Nathalie Jurisch-Yaksi
About
Nathalie Jurisch-Yaksi is a group leader at the Department of Clinical and Molecular Medicine at NTNU and an Associate Professor (10%) at the Kavli Institute for Systems Neuroscience.
Her research program aims at understanding cellular and molecular principles regulating the development, physiology and diseases of the nervous system. Her laboratory is particularly interested in one subcellular structure, the cilium, which play both signaling and mechanical functions, and in ependymal cells and astroglia, which are non-neuronal cell types of the brain.
Her team uses the genetically tractable small model organism zebrafish and a combination of techniques including genetics, molecular and cell biology, functional imaging, quantitative behavioral assays and applied mathematics.
The aims of her research program are to:
1. Unravel the cellular, genetic, and biophysical properties of motile ciliated cells
2. Unravel the function of motile ciliated cells in the nervous system
3. Identify the impact of primary cilia in neuronal development
4. Identify the role of astroglia in brain development and physiology
Current Team Members
Postdoc: Dr Inyoung Jung
PhD students: Mert Ege and Percival D’Gama
Medical students: Ahmed Jamali
Technician: Andreas Nygård
Master students: Anna-Lena Paszdior (NTNU Neuroscience) and Natalia Freus (UNiverity fo Erlangen, Germany)
List of publications: https://scholar.google.no/citations?user=MGQIp3wAAAAJ&hl=en
CV: https://yaksilab.com/cv-nathalie-jurisch-yaksi/
Publications
2023
-
Ringers, Christa Nelleke;
Bialonski, Stephan;
Ege, Mert;
Solovev, Anton;
Hansen, Jan;
Jeong, Inyoung;
Friedrich, Benjamin;
Jurisch-Yaksi, Nathalie.
(2023)
Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia.
eLIFE.
volum 12.
Academic article
2022
-
Jeong, Inyoung;
Hansen, Jan Niklas;
Wachten, Dagmar;
Jurisch-Yaksi, Nathalie.
(2022)
Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon.
STAR Protocols.
volum 3 (3).
Academic article
-
Myren-Svelstad, Sverre;
Jamali, Ahmed;
Ophus, Sunniva Sofie;
Dgama, Percival Paul Menino;
Ostenrath, Anna Maria;
Mutlu, Aytac Kadir;
Hoffshagen, Helene Homme;
Hotz, Adriana L.;
Neuhauss, Stephan C. F.;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2022)
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.
Epilepsia.
volum 63 (10).
Academic article
-
Salman, Huseyin Enes;
Jurisch-Yaksi, Nathalie;
Yalcin, Huseyin Cagatay.
(2022)
Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo.
Bioengineering.
volum 9.
Academic article
2021
-
Dgama, Percival Paul Menino;
Qiu, Tao;
Cosacak, Mehmet Ilyas;
Rayamajhi, Dheeraj;
Konac, Ahsen;
Hansen, Jan Niklas;
Ringers, Christa;
Acuna Hinrichsen, Francisca Daniela;
Hui, Subhra;
Olstad, Emilie Willoch;
Chong, Yan Ling;
Lim, Charlton Kang An;
Gupta, Astha;
Ng, Chee Peng;
Nilges, Benedikt S.;
Kashikar, Nachiket;
Wachten, Dagmar;
Liebl, David;
Kikuchi, Kazu;
Kizil, Caghan;
Yaksi, Emre;
Roy, Sudipto;
Jurisch-Yaksi, Nathalie.
(2021)
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.
Cell reports.
volum 37 (1).
Academic article
-
Hansen, Jan Niklas;
Rassmann, Sebastian;
Stüven, Birthe;
Jurisch-Yaksi, Nathalie;
Wachten, Dagmar.
(2021)
CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.
The European Physical Journal E : Soft matter.
volum 44 (2).
Academic article
-
Hotz, Adriana L.;
Jamali, Ahmed;
Rieser, Nicolas N.;
Niklaus, Stephanie;
Aydin, Ecem;
Myren-Svelstad, Sverre;
Lalla, Laetitia Noelle Patricia;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre;
Neuhauss, Stephan C.F..
(2021)
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity.
Glia.
volum 70 (1).
Academic article
-
Yaksi, Emre;
Jamali, Ahmed;
Diaz Verdugo, Carmen;
Jurisch-Yaksi, Nathalie.
(2021)
Past, present and future of zebrafish in epilepsy research.
The FEBS Journal.
Academic literature review
2020
-
Fore, Stephanie Liesbeth;
Acuna Hinrichsen, Francisca Daniela;
Mutlu, Aytac Kadir;
Bartoszek-Kandler, Ewelina Magdalena;
Serneels, Bram;
Faturos, Nicholas Guy;
Chau, Khac Thanh Phong;
Cosacak, Mehmet Ilyas;
Diaz Verdugo, Carmen;
Palumbo, Fabrizio;
Ringers, Christa;
Jurisch-Yaksi, Nathalie;
Kizil, Caghan;
Yaksi, Emre.
