Lise Lyngsnes Randeberg

About Lise Lyngsnes Randeberg

Associate professor of biomedical optics at NTNU since November 2009

Fields of interest and present research activities

Biomedical optics, including optical and thermal properties of tissue, light-tissue interactions, and diagnostic applications of medical technology such as optical imaging and spectroscopy. Research interests include instrumentation, modelling and signal processing for spectroscopy and hyperspectral imaging. Current projects covers a wide range of inter disciplinary applications which involves medicine, physics and engineering.

Current and previous research projects/themes

Hyperspectral imaging

• Instrumentation and algorithms
• Real time diagnostic systems
• Hyperspectral diagnostics and characterization of biological samples

Applications of hyperspectral imaging, optical spectroscopy and modeling

• Characterization of macro molecule diffusion in human skin
• Fluorescence and white light characterization of atherosclerotic plaques
• Optical characterisation of skin (connective tissue, diabetic ulcers, psoriasis, port-wine stains)
• Characterization of connective tissue and lipids in fish
• Forensic medical optics: characterization, modelling and age determination of skin bruises
• Optical monitoring of skin changes in psoriasis as a function of UV dose
• Optical characterization of photo induced reversible changes in riboflavin
• Monitoring of laser treatment of port-wine stains (treatment response and immediate reactions), and measurements of cryogen cooling profiles
• Trans dermal bilirubinometri and monitoring of skin effects of photo-treatment of neonatal jaundice
• PDT and PCI in a rat bladder cancer model (dosimetry and treatment monitoring)
• UV and visible light effects on oral tissues and skin

Awards

• Technoport Awards: Ung innovasjonspris (Young innovator award), NOK 100.000, 2007
• American Society for Laser Medicine and Surgery: ASLMS $15.000 Research Grant, 2006
• US-Air Force Office of Scientific Research Travel Grant, 2005 and 2006

Scientific committee positions

• Scientific committee member: Clinical and Biomedical Spectroscopy at the European Conferences on Biomedical Optics (ECBO), Munich, 2009 and 2011
• 1st opponent on the PhD evaluation committee for Tobias Lindberg, Dept. of Biomedical Engineering, University of Lindköping, Sweden. Dissertation 30. Oct 2009
• Committee administrator for the PhD evaluation committee for Vegard Larsen Tuft, Dept. of Electronics and Telecommunications, NTNU. Dissertation 30. Sept. 2010

Other positions

• Wireless Trondheim, board member, 2010 -
• NTNU, University board member, 2007 - 2009; deputy member, 2006 - 2007
• NTNU Strategic area of medical technology, Network leader Biomedical optics, 2006 - 2009
• NTNU, Member of the Advisory Committee on Gender and Equity Issues, 2006 -
• Tekna - The Norwegian Society of Chartered Technical and Scientific Professionals, vice president, 2011 - 2013
• Tekna, board member Research politics group, 2005 - 2010
• Tekna NTNU, board member 2003 -2013; leader 2010 and 2011
• NTNU, Faculty of Mathematics, Informatics and Telecommunications, Member of the Research Committee, 2002 - 2005
• The organization for PhD students at NTNU (DION), Board member, 2001 - 2004
• NTNU, Department of Physical Electronics, Board member, 1999 - 2001
• Nidelv athletics team, Board member, 2006 - ; Board leader from 2010.

Curerent teaching responsibilities

TFE 4235 Biomedical optics (7.5 credits)

Previous and current PhD students

• Eivind La Puebla Larsen, Thesis entitled:Biomedical application of diffuse reflectance spectroscopy and hyperspectral imaging. Thesis defended Dec. 2010
• Julio E. Hernandez-Palacios: Low light hyperspectral systems
• Martin Denstedt: Real-time hyperspectral imaging
• Lucas Paluchowski: Hyperspectral image processing

Publications

One invited book chapter, 11 published journal papers (2 additional papers currently in preparation), 22 proceedings papers, more than 40 presentations at international conferences, and more than 30 invited international seminars and national conferences. Several newspaper articles, radio interviews and contributions to national TV (science programs). A full list of publications (updated January 2012) is available in Cristin

Doctoral thesis
L.L. Randeberg, Diagnostic applications of reflectance spectroscopy, Doctoral thesis at NTNU, ISSN 1503-8181;2005:100, ISBN: 82-471-7078-7, URL: http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-691

Book chapters
L.L. Randeberg, B. Skallerud, N.E.I. Langlois, O.A. Haugen, L.O. Svaasand, The optics of bruising, In: Optical Response of Laser-Irradiated Tissue (Lasers, Photonics, and Electro-Optics), 2nd edition, Editors: A.J. Welch, M.J.C. van Gemert, Springer Verlag, 2011.

