Menno Oudhoff
About
About the lab
The overarching goal of research our group is to define the cellular and molecular mechanisms that control infection, regeneration, and inflammation at mucosal surfaces. For example, the digestive tract is responsible for absorption of nutrients and water, but at the same time it has a crucial role in acting as a barrier to the external environment. The barrier function is complicated by the requirement to simultaneously be able to respond appropriately to dangerous pathogens, and remain tolerant to innocuous antigens like commensal organisms and food. Dysregulation of this equilibrium, either by exposure to infection and/or chemicals or by genetic predisposition can lead to (chronic) diseases such as inflammatory bowel diseases (IBDs), food allergies, and cancer. Understanding the molecular and cellular principles underlying development, homeostasis, and disease provide important means for identifying novel therapeutics.
About me
I am currently a group leader at the Centre of Molecular Inflammation Research (CEMIR, www.ntnu.edu/cemir) which is hosted by the Faculty of Medicine at the Norwegian University of Science and Technology (NTNU) in Trondheim. After completing my MSc degree in Biology in 2006, I did my PhD at the Department of Oral Biochemistry (VU University, Amsterdam) under supervision of Dr. Enno Veerman where I studied salivary peptides in wound healing. In 2011, I joined the Mucosal Immunology lab of Dr. Colby Zaph at UBC in Vancouver (www.zaphlab.com, go see the profile pictures!).
Publications
2022
-
Horsnell, William G C;
Oudhoff, Menno.
(2022)
Helminths are positively AMPing up gut de-bugging.
Cell Host and Microbe.
volum 30 (1).
Academic article
-
Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny;
Sanchez, Alberto Diez;
Maizels M, Rick;
Oudhoff, Menno.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology.
volum 7 (71).
Academic article
-
Vornewald, Pia;
Oudhoff, Menno.
(2022)
Helminths get MIFfed by the tuft cell - ILC2 circuit.
Immunology and Cell Biology.
volum 100 (5).
Academic article
2021
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando;
Hoel, Sigrid;
Sanchez, Alberto Diez;
Altelaar, Maarten;
Katajisto, Pekka;
Arroyo, Alicia G.;
Oudhoff, Menno.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications.
volum 12 (1).
Academic article
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle;
Díez-Sánchez, Alberto;
Parmar, Naveen;
Radetzki, Silke;
von Kries, Jens P.;
Jay, Philippe;
Jensen, Kim B.;
Arrowsmith, Cheryl;
Oudhoff, Menno.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology.
volum 8:618552.
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel;
McSorley, Henry;
Masson, Lindi;
Smith, Katherine;
Brombacher, Frank;
O'Shea, Matthew;
Cunningham, Adam;
Ryffel, Bernhard;
Oudhoff, Menno;
Dewals, Benjamin;
Layland, Laura;
Horsnell, WG.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe.
Academic article
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM).
publications.INTERVJUSKRIFTL
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez;
Alonso, Mara Martin;
Fosslie, Madeleine Lystad;
Vallance, Bruce A.;
Dahl, John Arne;
Zaph, Colby;
Oudhoff, Menno.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens.
volum 17 (3).
Academic article
-
Roberts, Luke B.;
Schnoeller, Corinna;
Berkachy, Rita;
Darby, Matthew;
Pillaye, Jamie;
Oudhoff, Menno;
Parmar, Naveen;
Mackowiak, Claire;
Sedda, Delphine;
Quesniaux, Valerie;
Ryffel, Bernhard;
Vaux, Rachel;
Gounaris, Kleoniki;
Berrard, Sylvie;
Withers, David R.;
Horsnell, William G.C.;
Selkirk, Murray E..
(2021)
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.
Science immunology.
volum 6 (57).
Academic article
2020
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez;
Martin Alonso, Mara;
Ostrop, Jenny;
Matano, Mami;
Parmar, Naveen;
Kvaløy, Emilie;
Spanjers, Roos;
Nazmi, Kamran;
Rye, Morten Beck;
Drabløs, Finn;
Arrowsmith, Cheryl H;
Dahl, John Arne;
Jensen, Kim B.;
Sato, Toshiro;
Oudhoff, Menno.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances.
volum 6 (37).
