Menno Oudhoff
About
About the lab
The overarching goal of research our group is to define the cellular and molecular mechanisms that control infection, regeneration, and inflammation at mucosal surfaces. For example, the digestive tract is responsible for absorption of nutrients and water, but at the same time it has a crucial role in acting as a barrier to the external environment. The barrier function is complicated by the requirement to simultaneously be able to respond appropriately to dangerous pathogens, and remain tolerant to innocuous antigens like commensal organisms and food. Dysregulation of this equilibrium, either by exposure to infection and/or chemicals or by genetic predisposition can lead to (chronic) diseases such as inflammatory bowel diseases (IBDs), food allergies, and cancer. Understanding the molecular and cellular principles underlying development, homeostasis, and disease provide important means for identifying novel therapeutics.
About me
I am currently a group leader at the Centre of Molecular Inflammation Research (CEMIR, www.ntnu.edu/cemir) which is hosted by the Faculty of Medicine at the Norwegian University of Science and Technology (NTNU) in Trondheim. After completing my MSc degree in Biology in 2006, I did my PhD at the Department of Oral Biochemistry (VU University, Amsterdam) under supervision of Dr. Enno Veerman where I studied salivary peptides in wound healing. In 2011, I joined the Mucosal Immunology lab of Dr. Colby Zaph at UBC in Vancouver (www.zaphlab.com, go see the profile pictures!).
Publications
2023
-
Martin Alonso, Mara;
Oudhoff, Menno Johannes;
Vornewald, Pia Magdalena.
(2023)
Orchestrating the intestinal epithelial niche: Intestinal Smooth Muscle tissue and cytokines in epithelial regulation.
Norwegian University of Science and Technology
Doctoral dissertation
-
Vornewald, Pia Magdalena;
Forman, Ruth;
Yao, Rouan;
Parmar, Naveen;
Lindholm, Håvard Takle;
Lee, Lilith Sian Kaspersen.
(2023)
Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection.
Frontiers in Immunology
Academic article
-
Vornewald, Pia Magdalena;
Forman, Ruth;
Yao, Rouan;
Parmar, Naveen;
Lindholm, Håvard Takle;
Lee, Lilith Sian Kaspersen.
(2023)
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection.
Frontiers in Immunology
Academic article
2022
-
Horsnell, William G C;
Oudhoff, Menno.
(2022)
Helminths are positively AMPing up gut de-bugging.
Cell Host and Microbe
Academic article
-
Vornewald, Pia;
Oudhoff, Menno.
(2022)
Helminths get MIFfed by the tuft cell - ILC2 circuit.
Immunology and Cell Biology
Academic article
-
Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology
Academic article
2021
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens
Academic article
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications
Academic article
-
Roberts, Luke B.;
Schnoeller, Corinna;
Berkachy, Rita;
Darby, Matthew;
Pillaye, Jamie;
Oudhoff, Menno.
(2021)
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.
Science immunology
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe
Academic article
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM)
Interview Journal
-
Zwiggelaar, Rosalie Theda Margien;
Oudhoff, Menno.
(2021)
Epigenetic control of the intestinal epithelium: A role for lysine-specific demethylase 1A during homeostasis and disease.
NTNU
Doctoral dissertation
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology
Academic article
2020
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Academic article
2018
-
Judson, Robert N;
Quarta, Marco;
Oudhoff, Menno;
Soliman, Hesham;
Yi, Lin;
Chang, Chih Kai.
(2018)
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell Stem Cell
Academic article
2017
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel.
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional
signaling and epithelial homeostasis in the intestine.
Journal of Cell Science
Academic article
2016
-
Oudhoff, Menno;
Braam, Mitchell JS;
Freeman, Spencer A;
Wong, Denise;
Rattray, David G;
Wang, Jia.
(2016)
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Developmental Cell
Academic article
-
Oudhoff, Menno;
Antignano, Frann;
Chenery, Alistair L;
Burrows, Kyle;
Redpath, Stephen A;
Braam, Mitchell J.
(2016)
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
PLoS Pathogens
Academic article
Journal publications
-
Vornewald, Pia Magdalena;
Forman, Ruth;
Yao, Rouan;
Parmar, Naveen;
Lindholm, Håvard Takle;
Lee, Lilith Sian Kaspersen.
(2023)
Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection.
Frontiers in Immunology
Academic article
-
Vornewald, Pia Magdalena;
Forman, Ruth;
Yao, Rouan;
Parmar, Naveen;
Lindholm, Håvard Takle;
Lee, Lilith Sian Kaspersen.
(2023)
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection.
Frontiers in Immunology
Academic article
-
Horsnell, William G C;
Oudhoff, Menno.
(2022)
Helminths are positively AMPing up gut de-bugging.
Cell Host and Microbe
Academic article
-
Vornewald, Pia;
Oudhoff, Menno.
(2022)
Helminths get MIFfed by the tuft cell - ILC2 circuit.
Immunology and Cell Biology
Academic article
-
Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology
Academic article
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens
Academic article
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications
Academic article
-
Roberts, Luke B.;
Schnoeller, Corinna;
Berkachy, Rita;
Darby, Matthew;
Pillaye, Jamie;
Oudhoff, Menno.
(2021)
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.
Science immunology
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe
Academic article
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM)
Interview Journal
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology
Academic article
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Academic article
-
Judson, Robert N;
Quarta, Marco;
Oudhoff, Menno;
Soliman, Hesham;
Yi, Lin;
Chang, Chih Kai.
(2018)
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell Stem Cell
Academic article
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel.