Journal papers

1. H. Watchman, G.S. Walker, L.L. Randeberg, N.E.I. Langlois, Re-oxygenation of post-mortem lividity by passive diffusion through the skin at low temperature, Forensic Sci Med Pathol., 7(4):333-5, 2011.
2. C.-J. Arum, O.A. Gederaas, E.L.P. Larsen, L.L. Randeberg, A. Hjelde, H. Krokan, L.O. Svaasand, D. Chen, C.-M. Zhao, Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthopic rat bladder cancer model: possible pathways of action, J Biomed Opt, 16(2), 2011
3. E.P.L Larsen, L.L. Randeberg, E.Olstad, O. A. Haugen, A. Aksnes, L. O. Svaasand, Hyperspectral imaging of atherosclerotic plaques in vitro, J Biomed Opt, 16(2), 2011
4. L.L. Randeberg, E.L.P. Larsen, L.O. Svaasand, Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory, J. Biophot., 3(1): 53-65, 2010
5. E.L.P. Larsen, L.L. Randeberg, O.A. Gederaas, C.-J. Arum, A. Hjelde, C.-M. Zhao, D. Chen, H.E. Krokan, L.O. Svaasand, Monitoring of HAL Induced PDT in rat bladder cancer by optical Spectroscopy, J Biomed Opt, 13, 044031 (Aug. 26, 2008)
6. L.L. Randeberg, A.M. Winnem, N.E. Langlois, E.L.P. Larsen, R. Haaverstad, B. Skallerud, O.A. Haugen, L.O. Svaasand, Skin changes following minor trauma, Lasers Surg Med, 39(5):403-413, 2007
7. L.L. Randeberg, O.A. Haugen, R. Haaverstad, L.O. Svaasand, A novel approach to age determination of traumatic injuries by reflectance spectroscopy, Lasers Surg Med, 38(4):277-89, 2006
8. L.L. Randeberg, E.B. Roll, L.T. Norvang Nilsen, T. Christensen, L.O. Svaasand, In vivo spectroscopy of newborn skin reveals more than a bilirubin index, Acta paediatrica, 94(1):65-71, 2005
9. L.L. Randeberg, J.H. Bonesrønning, M. Dalaker, J.S. Nelson, L.O. Svaasand, Methemoglobin formation during laser induced photothermolysis of vascular lesions, Lasers Surg Med, 34(5):414-419, 2004
10. L.O. Svaasand, G. Aguilar, J.A. Viator, L.L. Randeberg, S. Kimel, J.S. Nelson, Increase of dermal blood volume fraction reduces the threshold for laser-induced purpura: Implications for port wine stain laser treatment, Lasers Surg Med, 34(2):182-188, 2004
11. L.O. Svaasand, L.L. Randeberg, G. Agiular, B. Majaron, S. Kimel, E.J. Lavernia, J.S. Nelson, Cooling efficiency of cryogen spray during laser therapy of skin, Lasers Surg Med, 32(2):137-142, 2003

