Marit Otterlei
About
Curriculum:
- 2010- CSO, APIM Therapeutics, Trondheim, Norway (part time)
- 2003- Professor, Faculty of Medicine and Health Sciences, Department of Clinical and Molecular medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway (main position).
- Visiting scientist at Centre de Rescherche en Cancerologies de Marseille (CRCM), France (spring) and Department of Biology, University of Copenhagen, Denmark (fall), 2019.
- Visiting scientist at Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, USA, 2003-2003.
- Researcher/group leader, Department of Cancer Research, NTNU, after receiving a carrier grant from RCN on the project “Replication associated DNA repair”, 2002-2006.
- Associated professor II, UNIGEN, Center for Molecular biology and Dept. of Cancer Research, University of Trondheim, UNIT (now NTNU), 1988-2002.
- Postdoctoral fellow in DNA repair at UNIGEN, Center for Molecular biology, UNIT (now NTNU), 1994-2001.
- PhD (Dr.ing) in innate immunity at Department of Biotechnology in collaborations with the Department of Cancer Research, The Norwegian Institute of Technology, NTH/UNIT (now NTNU), 1994.
- MSc (Siv.ing) from the Department of Biotechnology, NTH (now NTNU), 1988.
Proteins in the DNA sliding clamp family are structurally conserved essential proteins in all three kingdoms of life. Their role in DNA replication and repair is well known, but the recently discovered roles of the eukaryote DNA sliding clamp PCNA in regulation of cellular signaling, cellular metabolism and apoptosis indicate that this family of proteins has additional functions of importance for cellular stress responses. This highlights the clamp family as promising drug targets.
Based on the scientific discovery of the novel PCNA interaction motif, APIM, Otterlei founded the NTNU spin-off company APIM Therapeutics in 2009, and has since then been in charge of the development of a peptide drug containing the APIM sequence for use in cancer therapy as a part time CSO in APIM Therapeutics (https://www.apimtherapeutics.com/). Clinical trial (phase I) started fall 2018 and will be closed within the summer/early fall of 2020. The drug is well tolerated, and further Phase II studies are planned.
Central studies for understanding of the processes regulated by APIM-PCNA interactions and therefore important for understanding the mode of action of the APIM-peptide drug are:
- Basic research exploring the roles of the APIM – PCNA interactions in the regulation of DNA repair (Gilljam et al., 2009 (PMID 19736315) and 2012 (PMID 23152873)), DNA damage tolerance (Ræder et al., 2018 (PMID 30597836) and Seelinger and Otterlei, 2019 (PMID 31973093)) and cellular stress signaling (Olaisen et al, 2015 (PMID 25797046) and 2018 (PMID 29988559)
- In vivo anti-cancer effects (animal models) and cellular effects of targeting PCNA with peptides containing APIM (Gederaas et al., 2014 (PMID 25500092), Søgaard et al., 2018 (PMID 29545934) and (PMID 30197755), Søgaard et al., 2019 (PMID 31921382), Røst et al., 2020 (doi.org/10.1101/2020.04.29.067512).
During studies of the peptide as an anti-cancer drug, an infection in one of the cell cultures lead to the discovery of the peptide’s antibacterial activity. This activity is recently shown to be linked its interaction with the beta-clamp (Nedal et al. 2020 (PMID 32347931).
The research group’s current focus is to further explore peptides targeting the bacterial DNA sliding clamp for anti-bacterial activities.
- Select a clinical indication for further development
- Explore the beta-clamp’s role outside DNA replication, i.e. elucidate the involvement in regulation of cellular signaling and metabolism
- Explore the interaction between the APIM-peptide and its target.
Increase the understanding of the complex roles of the DNA clamp in prokaryotes is important for development of drugs targeting the beta-clamp.
The project “Targeting AMR by inhibition of bacterial stress responses”, TAMiR, (https://www.ntnu.edu/ikom/tamir#/view/about) is one out of four AMR related projects in Norway funded by the Trond Mohn Foundation (TMS) (see: https://mohnfoundation.no/amr-prosjekter/).
Publications
2022
- Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lisa M.; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2022) Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide. Antibiotics. volum 11 (8).
