Rajeevkumar Raveendran Nair

About

Currently, Core Manager/Researcher at the Viral Vector Core (VVC), Kavli Institute for Systems Neuroscience/CNC, NTNU. Viral Vector Core

PhD in Biotechnology from Rajiv Gandhi Centre for Biotechnology, Kerala, India. Thesis title: ‘Structure-Function relationships in the interactions between Calcium/calmodulin dependent protein kinase type II (CaMKII) and N-methyl-D-aspartate receptor (NMDAR) subunits’. After PhD, I joined Bramham group, UiB, Norway as Post Doctoral Fellow/Researcher (2006-2010, studying the post-translational modifications of another memory-associated protein Arc/Arg3.1). Later, I joined Tashiro group (2010-2013, investigating the role of NMDA receptors in adult-neurogenesis) and Kentros group (2013-2018, developing cell type-specific viral vectors) at Kavli Institute for Systems Neuroscience/CNC, NTNU as Post Doctoral Fellow/Researcher. Google scholar profile

Passionate in understanding the secrets of brain, interested in creating novel molecular tools, and designing & creating viral vectors to deliver genes inside the cells in a petriplate to complex mammalian brains. A Science enthusiast interested in writing blogs for communicating Science to general audience. Scientific blogs

Management Committee member representing Norway for COST Action (CA21113- Genome Editing to Treat Humans Diseases).

Publications

2026

Donate Lagartos, Maria Jose; Escobar-Doncel, Beatriz; Zhang, Shi-qi; Pan, Junping; González, Noemí Villaseca; Anisimov, Aleksander; Montaldo, Nicola Pietro; Jensen, Vidar; Mao, Lipeng; Li, Bailei. (2026) Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD+. Brain
Academic article

2025

Ortiz-Bueno, María; Ramos-Hernández, Iris; Algeciras-Jiménez, Luis; Kalter, Nechama; Rodríguez-Madoz, Juan Roberto; Bonafont, Jose; Raveendran Nair, Rajeevkumar; Feeney, Oliver; Torella, Laura; Montoliu, Lluis. (2025) Proceedings of the second annual meeting of GenE-HumDi (COST Action 21113). Frontiers in Genome Editing
Academic article
Ai, Ruixue; Mao, Lipeng; Jin, Xurui; Campos-Marques, Carlos; Zhang, Shi-qi; Pan, Junping; Donate Lagartos, Maria Jose; Cao, Shuqin; Barros-Santos, Beatriz; Nóbrega-Martins, Rita. (2025) NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C. Science Advances
Academic article
Swaminathan, Priyanka; Godø, Karsten Sættem; Bjørn, Eline Bærøe; Klingstedt, Therése; Chatterjee, Debdeep; Hammarström, Per; Raveendran Nair, Rajeevkumar; Lindgren, Mikael. (2025) Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn. Cells
Academic article

2024

Courcelles, Erik Justin; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno Peter; Nigro, Maximiliano Jose. (2024) Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin. European Journal of Neuroscience
Academic article
Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel; Grimstvedt, Joachim Schweder; Di Maria, Valentina; Moan, Kristian Magnus; Raveendran Nair, Rajeevkumar; Flatset, Marcus Sandbukt; Zhang, Qiangwei; Thomas, Laurent Francois. (2024) Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. Frontiers in Neuroscience
Academic article

2023

Courcelles, Erik Justin; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno Peter; Nigro, Maximiliano Jose. (2023) Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin. BioRxiv
Academic article
Grimstvedt, Joachim Schweder; Shelton, Andrew M; Hoerder-Suabedissen, Anna; Oliver, David K; Berndtsson, Christin Høiberget; Blankvoort, Stefan Matthias Adriaan; Raveendran Nair, Rajeevkumar; Packer, Adam M; Witter, Menno Peter; Kentros, Clifford George. (2023) A multifaceted architectural framework of the mouse claustrum complex. Journal of Comparative Neurology
Academic article
Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter. (2023) Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain Communications
Academic article

2022

Nigro, Maximiliano Jose; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno. (2022) Enrichment of specific GABAergic neuronal types in the mouse perirhinal cortex. BioRxiv
Academic article
Jacobsen, R. Irene; Raveendran Nair, Rajeevkumar; Obenhaus, Horst-Andreas; Donato, Flavio; Slettmoen, Torstein; Moser, May-Britt; Moser, Edvard Ingjald. (2022) All-viral tracing of monosynaptic inputs to single birthdate-defined neurons in the intact brain. Cell Reports Methods
Academic article
Bauer, Ulrich Stefan; Fiskum, Vegard; Raveendran Nair, Rajeevkumar; Wijdeven, Rosanne Francisca van de; Kentros, Clifford; Sandvig, Ioanna; Sandvig, Axel. (2022) Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing. Frontiers in Integrative Neuroscience
Academic article

