TKJ4155 - Organic Synthesis II


Examination arrangement

Examination arrangement: Written examination
Grade: Letters

Evaluation form Weighting Duration Examination aids Grade deviation
Written examination 100/100 4 hours D

Course content

A broad introduction to modern synthetic organic chemistry will be given; preparation and reactions with organometallic compounds (Mg, Li), reactions involving transition metals (organo-Cu, -Pd, -Ru), C-C bond formation reactions from organoboron and organotin compounds, oxidationreactions (alcohols, C=C bonds), reactions via electron deficient intermediates: cations, karbenes and metallocarbenes, nitrenes, radical chemistry with alkenes and alkynes, functionalisation of aromatic structures by electrophilic aromatic substitution, via aryl diazonium ions, nucleophilic aromatic substitution and palladium/cupper catalysed nuleophilic aromatic substitution as well as retrosynthesis.

Learning outcome

The course covers the theoretical basis for the chemical reactions that are important in the synthesis of organic compounds, particularly organometallic chemistry, including transition metals, C-C bond formation of organoboranes and -stannanes, carbene chemistry, aromatic substitutions and oxidations. By solving assigned problems, the students will learn to design multi step synthesis.
After the course the students are supposed to be able to:
- plan syntheses of organic molecules by proper choice of starting materials, reagents and reaction conditions,
- predict competing reactions afromd potential by-products,
- know how functional groups do affect the electron density, the properties and, in particular, the reactivity of organic compounds,
- show reaction mechanisms for the reactions,
- plan simple synthetic routes based on retrosynthetic synthesis strategy.

Learning methods and activities

If there is a re-sit examination, the examination form may be changed from written to oral.

Course materials

1) F. A. Carey and R. J. Sundberg: "Advanced Organic Chemistry. Part B, Reactions and Synthesis", 5. Ed., Springer, 2007.
2) S. Warren and P. Wyatt: "Organic Synthesis. The disconnection Approach". 2. Ed. Wiley, 2008.

Credit reductions

Course code Reduction From To
TKJ4111 3.5 2013-09-01
TKJ4135 4.0 2012-09-01


Detailed timetable


Examination arrangement: Written examination

Term Statuskode Evaluation form Weighting Examination aids Date Time Room *
Autumn ORD Written examination 100/100 D 2017-12-06 09:00 R73 , E4
  • * The location (room) for a written examination is published 3 days before examination date.
If more than one room is listed, you will find your room at Studentweb.