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Språkvelger

Norsk

Nathalie Jurisch-Yaksi

Nathalie Jurisch-Yaksi

Researcher and Associate Professor
Faculty of Medicine and Health Sciences
Department of Clinical and Molecular Medicine

nathalie.jurisch-yaksi@ntnu.no
Laboratoriesenteret, Øya, Erling Skjalgsons gate 1
Google Scholar lab website IKOM website
About Publications Teaching Media

About

CV

Nathalie Jurisch-Yaksi is a group leader at the Department of Clinical and Molecular Medicine at NTNU and an Associate Professor (10%) at the Kavli Institute for Systems Neuroscience. 

Her research program aims at understanding cellular and molecular principles regulating the development, physiology and diseases of the nervous system.

Her laboratory is particularly interested in one subcellular structure, the cilium, which play both signaling and mechanical functions, and in ependymal cells and astroglia, which are non-neuronal cell types of the brain.

Her laboratory focuses on various disease conditions affecting the brain including cilia-related disorders, hydrocephalus, epilepsy and glioblastoma.

Her team uses the genetically tractable small model organism zebrafish and a combination of techniques including genetics, molecular and cell biology, functional imaging, quantitative behavioral assays and applied mathematics.

The aims of her research program are to:

1. Unravel the cellular, genetic, and biophysical properties of motile ciliated cells 

2. Unravel the function of motile ciliated cells in the nervous system 

3. Identify the impact of primary cilia in neuronal development 

4. Identify the role of astroglia in brain development and physiology 

5. Develop personalized medicine approaches for the treatment of ciliopathies, hydrocephalus, epilepsy and glioblastoma 

Current Team Members

Postdoc: Dr Inyoung Jung

PhD students: Mert Ege and Percival D’Gama

Technician: Andreas Nygård

Master students: Anna-Lena Paszdior (NTNU MSc in Neuroscience) 

Internship students: Pauline Lestienne (MSc in Neuroscience Paris) 

List of publications: https://scholar.google.no/citations?user=MGQIp3wAAAAJ&hl=en 

Current funding:

  • 2023-2026: ERA-PerMed consortium "Glioma PerMed: Glioma invasion assays as a predictive tool for personalized glioma medicine" (ERA-PerMed, 300K EUR)
  • 2021-2024: Researcher project for scientific renewal (NFR, 12M NOK)
  • 2021-2024: NTNU enabling technology program (4 years PhD position)

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2023

  • Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan; Jeong, Inyoung. (2023) Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia. eLIFE
    Academic article

2022

  • Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols
    Academic article
  • Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering
    Academic article
  • Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva Sofie; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia
    Academic article

2021

  • Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports
    Academic article
  • Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal
    Academic literature review
  • Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia
    Academic article
  • Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter
    Academic article

2020

  • Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia
    Academic literature review
  • Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology
    Academic article
  • Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE
    Academic article
  • Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances
    Academic article
  • Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE
    Academic article

2019

  • Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology
    Academic article
  • Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications
    Academic article
  • Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences
    Academic literature review

2018

  • Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology
    Short communication

2017

  • Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology
    Academic article

2016

  • Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
    Academic article

Journal publications

  • Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan; Jeong, Inyoung. (2023) Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia. eLIFE
    Academic article
  • Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols
    Academic article
  • Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering
    Academic article
  • Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva Sofie; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia
    Academic article
  • Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports
    Academic article
  • Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal
    Academic literature review
  • Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia
    Academic article
  • Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter
    Academic article
  • Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia
    Academic literature review
  • Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology
    Academic article
  • Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE
    Academic article
  • Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances
    Academic article
  • Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE
    Academic article
  • Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology
    Academic article
  • Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications
    Academic article
  • Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences
    Academic literature review
  • Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology
    Short communication
  • Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology
    Academic article
  • Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
    Academic article

Teaching

Courses

  • MOL3000 - Introduction to Molecular Medicine
  • NEVR2010 - Introduction to Neuroscience
  • NEVR2030 - Condensed Introduction to Neuroscience
  • MOL3100 - Introduction to Molecular Medicine with Project

Media

2022

  • Poster
    Lal, Pradeep; Fiskum, Vegard; Kermen, Florence; Ostenrath, Anna Maria; Palumbo, Fabrizio; Jurisch-Yaksi, Nathalie. (2022) The role of GnRH3 neurons in modulating olfactory computations and odor induced feeding behaviors. NTNU Imaging Structure and Function of the Zebrafish Brain Conference , Trondheim 2022-07-30 - 2022-08-01

2019

  • Interview
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Brandslet, Steinar. (2019) Hjernens forsvar bryter sammen ved epilepsi. Gemini.no Gemini.no [Internet] 2019-08-23
  • Academic lecture
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Muto, Akira; Kawakami, Koichi. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. EAN 5th Congress of the European Academy of Neurology , Oslo 2019-06-29 - 2019-07-02

2018

  • Academic lecture
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Neuron-glia interactions underlie state transitions to generalized seizures. Norsk Epilepsiselskap Norwegian Epilepsy Society Annual Meeting , Trondheim 2018-05-31 - 2018-06-02
  • Poster
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. American Epilepsy Society American Epilepsy Society Annual Meeting , New Orleans 2018-11-30 - 2018-12-04
  • Lecture
    Olstad, Emilie Willoch; Ringers, Christa; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The function of motile-cilia driven flow in the nervous system. zebrafish PI meeting 2018 2018-02-20 - 2018-02-23
  • Poster
    Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) Cilia-driven flow in the zebrafish brain ventricles. EMBO cilia meeting 2018-10-02 - 2018-10-05
  • Poster
    Ringers, Christa; Hansen, Jan; Reiten, Ingrid; Pelgrims, Robbrecht; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The role of second messengers in the regulation of ciliary beating. SPP 1726 Microswimmers , Bonn 2018-04-26 - 2018-04-27
  • Academic lecture
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. NRSN The 6th NRSN National PhD Conference in Neuroscience , Inderøya 2018-09-19 - 2018-09-21
  • Poster
    Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. 5th Imaging Structure and Function in the Zebrafish Brain Conference 2018 , Brighton 2018-11-30 - 2018-12-02
  • Poster
    Olstad, Emilie Willoch; Ringers, Christa; Wens, Adinda; Hansen, Jan; Brandt, Cecilia; Yaksi, Emre. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. FENS 11th FENS Forum of Neuroscience 2018 , Berlin 2018-07-07 - 2018-07-11
  • Lecture
    Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2018) The function of motile-cilia driven flow in the nervous system. cilia 2018 2018-10-02 - 2018-10-06
  • Poster
    Lal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Kermen, Florence; Palumbo, Fabrizio; Pelgrims, Robbrecht. (2018) Gonadotropin-releasing hormone (GnRH) neuromodulation of olfactory computations in zebrafish brain. The 11th FENS Forum of Neuroscience 2018 2018-07-07 - 2018-07-11
  • Poster
    Lal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Palumbo, Fabrizio; Kermen, Florence; Pelgrims, Robbrecht. (2018) The function of gonadotropin-releasing hormone (GnRH) neurons in olfactory computations. The European Chemoreception Research Organization (ECRO) 2018 2018-09-05 - 2018-09-05

2017

  • Poster
    Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2017) Studying neural circuit activity and connectivity during epileptogenesis in zebrafish brain. American Epilepsy Society American Epilepsy Society Annual Meeting , Washington D.C. 2017-12-01 - 2017-12-05
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