- Gravina, Giovanni Luca; Colapietro, Alessandro; Andrea, Mancini; Rossetti, Alessandra; Martelucci, Stefano; Ventura, Luca; Di Franco, Martina; Marampon, Francesco; Mattei, Vinvenzo; Biordi, Leda Assunta; Otterlei, Marit; Festuccia, Claudio. (2022) ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma. Cancers.
2021
- Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents. European Journal of Organic Chemistry.
- Frimodt-Møller, Jakob; Koulouktsis, Andreas; Charbon, Godefroid; Otterlei, Marit; Nielsen, Peter E.; Løbner-Olesen, Anders. (2021) Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli. Molecular Therapy - Nucleic Acids. volum 25.
- Nepal, Anala; Ræder, Synnøve Brandt; Søgaard, Caroline Krogh; Haugan, Maria Schei; Otterlei, Marit. (2021) Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization. Frontiers in Microbiology.
- Ræder, Synnøve Brandt; Sandbakken, Erik Thorvaldsen; Nepal, Anala; Løseth, Kirsti; Bergh, Kåre; Witsø, Eivind; Otterlei, Marit. (2021) Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo. Frontiers in Microbiology.
- Strømme, Olaf; Heck, Kathleen; Brede, Gaute; Lindholm, Håvard Takle; Otterlei, Marit; Arum, Carl-Jørgen. (2021) Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors. Current Issues in Molecular Biology. volum 43 (1).
- Sumabe, Balagra Kasim; Ræder, Synnøve Brandt; Røst, Lisa M.; Sharma, Animesh; Donkor, Eric S.; Mosi, Lydia; Duodu, Samuel; Bruheim, Per; Otterlei, Marit. (2021) Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis. Biomolecules. volum 11 (6).
2020
- Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit. (2020) Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis. Nucleic Acids Research (NAR). volum 48 (10).
- Seelinger, Mareike; Søgaard, Caroline Krogh; Otterlei, Marit. (2020) The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type. Biomolecules. volum 10 (3).
- Seelinger, Mareike; Otterlei, Marit. (2020) Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA). International Journal of Molecular Sciences. volum 21 (693).
2019
- Montaldo, Nicola Pietro; Bordin, Diana Lilian; Brambilla, Alessandro; Rösinger, Marcel; Martin, Sarah Fordyce; Bjørås, Karine Øian; Bradamante, Stefano; Aas, Per Arne; Furrer, Antonia; Olsen, Lene Christin; Kunath, Nicolas; Otterlei, Marit; Sætrom, Pål; Bjørås, Magnar; Samson, Leona D.; van Loon, Barbara. (2019) Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. volum 10 (1).
- Prestel, Andreas; Wichmann, Nanna; Martins, Joao M; Marabini, Riccardo; Kassem, Noah; Broendum, Sebastian S; Otterlei, Marit; Nielsen, Olaf; Willemoës, Martin; Ploug, Michael; Boomsma, Wouter; Kragelund, Birthe B. (2019) The PCNA interaction motifs revisited: thinking outside the PIP-box. Cellular and Molecular Life Sciences (CMLS). volum 76 (24).
- Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Maiken Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian. (2019) 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication. Scientific Reports. volum 9.
- Søgaard, Caroline Krogh; Nepal, Anala; Petrovic, Voin; Sharma, Animesh; Liabakk, Nina-Beate; Steigedal, Tonje S.; Otterlei, Marit. (2019) Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy. OncoTarget. volum 10 (68).
2018
- Olaisen, Camilla; Kvitvang, Hans Fredrik Nyvold; Lee, Sungmin; Almaas, Eivind; Bruheim, Per; Drabløs, Finn; Otterlei, Marit. (2018) The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans. FEBS Open Bio. volum 8 (7).
- Petrovic, Voin; Nepal, Anala; Olaisen, Camilla; Bachke, Siri; Hira, Jonathan; Søgaard, Caroline Krogh; Røst, Lisa Marie; Misund, Kristine; Andreassen, Trygve; Melø, Torun Margareta; Bartosova, Zdenka; Bruheim, Per; Otterlei, Marit. (2018) Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress. Nutrients. volum 10 (4).
- Ræder, Synnøve Brandt; Nepal, Anala; Bjørås, Karine; Seelinger, Mareike; Kolve, Rønnaug Steen; Nedal, Aina; Müller, Rebekka; Otterlei, Marit. (2018) APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells. International Journal of Molecular Sciences. volum 20 (1).