(2020)
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis.
Science Advances.
Academic article
-
Hansen, Jan;
Kaiser, Fabian;
Klausen, Christina;
Stüven, Birthe;
Chong, Raymond;
Bönigk, Wolfgang;
Mick, David;
Möglich, Andreas;
Jurisch-Yaksi, Nathalie;
Schmidt, Florian;
Wachten, Dagmar.
(2020)
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
eLIFE.
Academic article
-
Jurisch-Yaksi, Nathalie;
Yaksi, Emre;
Kizil, Caghan.
(2020)
Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia.
Glia.
Academic literature review
-
Ringers, Christa;
Jurisch-Yaksi, Nathalie.
(2020)
Development: How the Reissner Fiber Keeps Our Back Straight.
Current Biology.
volum 30 (12).
Academic article
-
Thouvenin, Olivier;
Keiser, Ludovic;
Cantaut-Belarif, Yasmine;
Carbo-Tano, Martin;
Verweij, Frederik J.;
Jurisch-Yaksi, Nathalie;
Bardet, Pierre-Luc;
Van Niel, Guillaume;
Gallaire, Francois;
Wyart, Claire.
(2020)
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal.
eLIFE.
volum 9.
Academic article
2019
-
Diaz Verdugo, Carmen;
Myren-Svelstad, Sverre;
Aydin, Ecem;
Evelien, Van Hoeymissen;
Deneubourg, Celine;
van Derhaeghe, Silke;
Craeyhest, Julie von;
Pelgrims, Robbrecht;
Casacak, Mehmet Ilyas;
Muto, Akira;
Kizil, Caghan;
Kawakami, Koichi;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2019)
Glia-neuron interactions underlie state transitions to generalized seizures.
Nature Communications.
volum 10.
Academic article
-
Olstad, Emilie Willoch;
Ringers, Christa;
Hansen, Jan Niklas;
Wens, Adinda;
Brandt, Cecilia;
Wachten, Dagmar;
Yaksi, Emre;
Jurisch-Yaksi, Nathalie.
(2019)
Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development.
Current Biology.
volum 29 (2).
Academic article
-
Ringers, Christa;
Olstad, Emile Willoch;
Jurisch-Yaksi, Nathalie.
(2019)
The role of motile cilia in the development and physiology of the nervous system.
Philosophical Transactions of the Royal Society of London. Biological Sciences.
volum 375:20190156.
Academic literature review
2018
-
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2018)
Nathalie Jurisch-Yaksi and Emre Yaksi.
Current Biology.
volum 28 (5).
Short communication
2017
-
Reiten, Ingrid;
Uslu, Fazil Emre;
Forè, Stèphanie;
Pelgrims, Robbrecht;
Ringers, Christa;
Diaz Verdugo, Carmen;
Hoffmann, Maximilian;
Lal, Pradeep;
Kawakami, Koichi;
Pekkan, Kerem;
Yaksi, Emre;
Jurisch-Yaksi, Nathalie.
(2017)
Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations.
Current Biology.
volum 27 (2).
Academic article
2016
-
Bugge, Steffen;
Buene, Audun Formo;
Jurisch-Yaksi, Nathalie;
Moen, Ingri Ullestad;
Skjønsfjell, Ellen Martine;
Sundby, Eirik;
Hoff, Bård Helge.
(2016)
Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties.
European Journal of Medicinal Chemistry.
volum 107.
Academic article
Journal publications
-
Ringers, Christa Nelleke;
Bialonski, Stephan;
Ege, Mert;
Solovev, Anton;
Hansen, Jan;
Jeong, Inyoung;
Friedrich, Benjamin;
Jurisch-Yaksi, Nathalie.
(2023)
Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia.
eLIFE.
volum 12.
Academic article
-
Jeong, Inyoung;
Hansen, Jan Niklas;
Wachten, Dagmar;
Jurisch-Yaksi, Nathalie.
(2022)
Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon.
STAR Protocols.
volum 3 (3).
Academic article
-
Myren-Svelstad, Sverre;
Jamali, Ahmed;
Ophus, Sunniva Sofie;
Dgama, Percival Paul Menino;
Ostenrath, Anna Maria;
Mutlu, Aytac Kadir;
Hoffshagen, Helene Homme;
Hotz, Adriana L.;
Neuhauss, Stephan C. F.;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2022)
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.
Epilepsia.
volum 63 (10).
Academic article
-
Salman, Huseyin Enes;
Jurisch-Yaksi, Nathalie;
Yalcin, Huseyin Cagatay.
