Course - Biophysics of Ionizing Radiation - TFY4315
TFY4315 - Biophysics of Ionizing Radiation
This course gives an introduction to the deposition of energy from ionizing radiation in biologic materials. Topics presented includes direct and indirect radiation effects, radiation-induced DNA damage and repair, mechanisms of cell death following radiation, quantitative models of cell kill and cell survival, dose-response relationships, tumor and normal tissue responses to radiation, main principles for use of ionizing radiation in cancer therapy, the 5 R's of fractionation, time-dose fractionation, therapeutic ratio, the linear-quadratic model, tumor control probability and normal tissue complication probability models, the dose-rate effect, the volume effect, the oxygen effect, tumor microenvironment and hypoxia, combination of radiotherapy with chemotherapy and molecularly targeted agents, sensitizing and protective agents, hyperthermia, proton and ion therapy.
Knowledge the candidate should have knowledge about:
- The interaction of ionizing radiation with biological materials.
- Mechanisms behind the induction and repair of radiation-induced molecular and cellular effects. - The use of ionizing radiation in cancer therapy.
Skills the candidate should be able to:
- The use of various mathematical models for the estimation of cell kill and cell survival after irradiation of ionizing radiation.
General competence the candidate should be able to:
- Interpretation and presentation of scientific data obtained during the practical work in the laboratory, computer simulations and group work.
- Reading and presenting research literature.
Learning methods and activities
Lectures, compulsory laboratory exercises/demonstrations, and compulsory project work in groups with presentation. Teaching will be in English if students on international master programs are attending the course. Expected work load in the course is 225 hours.
- Laboratory exercises
- Project with presentation
Further on evaluation
Portfolio assessment is the basis for the grade in the course. The portfolio includes laboratory report (20%) and a final written (digital) exam (80%). The results for the parts are given
in % scores, while the entire portfolio is assigned a letter grade.
The re-sit examination (in August) may be changed from written to oral.
For a re-take of an examination, all assessments in the portfolio must be re-taken.
Exam registration requires that class registration is approved in the same semester. Compulsory activities from previous semester may be approved by the department.
Recommended previous knowledge
Course TFY4225 Nuclear and Radiation Physics or equivalent. Knowledge of cell biology (TFY4260 or equivalent) would be useful.
To be announced at the start of the semester.
Credits: 7.5 SP
Study level: Second degree level
Term no.: 1
Teaching semester: SPRING 2021
No.of lecture hours: 3
Lab hours: 1
No.of specialization hours: 8
Language of instruction: English
- Biophysics and Medical Technology
Examination arrangement: Portfolio assessment
- Term Status code Evaluation form Weighting Examination aids Date Time Digital exam Room *
- Spring ORD Approved report 20/100 ALLE INSPERA
Room Building Number of candidates
- Spring ORD Written examination 80/100 C INSPERA
Room Building Number of candidates
- * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
For more information regarding registration for examination and examination procedures, see "Innsida - Exams"