Academic article
2018
-
Judson, Robert N;
Quarta, Marco;
Oudhoff, Menno;
Soliman, Hesham;
Yi, Lin;
Chang, Chih Kai;
Loi, Gloria;
Vander Werff, Ryan;
Cait, Alissa;
Hamer, Mark;
Blonigan, Justin;
Paine, Patrick;
Doan, Linda TN;
Groppa, Elena;
He, WenJun;
Su, Le;
Zhang, Regan H;
Xu, Peter;
Eisner, Christine;
Low, Marcela;
Barta, Ingrid;
Lewis, Coral-Ann B;
Zaph, Colby;
Karimi, Mohammad M;
Rando, Thomas A;
Rossi, Fabio M.
(2018)
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell Stem Cell.
volum 22 (2).
Academic article
2017
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel;
Calvo, Enrique;
Camfeita, Emilio;
Martinez, Fernando;
Oudhoff, Menno;
Weiss, Stephen J.;
Arrayo, Alicia G..
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
Journal of Cell Science.
volum 130 (23).
Academic article
2016
-
Oudhoff, Menno;
Antignano, Frann;
Chenery, Alistair L;
Burrows, Kyle;
Redpath, Stephen A;
Braam, Mitchell J;
Perona-Wright, Georgia;
Zaph, Colby.
(2016)
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
PLoS Pathogens.
volum 12 (9).
Academic article
-
Oudhoff, Menno;
Braam, Mitchell JS;
Freeman, Spencer A;
Wong, Denise;
Rattray, David G;
Wang, Jia;
Antignano, Frann;
Snyder, Kimberly;
Refaeli, Ido;
Hughes, Michael R;
McNagny, Kelly M;
Gold, Michael R;
Arrowsmith, Cheryl H;
Sato, Toshiro;
Rossi, Fabio MV;
Tatlock, John H;
Owen, Dafydd R;
Brown, Peter J;
Zaph, Colby.
(2016)
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Developmental Cell.
volum 37 (1).
Academic article
Scientific articles
-
Horsnell, William G C;
Oudhoff, Menno.
(2022)
Helminths are positively AMPing up gut de-bugging.
Cell Host and Microbe.
volum 30 (1).
Academic article
-
Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny;
Sanchez, Alberto Diez;
Maizels M, Rick;
Oudhoff, Menno.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology.
volum 7 (71).
Academic article
-
Vornewald, Pia;
Oudhoff, Menno.
(2022)
Helminths get MIFfed by the tuft cell - ILC2 circuit.
Immunology and Cell Biology.
volum 100 (5).
Academic article
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando;
Hoel, Sigrid;
Sanchez, Alberto Diez;
Altelaar, Maarten;
Katajisto, Pekka;
Arroyo, Alicia G.;
Oudhoff, Menno.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications.
volum 12 (1).
Academic article
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle;
Díez-Sánchez, Alberto;
Parmar, Naveen;
Radetzki, Silke;
von Kries, Jens P.;
Jay, Philippe;
Jensen, Kim B.;
Arrowsmith, Cheryl;
Oudhoff, Menno.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology.
volum 8:618552.
Academic article
-
Chetty, Alisha;
Darby, Matthew;
Vornewald, Pia;
Alonso, Mara Martin;
Filz, Anna;
Ritter, Manuel;
McSorley, Henry;
Masson, Lindi;
Smith, Katherine;
Brombacher, Frank;
O'Shea, Matthew;
Cunningham, Adam;
Ryffel, Bernhard;
Oudhoff, Menno;
Dewals, Benjamin;
Layland, Laura;
Horsnell, WG.
(2021)
Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.
Cell Host and Microbe.
Academic article
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez;
Alonso, Mara Martin;
Fosslie, Madeleine Lystad;
Vallance, Bruce A.;
Dahl, John Arne;
Zaph, Colby;
Oudhoff, Menno.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens.
volum 17 (3).
