Yashwanth Subbannayya

About

About me

My main research focus is to use Systems Biology approaches to identify fundamental molecular mechanisms of innate immunity and cancers to develop actionable targets for the clinic. In addition, I use bioinformatics and computational biology approaches to analyze omics-based data.

My work in innate immunity pertains to the omics-based characterization of Toll-like receptor (TLR) signaling pathways. I am using proteomics and metabolomics approaches to study TLR signaling.

I work on the cancer biology of lung, gastric, head-and-neck and rare gynecological cancers. During my doctoral studies, I discovered CAMKK2 as a potential therapeutic target for gastric cancer and identified potential serum biomarkers for gastric cancer. I currently work on the omics characterization of rare gynecological cancers and am part of the GYNOCARE COST (gynocare.net) action to study these cancers.

Previously, I was involved in the draft map of the human proteome project, which was published in Nature, Netpath- a resource on signaling pathways and proteome projects on body fluids and eye tissues.

Complete profile

ORCID

Qualifications

Ph.D. (Medical Biochemistry), Rajiv Gandhi University of Health Sciences, Bangalore, India, 2015
M.Sc. (Medical Biochemistry), Kasturba Medical College, Manipal University, India, 2006

Current and previous positions

Researcher, Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway, May 2020- Present
Post Doctoral Fellow, Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway, May 2018- May 2020
Assistant Professor (AP-II), Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, August 2017 - May 2018
Faculty Scientist, YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, June 2015 - July 2017
Ph.D. student, Institute of Bioinformatics (IOB), Bangalore, June 2008 - May 2015
Junior Research Fellow, Department of Clinical Proteomics and Molecular Medicine, St. John’s Research Institute, Bangalore, October 2007 - May 2008
Project Assistant, Department of Biotechnology, Manipal Life Science Centre, Manipal, March 2007 -June 2007

Research interests

Cancer Biology, Innate Immunity; Systems Biology

Awards

UGC Junior Research Fellowship, University Grants Commission, Government of India, 2008-2011
UGC Senior Research Fellowship, University Grants Commission, Government of India, 2011-2013

Supervision of Undergraduate and Postgraduate students

Master's students	Ph.D. students	University/institution - Country
2 M.Sc.		NTNU, Trondheim, Norway
7 M.D.S 2 M.D., 8 M.Sc.	3	Yenepoya University, Mangalore, India
3 M.Sc.		Institute of Bioinformatics, Bangalore, India

Institutional responsibilities

2016-2018 Member, Scientific Review Board, Yenepoya Research Center, Yenepoya University, Mangalore, India
2015-2018 Additional in-charge of proteomics and metabolomics facility, Yenepoya University, Mangalore, India
2017-2018 Teaching instructor and syllabus in-charge for the Post-Graduate Diploma in Multi-omics Technology, Yenepoya University. Created a syllabus for the course.
2016-2018 Internal Ph.D. coursework instructor and syllabus in-charge for OMICS approaches including proteomics, metabolomics, and bioinformatics to Ph.D. students at Yenepoya University, India

Commissions of trust

Associate Editor, Gene
Associate Editor, Gene Reports
Review Editor for Frontiers in Oncology and Frontiers in Genetics
Guest Associate Editor for Frontiers in Systems Biology, Integrative Systems Neuroscience section
Guest Editor for International Journal of Molecular Sciences
Reviewer: Proteomics, Scientific Reports, Journal of Dermatological Science, Frontiers in Genetics, Frontiers in Molecular Biosciences, International Journal of Molecular Sciences, Cancers, Cancer Biomarkers

Professional memberships

Management committee member (Norway) and working group member, CA18117 - European network for Gynaecological Rare Cancer research: From Concept to Cure, COST (European Cooperation in Science and Technology)
Member, Society for Leukocyte Biology, 2019-present
Member, Digital Life Norway Research School, 2018-present
Life Member, Proteomics Society, India (PSI)
Life Member, Indian Society for Mass Spectrometry (LM807)
Member, Human Proteome Organization(HUPO), 2015-2019
Post Doc member, NORBIS (National research school in bioinformatics, biostatistics and systems biology), Norway, 2018-present
Member, Scientific Review Board, Yenepoya Research Center, Yenepoya University, Mangalore, 2016-2018

Publications

Publications: 59
Research Articles: 49
Review Article: 6
Book Chapters: 1
Pre-print: 3
Primary author: 14
Corresponding author: 8