(2022)
Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo.
Bioengineering.
volum 9.
Academic article
-
Dgama, Percival Paul Menino;
Qiu, Tao;
Cosacak, Mehmet Ilyas;
Rayamajhi, Dheeraj;
Konac, Ahsen;
Hansen, Jan Niklas;
Ringers, Christa;
Acuna Hinrichsen, Francisca Daniela;
Hui, Subhra;
Olstad, Emilie Willoch;
Chong, Yan Ling;
Lim, Charlton Kang An;
Gupta, Astha;
Ng, Chee Peng;
Nilges, Benedikt S.;
Kashikar, Nachiket;
Wachten, Dagmar;
Liebl, David;
Kikuchi, Kazu;
Kizil, Caghan;
Yaksi, Emre;
Roy, Sudipto;
Jurisch-Yaksi, Nathalie.
(2021)
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.
Cell reports.
volum 37 (1).
Academic article
-
Hansen, Jan Niklas;
Rassmann, Sebastian;
Stüven, Birthe;
Jurisch-Yaksi, Nathalie;
Wachten, Dagmar.
(2021)
CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.
The European Physical Journal E : Soft matter.
volum 44 (2).
Academic article
-
Hotz, Adriana L.;
Jamali, Ahmed;
Rieser, Nicolas N.;
Niklaus, Stephanie;
Aydin, Ecem;
Myren-Svelstad, Sverre;
Lalla, Laetitia Noelle Patricia;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre;
Neuhauss, Stephan C.F..
(2021)
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity.
Glia.
volum 70 (1).
Academic article
-
Yaksi, Emre;
Jamali, Ahmed;
Diaz Verdugo, Carmen;
Jurisch-Yaksi, Nathalie.
(2021)
Past, present and future of zebrafish in epilepsy research.
The FEBS Journal.
Academic literature review
-
Fore, Stephanie Liesbeth;
Acuna Hinrichsen, Francisca Daniela;
Mutlu, Aytac Kadir;
Bartoszek-Kandler, Ewelina Magdalena;
Serneels, Bram;
Faturos, Nicholas Guy;
Chau, Khac Thanh Phong;
Cosacak, Mehmet Ilyas;
Diaz Verdugo, Carmen;
Palumbo, Fabrizio;
Ringers, Christa;
Jurisch-Yaksi, Nathalie;
Kizil, Caghan;
Yaksi, Emre.
(2020)
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis.
Science Advances.
Academic article
-
Hansen, Jan;
Kaiser, Fabian;
Klausen, Christina;
Stüven, Birthe;
Chong, Raymond;
Bönigk, Wolfgang;
Mick, David;
Möglich, Andreas;
Jurisch-Yaksi, Nathalie;
Schmidt, Florian;
Wachten, Dagmar.
(2020)
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
eLIFE.
Academic article
-
Jurisch-Yaksi, Nathalie;
Yaksi, Emre;
Kizil, Caghan.
(2020)
Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia.
Glia.
Academic literature review
-
Ringers, Christa;
Jurisch-Yaksi, Nathalie.
(2020)
Development: How the Reissner Fiber Keeps Our Back Straight.
Current Biology.
volum 30 (12).
Academic article
-
Thouvenin, Olivier;
Keiser, Ludovic;
Cantaut-Belarif, Yasmine;
Carbo-Tano, Martin;
Verweij, Frederik J.;
Jurisch-Yaksi, Nathalie;
Bardet, Pierre-Luc;
Van Niel, Guillaume;
Gallaire, Francois;
Wyart, Claire.
(2020)
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal.
eLIFE.
volum 9.
Academic article
-
Diaz Verdugo, Carmen;
Myren-Svelstad, Sverre;
Aydin, Ecem;
Evelien, Van Hoeymissen;
Deneubourg, Celine;
van Derhaeghe, Silke;
Craeyhest, Julie von;
Pelgrims, Robbrecht;
Casacak, Mehmet Ilyas;
Muto, Akira;
Kizil, Caghan;
Kawakami, Koichi;
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2019)
Glia-neuron interactions underlie state transitions to generalized seizures.
Nature Communications.
volum 10.
Academic article
-
Olstad, Emilie Willoch;
Ringers, Christa;
Hansen, Jan Niklas;
Wens, Adinda;
Brandt, Cecilia;
Wachten, Dagmar;
Yaksi, Emre;
Jurisch-Yaksi, Nathalie.
(2019)
Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development.
Current Biology.
volum 29 (2).
Academic article
-
Ringers, Christa;
Olstad, Emile Willoch;
Jurisch-Yaksi, Nathalie.
(2019)
The role of motile cilia in the development and physiology of the nervous system.
Philosophical Transactions of the Royal Society of London. Biological Sciences.
volum 375:20190156.
