Nathalie Jurisch-Yaksi
Laboratoriesenteret, Øya, Erling Skjalgsons gate 1
About
Nathalie Jurisch-Yaksi is a group leader at the Department of Clinical and Molecular Medicine at NTNU and an Associate Professor (10%) at the Kavli Institute for Systems Neuroscience.
Her research program aims at understanding cellular and molecular principles regulating the development, physiology and diseases of the nervous system. Her laboratory is particularly interested in one subcellular structure, the cilium, which play both signaling and mechanical functions, and in ependymal cells and astroglia, which are non-neuronal cell types of the brain.
Her team uses the genetically tractable small model organism zebrafish and a combination of techniques including genetics, molecular and cell biology, functional imaging, quantitative behavioral assays and applied mathematics.
The aims of her research program are to:
1. Unravel the cellular, genetic, and biophysical properties of motile ciliated cells
2. Unravel the function of motile ciliated cells in the nervous system
3. Identify the impact of primary cilia in neuronal development
4. Identify the role of astroglia in brain development and physiology
Current Team Members
Postdoc: Dr Inyoung Jung
PhD students: Mert Ege and Percival D’Gama
Medical students: Ahmed Jamali
Technician: Andreas Nygård
Master students: Anna-Lena Paszdior (NTNU Neuroscience) and Natalia Freus (UNiverity fo Erlangen, Germany)
List of publications: https://scholar.google.no/citations?user=MGQIp3wAAAAJ&hl=en
CV: https://yaksilab.com/cv-nathalie-jurisch-yaksi/
Publications
2022
- Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols. volum 3 (3).
- Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva S.; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir; Hoffshagen, Helene H.; Hotz, Adriana L.; Neuhauss, Stephan C. F.; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia. volum 63 (10).
- Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering. volum 9 (9).
2021
- Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports. volum 37 (1).
- Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter. volum 44 (2).
- Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F.. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. volum 70 (1).
- Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal.
2020
- Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy; Chau, Khac Thanh Phong; Cosacak, Mehmet Ilyas; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Kizil, Caghan; Yaksi, Emre. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances.
- Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang; Mick, David; Möglich, Andreas; Jurisch-Yaksi, Nathalie; Schmidt, Florian; Wachten, Dagmar. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE.
- Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia.
- Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology. volum 30 (12).
- Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. volum 9.
2019
- Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke; Craeyhest, Julie von; Pelgrims, Robbrecht; Casacak, Mehmet Ilyas; Muto, Akira; Kizil, Caghan; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications. volum 10.
- Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology. volum 29 (2).
- Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 375:20190156.
2018
- Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology. volum 28 (5).
2017
- Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen; Hoffmann, Maximilian; Lal, Pradeep; Kawakami, Koichi; Pekkan, Kerem; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology. volum 27 (2).
2016
- Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik; Hoff, Bård Helge. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry. volum 107.
Journal publications
- Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols. volum 3 (3).
- Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva S.; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir; Hoffshagen, Helene H.; Hotz, Adriana L.; Neuhauss, Stephan C. F.; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia. volum 63 (10).
- Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering. volum 9 (9).
- Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports. volum 37 (1).
- Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter. volum 44 (2).
- Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F.. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. volum 70 (1).
- Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal.
- Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy; Chau, Khac Thanh Phong; Cosacak, Mehmet Ilyas; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Kizil, Caghan; Yaksi, Emre. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances.
- Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang; Mick, David; Möglich, Andreas; Jurisch-Yaksi, Nathalie; Schmidt, Florian; Wachten, Dagmar. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE.
- Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia.
- Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology. volum 30 (12).
- Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. volum 9.
- Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke; Craeyhest, Julie von; Pelgrims, Robbrecht; Casacak, Mehmet Ilyas; Muto, Akira; Kizil, Caghan; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications. volum 10.
- Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology. volum 29 (2).
- Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 375:20190156.
- Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology. volum 28 (5).
- Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen; Hoffmann, Maximilian; Lal, Pradeep; Kawakami, Koichi; Pekkan, Kerem; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology. volum 27 (2).
- Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik; Hoff, Bård Helge. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry. volum 107.
Teaching
Courses
Media
2019
- Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Brandslet, Steinar. (2019) Hjernens forsvar bryter sammen ved epilepsi. Gemini.no [Internett]. 2019-08-23.