Background and activities

My primary research interests include the design and interpretation of clinical trials, Bayesian methods, and survival analysis and meta-analysis.
 

PhD Medicine (University of Alberta, Canada) / MSc Clinical Research (Cardiff University, Wales) / MSc Biometry (Reading University, England) / First Class Honours Mathematics and Statistics (Griffith University, Australia)

 

Recent Publications

-Research Methodology

Brown, P. M., & Ezekowitz, J. A. 2018. Examining the influence of component outcomes on the overall composite at the design stage. Circulation: Cardiovascular Quality and Outcomes. [Link]

Brown, P. M., & Ezekowitz, J. A. 2017. Multitype events and the analysis of heart failure readmissions: illustration of a new modelling approach and comparison with familiar composite end points. Circulation: Cardiovascular Quality and Outcomes. [Link]

Brown, P. M., & Ezekowitz, J. A. 2017. Composite end points in clinical trials of heart failure therapy: how do we measure the effect size? Circulation: Heart Failure. [Link]

Brown, P. M., & Ezekowitz, J. A. 2017. Frailty modelling for multitype recurrent events in clinical trials. Statistical Modelling. [Link]

Brown, P. M., & Ezekowitz, J. A. 2017. Power and sample size estimation for composite endpoints: practical implementation using data simulations. Journal of Modern Applied Statistical Methods. [Link]

Brown, P. M., & Ezekowitz, J. A. 2017. Letter Regarding Article, “Development and evolution of a hierarchical clinical composite end point for the evaluation of drugs and devices for acute and chronic heart failure: a 20-year perspective” Circulation. [Link]

Brown, P. M., Anstrom, K. J., Felker, G. M. & Ezekowitz, J. A. 2016. Composite end points in acute heart failure research: data simulations illustrate the limitations. The Canadian Journal of Cardiology. [Link]

-Studies/Collaboration

R. Reid, J. A. Ezekowitz, P. M. Brown, F. A. McAlister, B. H. Rowe, and B. Braam. 2015. The prognostic importance of changes in renal function during treatment for acute heart failure depends on admission renal function. PLOS One. [Link]

P. Gouda, P. Brown, B. H. Rowe, F. A. McAlister, and J. A. Ezekowitz. 2016. Insights into the importance of the electrocardiogram in patients with acute heart failure. European Journal of Heart Failure. [Link]

Ismail R Raslan, Paul Brown, Cynthia M. Westerhout, et al. 2017. Characterization of hemodynamically stable acute heart failure patients requiring a critical care unit admission: derivation, validation, and refinement of a risk score. American Heart Journal. [Link]