Academic literature review
-
Jurisch-Yaksi, Nathalie;
Yaksi, Emre.
(2018)
Nathalie Jurisch-Yaksi and Emre Yaksi.
Current Biology.
volum 28 (5).
Short communication
-
Reiten, Ingrid;
Uslu, Fazil Emre;
Forè, Stèphanie;
Pelgrims, Robbrecht;
Ringers, Christa;
Diaz Verdugo, Carmen;
Hoffmann, Maximilian;
Lal, Pradeep;
Kawakami, Koichi;
Pekkan, Kerem;
Yaksi, Emre;
Jurisch-Yaksi, Nathalie.
(2017)
Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations.
Current Biology.
volum 27 (2).
Academic article
-
Bugge, Steffen;
Buene, Audun Formo;
Jurisch-Yaksi, Nathalie;
Moen, Ingri Ullestad;
Skjønsfjell, Ellen Martine;
Sundby, Eirik;
Hoff, Bård Helge.
(2016)
Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties.
European Journal of Medicinal Chemistry.
volum 107.
Academic article
Teaching
Courses
Media
2022
-
PosterLal, Pradeep; Fiskum, Vegard; Kermen, Florence; Ostenrath, Anna Maria; Palumbo, Fabrizio; Jurisch-Yaksi, Nathalie; Muto, Akira; Kawakami, Koichi; Yaksi, Emre. (2022) The role of GnRH3 neurons in modulating olfactory computations and odor induced feeding behaviors. Imaging Structure and Function of the Zebrafish Brain Conference . NTNU; Trondheim. 2022-07-30 - 2022-08-01.
2019
-
Academic lectureMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Muto, Akira; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. 5th Congress of the European Academy of Neurology . EAN; Oslo. 2019-06-29 - 2019-07-02.
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InterviewMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Brandslet, Steinar. (2019) Hjernens forsvar bryter sammen ved epilepsi. Gemini.no [Internett]. 2019-08-23.
2018
-
PosterLal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Kermen, Florence; Palumbo, Fabrizio; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Muto, Akira; Kawakami, Koichi; Yaksi, Emre. (2018) Gonadotropin-releasing hormone (GnRH) neuromodulation of olfactory computations in zebrafish brain. The 11th FENS Forum of Neuroscience 2018 ; 2018-07-07 - 2018-07-11.
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PosterLal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Palumbo, Fabrizio; Kermen, Florence; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Muto, Akira; Kawakami, Koichi; Yaksi, Emre. (2018) The function of gonadotropin-releasing hormone (GnRH) neurons in olfactory computations. The European Chemoreception Research Organization (ECRO) 2018 ; 2018-09-05 - 2018-09-05.
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Academic lectureMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. The 6th NRSN National PhD Conference in Neuroscience . NRSN; Inderøya. 2018-09-19 - 2018-09-21.
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PosterMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. American Epilepsy Society Annual Meeting . American Epilepsy Society; New Orleans. 2018-11-30 - 2018-12-04.
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Academic lectureMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Neuron-glia interactions underlie state transitions to generalized seizures. Norwegian Epilepsy Society Annual Meeting . Norsk Epilepsiselskap; Trondheim. 2018-05-31 - 2018-06-02.
-
PosterOlstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. 5th Imaging Structure and Function in the Zebrafish Brain Conference 2018 ; Brighton. 2018-11-30 - 2018-12-02.
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LectureOlstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The function of motile-cilia driven flow in the nervous system. cilia 2018 ; 2018-10-02 - 2018-10-06.
-
PosterOlstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) Cilia-driven flow in the zebrafish brain ventricles. EMBO cilia meeting ; 2018-10-02 - 2018-10-05.
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PosterOlstad, Emilie Willoch; Ringers, Christa; Wens, Adinda; Hansen, Jan; Brandt, Cecilia; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. 11th FENS Forum of Neuroscience 2018 . FENS; Berlin. 2018-07-07 - 2018-07-11.
-
LectureOlstad, Emilie Willoch; Ringers, Christa; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The function of motile-cilia driven flow in the nervous system. zebrafish PI meeting 2018 ; 2018-02-20 - 2018-02-23.
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PosterRingers, Christa; Hansen, Jan; Reiten, Ingrid; Pelgrims, Robbrecht; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The role of second messengers in the regulation of ciliary beating. Microswimmers . SPP 1726; Bonn. 2018-04-26 - 2018-04-27.
2017
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PosterMyren-Svelstad, Sverre; Diaz Verdugo, Carmen; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2017) Studying neural circuit activity and connectivity during epileptogenesis in zebrafish brain. American Epilepsy Society Annual Meeting . American Epilepsy Society; Washington D.C.. 2017-12-01 - 2017-12-05.