Background and activities
Professor in bioinformatics and Group Leader for Bioinformatics & Gene Regulation (BiGR): http://bigr.medisin.ntnu.no
NTNU Node Leader and Deputy Head for ELIXIR Norway: https://www.elixir-europe.org/about/elixir-norway
PubMed publications: http://www.ncbi.nlm.nih.gov/pubmed?term=drablos+f
Trained in organic chemistry at University of Bergen (MSc 1983), including using computer-based expert system (SECS) and computational methods for strategies in organic synthesis. The computational aspects were basis for a PhD in chemometrics, also at University of Bergen. I was then recruited as a research scientist at SINTEF in Trondheim, where I did contract research on molecular modelling, in particular for pharmaceutical industry. This was gradually expanded into various methods in bioinformatics, in particular for sequence analysis and protein structure prediction. The SINTEF unit was closed down in 2002, and I was offered a position at NTNU as a research scientist. I got a qualification fellowship in 2004, and became full professor in bioinformatics in 2007. Since 2002 I have been strongly involved in building up bioinformatics as a research area at NTNU, initially as leader of Programme for Bioinformatics, later also as NTNU node leader for the FUGE technology platform and the ELIXIR Norway infrastructure for bioinformatics.
Focus of my research for the last 10 years has been on gene regulation, initially based on transcription factors, promoters and enhancers, but increasingly also including epigenetics, in particular histone modifications. The research group has established rigorous methods for benchmarking methods for motif discovery (BMC Bioinformatics 2007, 2008) and ChIP-seq data analysis (Nucleic Acids Res 2011). We have also developed novel methods for motif discovery (BMC Bioinformatics 2008), a tool for detailed analysis of regulatory regions (Bioinformatics 2010; BMC Bioinformatics 2013), and a tool for identification of ChIP-seq peaks (BMC Bioinformatics 2012). This has provided a basis for detailed analysis of gene regulation in several systems, both at the level of transcription factors (J Biol Chem 2010; BMC Genomics 2012; BMC Med 2013; PLoS One 2015), and with respect to histone modifications (PLoS One 2011; BMC Biology 2011; BMC Genomics 2014). This research is now done in collaboration with the international FANTOM consortium, leading to important papers where our main contribution has been on epigenetic regulation (BMC Genomics 2014; Nature 2014; Science 2015; Database 2015; NAR 2017).
For some years we have also built up a cancer-related research activity, in particular on colorectal cancer (CRC) and prostate cancer (PCa). For colorectal cancer we have mainly worked on identification of a specific mutation leading to increased risk for CRC (Familial Cancer 2015), whereas the research on prostate cancer has focused on identification of reliable gene sets for PCa prognosis (BMC Med Genomics 2014; PLoS ONE 2016; Oncotarget 2017).
Through the service and infrastructure activities the group has also been involved in several other projects, like research on prokaryotes, including oil well metagenomics, biodegradation, pathogenic bacteria, and characterization of novel bacterial genes.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2017) Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome. Clinical Genetics.
- (2017) Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals. Nucleic Acids Research. vol. 45 (D1).
- (2017) GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience.
- (2016) Gene regulation in the immediate-early response process. Advances in Biological Regulation. vol. 62.
- (2016) Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function. BMC Bioinformatics. vol. 17 (459).
- (2016) TopoICSim: A new semantic similarity measure based on gene ontology. BMC Bioinformatics. vol. 17 (1).
- (2016) Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α. PLoS ONE. vol. 11 (12).
- (2016) Discovery and Characterization of a Thermostable Esterase from an Oil Reservoir Metagenome. Advances in Enzyme Research. vol. 4 (2).
- (2016) A novel non-canonical Wnt signature for prostate cancer aggressiveness. OncoTarget. vol. 8 (6).
- (2016) A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer. PLoS ONE. vol. 11 (4).
- (2015) Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. vol. 347 (6225).
- (2015) Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model. Photodiagnosis and Photodynamic Therapy. vol. 12 (1).
- (2015) A property-based analysis of human transcription factors. BMC Research Notes. vol. 8 (1).
- (2015) c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. PLoS ONE. vol. 10 (7).
- (2015) A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. Familial Cancer. vol. 14 (3).
- (2015) A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers. Familial Cancer. vol. 14 (1).
- (2015) The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS biology. vol. 13:e1002315 (12).
- (2015) EpiFactors: A comprehensive database of human epigenetic factors and complexes. Database: The Journal of Biological Databases and Curation. vol. 2015.
- (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. vol. 30.
- (2014) Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization. BioMed Research International. vol. 14 (74).