Proceedings papers

1. L.L. Randeberg, J. Hernandez-Palacios, Hyperspectral imaging of bruises in the SWIR spectral region, Proceedings of SPIE, Vol. 8207, 2012
2. J. Hernandez-Palacios, L.L. Randeberg, Intercomparison of EMCCD- and sCMOS-based imaging spectrometers for biomedical applications in low-light conditions, Proceedings of SPIE, Vol. 8215, 2012
3. J.Hernandez-Palacios, I.J. Haug, Ø. Grimstad, L. L. Randeberg,Hyperspectral characterization of fluorophore diffusion in human skin using a sCMOS based hyperspectral camera. Proceedings of SPIE, Vol. 8087, 2011
4. J. Hernandez-Palacios, L. L. Randeberg, I. Baarstad, T. Løke, T. Skauli, A hyperspectral imagins system for characterization of biological samples in low light enviroments, Proceedings of SPIE, Vol. 7891, 2011
5. L.L. Randeberg, J. Hernandez-Palacios, M. Lilleeng, L.T.N. Nilsen, A. L. Krogstad, UV doses and skin effects during psoriasis climate therapy, Proceedings of SPIE, Vol. 7883, 2011
6. J. Hernandez-Palacios, L. L. Randeberg, I. Baarstad, T. Løke, T. Skauli, Hyperspectral low-light camera for macroscopic imaging of biological samples, IEEE-Whispers 2010, 2nd workshop on hyperspectral imaging and signal processing: The evolution of remote sensing, Reykjavik, June 14.-16., 2010.
7. L.L. Randeberg, E.L.P. Larsen, A. Aksnes, L.O. Svaasand, Hyperspectral characterization of atherosclerotic plaques, European Conference on Biomedical Optics (ECBO), Munich, June 14.-18., 2009, Proceedings of SPIE vol. 7368, 2009
8. J. Hernandez-Palacios, I. Baarstad, T. Løke, L.L. Randeberg, T. Skauli, Design and characterization of a hyperspectral camera for low light imaging with example results from field and laboratory applications, 6th EARSeL SIG Imaging Spectroscopy Workshop, Tel Aviv, 16.-19. March, 2009
9. L.L. Randeberg, E.L.P. Larsen, L.O. Svaasand, Hyperspectral imaging of blood perfusion and chromophore distribution in skin. Proceedings of SPIE, Vol. 7161, 2009
10. L.L. Randeberg, A.M. Winnem, E.L.P. Larsen, R. Haaverstad, O.A. Haugen, L.O. Svaasand, In vivo hyperspectral imaging of traumatic skin injuries in a porcine model. Proceedings of SPIE, Vol. 6424, 2007
11. A.M. Winnem, L.L. Randeberg, E.L.P. Larsen, M.B. Lilledahl, B. Skallerud, R. Haaverstad, O.A. Haugen, L.O. Svaasand, Biomechanical characterization of soft tissue injuries. Proceedings of SPIE, Vol. 6424, 2007
12. E.L.P.Larsen, L.L. Randeberg, O.A. Gederaas, H.E. Krokan, D.R. Hjelme, L.O. Svaasand, In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy. Proceedings of SPIE, Vol. 6427, 2007
13. L.L. Randeberg, I. Baarstad, T. Løke, A.M. Winnem, E.L.P. Larsen, P. Kaspersen, O.A. Haugen, L.O. Svaasand, Hyperspectral imaging of bruised skin, Proceedings of SPIE, Vol. 6078:100-110, 2006
14. E.L.P. Larsen, L.L. Randeberg, O.A. Gederaas, C. Arum, H.E. Krokan, D. Chen, D.R. Hjelme, L.O. Svaasand, Optical spectroscopy by 5-aminolevulinic acid hexylester induced photodynamic treatment in rat bladder cancer, Proceedings of SPIE Vol. 6139:74-82, 2006
15. A.M. Winnem, L.L. Randeberg, B. Skallerud, R. Haaverstad, O.A. Haugen, L.O. Svaasand, Subcutaneous transport of extravascular hemoglobin, Proceedings of SPIE Vol. 6078:40-48, 2006
16. L.L. Randeberg, A.M. Winnem, R. Haaverstad, O.A. Haugen, L.O. Svaasand, Performance of Diffusion theory vs. Monte Carlo methods, Proceedings of SPIE, Vol. 5862:137-144, 2005
17. M.B. Lilledahl, O.A. Haugen, L.L. Randeberg, L.O. Svaasand, Optical characterization of artherosclerotic plaque by reflection spectroscopy, Proceeding of SPIE, Vol. 5686:415-425, 2005
18. L.L. Randeberg, A. Winnem, S. Blindheim, O.A. Haugen, L.O. Svaasand, Optical classification of bruises, Proceedings of SPIE, Vol. 5312:54-64, 2004
19. L.L. Randeberg, O.A. Haugen, L.O. Svaasand, Optical diagnostics of liver pathology, Proceedings of SPIE, 5141:187-196, 2003
20. L.L. Randeberg, A.J. Daae Hagen, L.O. Svaasand, Optical properties of human blood as a function of temperature, Proceedings of SPIE, 4609:20-28, 2002
21. L.L. Randeberg, L.O. Svaasand, Simulated color: a diagnostic tool for skin lesions like port-wine stain, Proceedings of SPIE, 4244:1-12, 2001
22. B. Majaron, G. Aguilar, B. Basinger, L.L. Randeberg, L.O. Svaasand, E.J. Lavernia, J.S. Nelson, Sequential cryogen spraying for heat flux control at the skin surface, Proceedings of SPIE, 4244:74-82, 2001