Yashwanth Subbannayya
Background and activities
About me
My main research focus is to use Systems Biology approaches to identify fundamental molecular mechanisms of innate immunity and cancers to develop actionable targets for the clinic. In addition, I use bioinformatics and computational biology approaches to analyze omics-based data.
My work in innate immunity pertains to the omics-based characterization of Toll-like receptor (TLR) signaling pathways. I am using proteomics and metabolomics approaches to study TLR signaling.
I work on the cancer biology of lung, gastric, head-and-neck and rare gynecological cancers. During my doctoral studies, I discovered CAMKK2 as a potential therapeutic target for gastric cancer and identified potential serum biomarkers for gastric cancer. I currently work on the omics characterization of rare gynecological cancers and am part of the GYNOCARE COST (gynocare.net) action to study these cancers.
Previously, I was involved in the draft map of the human proteome project, which was published in Nature, Netpath- a resource on signaling pathways and proteome projects on body fluids and eye tissues.
Qualifications
- Ph.D. (Medical Biochemistry), Rajiv Gandhi University of Health Sciences, Bangalore, India, 2015
- M.Sc. (Medical Biochemistry), Kasturba Medical College, Manipal University, India, 2006
Current and previous positions
- Researcher, Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway, May 2020- Present
- Post Doctoral Fellow, Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway, May 2018- May 2020
- Assistant Professor (AP-II), Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, August 2017 - May 2018
- Faculty Scientist, YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, June 2015 - July 2017
- Ph.D. student, Institute of Bioinformatics (IOB), Bangalore, June 2008 - May 2015
- Junior Research Fellow, Department of Clinical Proteomics and Molecular Medicine, St. John’s Research Institute, Bangalore, October 2007 - May 2008
- Project Assistant, Department of Biotechnology, Manipal Life Science Centre, Manipal, March 2007 -June 2007
Research interests
Cancer Biology, Innate Immunity; Systems Biology
Awards
- UGC Junior Research Fellowship, University Grants Commission, Government of India, 2008-2011
- UGC Senior Research Fellowship, University Grants Commission, Government of India, 2011-2013
Supervision of Undergraduate and Postgraduate students
|
Master's students |
Ph.D. |
University/institution - Country |
| 2 M.Sc. | NTNU, Trondheim, Norway | |
|
7 M.D.S 2 M.D., 8 M.Sc. |
3 |
Yenepoya University, Mangalore, India |
|
3 M.Sc. |
|
Institute of Bioinformatics, Bangalore, India |
Institutional responsibilities
- 2016-2018 Member, Scientific Review Board, Yenepoya Research Center, Yenepoya University, Mangalore, India
- 2015-2018 Additional in-charge of proteomics and metabolomics facility, Yenepoya University, Mangalore, India
- 2017-2018 Teaching instructor and syllabus in-charge for the Post-Graduate Diploma in Multi-omics Technology, Yenepoya University. Created a syllabus for the course.
- 2016-2018 Internal Ph.D. coursework instructor and syllabus in-charge for OMICS approaches including proteomics, metabolomics, and bioinformatics to Ph.D. students at Yenepoya University, India
Commissions of trust
- Associate Editor, Gene
- Associate Editor, Gene Reports
- Review Editor for Frontiers in Oncology and Frontiers in Genetics
- Guest Associate Editor for Frontiers in Systems Biology, Integrative Systems Neuroscience section
- Guest Editor for International Journal of Molecular Sciences
- Reviewer: Proteomics, Scientific Reports, Journal of Dermatological Science, Frontiers in Genetics, Frontiers in Molecular Biosciences, International Journal of Molecular Sciences, Cancers, Cancer Biomarkers
Professional memberships
- Management committee member (Norway) and working group member, CA18117 - European network for Gynaecological Rare Cancer research: From Concept to Cure, COST (European Cooperation in Science and Technology)
- Member, Society for Leukocyte Biology, 2019-present
- Member, Digital Life Norway Research School, 2018-present
- Life Member, Proteomics Society, India (PSI)
- Life Member, Indian Society for Mass Spectrometry (LM807)
- Member, Human Proteome Organization(HUPO), 2015-2019
- Post Doc member, NORBIS (National research school in bioinformatics, biostatistics and systems biology), Norway, 2018-present
- Member, Scientific Review Board, Yenepoya Research Center, Yenepoya University, Mangalore, 2016-2018
Publications
Publications: 59
Research Articles: 49
Review Article: 6
Book Chapters: 1
Pre-print: 3
Primary author: 14
Corresponding author: 8
| Citations | 4044 |
| h-index | 21 |
| i10-index | 29 |
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
2022
- (2022) Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. International Journal of Molecular Sciences. vol. 23 (9).
- (2022) Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review. International Journal of Molecular Sciences. vol. 23 (13).
- (2022) Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation. Cells. vol. 11 (1).
- (2022) Proteogenomics Analysis Reveals Novel Micropeptides in Primary Human Immune Cells. Immuno. vol. 2 (2).
2021
- (2021) LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?. International Journal of Molecular Sciences. vol. 22 (15).
- (2021) UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis. PLOS ONE. vol. 16 (10).
- (2021) Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics. Cancer Biomarkers.
- (2021) Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue. Journal of cell communication and signaling.
- (2021) Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation. Frontiers in Immunology. vol. 12.
- (2021) The Role of Omics Approaches to Characterize Molecular Mechanisms of Rare Ovarian Cancers: Recent Advances and Future Perspectives. Biomedicines. vol. 9 (10).
- (2021) Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions. Cancers. vol. 13 (8).
2020
- (2020) The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. International Journal of Molecular Sciences. vol. 22 (1).