Background and activities
In my research, I study how the human body reacts and adapts to diving. Currently, my main research activity is in the project Fitness to dive – a translational approach to physiological challenges in the hyperbaric working environment, through which we aim to provide applicable knowledge for preparing and protecting occupational divers from injury. Two researchers, one senior engineer, one post doc and several students are affiliated with the project, and we collaborate with researchers in Norway, Sweden, Denmark, Croatia and the USA.
For me, the main attractions in diving medicine and barophysiology lie in the highly complex interactions between human biology and the underwater environment. Besides being at the core of my professional curiosity, I believe that better understanding of the biological mechanisms involved in health protection will promote safe diving.
I am a civil engineer in Biophysics and Medical Technology, and hold a Molecular Biology PhD from NTNU. My prior experience includes a post doc in Strasbourg, molecular biologist at University Hospital Rigshospitalet Copenhagen, consultancy in forensic genetics and several years of leadership of the Medical Genetics Section at St Olav’s University Hospital in Trondheim.
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
- (2016) Age, weight and decompression sickness in rats. Archives of Physiology and Biochemistry. vol. 122 (2).
- (2016) Diving into the rat plasma proteome to get to the bottom of decompression sickness. PROTEOMICS - Clinical Applications.
- (2016) Immune and inflammatory responses to freediving calculated from leukocyte gene expression profiles. Physiological Genomics. vol. 48 (11).
- (2015) The aging diver: endothelial biochemistry and its potential implications for cardiovascular health. Diving and Hyperbaric Medicine. vol. 45 (4).
- (2015) Evaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric air. Physiological Reports. vol. 3 (6).
- (2014) Eccentric exercise 48 h prior to simulated diving has no effect on vascular bubble formation in rats. European Journal of Applied Physiology. vol. 115 (3).
- (2013) Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers. Physiological Genomics. vol. 45 (20).
- (2013) Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving. Physiological Reports. vol. 1 (6).
- (2013) Exercise-induced myofibrillar disruption with sarcolemmal integrity prior to simulated diving has no effect on vascular bubble formation in rats. European Journal of Applied Physiology. vol. 113 (5).
- (2012) Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional mutlicentre study. European Journal of Clinical Pharmacology. vol. 68 (1).
- (2012) Early genetic responses in rat vascular tissue after simulated diving. Physiological Genomics. vol. 44 (24).
- (2001) Embryonale stamceller og terapeutisk cloning. Tidsskrift for Den norske legeforening. vol. 121.
- (2001) Single intragenic microsatellite preimplantation genetic diagnosis for cystic fibrosis provides positive allele identification of all CFTR genotypes for informative couples. Molecular human reproduction. vol. 7 (3).
- (1996) Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics. vol. 36.
- (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Biochemical and Biophysical Research Communications - BBRC.
- (1996) Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16. Biochemical and Biophysical Research Communications - BBRC. vol. 224.
- (1995) Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots. FEBS Letters. vol. 362.
- (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry. vol. 34.
- (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research. vol. 21 (9).
- (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry. vol. 211.
- (1993) Heterogeneity in the incorporation and excision of uracil in DNA. 1993. ISBN 82-7119-591-3. Doktor ingeniøravhandling (1993:12).
- (1989) Automatization of pressure chamber : Monitoring & control of hyperbaric environment for animalresearch. 1989.