Siver Andreas Moestue

About

I earned my PhD at the Norwegian University of Science and Technology (NTNU), and am now a research professor at the Dept. of Clinical and Molecular Medicine. Trained a MSc. Pharm at the University of Oslo, I started my career as a preclinical researcher in GE Healthcare. Here, I was involved in development of molecularly targeted contrast agents for SPECT/PET, and development of the Sonazoid® microbubble for diagnostic ultrasound imaging of liver cancer. In my current research, I study the role of metabolism in cancer, with focus on diagnostic and therapeutic applications in breast cancer. In an ongoing project funded by the Norwegian Research Council, I study the effect drugs inhibiting the metabolic enzyme cPLA2 in an aggressive subtype of breast cancer. Realizing the importance of the tumor microenvironment, I also have established activities in the interface between immunology, metabolism and metastasis.

Publications

2017

Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre Røsstad; Hatem, Rana; El Botty, Rania; Bieche, Ivan; Marangoni, Elisabetta; Bathen, Tone Frost; Moestue, Siver Andreas. (2017) Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts. Journal of Proteome Research. volum 16 (5).

2016

Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey. (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. OncoTarget. volum 7 (11).
Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui; Zhao, Chunyan; Haldosen, Lars-Arne; Cao, Yihai; Girnita, Leonard; Moestue, Siver Andreas; Dahlman-Wright, Karin. (2016) Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer Research. volum 76 (19).
Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas. (2016) Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model. BMC Cancer. volum 16:191.

2015

Burggraf, Jacobus; Kamerling, Ingrid; Gordon, Paul B.; Schrier, Lennecke; de Kam, Marijke; Kales, Andrea J; Bendiksen, Ragnar; Indrevoll, Bård; Bjerke, Roger Malerbakken; Moestue, Siver Andreas; Yazdanfar, Siawash; Langers, Alexandra; Swaerd-Nordmo, Marit; Torheim, Geir; Warren, Madhuri; Morreau, Hans; Voorneveld, Philip; Buckle, Tessa; van Leeuven, Fijs; ødegårdstuen, liv ingrid; Dalsgaard, Grethe T; Healey, Andrew J.; Hardwick, James. (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nature Medicine. volum 21 (8).
Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas. (2015) MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity. British Journal of Cancer. volum 112 (3).
Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Bathen, Tone; Heerschap, Arend. (2015) In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts. Journal of Magnetic Resonance Imaging. volum 41 (3).
Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K. (2015) Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS. Neoplasia. volum 17 (10).

2014

Esmaeili, Morteza; Bathen, Tone Frost; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Moestue, Siver Andreas. (2014) Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magnetic Resonance in Medicine. volum 71 (6).
Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S. (2014) Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. Breast Cancer Research. volum 16 (1).

2013

Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild; Engebråten, Olav; Gribbestad, Ingrid S; Bjørkøy, Geir. (2013) Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer. Breast Cancer Research. volum 15 (1:R16).
Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Bofin, Anna M.; Engebråten, Olav; Mælandsmo, Gunhild; Akslen, Lars A.; Gribbestad, Ingrid S. (2013) Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts. Journal of Magnetic Resonance Imaging. volum 38 (5).

2012

Moestue, Siver Andreas; Giskeødegård, Guro F.; Cao, Maria Dung; Bathen, Tone Frost; Gribbestad, Ingrid S. (2012) Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. volum 109 (38).

2011

Glunde, Kristine; Jiang, Liu; Moestue, Siver Andreas; Gribbestad, Ingrid S. (2011) MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR in Biomedicine. volum 24 (6).

2010

Moestue, Siver Andreas; Borgan, Eldrid; Huuse, Else Marie; Lindholm, Evita Maria; Sitter, Beathe; Børresen-Dale, Anne-Lise; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S. (2010) Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer. volum 10.

Journal publications

Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre Røsstad; Hatem, Rana; El Botty, Rania; Bieche, Ivan; Marangoni, Elisabetta; Bathen, Tone Frost; Moestue, Siver Andreas. (2017) Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts. Journal of Proteome Research. volum 16 (5).
Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey. (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. OncoTarget. volum 7 (11).
Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui; Zhao, Chunyan; Haldosen, Lars-Arne; Cao, Yihai; Girnita, Leonard; Moestue, Siver Andreas; Dahlman-Wright, Karin. (2016) Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer Research. volum 76 (19).
Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas. (2016) Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model. BMC Cancer. volum 16:191.
Burggraf, Jacobus; Kamerling, Ingrid; Gordon, Paul B.; Schrier, Lennecke; de Kam, Marijke; Kales, Andrea J; Bendiksen, Ragnar; Indrevoll, Bård; Bjerke, Roger Malerbakken; Moestue, Siver Andreas; Yazdanfar, Siawash; Langers, Alexandra; Swaerd-Nordmo, Marit; Torheim, Geir; Warren, Madhuri; Morreau, Hans; Voorneveld, Philip; Buckle, Tessa; van Leeuven, Fijs; ødegårdstuen, liv ingrid; Dalsgaard, Grethe T; Healey, Andrew J.; Hardwick, James. (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nature Medicine. volum 21 (8).
Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas. (2015) MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity. British Journal of Cancer. volum 112 (3).
Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Bathen, Tone; Heerschap, Arend. (2015) In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts. Journal of Magnetic Resonance Imaging. volum 41 (3).
Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K. (2015) Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS. Neoplasia. volum 17 (10).
Esmaeili, Morteza; Bathen, Tone Frost; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Moestue, Siver Andreas. (2014) Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magnetic Resonance in Medicine. volum 71 (6).
Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S. (2014) Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. Breast Cancer Research. volum 16 (1).
Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild; Engebråten, Olav; Gribbestad, Ingrid S; Bjørkøy, Geir. (2013) Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer. Breast Cancer Research. volum 15 (1:R16).
Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Bofin, Anna M.; Engebråten, Olav; Mælandsmo, Gunhild; Akslen, Lars A.; Gribbestad, Ingrid S. (2013) Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts. Journal of Magnetic Resonance Imaging. volum 38 (5).
Moestue, Siver Andreas; Giskeødegård, Guro F.; Cao, Maria Dung; Bathen, Tone Frost; Gribbestad, Ingrid S. (2012) Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. volum 109 (38).
Glunde, Kristine; Jiang, Liu; Moestue, Siver Andreas; Gribbestad, Ingrid S. (2011) MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR in Biomedicine. volum 24 (6).
Moestue, Siver Andreas; Borgan, Eldrid; Huuse, Else Marie; Lindholm, Evita Maria; Sitter, Beathe; Børresen-Dale, Anne-Lise; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S. (2010) Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer. volum 10.

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