2021

Ohara, Shinya; Blankvoort, Stefan; Raveendran, Rajeevkumar Nair; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno. (2021) Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex. eLIFE
Academic article
Nigro, Maximiliano Jose; Kirikae, Hinaco; Kjelsberg, Kasper; Raveendran, Rajeevkumar Nair; Witter, Menno P.. (2021) Not All That Is Gold Glitters: PV-IRES-Cre Mouse Line Shows Low Efficiency of Labeling of Parvalbumin Interneurons in the Perirhinal Cortex. Frontiers in Neural Circuits
Academic article
Nigro, Maximiliano Jose; Kirikae, Hinako; Kjelsberg, Kasper; Raveendran Nair, Rajeevkumar; Witter, Menno. (2021) Not all that is gold glitters: PV-IRES-Cre mouse line shows low efficiency of labeling of parvalbumin interneurons in the perirhinal cortex. BioRxiv
Academic article
Åmellem, Ingrid; Yovianto, Glen; Chong, Hai Tarng; Raveendran, Rajeevkumar Nair; Cnops, Vanja; Thanawalla, Ayesha; Tashiro, Ayumu. (2021) Role of NMDA receptors in adult neurogenesis and normal development of the dentate gyrus. eNeuro
Academic article

2020

Raveendran, Rajeevkumar Nair; Blankvoort, Stefan; Donate Lagartos, Maria Jose; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) Enables the Generation of Viral Vectors Specific to Neuronal Subtypes. iScience
Academic article
Madhavan, Mayadevi; G.Mohanan, Archana; Jacob, Reena Sarah; Gunasekaran, Sowmya; Raveendran, Rajeevkumar Nair; V, Omkumar Ramakrishnapillai. (2020) Glu60 of α-Calcium/calmodulin dependent protein kinase II mediates crosstalk between the regulatory T-site and protein substrate binding region of the active site. Archives of Biochemistry and Biophysics
Academic article

2019

Bauer, Ulrich Stefan; van de Wijdeven, Rosanne Francisca; Raveendran Nair, Rajeevkumar; Fiskum, Vegard; Kentros, Clifford; Sandvig, Ioanna; Sandvig, Axel. (2019) Modelling functional human neuromuscular junctions in a differentially-perturbable microfluidic environment, validated through recombinant monosynaptic pseudotyped ΔG-rabies virus tracing. BioRxiv
Academic article

2018

Nilssen, Eirik Stamland; Jacobsen, Bente; Raveendran, Rajeevkumar Nair; Fjeld, Gunhild; Blankvoort, Stefan; Kentros, Clifford; Witter, Menno. (2018) Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex. Journal of Neuroscience
Academic article
Raveendran, Rajeevkumar Nair; Chandrika, Arunkumar Renganathan; Steephan, Mathew; Devi, Suma Priya Sudarsana; Kumar, Mantosh; Paul, Soumya; Madhavan, Mayadevi; V, Omkumar Ramakrishnapillai. (2018) A simple end-point assay for calcium channel activity. Cell Calcium
Academic article

2017

Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Raveendran, Rajeevkumar Nair. (2017) Arc interacts with the integral endoplasmic reticulum protein, calnexin. Frontiers in Cellular Neuroscience
Academic article
Raveendran, Rajeevkumar Nair; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R.. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. Frontiers in Synaptic Neuroscience
Academic article

2015

Hall, Malgorzata H.; Magalska, Adriana; Malinowska, Monika; Ruszczycki, Blazej; Czaban, Iwona; Patel, Satyam; Ambrozek-Latecka, Magdalena; Zolocinska, Ewa; Broszkiewicz, Hanna; Parobczak, Kamil. (2015) Localization and regulation of PML bodies in the adult mouse brain. Brain Structure and Function
Academic article

2010

Bramham, Clive R. Evjen; Alme, Maria Nordheim; Bittins, Margarethe; Kuipers, Sjoukje; Nair, Rajeevkumar R; Pai, Balagopal Sreenivasa; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian. (2010) The Arc of synaptic memory. Experimental Brain Research
Academic literature review

