Olav Haraldseth

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Emailolav.haraldseth@ntnu.no
Phone+47 72828040
Mobile phone+47 98468940
Office addressAHL*342.03.015, Prinsesse Kristinas gate 3
PositionProfessor
UnitDepartment of Circulation and Medical Imaging


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Born:                           1956

Present position:           Professor, MI Lab director

Degrees:                      MD, PhD [dr. med.]

 

Education

1992                PhD in Medicine [dr. med.], NTNU, Trondheim, Norway.

                        Thesis: “NMR spectroscopy of cerebral ischemia and reperfusion in rat”

1984                Medical Doctor, University of Bergen.

 

Work experience

2007 -             Director of medical imaging centre (SFI) “MI Lab” (www.ntnu.no/milab)

2006 - 07        Dean for research, Faculty of Medicine, NTNU

2005                Head of Department of Circulation and Medical Imaging, NTNU

2002 - 05        Vice-head of Department of Circulation and Medical Imaging, NTNU

1998 - present Professor in MR, NTNU, Trondheim, Norway

1991 - 97        Research scientist, Sintef, Trondheim, Norway

1988 - 91        Research fellowship, the Research Council of Norway

1985 - 87        Hospital physician, Harstad and Trondheim, Norway

 

Special assignments active in 2009

·      Appointed by European Science Foundation to be main author of a Science Policy Briefing on “Medical Imaging for Improved Patient Care”

·      Leader of “Whole animal imaging network” in the national FUGE technology platform in Molecular Imaging (NorMIC)

·      Leader of “The Norwegian Interdisciplinary Research Training Programme in Medical Imaging”.

·      Research leader, Department of Medical Imaging, St. Olavs Hospital

·      NTNU contact person for European Technology Platform in Nanomedicine.

·      Member of National User Committee for the PET Centre in Oslo

 

Main Research Interest

Clinical and preclinical application of new functional and molecular MR methods for information about tissue physiology and organ function in brain, heart and cancer research.

 

Full scientific papers in peer-reviewed journals 1990-2007

 

1.       Eide KR, Odegard A, Myhre HO, Lydersen S, Hatlinghus S, Haraldseth O. Dyna-CT during EVAR - A comparison with Multidetector CT. Eur J Vasc Endovasc Surg 2009; 37(1):23-30

2.       Thuen M, Olsen Ø, Martin Berry M, Bugge Pedersen T, Kristoffersen A, Haraldseth O, Sandvig A, Brekken C. Combination of Mn2+-enhanced and diffusion tensor MR imaging gives complementary information about injury and regeneration in the adult rat optic nerve. J Magn Reson Imag 2009;29(1):39-51

3.       Thuen M, Goa PE, Bugge Pedersen T, Berry M, Summerfield MR, Sandvig A, Haraldseth O, Brekken C. Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport and clearance of Mn2+. J Magn Reson Imag 2008;28(4):855-65

4.       Berntsen EM, Samuelsen P, Lagopoulos J, Jr IA, Håberg AK, Haraldseth O. Mapping the primary motor cortex in healthy subjects and patients with peri-rolandic brain lesions before neurosurgery. Neurol Res. 2008;30(9):968-73

5.       Larsson HBW, Hansen AE, Berg HK, Rostrup E, Haraldseth O. Dynamic contrast enhanced quantitative perfusion measurement of the brain using T1 weighted MRI at 3 tesla. J Magn Reson Imag 2008;27(4):754-62.