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional
signaling and epithelial homeostasis in the intestine.
Journal of Cell Science
Academic article
-
Oudhoff, Menno;
Braam, Mitchell JS;
Freeman, Spencer A;
Wong, Denise;
Rattray, David G;
Wang, Jia.
(2016)
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Developmental Cell
Academic article
-
Oudhoff, Menno;
Antignano, Frann;
Chenery, Alistair L;
Burrows, Kyle;
Redpath, Stephen A;
Braam, Mitchell J.
(2016)
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
PLoS Pathogens
Academic article
Report
-
Martin Alonso, Mara;
Oudhoff, Menno Johannes;
Vornewald, Pia Magdalena.
(2023)
Orchestrating the intestinal epithelial niche: Intestinal Smooth Muscle tissue and cytokines in epithelial regulation.
Norwegian University of Science and Technology
Doctoral dissertation
-
Zwiggelaar, Rosalie Theda Margien;
Oudhoff, Menno.
(2021)
Epigenetic control of the intestinal epithelium: A role for lysine-specific demethylase 1A during homeostasis and disease.
NTNU
Doctoral dissertation
Media
2023
-
PosterDiez Sanchez, Alberto; Martin Alonso, Mara; Oudhoff, Menno Johannes; Vornewald, Pia Magdalena. (2023) Tumor Promoter or suppressor?: The LSD1/KMD1A conundrum in the small intestine. GRC Gordon Research Conference on Stem cells and Cancer 2023-05-14 - 2023-05-19
2019
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Academic lectureOudhoff, Menno. (2019) AI-based organoid image analysis combined with cell compositional and transcriptome analysis to define type II epithelial responses. Keystone - Helminths: New Insights from Immunity to Global Health 2019-12-08 - 2019-12-12
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Academic lectureOudhoff, Menno. (2019) Regulation of Intestinal Stem Cells and Niche-Providing Paneth Cells by Epigenetic Modifiers. Invited Speaker 2019-01-17 - 2019-01-17
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PosterOudhoff, Menno. (2019) Lysine-specific demethylase 1a (LSD1) is a regulator of postnatal intestinal epithelial development. Copenhagen Bioscience Conference - Intestinal organoids 2019-09-29 - 2019-10-02
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Academic lectureOudhoff, Menno. (2019) Epigenetic regulation of the Intestinal Epithelium in Homeostasis and Disease . CMMI - Conference on Molecular Mechanisms of Inflammation 2019-06-03 - 2019-06-06
-
PosterOstrop, Jenny; Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Martin Alonso, Mara; Sanchez, Alberto Diez; Nonstad, Unni. (2019) Development of a semi-automated intestinal organoid screening method. Conference on Molecular Mechanisms of Inflammation 2019 2019-06-03 - 2019-06-05
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PosterOstrop, Jenny; Zwiggelaar, Rosalie; T. Pedersen, Marianne; Lindholm, Håvard Takle; Bösl, Korbinian; Sanchez, Alberto Diez. (2019) A semi-automated intestinal organoid screening method to study plasticity of intestinal epithelial cell differentiation. Novo Nordisk Fourndation Intestinal Organoids - from stem cells to metabolism and microbiome interactions , Hillerød 2019-09-29 - 2019-10-02
2018
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PosterMartin Alonso, Mara; Oudhoff, Menno. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. EMBO meeting on Tissue Regeneration 2018-09-15 - 2018-09-19
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Academic lectureMartin Alonso, Mara; Oudhoff, Menno; Garcia Arroyo, Alicia. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. Gordon's Research Conference Stem Cells 2018-08-16 - 2018-08-21
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PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Nonstad, Unni; Spanjers, Roos; Arrowsmith, Cheryl H. (2018) Development of a semi-automated intestinal organoid screening method. NEUBIAS Network of European Bioimage Analysts Conference , Szeged 2018-01-30 - 2018-02-02
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PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. European Light Microscopy Initiative (ELMI) , Dublin 2018-06-05 - 2018-06-08
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PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. Focus on Microscopy 2018-03-25 - 2018-03-28
2017
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Academic lectureOudhoff, Menno. (2017) SETD7 Controls Developmental Pathways During Bacterial and Helminth Infection. 35th Annual Meeting and General Assembly of the NSI 2017-11-17 - 2017-11-17
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Popular scientific lectureOudhoff, Menno. (2017) How is organ size controlled? The fable of the fly, the hippo, and all other animals. Norwegian Biochemical Society Popular Science Talk 2017-10-05 - 2017-10-05
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PosterOstrop, Jenny; Kerntke, Christina; Gullik Sørbø, Håvard; Jozefowski, Katrin; Hupfer, Thomas; Louet, Claire. (2017) FcRγ is a central adaptor subunit for immune receptors on myeloid cells. EMBL EMBL course Bioimage Data Analysis - poster session , Heidelberg 2017-05-14 - 2017-05-14
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PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Spanjers, Roos; Arrowsmith, Cheryl H; Oudhoff, Menno. (2017) Semi-automated screening of organoid cultures to test effects of potential therapeutics on antimicrobial functions and tissue regeneration in the intestine. German Society for Immunology Annual Meeting of German Society for Immunology , Erlangen 2017-09-12 - 2017-09-15
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PosterOstrop, Jenny; Kerntke, Christina; Gullik Sørbø, Håvard; Spanjers, Roos; Louet, Claire; Gidon, Alexandre. (2017) FcRγ is a central adaptor subunit for immune receptors on human macrophages. German Society for Immunology Annual Meeting of German Society for Immunology , Erlangen 2017-09-12 - 2017-09-15