PosterKrokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. , 1-7 november 1999
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PosterOtterlei, Marit; Kavli, B.; Standal, R.; Skjelbred, Camilla; Bharati, S.; Krokan, Hans Einar. (1999) In vivo Repair of AP-sites in the E.coli Chromosome. , 1-7 november 1999
1998
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Academic lectureBharati, Sangeeta; Krokan, Hans Einar; Kristiansen, Lena; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1)is processed to two forms one of which is resistant to inhibition by AP-sites. AACR Special Conference in Cancer Research. Endogeneous sources of Mutations. , Ft. Myers, Florida
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PosterKavli, Bodil; Otterlei, Marit; Skjelbred, Camilla; Standal, Rune; Bharati, Sangeeta; Krokan, Hans Einar. (1998) Mutation frequency and mutation spectra caused by chromosomal AP-site in repair deficient E.coli strains. Norsk Biokjemisk Selskaps møte , Lillehammer
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Popular scientific lectureOtterlei, Marit. (1998) Signals for nuclear and mitochondrial targeting of human uracil-DNA-glycosylases and co-localisation of the nuclear form with replication protein A. Norsk Biokjemisk Selskaps møte , Lillehammer
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Popular scientific lectureOtterlei, Marit. (1998) Studies on intracellular sorting of proteins fused to Enhanced Green Fluorescent Protein (EGFP). Storlienmøøte , Storlien