Background and activities
Pål Sætrom works to develop and use computational models to predict how changes in gene regulation can control development and cause disease.
Sætrom’s research focuses on non-coding RNAs (ncRNAs) and their roles in gene regulation and disease. Three major areas of research are (i) developing and validating computer models that can predict how genetic variation affects gene regulation (Nucleic Acids Res, 2011; PLoS Comput Biol, 2012; Bioinformatics, 2014); (ii) understanding the roles of ncRNAs in epigenetics and cell cycle regulation (Nucleic Acids Res, 2013; DNA Repair, 2015); and (iii) designing artificial RNAs for targeted gene regulation and therapy (Mol Ther, 2010; RNA, 2010; Hepatology, 2014).
|YEAR(s)||INSTITUTION AND LOCATION||DEGREE||FIELD OF STUDY|
|2005||NTNU, Trondheim, Norway||DPhil||Computer science (bioinformatics)|
|1996-2001||NTNU, Trondheim, Norway||M.Sc.||Computer science (algorithms)|
Positions and Employment
|2013-present||Adjunct Professor, Faculty of Biosciences and Aquaculture, University of Nordland, Norway|
|2012-present||Professor in bioinformatics, Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway|
|2011-present||Professor in bioinformatics, Department of Computer and Information Science, NTNU, Trondheim, Norway|
|2011||Guest researcher, Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden with Dr. Mikael Benson|
|2008-2011||Adjunct Associate Professor, Department of Computer and Information Science, NTNU, Trondheim, Norway|
|2007-2011||Post doctoral fellowship (Career development fellowships from NTNU and the Norwegian Research Council), Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway|
|2007||Adjunct Senior Lecturer, Department of Computer and Information Science, NTNU, Trondheim, Norway|
|2006-2007||Post doctoral fellowship (Leiv Erikson research scholarship from the Norwegian Research Council), Department of Molecular and Cellular Biology, City of Hope, Duarte, CA (12 months) with Prof. John J. Rossi|
|2002-2006||Research scientist, Interagon AS, Trondheim, Norway|
|2001-2002||Software Developer, Fast Search & Transfer ASA, Trondheim, Norway|
|2014||Outstanding Academic Fellow, NTNU|
|2008||PNAS Cozzarelli Prize in Biological Sciences (with D.H. Kim, O. Snøve, Jr., and J.J. Rossi)|
|2007-2010||Career research fellowship, Norwegian Functional Genomics Program (FUGE), Norwegian Research Council (NRC)|
|2007-2009||Career fellowship in Medical Technology, NTNU|
|2006||Research scholarship, FUGE, NRC|
|2006||Leiv Erikson research scholarship, NRC|
Publications listed in publication databases
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2015) RNA motif discovery: a computational overview. Biology Direct. vol. 10 (1).
- (2015) A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. Familial Cancer. vol. 14 (3).
- (2015) A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers. Familial Cancer. vol. 14 (1).
- (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. vol. 30.
- (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair. vol. 25.
- (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring. PLoS ONE. vol. 10:e0143496 (12).
- (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair. vol. 19.
- (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics. vol. 94 (2).
- (2014) Exploiting Human CD34(+) Stem Cell-conditioned Medium for Tissue Repair. Molecular Therapy. vol. 22 (1).
- (2014) The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences. Database: The Journal of Biological Databases and Curation.
- (2014) Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA. Diabetes. vol. 63 (12).
- (2014) A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo. Hepatology. vol. 59 (1).
- (2014) Circular RNAs are depleted of polymorphisms at microRNA binding sites. Bioinformatics. vol. 30 (16).
- (2013) MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases. RNA: A publication of the RNA Society. vol. 19 (11).
- (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Nucleic Acids Research. vol. 41 (5).
- (2013) Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase. DNA Repair. vol. 12 (1).
- (2013) Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells. Circulation Research. vol. 113 (3).
- (2013) A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells. Molecular Therapy - Nucleic Acids. vol. 2.
- (2013) Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting. Methods in Molecular Biology. vol. 942.
- (2012) Cell-type specificity of ChIP-predicted transcription factor binding sites. BMC Genomics. vol. 13.