- Søgaard, Caroline Danielsen; Moestue, Siver Andreas; Rye, Morten Beck; Kim, Jana; Nepal, Anala; Liabakk, Nina-Beate; Bachke, Siri; Bathen, Tone Frost; Otterlei, Marit; Hill, Deborah Katherine. (2018) APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer. OncoTarget. volum 9 (14).
- Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit. (2018) "Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling. OncoTarget. volum 9 (65).
2017
- Bjørås, Karine; Sousa, Mirta; Sharma, Animesh; Fonseca, Davi de Miranda; Søgaard, Caroline Danielsen; Bjørås, Magnar; Otterlei, Marit. (2017) Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Nucleic Acids Research (NAR). volum 45 (14).
- Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief. volum 12.
- Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry. volum 523.
- Sousa, Mirta; Bjørås, Karine; Hanssen-Bauer, Audun; Solvang-Garten, Karin; Otterlei, Marit. (2017) P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage. Scientific Reports. volum 7 (1).
2016
- Marstad, Anne; Landsverk, Ole J. B.; Strømme, Olaf; Otterlei, Marit; Collas, Philippe; Sundan, Anders; Brede, Gaute. (2016) A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. The FEBS Journal. volum 283 (4).
2015
- Olaisen, Camilla; Müller, Rebekka; Nedal, Aina; Otterlei, Marit. (2015) PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling. Cellular Signalling. volum 27 (7).
2014
- Baglo, Yan; Hagen, Lars; Høgset, Anders; Drabløs, Finn; Otterlei, Marit; Gederaas, Odrun Arna. (2014) Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization. BioMed Research International. volum 14 (74).
- Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit. (2014) Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide. Translational Oncology. volum 7 (6).
2013
- Hegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Otterlei, Marit; Krokan, Hans Einar. (2013) Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase. DNA Repair. volum 12 (1).
- Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit. (2013) Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells. PLOS ONE. volum 8 (7).
2012
- Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål. (2012) Human ALKBH4 Interacts with Proteins Associated with Transcription. PLOS ONE. volum 7 (11).
- Gilljam, Karin Margaretha; Müller, Rebekka; Liabakk, Nina-Beate; Otterlei, Marit. (2012) Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLOS ONE. volum 7 (11).
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit. (2012) X-ray repair cross complementing protein 1 in base excision repair. International Journal of Molecular Sciences. volum 13 (12).
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Gilljam, Karin Margaretha; Torseth, Kathrin; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2012) The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA Repair. volum 11 (4).
- Otterlei, Marit; Müller, R.; Gilljam, Karin Margaretha; Holien, Toril; Midsund, K.; Vatsveen, TK; Ro, T.B.; Bellacchio, E.; Sundan, Anders. (2012) PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS. Annals of Oncology. volum 23.
- Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair. volum 11 (6).
2011
- Alevizopoulos, K; Otterlei, Marit. (2011) ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control. Annals of Oncology. volum 22.
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis. volum 52 (8).
- Sletta, Håvard; Klinkenberg, Geir; Winnberg, Asgeir; Kvitvang, Hans Fredrik Nyvold; Nilsen, Marianne Bakke; Krokan, Hans Einar; Otterlei, Marit; Bruheim, Per. (2011) A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. Journal of Microbiological Methods. volum 87 (3).
2010
- Akbari, Mansour; Solvang-Garten, Karin; Hanssen-Bauer, Audun; Lieske, Nora V.; Pettersen, Henrik P Sahlin; Pettersen, Grete Klippenvåg; Wilson, DM; Krokan, Hans Einar; Otterlei, Marit. (2010) Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair. volum 9 (7).
- Arum, Carl-Jørgen; Kodama, Yosuke; Rolim, Natale Pinheiro Lage; Widerøe, Marius; Anderssen, Endre; Viset, Trond; Otterlei, Marit; Lundgren, Steinar; Chen, Duan; Zhao, Chun-Mei. (2010) A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma. World Journal of Urology. volum 28 (4).
- Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer. volum 8 (5).
2009
- Akbari, Mansour; Diaz, Javier Pena; Andersen, Sonja Benedikte; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2009) Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair. volum 8 (7).
- Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
- Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology. volum 83 (19).
- Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 364 (1517).
2008
- Akbari, Mansour; Visnes, Torkild; Krokan, Hans Einar; Otterlei, Marit. (2008) Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair. volum 7.
- Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N; Krokan, Hans Einar; Slupphaug, Geir. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal. volum 27 (1).
- Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
2007
- Akbari, Mansour; Otterlei, Marit; Pena-Diaz, J; Krokan, Hans Einar. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. volum 145.
- Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
- Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair.
- Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair.
2006
- Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Krokan, Hans Einar. (2006) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience.
- Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research. volum 312.
- Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal. volum 273.
- Otterlei, Marit; Bruheim, Per; Ahn, Byungchan; Bussen, Wendy; Karmakar, Parimal; Baynton, Kathy; Bohr, Vilhelm A.. (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. Journal of Cell Science. volum 119 (24).
2005
- Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM). volum 201.
- Luna, Gomez Luisa; Luna, L; Rolseth, V; Hildrestrand, GA; Otterlei, Marit; Dantzer, F; Bjørås, Magnar; Bjoras, M; Seeberg, E. (2005) Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant. Nucleic Acids Research (NAR). volum 33.
- Pohler, JRG; Otterlei, Marit; Warbrick, E. (2005) An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit. BMC Molecular Biology. volum 6.
2004
- Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir; Krokan, Hans Einar. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR). volum 32.
- Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
- Fan, JS; Otterlei, Marit; Wong, HK; Tomkinson, AE; Wilson, DM. (2004) XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Research (NAR). volum 32 (7).
- Opresko, PL; Otterlei, Marit; Graakjaer, J; Bruheim, P; Dawut, L; Kolvraa, S; May, A; Seidman, MM; Bohr, VA. (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2. Molecular Cell.
- Sharma, S; Otterlei, Marit; Sommers, JA; Driscoll, HC; Dianov, GL; Kao, HI; Bambara, RA; Brosh, RM. (2004) WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork. Molecular Biology of the Cell. volum 15 (2).
2003
- Baynton, Kathy; Otterlei, Marit; Bjørås, M.; von Kobbe, Cayetano; Bohr, Vilhelm; Seeberg, E.. (2003) WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*. JBC Papers in Press. volum 278 (38).
- Bayton, Kathy; Otterlei, Marit; Bjørås, Magnar; Kobbe, C von; Bohr, V.A.; Seeberg, Erling Christen. (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. Journal of Biological Chemistry. volum 278.
- Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
2002
- Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. volum 18.
2001
- Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology. volum 68.
2000
- Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters.
- Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters.
- Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
- Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
- Otterlei, Marit; Kavli, B; Standal, R; Skjelbred, Camilla; Bharati, S; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal.
- Otterlei, Marit; Kavli, Bodil; Standal, Rune; Skjelbred, Camilla; Bharati, Sangeeta; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal.
1999
- Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences. volum 302.
- Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal. volum 18 (13).
1998
- Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR).
- Holsve, Marianne; Otterlei, Marit. (1998) Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder. 1998.
- Holsve, Marianne; Otterlei, Marit. (1998) Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering. 1998.
- Jørgensen, Kjersti; Otterlei, Marit. (1998) Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens. 1998.
- Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bharati, S; Steinsbekk, Kristin; Nilsen, Hilde; Nagelhus-Hernes, T; Haug, T; Aas, Per A; Akbari, M; Skjelbred, Camilla; Kavli, Bodil. (1998) Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis. 1998. DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences..
- Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR). volum 26 (20).
1997
- Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases. Base excision repair on DNA damage.
- Nagelhus, T.; Haug, T.; Singh, K.K.; Keshav, K.F.; Skorpen, Frank; Bharati, S.; Otterlei, Marit; Lindmo, T.; Benichou, S.; Benarous, R.; Krokan, Hans Einar. (1997) A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A. Journal of Biological Chemistry.
- Nilsen, H.; Otterlei, Marit; Haug, T.; Solum, K.; Nagelhus, T.A; Skorpen, Frank; Krokan, Hans Einar. (1997) Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Research (NAR).
1995
- Skjåk-Bræk, Gudmund; Espevik, Terje; Otterlei, Marit; Smidsrød, Olav; Soon-Shiong, P.. (1995) Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same. 1995. US-Patent 5459 054, Oct. 1995.
Journal publications
- Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lisa M.; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2022) Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide. Antibiotics. volum 11 (8).
