Viral Vector Core


Viral Vector Core

The Viral Vector Core at Kavli Institute for Systems Neuroscience is a well-equipped facility having rare expertise to make high quality viruses for research purposes. We are a non-profit facility that offers consultation, design and construction of a wide variety of viral vectors to augment scientific research.

Viral vector Core

Recombinant viruses

Recombinant viruses are highly efficient gene delivery vehicles for introducing molecular tools to difficult-to-transfect primary cells, to create stable cell lines, to transduce tissues in vivo for elucidating underlying biological mechanisms and nowadays for gene therapy applications in clinics.

A combinatorial approach using viral vectors with the vast repertoire of transgenic animals available is a powerful strategy to target specific cells in complex organs such as mammalian brains.

Adeno-associated virus, Moloney murine leukemia virus, Lenti virus and pseudotyped G-deleted rabies virus are all common transgene-delivery agents, each having distinct characteristics making them suitable for specific research questions.

Depending on the scientific question, one may need viral tools with specific features, demanding novel vector designs.

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Viral Vector Core

Adeno-associated virus mediated transgene expression (yellow and green color) in medial entorhinal cortex of rat brain. Neurons are shown in red color. This specific gene expression is driven by a medial entorhinal cortex specific enhancer.


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