Background and activities
I am a civil engineer in biotechnology and a PhD in pharmacology. Previously, I have worked in several laboratories both nationally and internationally within different disciplines. Through my PhD I became a specialist in lipid metabolism associated with type 2 diabetes and obesity in muscle cells. I also have experience with different live cell imaging techniques and teaching, as well as analysis with big gene expression data sets.
I work as a post doc at Centre of Molecular Inflammation Research (CEMIR) at NTNU. Here I am working on revealing the mechanisms behind inflammation and complement system activation in regards to cholesterol crystal accumulation in atherosclerotic plaques and to find new novel treatments against atherosclerosis.15 september 2014 - 1st of june I was in the lab of Prof Eicke Latz, Institute of Innate Immunity, University of Bonn, Germany.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
Journal publications
- (2017) Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. Journal of Immunology. vol. 199 (8).
- (2017) Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research. vol. 58 (11).
- (2016) Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis. Journal of Immunology. vol. 196 (12).
- (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine. vol. 8 (333).
- (2015) Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects. PLoS ONE. vol. 10 (3).
- (2015) Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise. American Journal of Physiology - Cell Physiology. vol. 308 (7).
- (2015) Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. vol. 1851 (9).
- (2015) Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation. Journal of Immunology. vol. 195 (1).
- (2014) PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference. Archives of Physiology and Biochemistry. vol. 120 (1).
- (2014) Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. Journal of Immunology. vol. 192 (6).
- (2013) Are cultured human myotubes far from home?. Cell and Tissue Research. vol. 354 (3).
- (2013) Remodelling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells. PLoS ONE. vol. 8 (4).
- (2012) Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. vol. 1821 (10).
- (2012) Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance. Archives of Physiology and Biochemistry. vol. 118 (1).
- (2012) The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology. vol. 128.
- (2012) Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise. PLoS ONE. vol. 7 (3).
- (2011) Metabolic switching of human skeletal muscle cells in vitro. Prostaglandins, Leukotrienes and Essential Fatty Acids. vol. 85 (5).
- (2010) Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. American Journal of Physiology. Endocrinology and Metabolism. vol. 299 (1).
- (2010) Metabolic switching of human myotubes is improved by n-3 fatty acids. Journal of Lipid Research. vol. 51 (8).
Report/dissertation
- (2013) Regulation of energy metabolism in human skeletal muscle cells. Effects of fatty acids, in vitro exercise and extreme obesity with and without type 2 diabetes. Akademika forlag. 2013. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo. (1319).