6.       Olsen Ø, Thuen M, Berry M, Kovalev V, Petrou M, Goa PE, Sandvig A, Haraldseth O, Brekken C. Axon tracing in the adult rat optic nerve and tract after intravitreal injection of MnDPDP using a semi-automatic segmentation technique. J Magn Reson Imag 2008;27:34-42

7.       Alvestad S, Goa PE, Qu H, Risa Ø, Brekken C, Sonnewald U, Haraldseth O,Hammer J, Ottesen OP, Håberg A. In vivo mapping of temperospatial changes in manganese enhancement in rat brain during epileptogenesis. Neuroimage 2007;38:57-66

8.       Skjold A, Amundsen BH, Wiseth R, Støylen A, Haraldseth O, Larsson HBW, Jynge P. Manganese dipyridoxyl-diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction. J Magn Reson Imag 2007;26:720-727

9.       Skranes J, Vangberg TR, Kulseng S, Indredavik MS, Evensen KAI, Martinussen M, Dale AM, Haraldseth O, Brubakk AM. Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight. Brain 2007;130:654-666

10.   Eide KR, Odegard A, Myhre HO, Haraldseth O. Initial observations of endovascular aneurysm repair using Dyna-CT. J Endovasc Ther 2007;14:50-3.

11.   Skjold A, Kristoffersen A, Vangberg TR, Haraldseth O, Jynge P, Larsson H. An Apparent Unidirectional Influx Constant for Manganese as a Measure of Myocardial Calcium Channel Activity. J Magn Reson Imag 2006;24:1047-1055

12.   Vangberg TR, Skranes J, Dale AM, Martinussen M, Brubakk A-M, Haraldseth O. Changes in white matter diffusion anisotropy in adolescents born prematurely. Neuroimage 2006;32:1538-1548

13.   Sæther O, Midelfart A, Risa Ø, Haraldseth O, Krane J. Proton decoupled 19F NMR spectroscopy of drugs used in eye treatment. Spectroscopy Letters 2006;39:135-144

14.   Brekke C, Lundervold A, Enger PO, Brekken C, Stalsett E, Pedersen TB, Haraldseth O, Kruger PG, Bjerkvig R, Chekenya M. NG2 expression regulates vascular morphology and function in human brain tumours.
Neuroimage 2006;29:965-76.

15.   Huszhty PC, Brekken C, Pedersen TB, Thorsen F, Sakariassen PØ, Skaftnesmo KO, Haraldseth O, Lønning PE, Bjerkvig R, Enger PØ. Antitumor efficacy improved by local delivery of species-specific endostatin. J Neurosurg 2006;104:118-128

16.   Berntsen EM, Rasmussen I-A, Samuelsen P, Xu J, Haraldseth O, Lagopoulos J, Gin S, M. Putting the brain in jeopardy: a novel comprehensive and expressive language task ?. Acta Neuropsychiatrica 2006;18:115-119

17.   Martinussen M, Fischl B, Larsson HB, Skranes J, Kulseng S, Vangberg TR, Vik T, Brubakk AM, Haraldseth O, Dale AM. Cerebral cortex thickness in 15-year-old adolescents with low birth weight measured by an automated MRI-based method. Brain 2005;128:2588-2596

18.   Thuen M, Singstad TE, Pedersen TB, Haraldseth O, Berry M, Sandvig A, Brekken C. Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats. JMRI 2005;22:492-500

19.   Skjold A, Vangberg TR, Kristoffersen A, Haraldseth O, Jynge P Larsson HBW.  Relaxation enhancing properties of MnDPDP in human myocardium. J Magn Reson Imag 2004;20:948-52.

20.   Håberg A, Kvistad KA, Unsgård G, Haraldseth O. Preoperative blood oxygen level-dependent functional magnetic resonance imaging in patients with primary brain tumors: clinical application and outcome. Neurosurgery 2004;54:902-14

21.   Daldrup-Link HE, Rydland J, Helbich T, Bjornerud A, Turetschek K, Kvistad KA, Link TM, Staudacher K, Shames D, Brasch RC, Haraldseth O, Rummeny EJ. Quantification of Breast Tumor Microvascular Permeability with Feruglose (ClariscanTM) enhanced MR Mammography: Initial Phase II Clinical Trial. Radiology 2003;229:885-92