Citations	4044
h-index	21
i10-index	29

Publications

2022

Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Subbannayya, Yashwanth; Pentimalli, Francesca; Giordano, Antonio. (2022) Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. International Journal of Molecular Sciences
Academic literature review
Drago-Ferrante, Rosa; Di Fiore, Riccardo; Karouia, Fathi; Subbannayya, Yashwanth; Das, Saswati; Aydogan Mathyk, Begum. (2022) Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review. International Journal of Molecular Sciences
Academic literature review
Rex, D. A. B.; Subbannayya, Yashwanth; Modi, Prashant Kumar; Palollathil, Akhina; Gopalakrishnan, Lathika; Bhandary, Yashodhar P.. (2022) Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation. Cells
Academic article
Subbannayya, Yashwanth; Bhatta, Ankit; Pinto, Sneha M.; Fitzgerald, Kate; Kandasamy, Richard Kumaran. (2022) Proteogenomics Analysis Reveals Novel Micropeptides in Primary Human Immune Cells. Immuno
Short communication

2021

Subbannayya, Yashwanth; Di Fiore, Riccardo; Urru, Silvana Anna Maria; Calleja-Agius, Jean. (2021) The Role of Omics Approaches to Characterize Molecular Mechanisms of Rare Ovarian Cancers: Recent Advances and Future Perspectives. Biomedicines
Academic literature review
Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam. (2021) UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis. PLOS ONE
Academic article
Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Félix, Ana; O’Toole, Sharon A.; O’Leary, John J.. (2021) LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?. International Journal of Molecular Sciences
Academic article
Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv. (2021) Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation. Frontiers in Immunology
Academic article
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne. (2021) Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions. Cancers
Academic article
Mohanty, Varshasnata; Subbannayya, Yashwanth; Patil, Shankargouda; Abdulla, Riaz; Mandakulutur S., Ganesh; Pal, Arnab. (2021) Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics. Cancer Biomarkers
Academic article
Mohanty, Varshasnata; Subbannayya, Yashwanth; Patil, Shankargouda; Puttamallesh, Vinuth N; Najar, Mohd Altaf; Datta, Keshava K. (2021) Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue. Journal of cell communication and signaling
Academic article

2020

Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen. (2020) The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. International Journal of Molecular Sciences
Academic article

2019

Rex, D. A. B.; Agarwal, Nupur; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran; Subbannayya, Yashwanth; Pinto, Sneha. (2019) A comprehensive pathway map of IL-18-mediated signalling. Journal of cell communication and signaling
Academic article
Subbannayya, Yashwanth; Pinto, Sneha; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran. (2019) Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. International Journal of Molecular Sciences
Academic article

Journal publications

Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Subbannayya, Yashwanth; Pentimalli, Francesca; Giordano, Antonio. (2022) Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. International Journal of Molecular Sciences
Academic literature review
Drago-Ferrante, Rosa; Di Fiore, Riccardo; Karouia, Fathi; Subbannayya, Yashwanth; Das, Saswati; Aydogan Mathyk, Begum. (2022) Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review. International Journal of Molecular Sciences
Academic literature review
Rex, D. A. B.; Subbannayya, Yashwanth; Modi, Prashant Kumar; Palollathil, Akhina; Gopalakrishnan, Lathika; Bhandary, Yashodhar P.. (2022) Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation. Cells
Academic article
Subbannayya, Yashwanth; Bhatta, Ankit; Pinto, Sneha M.; Fitzgerald, Kate; Kandasamy, Richard Kumaran. (2022) Proteogenomics Analysis Reveals Novel Micropeptides in Primary Human Immune Cells. Immuno
Short communication
Subbannayya, Yashwanth; Di Fiore, Riccardo; Urru, Silvana Anna Maria; Calleja-Agius, Jean. (2021) The Role of Omics Approaches to Characterize Molecular Mechanisms of Rare Ovarian Cancers: Recent Advances and Future Perspectives. Biomedicines
Academic literature review
Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam. (2021) UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis. PLOS ONE
Academic article
Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Félix, Ana; O’Toole, Sharon A.; O’Leary, John J.. (2021) LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?. International Journal of Molecular Sciences
Academic article
Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv. (2021) Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation. Frontiers in Immunology
Academic article
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne. (2021) Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions. Cancers
Academic article
Mohanty, Varshasnata; Subbannayya, Yashwanth; Patil, Shankargouda; Abdulla, Riaz; Mandakulutur S., Ganesh; Pal, Arnab. (2021) Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics. Cancer Biomarkers
Academic article
Mohanty, Varshasnata; Subbannayya, Yashwanth; Patil, Shankargouda; Puttamallesh, Vinuth N; Najar, Mohd Altaf; Datta, Keshava K. (2021) Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue. Journal of cell communication and signaling
Academic article
Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen. (2020) The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. International Journal of Molecular Sciences
Academic article
Rex, D. A. B.; Agarwal, Nupur; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran; Subbannayya, Yashwanth; Pinto, Sneha. (2019) A comprehensive pathway map of IL-18-mediated signalling. Journal of cell communication and signaling
Academic article
Subbannayya, Yashwanth; Pinto, Sneha; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran. (2019) Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. International Journal of Molecular Sciences
Academic article

Språkvelger

Yashwanth Subbannayya