2009

Bramham, Clive R. Evjen; Panja, Debabrata; Tiron, Adrian; Raveendran Nair, Rajeevkumar; Wibrand, Karin; Kuipers, S. (2009) Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. European Neuropsychopharmacology
Conference abstract
Raveendran Nair, Rajeevkumar; Devi, Suma Priya Sudarsana; Madhavan, Mayadevi; Mathew, Steephan; R., Santhoshkumar Thankayyan; John, Cheriyan; Rajendran, Sanalkumar; Jackson, James; V, Omkumar Ramakrishnapillai. (2009) Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin‐dependent protein kinase II. Journal of Neurochemistry
Academic article

Journal publications

Donate Lagartos, Maria Jose; Escobar-Doncel, Beatriz; Zhang, Shi-qi; Pan, Junping; González, Noemí Villaseca; Anisimov, Aleksander; Montaldo, Nicola Pietro; Jensen, Vidar; Mao, Lipeng; Li, Bailei. (2026) Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD+. Brain
Academic article
Ortiz-Bueno, María; Ramos-Hernández, Iris; Algeciras-Jiménez, Luis; Kalter, Nechama; Rodríguez-Madoz, Juan Roberto; Bonafont, Jose; Raveendran Nair, Rajeevkumar; Feeney, Oliver; Torella, Laura; Montoliu, Lluis. (2025) Proceedings of the second annual meeting of GenE-HumDi (COST Action 21113). Frontiers in Genome Editing
Academic article
Ai, Ruixue; Mao, Lipeng; Jin, Xurui; Campos-Marques, Carlos; Zhang, Shi-qi; Pan, Junping; Donate Lagartos, Maria Jose; Cao, Shuqin; Barros-Santos, Beatriz; Nóbrega-Martins, Rita. (2025) NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C. Science Advances
Academic article
Swaminathan, Priyanka; Godø, Karsten Sættem; Bjørn, Eline Bærøe; Klingstedt, Therése; Chatterjee, Debdeep; Hammarström, Per; Raveendran Nair, Rajeevkumar; Lindgren, Mikael. (2025) Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn. Cells
Academic article
Courcelles, Erik Justin; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno Peter; Nigro, Maximiliano Jose. (2024) Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin. European Journal of Neuroscience
Academic article
Hall, Malgorzata H.; Magalska, Adriana; Malinowska, Monika; Ruszczycki, Blazej; Czaban, Iwona; Patel, Satyam; Ambrozek-Latecka, Magdalena; Zolocinska, Ewa; Broszkiewicz, Hanna; Parobczak, Kamil. (2015) Localization and regulation of PML bodies in the adult mouse brain. Brain Structure and Function
Academic article
Courcelles, Erik Justin; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno Peter; Nigro, Maximiliano Jose. (2023) Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin. BioRxiv
Academic article
Bramham, Clive R. Evjen; Panja, Debabrata; Tiron, Adrian; Raveendran Nair, Rajeevkumar; Wibrand, Karin; Kuipers, S. (2009) Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. European Neuropsychopharmacology
Conference abstract
Ohara, Shinya; Blankvoort, Stefan; Raveendran, Rajeevkumar Nair; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno. (2021) Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex. eLIFE
Academic article
Raveendran, Rajeevkumar Nair; Blankvoort, Stefan; Donate Lagartos, Maria Jose; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) Enables the Generation of Viral Vectors Specific to Neuronal Subtypes. iScience
Academic article
Nigro, Maximiliano Jose; Kirikae, Hinaco; Kjelsberg, Kasper; Raveendran, Rajeevkumar Nair; Witter, Menno P.. (2021) Not All That Is Gold Glitters: PV-IRES-Cre Mouse Line Shows Low Efficiency of Labeling of Parvalbumin Interneurons in the Perirhinal Cortex. Frontiers in Neural Circuits
Academic article
Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Raveendran, Rajeevkumar Nair. (2017) Arc interacts with the integral endoplasmic reticulum protein, calnexin. Frontiers in Cellular Neuroscience
Academic article
Nigro, Maximiliano Jose; Kirikae, Hinako; Kjelsberg, Kasper; Raveendran Nair, Rajeevkumar; Witter, Menno. (2021) Not all that is gold glitters: PV-IRES-Cre mouse line shows low efficiency of labeling of parvalbumin interneurons in the perirhinal cortex. BioRxiv
Academic article