22.   Rydland J, Bjørnerud A, Haugen O, Kvistad KA, Haraldseth O. New intravascular contrast agent applied to dynamic contrast enhanced MRI of human breast cancer. Acta Radiol 2003;44:275-83

23.   Amundsen T, Torheim G, Kvistad KA, Waage A, Bjermer L, Nordlid KK, Johnsen H, Åsberg A, Haraldseth O. Perfusion abnormalities in pulmonary embolism studied with perfusion MR imaging and ventilation-perfusion scintigraphy – An intra-modality and inter-modality agreement study. J Magn Reson Imag 2002;15:386-394

24.   Chekenya M, Hjelstuen M, Enger PØ, Thorsen F, Jacob AL, Probst B, Haraldseth O, Pilkington G, Butt A, Levine JM, Bjerkvig R. NG2 proteoglycan promotes angiogenesis-dependent tumor growth in the central nervous system by sequestering angiostatin. FASEB J 2002;16:586-588

25.   Hjelde A, Hjelstuen M, Haraldseth O, Martin JD, Thom SR, Brubakk AO. Hyperbaric oxygen and neutrophil accumulation/tissue damage during permanent focal cerebral ischemia in rats. Eur J Appl Physiol 2002;86:401-405

26.   Torheim G, Godtliebsen F, Axelson D, Kvistad KA, Haraldseth O, Rinck PA. Feature extraction and classification of dynamic contrast-enhanced T2*-weighted breast image data. IEEE Transactions Med Imag 2001;20:1293-1301

27.   Håberg A, Qu H, Sæther O, Unsgård G,  Haraldseth O, Sonnewald U. Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of MCAO in the rat. The role of astrocytes in neuronal survival J Cereb Blood Flow Metab 2001;21:1451-1463

28.   Torheim G, Amundsen T, Rinck PA, Haraldseth O, Sebastiani G. Analysis of contrast-enhanced dynamic MR images of the lung. JMRI 2001;14:577-587

29.   Read T-A, Sorensen DR, Mahesparan R, Enger PØ, Timpl R, Olsen BR, Hjelstuen M, Haraldseth O, Bjerkvig R. Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nature Biotech 2001;19:29-34

30.   Qu H, Håberg A, Haraldseth O, Unsgård G, Sonnewald U. 13C MRS study of lactate as cerebral substrate for rat brain. Dev Neurosci 2000;22:429-436

31.   Amundsen T, Torheim G, Waage A, Bjermer L, Steen PA, Haraldseth O. Perfusion magnetic resonance imaging of  the lung: Characterization of pneumonia and chronic obstructive pulmonary disease. A feasibility study. J Magn Reson Imag 2000;12:224-231

32.   Amundsen T, Kværness J, Aadahl P, Waage A, Bjermer L, Ødegård A, Haraldseth O. A closed-chest pulmonary artery occlusion-reperfusion model in the pig. Invest Radiol 2000;35:295-303

33.   Lyng H, Haraldseth O, Rofstad EK. Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging. Magn Reson Med 2000;43:828-836

34.   Kvistad KA, Rydland J, Vainio J, Smethurst HB, Lundgren S, Fjøsne HE, Haraldseth O. MR evaluation of breast lesions with combined dynamic contrast enhanced MR T1-weighted imaging and T2*-weighted first pass perfusion imaging. Radiology 2000;216:545-553

35.   Kvistad KA, Rydland J, Smethurst HB, Lundgren S, Fjøsne HE, Haraldseth O. Axillary lymph node metastases in breast cancer: Preoperative detection with dynamic contrast enhanced MRI. Eur Radiol 2000;10:1464-1471

36.   Håberg A, Qu H,  Haraldseth O, Unsgård G, Sonnewald U. In vivo effects of adensosine A1 receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo 13C NMR spectroscopy. J Neurochem 2000;74:327-333

