course-details-portlet

MOL3007 - Functional Genomics

About

Examination arrangement

Examination arrangement: School exam
Grade: Letters

Evaluation Weighting Duration Grade deviation Examination aids
School exam 100/100 4 hours D

Course content

  • Fundamental principles within functional genomics, emphasizing the transcriptome and proteome
  • Contribution of functional genomics to systems biology and systems medicine
  • Socio-ethical aspects of functional genomics in biomedicine and biotechnology, including perspectives on genetic risk information
  • Hypothesis generation/experimental design
  • Experimental model systems
  • Next generation HTP sequenching technology
  • Microarray-technology. Protein separation (2D-PAGE, 2D-LC).
  • Mass spectrometry (MALDI-TOF, ESI-MS)
  • Protein structure analysis (X-ray chrystallography, NMR)
  • Molecular imaging

Learning outcome

After completing the course MOL3007, the student shall be able to:

  • describe what is meant by functional genomics and how this area of research contributes both to new basic biomedical knowledge and to new developments in biomedicine and biotechnology, including improved diagnostics and treatment of disease
  • apply insights in analyses and evaluations of how functional genomics contributes to systems biology and systems medicine
  • analyse and discuss the interdependence of biomedicine/biotechnology, bioinformatics and bioethics within functional genomics
  • reflect on ethical and societal aspects of functional genomics translated to health care
  • analyse and discuss how genetically modified organisms can contribute to functional genomics research
  • explain main principles of high throughput transcriptomic and genomic analysis by state of the art sequencing and microarray technology
  • explain mechanisms of gene regulation
  • explain the concepts of structural motifs and domains in proteins and methods used to assess these structures
  • explain main principles of central methods used in protein separation
  • explain main methods for ionisation of peptides and how mass analysis of peptides and fragments thereof can be used to identify and quantify proteins and determine their post-translational modifications
  • explain main principles of molecular imaging and its contribution to functional genomics research
  • explain and discuss main principles of bioinformatic tools used for –omics data analysis, biological background knowledge management and modeling
  • explain main methods for ionisation of peptides and how mass analysis of peptides and fragments thereof can be used to identify and quantify proteins and determine their post-translational modifications

Learning methods and activities

Seminars with active student participation according to Team Based Learning (TBL) principles, laboratory course. The seminars are held in the spring semester, and start end January/early February. The language of instruction and examination is English. Exam must be answered in English.

Compulsory assignments

  • Laboratory course

Further on evaluation

Retake of exam: The student must have completed the mandatory activities and assignments to take the exam. If taken in a previous semester, this is sufficient to take the exam. Exam must be answered in English.

Specific conditions

Compulsory activities from previous semester may be approved by the department.

Credit reductions

Course code Reduction From To
MOL3011 7.5 AUTUMN 2008
More on the course

No

Facts

Version: 1
Credits:  7.5 SP
Study level: Second degree level

Coursework

Term no.: 1
Teaching semester:  SPRING 2022

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Molecular Medicine
  • Biomedical Engineering
  • Biotechnology/Molecular Genetics
  • Bioinformatics
  • Biology
  • Biotechnology
  • Cell Biology
  • Medicine
Contact information
Course coordinator: Lecturer(s):

Department with academic responsibility
Department of Clinical and Molecular Medicine

Timetable

List view
Calendar view

Examination

Examination arrangement: Home exam

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Autumn UTS Home exam 100/100

Release
2021-12-17

Submission
2021-12-17


09:00


13:00

INSPERA
Room Building Number of candidates

Examination arrangement: School exam

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Spring ORD School exam 100/100 D 2022-05-12 15:00 INSPERA
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
Examination

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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