Academic article
-
Roberts, Luke B.;
Schnoeller, Corinna;
Berkachy, Rita;
Darby, Matthew;
Pillaye, Jamie;
Oudhoff, Menno;
Parmar, Naveen;
Mackowiak, Claire;
Sedda, Delphine;
Quesniaux, Valerie;
Ryffel, Bernhard;
Vaux, Rachel;
Gounaris, Kleoniki;
Berrard, Sylvie;
Withers, David R.;
Horsnell, William G.C.;
Selkirk, Murray E..
(2021)
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.
Science immunology.
volum 6 (57).
Academic article
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez;
Martin Alonso, Mara;
Ostrop, Jenny;
Matano, Mami;
Parmar, Naveen;
Kvaløy, Emilie;
Spanjers, Roos;
Nazmi, Kamran;
Rye, Morten Beck;
Drabløs, Finn;
Arrowsmith, Cheryl H;
Dahl, John Arne;
Jensen, Kim B.;
Sato, Toshiro;
Oudhoff, Menno.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances.
volum 6 (37).
Academic article
-
Judson, Robert N;
Quarta, Marco;
Oudhoff, Menno;
Soliman, Hesham;
Yi, Lin;
Chang, Chih Kai;
Loi, Gloria;
Vander Werff, Ryan;
Cait, Alissa;
Hamer, Mark;
Blonigan, Justin;
Paine, Patrick;
Doan, Linda TN;
Groppa, Elena;
He, WenJun;
Su, Le;
Zhang, Regan H;
Xu, Peter;
Eisner, Christine;
Low, Marcela;
Barta, Ingrid;
Lewis, Coral-Ann B;
Zaph, Colby;
Karimi, Mohammad M;
Rando, Thomas A;
Rossi, Fabio M.
(2018)
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell Stem Cell.
volum 22 (2).
Academic article
-
Gómez-Escudero, Jesús;
Moreno, Vanessa;
Martin Alonso, Mara;
Hernández-Riquer, M. Victoria;
Feinberg, Tamar;
Colmenar, Ángel;
Calvo, Enrique;
Camfeita, Emilio;
Martinez, Fernando;
Oudhoff, Menno;
Weiss, Stephen J.;
Arrayo, Alicia G..
(2017)
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
Journal of Cell Science.
volum 130 (23).
Academic article
-
Oudhoff, Menno;
Antignano, Frann;
Chenery, Alistair L;
Burrows, Kyle;
Redpath, Stephen A;
Braam, Mitchell J;
Perona-Wright, Georgia;
Zaph, Colby.
(2016)
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
PLoS Pathogens.
volum 12 (9).
Academic article
-
Oudhoff, Menno;
Braam, Mitchell JS;
Freeman, Spencer A;
Wong, Denise;
Rattray, David G;
Wang, Jia;
Antignano, Frann;
Snyder, Kimberly;
Refaeli, Ido;
Hughes, Michael R;
McNagny, Kelly M;
Gold, Michael R;
Arrowsmith, Cheryl H;
Sato, Toshiro;
Rossi, Fabio MV;
Tatlock, John H;
Owen, Dafydd R;
Brown, Peter J;
Zaph, Colby.
(2016)
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Developmental Cell.
volum 37 (1).
Academic article
Journal publications
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM).
publications.INTERVJUSKRIFTL
Teaching
Courses
Media
2019
-
PosterOstrop, Jenny; Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Martin Alonso, Mara; Sanchez, Alberto Diez; Nonstad, Unni; Radetzki, Silke; T. Pedersen, Marianne; Arrowsmith, Cheryl H; Oudhoff, Menno. (2019) Development of a semi-automated intestinal organoid screening method. Conference on Molecular Mechanisms of Inflammation 2019 ; 2019-06-03 - 2019-06-05.
-
PosterOstrop, Jenny; Zwiggelaar, Rosalie; T. Pedersen, Marianne; Lindholm, Håvard Takle; Bösl, Korbinian; Sanchez, Alberto Diez; Radetzki, Silke; Gerbe, Francois; Jay, Philippe; Arrowsmith, Cheryl H; Oudhoff, Menno. (2019) A semi-automated intestinal organoid screening method to study plasticity of intestinal epithelial cell differentiation. Intestinal Organoids - from stem cells to metabolism and microbiome interactions . Novo Nordisk Fourndation; Hillerød. 2019-09-29 - 2019-10-02.