37.   Haraldseth O, Amundsen T, Rinck PA. Contrast-enhanced pulmonary MR imaging. MAGMA 1999;8:146-53

38.   Kvistad KA, Bakken IJ, Gribbestad IS, Ehrnholm B, Lundgren S, Fjøsne HE, Haraldseth O. Characterization of neoplastic and normal human breast tissues with in-vivo 1H MR spectroscopy. J Magn Reson Imag 1999;10:159-164

39.   Lombardi M, Jones RA, Westby J, Torheim G, Southon TE, Haraldseth O, Michelassi C, Kvaerness J, Rinck PA, L'Abbate A. Use of the mean transit time of an intravascular contrast agent as an exchange-insensitive index of myocardial perfusion. J Magn Reson Imag 1999;9:402-408

40.   Kvistad KA, Lundgren S, Fjøsne H, Smenes E, Smethurst H-B, Haraldseth O. Differentiating benign and malignant breast lesions with T2*-weighted first pass perfusion imaging. Acta Radiol 1999;40:45-51

41.   Håberg A, Takahashi M, Yamaguchi T, Hjelstuen M, Haraldseth O. Neuroprotective effect of the novel glutamate AMPA receptor antagonist YM872 assessed with in-vivo MR imaging of rat MCA occlusion. Brain Res 1998;811:63-70

42.   Håberg A, Qu H, Bakken IJ, Sande LM, White LR, Haraldseth O, Unsgård G, Aasly J, Sonnewald U. In vitro and ex vivo 13C-NMR spectroscopy studies of pyruvate recycling in brain. Dev Neurosci 1998;20:389-398

43.   Håberg A, Qu H, Haraldseth O, Unsgård G, Sonnewald U. In-vivo injection of [1-13C]glucose and [1,2-13C]acetate combined with ex-vivo 13C NMR spectroscopy: A novel approach to the study of MCA occlusion in rat. J Cereb Blood Flow Metab 1998;18:1223-1232

44.   Borchgrevink G, Kaasa Aa, McDonagh D, Stiles TC, Haraldseth O, Lereim I. Acute treatment of whiplash neck sprain injuries. A randomized trial of treatment during the first 14 days following a car accident. Spine 1998;23:25-31

45.   Borchgrevink G, Smevik O, Haave I, Haraldseth O, Nordby A, Lereim I. MRI of cerebrum and cervical columna within two days after "whiplash" neck sprain injury. Injury 1997;28:331-335

46.   Borchgrevink G, Røyneland L, Haraldseth O, Lereim I, Bjørndal A. National health consumption and chronic symptoms following neck sprain injuries (whiplash) caused by car collisions. Scand J Soc Med 1997;24:264-271

47.   Amundsen T, Kværness J, Jones RA, Waage A, Bjermer L, Nilsen G, Haraldseth O. MR perfusion imaging of patients with pulmonary embolism - a feasibility study. Radiology 1997;203:181-185

48.   Haraldseth O, Jones RA, Skottner A. A quantitative in-vivo MR imaging study of brain dehydration in diabetic rats and rats treated with peptide hormones. Magn Reson Imag 1997;15:203-210

49.   Sebastiani G, Godtliebsen F, Jones RA, Haraldseth O, Müller TB, Rinck PA. Analysis of dynamic magnetic resonance images. IEEE Tran Med Imag 1996;15:268-277

50.   Müller TB, Jones RA, Haraldseth O, Westby J, Unsgård G: Comparison of MR perfusion imaging and microsphere measurements of regional cerebral blood flow in a rat model of middle cerebral artery occlusion. Magn Reson Imag 1996;14:1177-1183

51.   Jones RA, Haraldseth O, Baptista AM, Müller TB, Øksendal AN. A study of the contribution of changes in the cerebral blood volume to the haemodynamic response to anoxia in rat brain. NMR in Biomed 1996 ;9:233-240

52.   Jones RA, Müller TB, Haraldseth O, Baptista A, Øksendal AN. Cerebrovascular changes in rats during ischaemia and reperfusion: A comparison of BOLD and first pass bolus tracking techniques. Magn Rrson Med 1996;35:489-496

