Course - Functional Genomics - MOL3007
MOL3007 - Functional Genomics
About
Examination arrangement
Examination arrangement: Written examination
Grade: Letters
Evaluation form | Weighting | Duration | Examination aids | Grade deviation |
---|---|---|---|---|
Written examination | 100/100 | 4 hours | D |
Course content
Fundamental principles within functional genomics, emphasizing the transcriptome and proteome. Contribution of functional genomics to systems biology and systems medicine. Socio-ethical aspects of functional genomics in biomedicine and biotechnology, including perspectives on genetic risk information. Hypothesis generation/experimental design. Experimental model systems. Next generation HTP sequenching technology. Microarray-technology. Protein separation (2D-PAGE, 2D-LC). Mass spectrometry (MALDI-TOF, ESI-MS). Protein structure analysis (X-ray chrystallography, NMR). Molecular imaging.
Learning outcome
After completing the course, the student shall be able to:
- describe what is meant by functional genomics and how this area of research contributes both to new basic biomedical knowledge and to new developments in biomedicine and biotechnology, including improved diagnostics and treatment of disease
- apply insights in analyses and evaluations of how functional genomics contributes to systems biology and systems medicine
- analyse and discuss the interdependence of biomedicine/biotechnology, bioinformatics and bioethics within functional genomics
- reflect on ethical and societal aspects of functional genomics translated to health care
- analyse and discuss how genetically modified organisms can contribute to functional genomics research
- explain main principles of high throughput transcriptomic and genomic analysis by state of the art sequencing and microarray technology
- explain mechanisms of gene regulation
- explain the concepts of structural motifs and domains in proteins and methods used to assess these structures
- explain main principles of central methods used in protein separation
- explain main methods for ionisation of peptides and how mass analysis of peptides and fragments thereof can be used to identify and quantify proteins and determine their post-translational modifications
- explain main principles of molecular imaging and its contribution to functional genomics research
- explain and discuss main principles of bioinformatic tools used for omics data analysis, biological background knowledge management and modeling
- explain main methods for ionisation of peptides and how mass analysis of peptides and fragments thereof can be used to identify and quantify proteins and determine their post-translational modifications
Learning methods and activities
Seminars with active student participation according to Team Based Learning (TBL) principles, laboratory course. The seminars are held in the spring semester, and start end January/early February. The language of instruction and examination is English. Exam must be answered in English.
Compulsory assignments
- Laboratory course
Further on evaluation
Retake of exam: The student must have completed the mandatory activities and assignments to take the exam. If taken in a previous semester, this is sufficient to take the exam. Exam must be answered in English.
Specific conditions
Exam registration requires that class registration is approved in the same semester. Compulsory activities from previous semester may be approved by the department.
Recommended previous knowledge
Basic skills in molecular biology and physiology.
Credit reductions
Course code | Reduction | From | To |
---|---|---|---|
MOL3011 | 7.5 | 01.09.2008 |
No
Version: 1
Credits:
7.5 SP
Study level: Second degree level
Term no.: 1
Teaching semester: SPRING 2021
Language of instruction: English
Location: Trondheim
- Molecular Medicine
- Biomedical Engineering
- Biotechnology/Molecular Genetics
- Bioinformatics
- Biology
- Biotechnology
- Cell Biology
- Medicine
Department with academic responsibility
Department of Clinical and Molecular Medicine
Phone:
Examination
Examination arrangement: Written examination
- Term Status code Evaluation form Weighting Examination aids Date Time Digital exam Room *
- Spring ORD Written examination 100/100 D 2021-05-12 09:00 INSPERA
-
Room Building Number of candidates
Examination arrangement: Home examination
- Term Status code Evaluation form Weighting Examination aids Date Time Digital exam Room *
-
Autumn
UTS
Home examination
100/100
Release 2020-11-27
Submission 2020-11-27
Release 09:00
Submission 13:00
INSPERA -
Room Building Number of candidates
- * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
For more information regarding registration for examination and examination procedures, see "Innsida - Exams"