- Gravina, Giovanni Luca; Colapietro, Alessandro; Andrea, Mancini; Rossetti, Alessandra; Martelucci, Stefano; Ventura, Luca; Di Franco, Martina; Marampon, Francesco; Mattei, Vinvenzo; Biordi, Leda Assunta; Otterlei, Marit; Festuccia, Claudio. (2022) ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma. Cancers.
- Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge. (2021) Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents. European Journal of Organic Chemistry.
- Frimodt-Møller, Jakob; Koulouktsis, Andreas; Charbon, Godefroid; Otterlei, Marit; Nielsen, Peter E.; Løbner-Olesen, Anders. (2021) Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli. Molecular Therapy - Nucleic Acids. volum 25.
- Nepal, Anala; Ræder, Synnøve Brandt; Søgaard, Caroline Krogh; Haugan, Maria Schei; Otterlei, Marit. (2021) Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization. Frontiers in Microbiology.
- Ræder, Synnøve Brandt; Sandbakken, Erik Thorvaldsen; Nepal, Anala; Løseth, Kirsti; Bergh, Kåre; Witsø, Eivind; Otterlei, Marit. (2021) Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo. Frontiers in Microbiology.
- Strømme, Olaf; Heck, Kathleen; Brede, Gaute; Lindholm, Håvard Takle; Otterlei, Marit; Arum, Carl-Jørgen. (2021) Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors. Current Issues in Molecular Biology. volum 43 (1).
- Sumabe, Balagra Kasim; Ræder, Synnøve Brandt; Røst, Lisa M.; Sharma, Animesh; Donkor, Eric S.; Mosi, Lydia; Duodu, Samuel; Bruheim, Per; Otterlei, Marit. (2021) Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis. Biomolecules. volum 11 (6).
- Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit. (2020) Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis. Nucleic Acids Research (NAR). volum 48 (10).
- Seelinger, Mareike; Søgaard, Caroline Krogh; Otterlei, Marit. (2020) The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type. Biomolecules. volum 10 (3).
- Seelinger, Mareike; Otterlei, Marit. (2020) Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA). International Journal of Molecular Sciences. volum 21 (693).
- Montaldo, Nicola Pietro; Bordin, Diana Lilian; Brambilla, Alessandro; Rösinger, Marcel; Martin, Sarah Fordyce; Bjørås, Karine Øian; Bradamante, Stefano; Aas, Per Arne; Furrer, Antonia; Olsen, Lene Christin; Kunath, Nicolas; Otterlei, Marit; Sætrom, Pål; Bjørås, Magnar; Samson, Leona D.; van Loon, Barbara. (2019) Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. volum 10 (1).
- Prestel, Andreas; Wichmann, Nanna; Martins, Joao M; Marabini, Riccardo; Kassem, Noah; Broendum, Sebastian S; Otterlei, Marit; Nielsen, Olaf; Willemoës, Martin; Ploug, Michael; Boomsma, Wouter; Kragelund, Birthe B. (2019) The PCNA interaction motifs revisited: thinking outside the PIP-box. Cellular and Molecular Life Sciences (CMLS). volum 76 (24).
- Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Maiken Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian. (2019) 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication. Scientific Reports. volum 9.
- Søgaard, Caroline Krogh; Nepal, Anala; Petrovic, Voin; Sharma, Animesh; Liabakk, Nina-Beate; Steigedal, Tonje S.; Otterlei, Marit. (2019) Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy. OncoTarget. volum 10 (68).
- Olaisen, Camilla; Kvitvang, Hans Fredrik Nyvold; Lee, Sungmin; Almaas, Eivind; Bruheim, Per; Drabløs, Finn; Otterlei, Marit. (2018) The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans. FEBS Open Bio. volum 8 (7).
- Petrovic, Voin; Nepal, Anala; Olaisen, Camilla; Bachke, Siri; Hira, Jonathan; Søgaard, Caroline Krogh; Røst, Lisa Marie; Misund, Kristine; Andreassen, Trygve; Melø, Torun Margareta; Bartosova, Zdenka; Bruheim, Per; Otterlei, Marit. (2018) Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress. Nutrients. volum 10 (4).
- Ræder, Synnøve Brandt; Nepal, Anala; Bjørås, Karine; Seelinger, Mareike; Kolve, Rønnaug Steen; Nedal, Aina; Müller, Rebekka; Otterlei, Marit. (2018) APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells. International Journal of Molecular Sciences. volum 20 (1).
