Background and activities
Professor in bioinformatics and Group Leader for Bioinformatics & Gene Regulation (BiGR): http://bigr.medisin.ntnu.no
NTNU Node Leader and Deputy Head for ELIXIR Norway: https://www.elixir-europe.org/about/elixir-norway
PubMed publications: http://www.ncbi.nlm.nih.gov/pubmed?term=drablos+f
Trained in organic chemistry at University of Bergen (MSc 1983), including using computer-based expert system and computational methods for strategies in organic synthesis. The computational aspects were basis for a PhD in chemometrics, also at University of Bergen. I was then recruited as a research scientist at SINTEF in Trondheim, where I did contract research on molecular modelling, in particular for pharmaceutical industry. This was gradually expanded into various methods in bioinformatics, in particular for sequence analysis and protein structure prediction. Most of this research could be documented only in confidential SINTEF reports. The unit at SINTEF was closed down in 2002, and I was offered a position at NTNU as a research scientist. I got a qualification fellowship in 2004, and became full professor in bioinformatics in 2007. Since 2002 I have been strongly involved in building up bioinformatics as a research area at NTNU, initially as leader of Programme for Bioinformatics, later also as NTNU node leader for the FUGE technology platform and the ELIXIR Norway infrastructure for bioinformatics.
Focus of my research for the last 10 years has been on gene regulation, initially based on transcription factors, promoters and enhancers, but increasingly also including epigenetics, in particular histone modifications. The research group has established rigorous methods for benchmarking methods for motif discovery (BMC Bioinformatics 2007, 2008) and ChIP-seq data analysis (Nucleic Acids Res 2011). We have also developed novel methods for motif discovery (BMC Bioinformatics 2008), a tool for detailed analysis of regulatory regions (Bioinformatics 2010; BMC Bioinformatics 2013), and a tool for identification of ChIP-seq peaks (BMC Bioinformatics 2012). This has provided a basis for detailed analysis of gene regulation in several systems, both at the level of transcription factors (J Biol Chem 2010; BMC Genomics 2012; BMC Med 2013; PLoS One 2015), and with respect to histone modifications (PLoS One 2011; BMC Biology 2011; BMC Genomics 2014). This research is now done in collaboration with the international FANTOM consortium, leading to important papers where our main contribution has been on epigenetic regulation (BMC Genomics 2014; Nature 2014; Science 2015; Database 2015).
Through the service and infrastructure activities the group has also been involved in several other projects, like research on prokaryotes, including oil well metagenomics, biodegradation, pathogenic bacteria, and characterization of novel bacterial genes.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2016) A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer. PLoS ONE. vol. 11 (4).
- (2015) Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. vol. 347 (6225).
- (2015) Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model. Photodiagnosis and Photodynamic Therapy. vol. 12 (1).
- (2015) A property-based analysis of human transcription factors. BMC Research Notes. vol. 8 (1).
- (2015) c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. PLoS ONE. vol. 10 (7).
- (2015) Genome Sequences of 11 Shiga Toxin-Producing Escherichia coli Strains. Genome Announcements.
- (2015) A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. Familial Cancer. vol. 14 (3).
- (2015) A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers. Familial Cancer. vol. 14 (1).
- (2015) EpiFactors: A comprehensive database of human epigenetic factors and complexes. Database: The Journal of Biological Databases and Curation. vol. 2015.
- (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. vol. 30.
- (2014) Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization. BioMed Research International. vol. 14 (74).
- (2014) A promoter-level mammalian expression atlas. Nature. vol. 507 (7493).
- (2014) Comparative genomics to delineate pathogenic potential in Non-O157 Shiga toxin-producing Escherichia coli (STEC) from patients with and without haemolytic uremic syndrome (HUS) in Norway. PLoS ONE. vol. 9 (10).
- (2014) The microbial communities in two apparently physically separated deep subsurface oil reservoirs show extensive DNA sequence similarities. Environmental Microbiology. vol. 16 (2).
- (2014) Safety in numbers: multiple occurrences of highly similar homologs among Azotobacter vinelandii carbohydrate metabolism proteins probably confer adaptive benefits. BMC Genomics. vol. 15 (192).
- (2014) The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences. Database: The Journal of Biological Databases and Curation.
- (2014) Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer. BMC Medical Genomics. vol. 7 (50).
- (2014) Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines. BMC Genomics. vol. 15 (1).
- (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Nucleic Acids Research. vol. 41 (5).
- (2013) Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Medicine. vol. 11 (163).