Nilssen, Eirik Stamland; Jacobsen, Bente; Raveendran, Rajeevkumar Nair; Fjeld, Gunhild; Blankvoort, Stefan; Kentros, Clifford; Witter, Menno. (2018) Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex. Journal of Neuroscience
Academic article
Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel; Grimstvedt, Joachim Schweder; Di Maria, Valentina; Moan, Kristian Magnus; Raveendran Nair, Rajeevkumar; Flatset, Marcus Sandbukt; Zhang, Qiangwei; Thomas, Laurent Francois. (2024) Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. Frontiers in Neuroscience
Academic article
Nigro, Maximiliano Jose; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno. (2022) Enrichment of specific GABAergic neuronal types in the mouse perirhinal cortex. BioRxiv
Academic article
Bauer, Ulrich Stefan; van de Wijdeven, Rosanne Francisca; Raveendran Nair, Rajeevkumar; Fiskum, Vegard; Kentros, Clifford; Sandvig, Ioanna; Sandvig, Axel. (2019) Modelling functional human neuromuscular junctions in a differentially-perturbable microfluidic environment, validated through recombinant monosynaptic pseudotyped ΔG-rabies virus tracing. BioRxiv
Academic article
Raveendran, Rajeevkumar Nair; Chandrika, Arunkumar Renganathan; Steephan, Mathew; Devi, Suma Priya Sudarsana; Kumar, Mantosh; Paul, Soumya; Madhavan, Mayadevi; V, Omkumar Ramakrishnapillai. (2018) A simple end-point assay for calcium channel activity. Cell Calcium
Academic article
Madhavan, Mayadevi; G.Mohanan, Archana; Jacob, Reena Sarah; Gunasekaran, Sowmya; Raveendran, Rajeevkumar Nair; V, Omkumar Ramakrishnapillai. (2020) Glu60 of α-Calcium/calmodulin dependent protein kinase II mediates crosstalk between the regulatory T-site and protein substrate binding region of the active site. Archives of Biochemistry and Biophysics
Academic article
Jacobsen, R. Irene; Raveendran Nair, Rajeevkumar; Obenhaus, Horst-Andreas; Donato, Flavio; Slettmoen, Torstein; Moser, May-Britt; Moser, Edvard Ingjald. (2022) All-viral tracing of monosynaptic inputs to single birthdate-defined neurons in the intact brain. Cell Reports Methods
Academic article
Grimstvedt, Joachim Schweder; Shelton, Andrew M; Hoerder-Suabedissen, Anna; Oliver, David K; Berndtsson, Christin Høiberget; Blankvoort, Stefan Matthias Adriaan; Raveendran Nair, Rajeevkumar; Packer, Adam M; Witter, Menno Peter; Kentros, Clifford George. (2023) A multifaceted architectural framework of the mouse claustrum complex. Journal of Comparative Neurology
Academic article
Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter. (2023) Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain Communications
Academic article
Bauer, Ulrich Stefan; Fiskum, Vegard; Raveendran Nair, Rajeevkumar; Wijdeven, Rosanne Francisca van de; Kentros, Clifford; Sandvig, Ioanna; Sandvig, Axel. (2022) Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing. Frontiers in Integrative Neuroscience
Academic article
Åmellem, Ingrid; Yovianto, Glen; Chong, Hai Tarng; Raveendran, Rajeevkumar Nair; Cnops, Vanja; Thanawalla, Ayesha; Tashiro, Ayumu. (2021) Role of NMDA receptors in adult neurogenesis and normal development of the dentate gyrus. eNeuro
Academic article
Bramham, Clive R. Evjen; Alme, Maria Nordheim; Bittins, Margarethe; Kuipers, Sjoukje; Nair, Rajeevkumar R; Pai, Balagopal Sreenivasa; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian. (2010) The Arc of synaptic memory. Experimental Brain Research
Academic literature review
Raveendran, Rajeevkumar Nair; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R.. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. Frontiers in Synaptic Neuroscience
Academic article
Raveendran Nair, Rajeevkumar; Devi, Suma Priya Sudarsana; Madhavan, Mayadevi; Mathew, Steephan; R., Santhoshkumar Thankayyan; John, Cheriyan; Rajendran, Sanalkumar; Jackson, James; V, Omkumar Ramakrishnapillai. (2009) Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin‐dependent protein kinase II. Journal of Neurochemistry
Academic article

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