Background and activities
Diseases affecting the heart are characterized by the activation of a variety of intracellular signaling pathways and transcriptional mediators that causes breakdown of cardiac function, pathological remodeling as well as triggering of lethal cardiac arrhythmias.
My aim is to establish a clinical oriented basic research direction for developing new therapeutic strategies for heart failure based on a better understanding of the underlying cellular and molecular mechanisms of the disease.
The specific objective of my research is to form the basis for developing new therapeutic strategies for heart failure based on the hypothesis that altered regulation of a new class of non-coding RNA, microRNA, causes post- transcription repression or mRNA degradation of key proteins involved in cardiomyocyte excitation-contraction-coupling, Calcium homeostasis and electrical properties in the failing heart.
Publications listed in publication databases