-
Academic lectureOudhoff, Menno. (2019) AI-based organoid image analysis combined with cell compositional and transcriptome analysis to define type II epithelial responses. Keystone - Helminths: New Insights from Immunity to Global Health ; 2019-12-08 - 2019-12-12.
-
Academic lectureOudhoff, Menno. (2019) Epigenetic regulation of the Intestinal Epithelium in Homeostasis and Disease. CMMI - Conference on Molecular Mechanisms of Inflammation ; 2019-06-03 - 2019-06-06.
-
PosterOudhoff, Menno. (2019) Lysine-specific demethylase 1a (LSD1) is a regulator of postnatal intestinal epithelial development. Copenhagen Bioscience Conference - Intestinal organoids ; 2019-09-29 - 2019-10-02.
-
Academic lectureOudhoff, Menno. (2019) Regulation of Intestinal Stem Cells and Niche-Providing Paneth Cells by Epigenetic Modifiers. Invited Speaker ; 2019-01-17 - 2019-01-17.
2018
-
PosterMartin Alonso, Mara; Oudhoff, Menno. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. EMBO meeting on Tissue Regeneration ; 2018-09-15 - 2018-09-19.
-
Academic lectureMartin Alonso, Mara; Oudhoff, Menno; Garcia Arroyo, Alicia. (2018) Smooth muscle-specific Mmp17 (Mt4-mmp) regulates intestinal inflammatory and regenerative responses. Gordon's Research Conference Stem Cells ; 2018-08-16 - 2018-08-21.
-
PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Nonstad, Unni; Spanjers, Roos; Arrowsmith, Cheryl H; Oudhoff, Menno. (2018) Development of a semi-automated intestinal organoid screening method. Network of European Bioimage Analysts Conference . NEUBIAS; Szeged. 2018-01-30 - 2018-02-02.
-
PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. European Light Microscopy Initiative (ELMI) ; Dublin. 2018-06-05 - 2018-06-08.
-
PosterSporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Martin Alonso, Mara; Ostrop, Jenny; Zwiggelaar, Rosalie; Oudhoff, Menno. (2018) Intestinal diseases studied by imaging. Focus on Microscopy ; 2018-03-25 - 2018-03-28.
2017
-
PosterOstrop, Jenny; Kerntke, Christina; Gullik Sørbø, Håvard; Jozefowski, Katrin; Hupfer, Thomas; Louet, Claire; Gidon, Alexandre; Lepenies, Bernd; Flo, Trude Helen; Lang, Roland; Oudhoff, Menno. (2017) FcRγ is a central adaptor subunit for immune receptors on myeloid cells. EMBL course Bioimage Data Analysis - poster session . EMBL; Heidelberg. 2017-05-14 - 2017-05-14.
-
PosterOstrop, Jenny; Kerntke, Christina; Gullik Sørbø, Håvard; Spanjers, Roos; Louet, Claire; Gidon, Alexandre; Lang, Roland; Flo, Trude Helen; Oudhoff, Menno. (2017) FcRγ is a central adaptor subunit for immune receptors on human macrophages. Annual Meeting of German Society for Immunology . German Society for Immunology; Erlangen. 2017-09-12 - 2017-09-15.
-
PosterOstrop, Jenny; Martin Alonso, Mara; Zwiggelaar, Rosalie; Spanjers, Roos; Arrowsmith, Cheryl H; Oudhoff, Menno. (2017) Semi-automated screening of organoid cultures to test effects of potential therapeutics on antimicrobial functions and tissue regeneration in the intestine. Annual Meeting of German Society for Immunology . German Society for Immunology; Erlangen. 2017-09-12 - 2017-09-15.
-
Popular scientific lectureOudhoff, Menno. (2017) How is organ size controlled? The fable of the fly, the hippo, and all other animals. Norwegian Biochemical Society Popular Science Talk ; 2017-10-05 - 2017-10-05.
-
Academic lectureOudhoff, Menno. (2017) SETD7 Controls Developmental Pathways During Bacterial and Helminth Infection. 35th Annual Meeting and General Assembly of the NSI ; 2017-11-17 - 2017-11-17.