TFY4315 - Biophysics of Ionizing Radiation


Examination arrangement

Examination arrangement: Portfolio assessment
Grade: Letters

Evaluation Weighting Duration Grade deviation Examination aids
Oral examination 80/100
Approved report 20/100 ALLE

Course content

This course gives an introduction to the deposition of energy from ionizing radiation in biologic materials. Topics presented includes direct and indirect radiation effects, radiation-induced DNA damage and –repair, mechanisms of cell death following radiation, quantitative models of cell kill and cell survival, dose-response relationships, tumor and normal tissue responses to radiation, main principles for use of ionizing radiation in cancer therapy, the 5 R's of fractionation, time-dose fractionation, therapeutic ratio, the linear-quadratic model, tumor control probability and normal tissue complication probability models, the dose-rate effect, the volume effect, the oxygen effect, tumor microenvironment and hypoxia, combination of radiotherapy with chemotherapy and molecularly targeted agents, sensitizing and protective agents, hyperthermia, proton and ion therapy.

Learning outcome

Knowledge the candidate should have knowledge about: - The interaction of ionizing radiation with biological materials. - Mechanisms behind the induction and repair of radiation-induced molecular and cellular effects. - The use of ionizing radiation in cancer therapy. Skills the candidate should be able to: - The use of various mathematical models for the estimation of cell kill and cell survival after irradiation of ionizing radiation. General competence the candidate should be able to: - Interpretation and presentation of scientific data obtained during the practical work in the laboratory, computer simulations and group work. - Reading and presenting research literature.

Learning methods and activities

Lectures, compulsory laboratory exercises/demonstrations, and compulsory project work in groups with presentation. Teaching will be in English if students on international master programs are attending the course. Expected work load in the course is 225 hours.

Compulsory assignments

  • Project with presentation
  • Laboratory exercises

Further on evaluation

Portfolio assessment is the basis for the grade in the course. The portfolio includes laboratory report (20%) and a final written (digital) exam (80%). The results for the parts are given in % scores, while the entire portfolio is assigned a letter grade. The re-sit examination (in August) may be changed from written to oral. For a re-take of an examination, all assessments in the portfolio must be re-taken.

Specific conditions

Compulsory activities from previous semester may be approved by the department.

Course materials

To be announced at the start of the semester.

Credit reductions

Course code Reduction From To
SIF4092 7.5
FY8919 7.5 AUTUMN 2017
More on the course



Version: 1
Credits:  7.5 SP
Study level: Second degree level


Term no.: 1
Teaching semester:  SPRING 2022

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Biophysics and Medical Technology
  • Physics
Contact information
Course coordinator: Lecturer(s):

Department with academic responsibility
Department of Physics


Examination arrangement: Portfolio assessment

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Spring ORD Approved report 20/100 ALLE INSPERA
Room Building Number of candidates
Spring ORD Oral examination (1) 80/100 2022-06-01 09:00
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
  • 1) Merk at eksamensform er endret som et smittevernstiltak i den pågående koronasituasjonen.

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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