53.   Haraldseth O, Jones RA, Müller TB, Fahlvik AK, Øksendal A. Comparison of dysprosiumDTPA BMA and superparamagnetic iron oxide particles as susceptibility contrast agents for perfusion imaging of regional cerebral ischemia. J Magn Reson Imag 1996; 6:714-717

54.   Müller TB, Haraldseth O, Jones RA, Sebastiani G, Lindboe CF, Unsgård G, Øksendal AN. Perfusion and diffusion-weighted MR imaging for in vivo evaluation of treatment with U74389G in a rat stroke model. Stroke 1995;26:1453-1458

55.   Müller TB, Haraldseth O, Jones RA, Sebastiani G, Godtliebsen F, Lindboe CF, Unsgård G. Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion. Stroke 1995;26:451-458

56.   Müller TB, Haraldseth O, Unsgård G. Characterization of flow in the penumbra during ischemia and reperfusion in a rat model of temporary MCA occlusion; a laser Doppler flowmetry study. Int J Microcirc 1994;14:289-295

57.   Müller TB, Haraldseth O, Sonnewald U, Unsgård G, Petersen SB. NBQX (2.3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline) did not affect recovery of high energy phosphates and pH in early reperfusion in a rat model of transient forebrain ischemia. An in-vivo 31P NMR spectroscopy study. Acta Anaesthesiol Scand 1994;38:170-174

58.   Haraldseth O, Jones RA, Schjøtt J, Rinck PA, Jynge P, Øksendal AN. Early detection of regional myocardial ischaemia in ex-vivo piglet hearts using MR imaging with magnetisation transfer. J Magn Reson Imag 1994;4:603-608

59.   Jones RA, Haraldseth O, Schjøtt J, Brurok H, Jynge P, Øksendal AN. Effect of GD-DTPA-BMA on magnetization transfer: Application to rapid imaging of cardiac ischemia. J Magn Reson Imag 1993;3:31-39

60.   Jones RA, Haraldseth O, Müller TB, Rinck PA, Øksendal AN. K-space substitution: A novel dynamic imaging technique. MRM 1993;29:830-834

61.   Haraldseth O, Grønås T, Jynge P, Gisvold SE, Unsgård G. The effect of magnesium on recovery after temporary global ischemia in the rat brain as assessed by 31 phosphorous nuclear magnetic resonance spectroscopy. Magnesium 1993

62.   Haraldseth O, Nygård Ø, Grønås T, Southon T, Gisvold SE, Unsgård G. Hyperglycemia in global cerebral ischemia and reperfusion: a 31-phosphorous NMR spectroscopy study in rats. Acta Anaesthesiol Scand 1992;36:25-30

63.   Haraldseth O, Grønås T, Southon T, Thommessen L, Borchgrevink G, Jynge P, Gisvold SE, Unsgård G. The effects of brain temperature on temporary global ischemia in rat brain. A 31-phosphorous NMR spectroscopy study. Acta Anaesthesiol Scand 1992;36:393-399

64.   Haraldseth O, Grønås T, Unsgård G. Quicker metabolic recovery after forebrain ischemia in rats treated with the antioxidant U74006F. Stroke 1991;22:188-1192

65.   Haraldseth O, Grønås T, Southon T, Jynge P, Gisvold SE, Unsgård G. The NMDA antagonist MK-801 improved metabolic recovery after 10 minutes global cerebral ischemia in rats measured with 31 phosphorous magnetic resonance spectroscopy. Acta neurochir (Wien) 1990;106:32-36

66.   Haraldseth O, Southon T, Grønås T, Jynge P, Gisvold SE, Unsgård G. 31 Phosphorous nuclear magnetic resonance spectroscopy of rat brain with temporary global cerebral ischemia - Methodology. Acta Neurochir (Wien) 1990;103:158-162