Course - Introduction to Biomedical Laboratory Science - HBIO3015
HBIO3015 - Introduction to Biomedical Laboratory Science
Lessons are not given in the academic year 2020/2021
The course aims to provide a hands-on introduction to modern techniques used for analysis in medical laboratories. The course is divided in four modules (A, B, C and D) running in sequence and taking place in a laboratory setting under the supervision of one or several instructors who are trained to operate manual and robotized scientific instrumentation. There will also be final seminars tying up the course work done in the modules. Module A is devoted to routine techniques used for analysis of biological samples and will also address safety and health issues related to working in a laboratory environment. Students will learn how to handle human biological material and operate various instruments including spectrophotometer, fluorometer, reflectometer, electrochemical instruments and cells counters. Module B will focus on the analysis of data obtained from scientific instrumentation. The goal here is for students to learn how to evaluate the precision, accuracy, and sensitivity and linearity of the different methods of quantification using the various analytical instruments and interpret data.
Module C will explore the use of genome sequencing in clinical diagnosis via a tutorial taught in cooperation with staff from the department of pathology and molecular genetics at St. Olavs hospital. A tour of the Genomics Core Facility at NTNU will also be included. Students will learn about the theoretical principles of whole genome sequencing and practical aspects of its use in medical genetics. They will also explore and discuss ethical challenges arising from the use of this novel technology for patients and pre-symptomatic individuals in clinical medicine and in medical research.
Module D will focus on practical use of high throughput sequencing and bioinformatics in metagenomics applied to environmental microbiology.
After working with module A - Fundamentals of laboratory techniques the student should be able to:
- Organize herself/himself in a medical laboratory, and know about safety in the lab.
- Use and maintain pipettes and other volumetric tools in the laboratory
- Use spectrophotometers for reading absorbance to quantify analytes in biological samples
- Do enzyme activity measurements in biological samples
- Use automatized instrumentation for quantitative measurements
- Use cell counters and microscope to differentiate blood cells
- Explain theoretically how the techniques used in the laboratory course work
- Use control charts correctly, and to assess the quality of his/her own work
After working through Module B, Evaluation of Methods, the students should be able to:
- Interpret method evaluation data from assay kit inserts
- Investigate linearity, precision and accuracy of a quantitation method
- Process data from method evaluation statistically, and interpret it.
- Assess and compare analytical methods from obtained validation data, and choose between methods based on validation data.
After working through Module C,Genome sequencing in clinical practice;Practical and Ethical challenges, the students should be able to:
- Describe and show that they understand the basic steps of genome sequencing.
- Give examples of how genome sequencing is used in clinical practice and medical research today
- Explain advantages of todays genome sequencing technologies compared to traditional sequencing methods
- Describe some challenges that a clinical department as medical genetics have when they use genome sequencing today
- Give an overview of ethical issues highlighted when genetics and genomics are discussed.
- Present a specific use of genome sequencing in clinical medicine included ethical concerns by such use. In addition, explain, in depth, the bases for the ethical concerns raised by such use of genome sequencing.
For all modules:
- Be able to present and discuss the above bullet points with tutors and students in a seminar.
Learning methods and activities
Lectures, tutorials, laboratory classes, workshops, group and individual assignments
Further on evaluation
This course will be assessed as passed or failed. Obligatory lab courses, tutorials and final seminar have to be participated, in order to be assessed. All the elements in the three modules plus presentations at the seminars need to be assessed as a pass to be able to pass the whole course.
Admission to a programme of study is required:
Medical laboratory technology (MTBIO)
Required previous knowledge
This course has restricted access and is only offered to pre-approved students from OSU as part of the TRONDBUSS student mobility program. The number of places is restricted and approval goes first through OSU and then through NTNU/IBF
Manuals developed for this course. Selected textbooks and scientific articles. Details will be distributed at the start of the course.
Credits: 7.5 SP
Study level: Third-year courses, level III
Language of instruction: English
- Medical laboratory technology
Department with academic responsibility
Department of Biomedical Laboratory Science
- * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
For more information regarding registration for examination and examination procedures, see "Innsida - Exams"