- Søgaard, Caroline Danielsen; Moestue, Siver Andreas; Rye, Morten Beck; Kim, Jana; Nepal, Anala; Liabakk, Nina-Beate; Bachke, Siri; Bathen, Tone Frost; Otterlei, Marit; Hill, Deborah Katherine. (2018) APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer. OncoTarget. volum 9 (14).
- Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit. (2018) "Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling. OncoTarget. volum 9 (65).
- Bjørås, Karine; Sousa, Mirta; Sharma, Animesh; Fonseca, Davi de Miranda; Søgaard, Caroline Danielsen; Bjørås, Magnar; Otterlei, Marit. (2017) Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Nucleic Acids Research (NAR). volum 45 (14).
- Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief. volum 12.
- Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry. volum 523.
- Sousa, Mirta; Bjørås, Karine; Hanssen-Bauer, Audun; Solvang-Garten, Karin; Otterlei, Marit. (2017) P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage. Scientific Reports. volum 7 (1).
- Marstad, Anne; Landsverk, Ole J. B.; Strømme, Olaf; Otterlei, Marit; Collas, Philippe; Sundan, Anders; Brede, Gaute. (2016) A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. The FEBS Journal. volum 283 (4).
- Olaisen, Camilla; Müller, Rebekka; Nedal, Aina; Otterlei, Marit. (2015) PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling. Cellular Signalling. volum 27 (7).
- Baglo, Yan; Hagen, Lars; Høgset, Anders; Drabløs, Finn; Otterlei, Marit; Gederaas, Odrun Arna. (2014) Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization. BioMed Research International. volum 14 (74).
- Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit. (2014) Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide. Translational Oncology. volum 7 (6).
- Hegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Otterlei, Marit; Krokan, Hans Einar. (2013) Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase. DNA Repair. volum 12 (1).
- Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit. (2013) Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells. PLOS ONE. volum 8 (7).
- Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål. (2012) Human ALKBH4 Interacts with Proteins Associated with Transcription. PLOS ONE. volum 7 (11).
- Gilljam, Karin Margaretha; Müller, Rebekka; Liabakk, Nina-Beate; Otterlei, Marit. (2012) Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLOS ONE. volum 7 (11).
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit. (2012) X-ray repair cross complementing protein 1 in base excision repair. International Journal of Molecular Sciences. volum 13 (12).
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Gilljam, Karin Margaretha; Torseth, Kathrin; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2012) The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA Repair. volum 11 (4).
- Otterlei, Marit; Müller, R.; Gilljam, Karin Margaretha; Holien, Toril; Midsund, K.; Vatsveen, TK; Ro, T.B.; Bellacchio, E.; Sundan, Anders. (2012) PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS. Annals of Oncology. volum 23.
- Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair. volum 11 (6).
- Alevizopoulos, K; Otterlei, Marit. (2011) ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control. Annals of Oncology. volum 22.
- Hanssen-Bauer, Audun; Solvang-Garten, Karin; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis. volum 52 (8).
- Sletta, Håvard; Klinkenberg, Geir; Winnberg, Asgeir; Kvitvang, Hans Fredrik Nyvold; Nilsen, Marianne Bakke; Krokan, Hans Einar; Otterlei, Marit; Bruheim, Per. (2011) A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. Journal of Microbiological Methods. volum 87 (3).
- Akbari, Mansour; Solvang-Garten, Karin; Hanssen-Bauer, Audun; Lieske, Nora V.; Pettersen, Henrik P Sahlin; Pettersen, Grete Klippenvåg; Wilson, DM; Krokan, Hans Einar; Otterlei, Marit. (2010) Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair. volum 9 (7).
- Arum, Carl-Jørgen; Kodama, Yosuke; Rolim, Natale Pinheiro Lage; Widerøe, Marius; Anderssen, Endre; Viset, Trond; Otterlei, Marit; Lundgren, Steinar; Chen, Duan; Zhao, Chun-Mei. (2010) A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma. World Journal of Urology. volum 28 (4).
- Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer. volum 8 (5).
- Akbari, Mansour; Diaz, Javier Pena; Andersen, Sonja Benedikte; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2009) Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair. volum 8 (7).
- Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
- Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology. volum 83 (19).
- Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 364 (1517).
- Akbari, Mansour; Visnes, Torkild; Krokan, Hans Einar; Otterlei, Marit. (2008) Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair. volum 7.
- Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N; Krokan, Hans Einar; Slupphaug, Geir. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal. volum 27 (1).
- Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
- Akbari, Mansour; Otterlei, Marit; Pena-Diaz, J; Krokan, Hans Einar. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. volum 145.
- Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
- Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair.
- Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair.
- Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Krokan, Hans Einar. (2006) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience.
- Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research. volum 312.
- Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal. volum 273.
- Otterlei, Marit; Bruheim, Per; Ahn, Byungchan; Bussen, Wendy; Karmakar, Parimal; Baynton, Kathy; Bohr, Vilhelm A.. (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. Journal of Cell Science. volum 119 (24).
- Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM). volum 201.
- Luna, Gomez Luisa; Luna, L; Rolseth, V; Hildrestrand, GA; Otterlei, Marit; Dantzer, F; Bjørås, Magnar; Bjoras, M; Seeberg, E. (2005) Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant. Nucleic Acids Research (NAR). volum 33.
- Pohler, JRG; Otterlei, Marit; Warbrick, E. (2005) An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit. BMC Molecular Biology. volum 6.
- Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir; Krokan, Hans Einar. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR). volum 32.
- Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
- Fan, JS; Otterlei, Marit; Wong, HK; Tomkinson, AE; Wilson, DM. (2004) XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Research (NAR). volum 32 (7).
- Opresko, PL; Otterlei, Marit; Graakjaer, J; Bruheim, P; Dawut, L; Kolvraa, S; May, A; Seidman, MM; Bohr, VA. (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2. Molecular Cell.
- Sharma, S; Otterlei, Marit; Sommers, JA; Driscoll, HC; Dianov, GL; Kao, HI; Bambara, RA; Brosh, RM. (2004) WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork. Molecular Biology of the Cell. volum 15 (2).
- Baynton, Kathy; Otterlei, Marit; Bjørås, M.; von Kobbe, Cayetano; Bohr, Vilhelm; Seeberg, E.. (2003) WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*. JBC Papers in Press. volum 278 (38).
- Bayton, Kathy; Otterlei, Marit; Bjørås, Magnar; Kobbe, C von; Bohr, V.A.; Seeberg, Erling Christen. (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. Journal of Biological Chemistry. volum 278.
- Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
- Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. volum 18.
- Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology. volum 68.
- Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters.
- Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters.
- Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
- Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
- Otterlei, Marit; Kavli, B; Standal, R; Skjelbred, Camilla; Bharati, S; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal.
- Otterlei, Marit; Kavli, Bodil; Standal, Rune; Skjelbred, Camilla; Bharati, Sangeeta; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal.
- Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences. volum 302.
- Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal. volum 18 (13).
- Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR).
- Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR). volum 26 (20).
- Nagelhus, T.; Haug, T.; Singh, K.K.; Keshav, K.F.; Skorpen, Frank; Bharati, S.; Otterlei, Marit; Lindmo, T.; Benichou, S.; Benarous, R.; Krokan, Hans Einar. (1997) A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A. Journal of Biological Chemistry.
- Nilsen, H.; Otterlei, Marit; Haug, T.; Solum, K.; Nagelhus, T.A; Skorpen, Frank; Krokan, Hans Einar. (1997) Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Research (NAR).
Report/dissertation
- Holsve, Marianne; Otterlei, Marit. (1998) Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder. 1998.
- Holsve, Marianne; Otterlei, Marit. (1998) Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering. 1998.
- Jørgensen, Kjersti; Otterlei, Marit. (1998) Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens. 1998.
- Skjåk-Bræk, Gudmund; Espevik, Terje; Otterlei, Marit; Smidsrød, Olav; Soon-Shiong, P.. (1995) Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same. 1995. US-Patent 5459 054, Oct. 1995.
Part of book/report
- Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases. Base excision repair on DNA damage.
Books
- Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bharati, S; Steinsbekk, Kristin; Nilsen, Hilde; Nagelhus-Hernes, T; Haug, T; Aas, Per A; Akbari, M; Skjelbred, Camilla; Kavli, Bodil. (1998) Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis. 1998. DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences..
Teaching
Courses
Media
2002
- Sundan, Anders; Otterlei, Marit; Krokan, Hans Einar. (2002) Det gode liv på Øya: Rapport fra et vinnermiljø. Universitetsavisa null [Avis]. 2002-06-13.