The normal human brain is made up of about 100 billion nerve cells (neurons). Each nerve cell can have an average of approximately 10-20,000 points of contact with other nerve cells. These contact points are called synapses, which is where the storage of memories takes place.

Researchers at the Kavli Institute for Systems Neuroscience explore the brain's functioning by detecting and analysing the electrical signals in the brain, primarily in the regions of the brain called the entorhinal cortex and hippocampus. The hippocamus is an older part of the cerebral cortex and has a central role in the functioning of human and animal memory, while the entorhinal cortex contains grid cells, border cells, direction cells, and speed cells that together give the brain the ability to make highly advanced maps.

Since the centre’s inception, Kavli researchers have used laboratory rats as study animals. In the experiments, rats run around in boxes and corridors chasing treats. Simultaneously, very thin electrodes inserted into their brains enable researchers to detect their brain activity. The electrodes, placed in the space between the brain cells, are so sensitive that they distinguish signals from individual neurons in the network. Today KISN research groups study higher brain functions in rats, mice, zebrafish and humans using experimental and theoretical approaches.